Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models

Journal of Cellular and Molecular Medicine

Volumn 12, Issue 1, 2008, Pages 330-342

  Gali Muhtasib, Hala ^a   Ocker, Matthias ^b   Kuester, Doerthe ^c   Krueger, Sabine ^c   El Hajj, Zeina ^a   Diestel, Antje ^c   Evert, Matthias ^c   El Najjar, Nahed ^a   Peters, Brigitte ^c   Jurjus, Abdo ^a   Roessner, Albert ^c   Schneider Stock, Regine ^c  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

1,2 dimethyl hydrazine animal model; Cancer therapy; Colon cancer; Invasion; Thymoquinone; Xenograft

Indexed keywords

ANIMALIA; MURINAE; MUS;

EID: 41149137253     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2007.00095.x     Document Type: Article

References (34)

1. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001 2 : 533 43.
2. Lipkin M, Reddy B, Newmark H, Lamprecht SA. Dietary factors in human colorectal cancer. Annu Rev Nutr. 1999 19 : 545 86.
3. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003 3 : 768 80.
4. Worthen D, Ghosheh O, Crooks P. The in vitro antitumor activity of some crude and purified components of black seed, Nigella sativa L. Anticancer Res. 1998 18 : 1527 32.
5. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003 17 : 299 305.
6. Badary OA, Gamal El-Din AM. Inhibitory effects of thymoquinone against 20 methylcholanthrene-induced fibrosarcoma tumorigenesis. Cancer Detect Prev. 2001 25 : 362 8.
7. Badary OA, Al-Shabanah OA, Nagi MN, Al-Rikabi AC, Elmazar MM. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in rats by thymoquinone. Eur J Cancer Prev. 1999 8 : 435 40.
8. Badary OA. Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J Ethnopharmacol. 1999 67 : 135 42.
9. Badary OA, Nagi MN, al-Shabanah OA, al-Sawaf HA, al-Sohaibani MO, al-Bekairi AM. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can J Physiol Pharmacol. 1997 75 : 1356 61.
10. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A, Schneider-Stock R. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol. 2004 25 : 857 66.
11. Gali-Muhtasib HU, Younis I, Karchesy J, El-Sabban M. Plant tannins inhibit the induction of aberrant crypt foci and colonic tumors by 1,2-dimethyl hydrazine in mice. Nutr Cancer. 2001 39 : 108 16.
12. Ocker M, Neureiter D, Leuders M, Zopf S, Ganslmayer M, Hahn EG, Herold C, Schuppan D. Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer. Gut. 2005 54 : 1298 308.
13. Krueger S, Kalinski T, Wolf H, Kellner U, Roessner A. Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture-regulation of cathepsin B expression and invasiveness. Cancer Lett. 2005 223 : 313 22.
14. Krueger S, Kellner U, Buehling F, Roessner A. Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. Cancer Gene Ther. 2001 8 : 522 8.
15. Bird RP, Good CK. The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicol Lett. 2000 112-113 : 395 402.
16. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa K, Miyake H, Niiysu Y. Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med. 1998 339 : 1277 84.
17. Bent S, Ko R. Commonly used herbal medicines in the United States: a review. Am J Med. 2004 116 : 478 85.
18. Kelly WK, Richon VM, O'Connor O, Curley T, MacGregor-Curtelli B, Tong W, Mark K, Lawrence S, Stacie R, Eddie R, Marija D, Carlos C, Judy H, Paul A, Howard S. Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously. Clin Cancer Res. 2003 9 : 3578 88.
19. Neureiter D, Zopf S, Leu T, Dietze O, Herold C, Ocker M. Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models. Scand J Gastroenterol. 2007 42 : 103 16.
20. Cerutti PA. Oxy-radicals and cancer. Lancet. 1994 344 : 862 3.
21. Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct. 2002 20 : 143 51.
22. Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol. 2003 26 : 87 98.
23. El-Mahmoudy A, Shimizu Y, Shiina T, Matsuyama H, El-Sayed M, Takewaki T. Successful abrogation by thymoquinone against induction of diabetes Mellitus with streptozotocin via nitric oxide inhibitory mechanism. Int Immunopharmacol. 2005 5 : 195 07.
24. El-Mahmoudy A, Matsuyama H, Borgan MA, Shimizu Y, El-Sayed MG, Minamoto N, Takewati T. Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int Immunopharmacol. 2002 2 : 1603 11.
25. Salim EI, Fukushima S. Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr Cancer. 2003 45 : 195 202.
26. Kirui PK, Cameron J, Benghuzzi HA, Tucci M, Patel R, Adah F, Russel G. Effects of sustained delivery of thymoqiunone on bone healing of male rats. Biomed Sci Instrum. 2004 40 : 111 6.
27. Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine. 2004 11 : 56 64.
28. Badary O, Al-Shabanah O, Nagi M, Al-Bekairi A, Elmazar M. Acute and subchronic toxicity of thymoquinone in mice. Drug Dev Res. 1998 44 : 56 61.
29. Al-Shabanah OA, Badary OA, Nagi MN, al-Gharably NM, al-Rikabi AC, al-Bekairi AM. Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity. J Exp Clin Cancer Res. 1998 17 : 193 8.
30. Mansour MA, Ginawi OT, El-Hadiyah T, El-Khatib AS, Al-Shabanah OA, Al-Sawaf HA. Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Res Commun Mol Pathol Pharmacol. 2001 110 : 239 51.
31. Mansour MA. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sci. 2000 66 : 2583 91.
32. Sutherland RM, Durand RE. Growth and cellular characteristics of multicell spheroids. Recent Results Cancer Res. 1984 95 : 24 49.
33. Santini MT, Rainaldi G, Indovina PL. Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids. Crit Rev Oncol Hematol. 2000 36 : 75 87.
34. Mueller-Klieser W. Tumor biology and experimental therapeutics. Crit Rev Oncol Hematol. 2000 36 : 123 39.