Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells

International Journal of Oncology

Volumn 44, Issue 4, 2014, Pages 1309-1315

  Park, Ki Woong ^a   Kundu, Juthika ^a   Chae, In Gyeong ^a   Kim, Do Hee ^b   Yu, Mi Hee ^a   Kundu, Joydeb Kumar ^a   Chun, Kyung Soo ^a  

^a Keimyung University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Apoptosis; Carnosol; Colon cancer; p53; Reactive oxygen species; Signal transducer and activator of transcription 3

Indexed keywords

ABIETANE DERIVATIVE; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; BIRC5 PROTEIN, HUMAN; CARNOSOL; CASPASE 3; CASPASE 9; CCND2 PROTEIN, HUMAN; CCND3 PROTEIN, HUMAN; CYCLIN D1; CYCLIN D2; CYCLIN D3; DNA BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; MDM2 PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL X; PROTEIN MDM2; PROTEIN P53; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; BIOSYNTHESIS; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG EFFECTS; HCT116 CELL LINE; HUMAN; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIN D1; CYCLIN D2; CYCLIN D3; DITERPENES, ABIETANE; DNA-BINDING PROTEINS; HCT116 CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; JANUS KINASE 2; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-MDM2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STAT3 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84894470103     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2281     Document Type: Article

References (36)

1. Jemal A, Center MM, DeSantis C and Ward EM: Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 19: 1893-1907, 2010.
2. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
3. Merika E, Saif MW, Katz A, Syrigos K and Morse M: Review. Colon cancer vaccines: an update. In Vivo 24: 607-628, 2010.
4. Chung MY, Lim TG and Lee KW: Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development. World J Gastroenterol 19: 984-993, 2013.
5. Moran AE, Carothers AM, Weyant MJ, Redston M and Bertagnolli MM: Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse. Cancer Res 65: 1097-1104, 2005. (Pubitemid 40216473)
6. Cheng AC, Lee MF, Tsai ML, et al: Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Food Chem Toxicol 49: 485-493, 2011.
7. Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
8. Neergheen VS, Bahorun T, Taylor EW, Jen LS and Aruoma OI: Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention. Toxicology 278: 229-241, 2010.
9. Burz C, Berindan-Neagoe I, Balacescu O and Irimie A: Apoptosis in cancer: key molecular signaling pathways and therapy targets. Acta Oncol 48: 811-821, 2009.
10. Martin SJ and Green DR: Protease activation during apoptosis: death by a thousand cuts? Cell 82: 349-352, 1995.
11. Aggarwal BB, Takada Y and Oommen OV: From chemoprevention to chemotherapy: common targets and common goals. Expert Opin Investig Drugs 13: 1327-1338, 2004. (Pubitemid 39359662)
12. Johnston PA and Grandis JR: STAT3 signaling: anticancer strategies and challenges. Mol Interv 11: 18-26, 2011.
13. Masuda M, Suzui M, Yasumatu R, et al: Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 62: 3351-3355, 2002. (Pubitemid 34651376)
14. Lau GK and Ye D: STAT3 implicated in the development of colon cancer: a step closer for targeted therapy? Gastroenterology 139: 353-355, 2010.
15. Lin L, Liu A, Peng Z, et al: STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer Res 71: 7226-7237, 2011.
16. Slattery ML, Lundgreen A, Kadlubar SA, Bondurant KL and Wolff RK: JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. Mol Carcinog 52: 155-166, 2013.
17. Laird AD, Li G, Moss KG, et al: Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumor cells. Mol Cancer Ther 2: 461-469, 2003.
18. Kundu J, Wahab SM, Kundu JK, et al: Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting beta-catenin signaling. Int J Oncol 41: 839-848, 2012.
19. Kundu JK, Shin YK, Kim SH and Surh YJ: Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis 27: 1465-1474, 2006. (Pubitemid 43994860)
20. Johnson JJ: Carnosol: a promising anti-cancer and anti-inflammatory agent. Cancer Lett 305: 1-7, 2011.
21. Dorrie J, Sapala K and Zunino SJ: Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells. Cancer Lett 170: 33-39, 2001. (Pubitemid 32607658)
22. Johnson JJ, Syed DN, Heren CR, Suh Y, Adhami VM and Mukhtar H: Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5′-AMP-activated protein kinase (AMPK) pathway. Pharm Res 25: 2125-2134, 2008.
23. Cherbonnel-Lasserre C and Dosanjh MK: Suppression of apoptosis by overexpression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage. Biochimie 79: 613-617, 1997. (Pubitemid 28021570)
24. Zhu S, Li T, Tan J, et al: Bax is essential for death receptor-mediated apoptosis in human colon cancer cells. Cancer Biother Radiopharm 27: 577-581, 2012.
25. Valassiadou KE, Stefanaki K, Tzardi M, et al: Immunohistochemical expression of p53, bcl-2, mdm2 and waf1/p21 proteins in colorectal adenocarcinomas. Anticancer Res 17: 2571-2576, 1997. (Pubitemid 27352655)
26. Bonnotte B, Favre N, Moutet M, et al: Bcl-2-mediated inhibition of apoptosis prevents immunogenicity and restores tumorigenicity of spontaneously regressive tumors. J Immunol 161: 1433-1438, 1998. (Pubitemid 28380574)
27. Shaw P, Bovey R, Tardy S, Sahli R, Sordat B and Costa J: Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA 89: 4495-4499, 1992.
28. Kim DH, Kundu JK and Surh YJ: Redox modulation of p53: mechanisms and functional significance. Mol Carcinog 50: 222-234, 2011.
29. Rigatti MJ, Verma R, Belinsky GS, Rosenberg DW and Giardina C: Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells. Mol Carcinog 51: 363-378, 2012.
30. Miyashita T and Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299, 1995.
31. Miyashita T, Krajewski S, Krajewska M, et al: Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-1805, 1994. (Pubitemid 24163411)
32. Lotem J, Peled-Kamar M, Groner Y and Sachs L: Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds, and cytokines. Proc Natl Acad Sci USA 93: 9166-9171, 1996. (Pubitemid 26282036)
33. Corvinus FM, Orth C, Moriggl R, et al: Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia 7: 545-555, 2005. (Pubitemid 40967755)
34. Lin Q, Lai R, Chirieac LR, et al: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol 167: 969-980, 2005. (Pubitemid 41416250)
35. Kanda N, Seno H, Konda Y, et al: STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene 23: 4921-4929, 2004. (Pubitemid 38932164)
36. Asanuma K, Tsuji N, Endoh T, Yagihashi A and Watanabe N: Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells. J Immunol 172: 3922-3929, 2004. (Pubitemid 38337980)