메뉴 건너뛰기




Volumn 20, Issue 1, 2014, Pages 193-203

Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells

Author keywords

Apoptosis; Cell cycle; Diallyl trisulfide; p53; Pancreatic cancer

Indexed keywords

CYCLIN B1; CYCLIN D1; DIALLYL TRISULFIDE; FAS ANTIGEN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P21; PROTEIN P53;

EID: 84891795464     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i1.193     Document Type: Article
Times cited : (44)

References (52)
  • 1
    • 84855792427 scopus 로고    scopus 로고
    • Cancer statistics, 2012
    • [PMID: 22237781 DOI: 10.3322/caac.20138]
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012; 62: 10-29 [PMID: 22237781 DOI: 10.3322/caac.20138]
    • (2012) CA Cancer J Clin , vol.62 , pp. 10-29
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 2
    • 78049248860 scopus 로고    scopus 로고
    • Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells
    • [PMID: 20531243 DOI: 10.1097/MPA.0b013e3181dd63e1]
    • Deorukhkar A, Shentu S, Park HC, Diagaradjane P, Pudu-valli V, Aggarwal B, Guha S, Krishnan S. Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells. Pancreas 2010; 39: 1277-1283 [PMID: 20531243 DOI: 10.1097/MPA.0b013e3181dd63e1]
    • (2010) Pancreas , vol.39 , pp. 1277-1283
    • Deorukhkar, A.1    Shentu, S.2    Park, H.C.3    Diagaradjane, P.4    Pudu-Valli, V.5    Aggarwal, B.6    Guha, S.7    Krishnan, S.8
  • 3
    • 84864366177 scopus 로고    scopus 로고
    • Sensitization of human pancreatic cancer cells harboring mutated K-ras to apoptosis
    • [PMID: 22848379 DOI: 10.1371/journal. pone.0040435]
    • Shen L, Kim SH, Chen CY. Sensitization of human pancreatic cancer cells harboring mutated K-ras to apoptosis. PLoS One 2012; 7: e40435 [PMID: 22848379 DOI: 10.1371/journal. pone.0040435]
    • (2012) PLoS One , vol.7
    • Shen, L.1    Kim, S.H.2    Chen, C.Y.3
  • 4
    • 84861049919 scopus 로고    scopus 로고
    • Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways
    • [PMID: 22570653 DOI: 10.1155/2012/796729]
    • Farhana L, Dawson MI, Das JK, Murshed F, Xia Z, Hadden TJ, Hatfeld J, Fontana JA. Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways. J Oncol 2012; 2012: 796729 [PMID: 22570653 DOI: 10.1155/2012/796729]
    • (2012) J Oncol , vol.2012 , pp. 796729
    • Farhana, L.1    Dawson, M.I.2    Das, J.K.3    Murshed, F.4    Xia, Z.5    Hadden, T.J.6    Hatfeld, J.7    Fontana, J.A.8
  • 6
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • [PMID: 21376230 DOI: 10.1016/j.cell.2011.02.013]
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674 [PMID: 21376230 DOI: 10.1016/j.cell.2011.02.013]
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 67349150698 scopus 로고    scopus 로고
    • Targeting apoptosis as an approach for gastrointestinal cancer therapy
    • [PMID: 19278896 DOI: 10.1016/j.drup.2009.02.002]
    • Qiao L, Wong BC. Targeting apoptosis as an approach for gastrointestinal cancer therapy. Drug Resist Updat 2009; 12: 55-64 [PMID: 19278896 DOI: 10.1016/j.drup.2009.02.002]
    • (2009) Drug Resist Updat , vol.12 , pp. 55-64
    • Qiao, L.1    Wong, B.C.2
  • 8
    • 33644869135 scopus 로고    scopus 로고
    • Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial trans-location of BAD and caspase-mediated apoptosis in human prostate cancer cells
    • [PMID: 16169930]
    • Xiao D, Singh SV. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial trans-location of BAD and caspase-mediated apoptosis in human prostate cancer cells. Carcinogenesis 2006; 27: 533-540 [PMID: 16169930]
