Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells

Life Sciences

Volumn 93, Issue 21, 2013, Pages 783-790

  Rajput, Shashi ^a   Kumar, B N Prashanth ^a   Dey, Kaushik Kumar ^a   Pal, Ipsita ^a   Parekh, Aditya ^a   Mandal, Mahitosh ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Cyclin D1; G1 phase arrest; PI3K Akt signaling pathway; Thymoquinone; Translational proteins

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; CYTOCHROME C; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROCASPASE 3; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; RAF PROTEIN; SURVIVIN; THYMOQUINONE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BENZOQUINONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSLATION INITIATION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BREAST TUMOR; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; MCF 7 CELL LINE; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

NIGELLA SATIVA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZOQUINONES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR TARGETED THERAPY; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84887098861     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.09.009     Document Type: Article

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