    • (2006) Carcinogenesis , vol.27 , pp. 533-540
    • Xiao, D.1    Singh, S.V.2
  • 9
    • 34250721692 scopus 로고    scopus 로고
    • Mitochondria-mediated apop-tosis by diallyl trisulfde in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak
    • [PMID: 17513609]
    • Kim YA, Xiao D, Xiao H, Powolny AA, Lew KL, Reilly ML, Zeng Y, Wang Z, Singh SV. Mitochondria-mediated apop-tosis by diallyl trisulfde in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak. Mol Cancer Ther 2007; 6: 1599-1609 [PMID: 17513609]
    • (2007) Mol Cancer Ther , vol.6 , pp. 1599-1609
    • Kim, Y.A.1    Xiao, D.2    Xiao, H.3    Powolny, A.A.4    Lew, K.L.5    Reilly, M.L.6    Zeng, Y.7    Wang, Z.8    Singh, S.V.9
  • 10
    • 68049118825 scopus 로고    scopus 로고
    • Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells
    • [PMID: 19622577 DOI: 10.1158/1078-0432.CCR-09-0512]
    • Stan SD, Singh SV. Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells. Clin Cancer Res 2009; 15: 4895-4903 [PMID: 19622577 DOI: 10.1158/1078-0432.CCR-09-0512]
    • (2009) Clin Cancer Res , vol.15 , pp. 4895-4903
    • Stan, S.D.1    Singh, S.V.2
  • 11
    • 58049183376 scopus 로고    scopus 로고
    • Effects of diallyl disulfde (DADS) on expression of apoptosis associated proteins in androgen independent human prostate cancer cells (PC-3)
    • [PMID: 18759062 DOI: 10.1007/s11010-008-9903-5]
    • Gayathri R, Gunadharini DN, Arunkumar A, Senthilkumar K, Krishnamoorthy G, Banudevi S, Vignesh RC, Arunak-aran J. Effects of diallyl disulfde (DADS) on expression of apoptosis associated proteins in androgen independent human prostate cancer cells (PC-3). Mol Cell Biochem 2009; 320: 197-203 [PMID: 18759062 DOI: 10.1007/s11010-008-9903-5]
    • (2009) Mol Cell Biochem , vol.320 , pp. 197-203
    • Gayathri, R.1    Gunadharini, D.N.2    Arunkumar, A.3    Senthilkumar, K.4    Krishnamoorthy, G.5    Banudevi, S.6    Vignesh, R.C.7    Arunak-Aran, J.8
  • 12
    • 77951102768 scopus 로고    scopus 로고
    • Garlic-derived antican-cer agents: Structure and biological activity of ajoene
    • [PMID: 20108330 DOI: 10.1002/biof.76]
    • Kaschula CH, Hunter R, Parker MI. Garlic-derived antican-cer agents: structure and biological activity of ajoene. Biofac-tors 2010; 36: 78-85 [PMID: 20108330 DOI: 10.1002/biof.76]
    • (2010) Biofac-tors , vol.36 , pp. 78-85
    • Kaschula, C.H.1    Hunter, R.2    Parker, M.I.3
  • 13
    • 51349109112 scopus 로고    scopus 로고
    • Multitargeted prevention and therapy of cancer by diallyl trisulfde and related Allium vegetable-derived organosulfur compounds
    • [PMID: 18579286 DOI: 10.1016/j.canlet.2008.05.027]
    • Powolny AA, Singh SV. Multitargeted prevention and therapy of cancer by diallyl trisulfde and related Allium vegetable-derived organosulfur compounds. Cancer Lett 2008; 269: 305-314 [PMID: 18579286 DOI: 10.1016/j.canlet.2008.05.027]
    • (2008) Cancer Lett , vol.269 , pp. 305-314
    • Powolny, A.A.1    Singh, S.V.2
  • 14
    • 0035126826 scopus 로고    scopus 로고
    • Historical perspective on the use of garlic
    • [PMID: 11238795]
    • Rivlin RS. Historical perspective on the use of garlic. J Nutr 2001; 131: 951S-954S [PMID: 11238795]
    • (2001) J Nutr , vol.131
    • Rivlin, R.S.1
  • 16
    • 79960020615 scopus 로고    scopus 로고
    • Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis
    • [PMID: 21473867 DOI: 10.1053/ j.gastro.2011.03.057]
    • Zhou Y, Zhuang W, Hu W, Liu GJ, Wu TX, Wu XT. Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis. Gastroenterol-ogy 2011; 141: 80-89 [PMID: 21473867 DOI: 10.1053/ j.gastro.2011.03.057]
    • (2011) Gastroenterol-ogy , vol.141 , pp. 80-89
    • Zhou, Y.1    Zhuang, W.2    Hu, W.3    Liu, G.J.4    Wu, T.X.5    Wu, X.T.6
  • 18
    • 0023221785 scopus 로고
    • Diallyl sulfde, a favor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer
    • [PMID: 3815744]
    • Wargovich MJ. Diallyl sulfde, a favor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer. Carcinogenesis 1987; 8: 487-489 [PMID: 3815744]
    • (1987) Carcinogenesis , vol.8 , pp. 487-489
    • Wargovich, M.J.1
  • 19
    • 0024273970 scopus 로고
    • Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thio-ether, diallyl sulfde
    • [PMID: 3180095]
    • Wargovich MJ, Woods C, Eng VW, Stephens LC, Gray K. Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thio-ether, diallyl sulfde. Cancer Res 1988; 48: 6872-6875 [PMID: 3180095]
    • (1988) Cancer Res , vol.48 , pp. 6872-6875
    • Wargovich, M.J.1    Woods, C.2    Eng, V.W.3    Stephens, L.C.4    Gray, K.5
  • 20
    • 0026736766 scopus 로고
    • Enhancing effects of diallyl sulfde on hepatocarcinogen-esis and inhibitory actions of the related diallyl disulfde on colon and renal carcinogenesis in rats
    • [PMID: 1394833]
    • Takahashi S, Hakoi K, Yada H, Hirose M, Ito N, Fukushima S. Enhancing effects of diallyl sulfde on hepatocarcinogen-esis and inhibitory actions of the related diallyl disulfde on colon and renal carcinogenesis in rats. Carcinogenesis 1992; 13: 1513-1518 [PMID: 1394833]
    • (1992) Carcinogenesis , vol.13 , pp. 1513-1518
    • Takahashi, S.1    Hakoi, K.2    Yada, H.3    Hirose, M.4    Ito, N.5    Fukushima, S.6
  • 21
    • 0027290648 scopus 로고
    • Chemopreven-tion of colon carcinogenesis by organosulfur compounds
    • [PMID: 8339252]
    • Reddy BS, Rao CV, Rivenson A, Kelloff G. Chemopreven-tion of colon carcinogenesis by organosulfur compounds. Cancer Res 1993; 53: 3493-3498 [PMID: 8339252]
    • (1993) Cancer Res , vol.53 , pp. 3493-3498
    • Reddy, B.S.1    Rao, C.V.2    Rivenson, A.3    Kelloff, G.4
  • 22
    • 0029936481 scopus 로고    scopus 로고
    • Garlic and associated allyl sulfur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis
    • [PMID: 8603370]
    • Schaffer EM, Liu JZ, Green J, Dangler CA, Milner JA. Garlic and associated allyl sulfur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis. Cancer Lett 1996; 102: 199-204 [PMID: 8603370]
    • (1996) Cancer Lett , vol.102 , pp. 199-204
    • Schaffer, E.M.1    Liu, J.Z.2    Green, J.3    Dangler, C.A.4    Milner, J.A.5
  • 23
    • 0030761364 scopus 로고    scopus 로고
    • Inhibitory effects of diallyl disulfde or aspirin on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary carcinogenesis in rats
    • [PMID: 9330600]
    • Suzui N, Sugie S, Rahman KM, Ohnishi M, Yoshimi N, Wak-abayashi K, Mori H. Inhibitory effects of diallyl disulfde or aspirin on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary carcinogenesis in rats. Jpn J Cancer Res 1997; 88: 705-711 [PMID: 9330600]
    • (1997) Jpn J Cancer Res , vol.88 , pp. 705-711
    • Suzui, N.1    Sugie, S.2    Rahman, K.M.3    Ohnishi, M.4    Yoshimi, N.5    Wak-Abayashi, K.6    Mori, H.7
  • 24
    • 84862728631 scopus 로고    scopus 로고
    • Garlic constituent diallyl trisulfde induced apoptosis in MCF7 human breast cancer cells
    • [PMID: 19823037]
    • Malki A, El-Saadani M, Sultan AS. Garlic constituent diallyl trisulfde induced apoptosis in MCF7 human breast cancer cells. Cancer Biol Ther 2009; 8: 2175-2185 [PMID: 19823037]
    • (2009) Cancer Biol Ther , vol.8 , pp. 2175-2185
    • Malki, A.1    El-Saadani, M.2    Sultan, A.S.3
  • 25
    • 58149316018 scopus 로고    scopus 로고
    • Diallyl disulfde induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplas-mic reticulum stress, caspases casade and mitochondrial-dependent pathways
    • [PMID: 19038304 DOI: 10.1016/j.fct.2008.10.032]
    • Yang JS, Chen GW, Hsia TC, Ho HC, Ho CC, Lin MW, Lin SS, Yeh RD, Ip SW, Lu HF, Chung JG. Diallyl disulfde induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplas-mic reticulum stress, caspases casade and mitochondrial-dependent pathways. Food Chem Toxicol 2009; 47: 171-179 [PMID: 19038304 DOI: 10.1016/j.fct.2008.10.032]
    • (2009) Food Chem Toxicol , vol.47 , pp. 171-179
    • Yang, J.S.1    Chen, G.W.2    Hsia, T.C.3    Ho, H.C.4    Ho, C.C.5    Lin, M.W.6    Lin, S.S.7    Yeh, R.D.8    Ip, S.W.9    Lu, H.F.10    Chung, J.G.11
  • 26
    • 0034734611 scopus 로고    scopus 로고
    • Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
    • [PMID: 11048643]
    • Hong YS, Ham YA, Choi JH, Kim J. Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines. Exp Mol Med 2000; 32: 127-134 [PMID: 11048643]
    • (2000) Exp Mol Med , vol.32 , pp. 127-134
    • Hong, Y.S.1    Ham, Y.A.2    Choi, J.H.3    Kim, J.4
  • 27
    • 33947174588 scopus 로고    scopus 로고
    • Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells
    • [PMID: 17219050]
    • Karmakar S, Banik NL, Patel SJ, Ray SK. Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apopto-sis 2007; 12: 671-684 [PMID: 17219050]
    • (2007) Apopto-sis , vol.12 , pp. 671-684
    • Karmakar, S.1    Banik, N.L.2    Patel, S.J.3    Ray, S.K.4
  • 29
    • 0029038135 scopus 로고
    • Apoptosis, cancer and the p53 tumour suppressor gene
    • [PMID: 7554031]
    • Lee JM, Bernstein A. Apoptosis, cancer and the p53 tumour suppressor gene. Cancer Metastasis Rev 1995; 14: 149-161 [PMID: 7554031]
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 149-161
    • Lee, J.M.1    Bernstein, A.2
  • 30
    • 0029097316 scopus 로고
    • Molecular controls of growth arrest and apoptosis: P53-dependent and independent pathways
    • [PMID: 7624128]
    • Liebermann DA, Hoffman B, Steinman RA. Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways. Oncogene 1995; 11: 199-210 [PMID: 7624128]
    • (1995) Oncogene , vol.11 , pp. 199-210
    • Liebermann, D.A.1    Hoffman, B.2    Steinman, R.A.3
  • 32
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • [PMID: 1505019]
    • Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell 1992; 70: 523-526 [PMID: 1505019]
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 34
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • [PMID: 8242751]
    • Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75: 805-816 [PMID: 8242751]
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 35
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • [PMID: 12154352]
    • Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002; 2: 594-604 [PMID: 12154352]
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 36
    • 33646756222 scopus 로고    scopus 로고
    • Dissecting p53-dependent apoptosis
    • [PMID: 16543937]
    • Chipuk JE, Green DR. Dissecting p53-dependent apoptosis. Cell Death Differ 2006; 13: 994-1002 [PMID: 16543937]
    • (2006) Cell Death Differ , vol.13 , pp. 994-1002
    • Chipuk, J.E.1    Green, D.R.2
  • 37
    • 67349086630 scopus 로고    scopus 로고
    • The mitochondrial p53 pathway
    • [PMID: 19007744]
    • Vaseva AV, Moll UM. The mitochondrial p53 pathway. Bio-chim Biophys Acta 2009; 1787: 414-420 [PMID: 19007744]
    • (2009) Bio-chim Biophys Acta , vol.1787 , pp. 414-420
    • Vaseva, A.V.1    Moll, U.M.2
  • 38
    • 0034992779 scopus 로고    scopus 로고
    • Growth inhibitory effects of diallyl disulfde on human breast cancer cell lines
    • [PMID: 11375895]
    • Nakagawa H, Tsuta K, Kiuchi K, Senzaki H, Tanaka K, Hioki K, Tsubura A. Growth inhibitory effects of diallyl disulfde on human breast cancer cell lines. Carcinogenesis 2001; 22: 891-897 [PMID: 11375895]
    • (2001) Carcinogenesis , vol.22 , pp. 891-897
    • Nakagawa, H.1    Tsuta, K.2    Kiuchi, K.3    Senzaki, H.4    Tanaka, K.5    Hioki, K.6    Tsubura, A.7
  • 40
    • 0035196587 scopus 로고    scopus 로고
    • Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1
    • [PMID: 11694570]
    • Shin I, Bakin AV, Rodeck U, Brunet A, Arteaga CL. Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol Biol Cell 2001; 12: 3328-3339 [PMID: 11694570]
    • (2001) Mol Biol Cell , vol.12 , pp. 3328-3339
    • Shin, I.1    Bakin, A.V.2    Rodeck, U.3    Brunet, A.4    Arteaga, C.L.5
  • 41
    • 0034786019 scopus 로고    scopus 로고
    • BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • [PMID: 11583631]
    • Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lind-sten T, Korsmeyer SJ. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 2001; 8: 705-711 [PMID: 11583631]
    • (2001) Mol Cell , vol.8 , pp. 705-711
    • Cheng, E.H.1    Wei, M.C.2    Weiler, S.3    Flavell, R.A.4    Mak, T.W.5    Lind-Sten, T.6    Korsmeyer, S.J.7
  • 42
    • 34248177364 scopus 로고    scopus 로고
    • Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfde, a promising cancer chemopreventive constituent of processed garlic
    • [PMID: 17406033]
    • Herman-Antosiewicz A, Stan SD, Hahm ER, Xiao D, Singh SV. Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfde, a promising cancer chemopreventive constituent of processed garlic. Mol Cancer Ther 2007; 6: 1249-1261 [PMID: 17406033]
    • (2007) Mol Cancer Ther , vol.6 , pp. 1249-1261
    • Herman-Antosiewicz, A.1    Stan, S.D.2    Hahm, E.R.3    Xiao, D.4    Singh, S.V.5
  • 43
    • 3342895063 scopus 로고    scopus 로고
    • Diallyl trisulfde-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2
    • [PMID: 15184882]
    • Xiao D, Choi S, Johnson DE, Vogel VG, Johnson CS, Trump DL, Lee YJ, Singh SV. Diallyl trisulfde-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene 2004; 23: 5594-5606 [PMID: 15184882]
    • (2004) Oncogene , vol.23 , pp. 5594-5606
    • Xiao, D.1    Choi, S.2    Johnson, D.E.3    Vogel, V.G.4    Johnson, C.S.5    Trump, D.L.6    Lee, Y.J.7    Singh, S.V.8
  • 44
    • 77953231700 scopus 로고    scopus 로고
    • Diallyl trisulfde-induced G2/M phase cell cycle arrest in DU145 cells is associated with delayed nuclear trans-location of cyclin-dependent kinase 1
    • [PMID: 20143254 DOI: 10.1007/s11095-010-0060-7]
    • Herman-Antosiewicz A, Kim YA, Kim SH, Xiao D, Singh SV. Diallyl trisulfde-induced G2/M phase cell cycle arrest in DU145 cells is associated with delayed nuclear trans-location of cyclin-dependent kinase 1. Pharm Res 2010; 27: 1072-1079 [PMID: 20143254 DOI: 10.1007/s11095-010-0060-7]
    • (2010) Pharm Res , vol.27 , pp. 1072-1079
    • Herman-Antosiewicz, A.1    Kim, Y.A.2    Kim, S.H.3    Xiao, D.4    Singh, S.V.5
  • 45
    • 23344431622 scopus 로고    scopus 로고
    • Checkpoint kinase 1 regulates diallyl trisulfde-induced mitotic arrest in human prostate cancer cells
    • [PMID: 15961392]
    • Herman-Antosiewicz A, Singh SV. Checkpoint kinase 1 regulates diallyl trisulfde-induced mitotic arrest in human prostate cancer cells. J Biol Chem 2005; 280: 28519-28528 [PMID: 15961392]
    • (2005) J Biol Chem , vol.280 , pp. 28519-28528
    • Herman-Antosiewicz, A.1    Singh, S.V.2
  • 46
    • 68049136680 scopus 로고    scopus 로고
    • Diallyl trisulfde-induced apop-tosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest
    • [PMID: 19459175 DOI: 10.1002/mc.20553]
    • Xiao D, Zeng Y, Singh SV. Diallyl trisulfde-induced apop-tosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest. Mol Carcinog 2009; 48: 1018-1029 [PMID: 19459175 DOI: 10.1002/mc.20553]
    • (2009) Mol Carcinog , vol.48 , pp. 1018-1029
    • Xiao, D.1    Zeng, Y.2    Singh, S.V.3
  • 47
    • 63049105131 scopus 로고    scopus 로고
    • Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells
    • [PMID: 18800351 DOI: 10.1002/ em.20431]
    • Xiao D, Zeng Y, Hahm ER, Kim YA, Ramalingam S, Singh SV. Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells. Environ Mol Mutagen 2009; 50: 201-212 [PMID: 18800351 DOI: 10.1002/ em.20431]
    • (2009) Environ Mol Mutagen , vol.50 , pp. 201-212
    • Xiao, D.1    Zeng, Y.2    Hahm, E.R.3    Kim, Y.A.4    Ramalingam, S.5    Singh, S.V.6
  • 48
    • 27144458683 scopus 로고    scopus 로고
    • Cyclins and CDKS in development and cancer: Lessons from genetically modified mice
    • [PMID: 16146805]
    • Santamaria D, Ortega S. Cyclins and CDKS in development and cancer: lessons from genetically modified mice. Front Biosci 2006; 11: 1164-1188 [PMID: 16146805]
    • (2006) Front Biosci , vol.11 , pp. 1164-1188
    • Santamaria, D.1    Ortega, S.2
  • 49
    • 4143080409 scopus 로고    scopus 로고
    • Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells
    • [PMID: 15208674]
    • Yuan J, Yan R, Krämer A, Eckerdt F, Roller M, Kaufmann M, Strebhardt K. Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells. Oncogene 2004; 23: 5843-5852 [PMID: 15208674]
    • (2004) Oncogene , vol.23 , pp. 5843-5852
    • Yuan, J.1    Yan, R.2    Krämer, A.3    Eckerdt, F.4    Roller, M.5    Kaufmann, M.6    Strebhardt, K.7
  • 50
    • 60549107035 scopus 로고    scopus 로고
    • Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol
    • [PMID: 19113992 DOI: 10.1186/1471-2407-8-391]
    • Androic I, Krämer A, Yan R, Rödel F, Gätje R, Kaufmann M, Strebhardt K, Yuan J. Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol. BMC Cancer 2008; 8: 391 [PMID: 19113992 DOI: 10.1186/1471-2407-8-391]
    • (2008) BMC Cancer , vol.8 , pp. 391
    • Androic, I.1    Krämer, A.2    Yan, R.3    Rödel, F.4    Gätje, R.5    Kaufmann, M.6    Strebhardt, K.7    Yuan, J.8
  • 51
    • 0013439945 scopus 로고    scopus 로고
    • Cycling to cancer with cyclin D1
    • [PMID: 12432268]
    • Diehl JA. Cycling to cancer with cyclin D1. Cancer Biol Ther 2002; 1: 226-231 [PMID: 12432268]
    • (2002) Cancer Biol Ther , vol.1 , pp. 226-231
    • Diehl, J.A.1
  • 52
    • 34548408192 scopus 로고    scopus 로고
    • Molecular targets of cancer chemoprevention by garlic-derived or-ganosulfdes
    • [PMID: 17723169]
    • Herman-Antosiewicz A, Powolny AA, Singh SV. Molecular targets of cancer chemoprevention by garlic-derived or-ganosulfdes. Acta Pharmacol Sin 2007; 28: 1355-1364 [PMID: 17723169]
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1355-1364
    • Herman-Antosiewicz, A.1    Powolny, A.A.2    Singh, S.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.