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Volumn 17, Issue 4, 2016, Pages

Hepatoprotective effects of chinese medicinal herbs: A focus on anti-inflammatory and anti-oxidative activities

Author keywords

Anti inflammatory; Anti oxidative; Chinese medicinal herbs; Hepatoprotection; Liver diseases

Indexed keywords

ANDROGRAPHIS HERBA EXTRACT; CARNITINE PALMITOYLTRANSFERASE I; CHINESE DRUG; COPTIS RHIZOME EXTRACT; CURCUMIN; GINSENG EXTRACT; GLYCYRRHIZA EXTRACT; LYCII FRUCTUS EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; HERBACEOUS AGENT; PROTECTIVE AGENT;

EID: 84962069064     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17040465     Document Type: Review
Times cited : (121)

References (351)
  • 1
    • 77955806286 scopus 로고    scopus 로고
    • Liver: Nonobese individuals in the developing world are at risk of nonalcoholic fatty liver andliver disease
    • Wood, N.J. Liver: Nonobese individuals in the developing world are at risk of nonalcoholic fatty liver and liver disease. Nat. Rev. Gastroenterol. Hepatol. 2010, 7, 357-357
    • (2010) Nat. Rev. Gastroenterol. Hepatol , vol.7 , pp. 357-358
    • Wood, N.J.1
  • 2
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Incidence and riskfactors
    • Fattovich, G.; Stroffolini, T.; Zagni, I.; Donato, F. Hepatocellular carcinoma in cirrhosis: Incidence and risk factors. Gastroenterology 2004, 127, S35-S50
    • (2004) Gastroenterology , vol.127 , pp. S35-S50
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3    Donato, F.4
  • 5
    • 63349103768 scopus 로고    scopus 로고
    • Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses
    • Guo, J.; Loke, J.; Zheng, F.; Hong, F.; Yea, S.; Fukata, M.; Tarocchi, M.; Abar, O.T.; Huang, H.; Sninsky, J.J. Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses. Hepatology 2009, 49, 960-968
    • (2009) Hepatology , vol.49 , pp. 960-968
    • Guo, J.1    Loke, J.2    Zheng, F.3    Hong, F.4    Yea, S.5    Fukata, M.6    Tarocchi, M.7    Abar, O.T.8    Huang, H.9    Sninsky, J.J.10
  • 9
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • Karin, M.; Ben-Neriah, Y. Phosphorylation meets ubiquitination: The control of NF-κB activity. Annu. Rev. Immunol. 2000, 18, 621-663
    • (2000) Annu. Rev. Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 10
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh, S.; Karin, M. Missing pieces in the NF-κB puzzle. Cell 2010, 109, S81-S96
    • (2010) Cell , vol.109 , pp. S81-S96
    • Ghosh, S.1    Karin, M.2
  • 12
    • 33748344714 scopus 로고    scopus 로고
    • Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer:Role of lipid peroxidation, DNA damage, and repair
    • Bartsch, H.; Nair, J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: Role of lipid peroxidation, DNA damage, and repair. Langenbeck's Arch. Surg. 2006, 391, 499-510
    • (2006) Langenbeck's Arch. Surg , vol.391 , pp. 499-510
    • Bartsch, H.1    Nair, J.2
  • 13
    • 62149149998 scopus 로고    scopus 로고
    • New insights on oxidative stress in cancer
    • Visconti, R.; Grieco, D. New insights on oxidative stress in cancer. Curr. Opin. Drug Discov. Dev. 2009, 12, 240-245.
    • (2009) Curr. Opin. Drug Discov. Dev , vol.12 , pp. 240-245
    • Visconti, R.1    Grieco, D.2
  • 14
    • 84886289571 scopus 로고    scopus 로고
    • Liver auto-immunology: The paradox of autoimmunity in a tolerogenic organ
    • Invernizzi, P. Liver auto-immunology: The paradox of autoimmunity in a tolerogenic organ. J. Autoimmun. 2013, 46, 1-6
    • (2013) J. Autoimmun , vol.46 , pp. 1-6
    • Invernizzi, P.1
  • 15
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis
    • Elsharkawy, A.M.; Mann, D.A. Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 2007, 46, 590-597
    • (2007) Hepatology , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 16
    • 0033944607 scopus 로고    scopus 로고
    • Treatment of chronic liver diseases with traditional chinese medicine
    • Wang, B.E. Treatment of chronic liver diseases with traditional chinese medicine. J. Gastroenterol. Hepatol. 2000, 15, E67-E70
    • (2000) J. Gastroenterol. Hepatol , vol.15 , pp. E67-E70
    • Wang, B.E.1
  • 17
    • 84857435317 scopus 로고    scopus 로고
    • Recent update in research on the antihepatotoxic potential of medicinalplants. Zhong Xi Yi Jie He Xue Bao =
    • Dhiman, A.; Nanda, A.; Ahmad, S. A recent update in research on the antihepatotoxic potential of medicinal plants. Zhong Xi Yi Jie He Xue Bao = J. Chin. Integr. Med. 2012, 10, 117-127
    • (2012) J. Chin. Integr. Med , vol.10 , pp. 117-127
    • Dhiman, A.1    Nanda, A.2    Ahmad, S.A.3
  • 19
    • 85050578557 scopus 로고    scopus 로고
    • Chinese medicines for prevention and treatmentof human hepatocellular carcinoma: Current progress on pharmacological actions and mechanisms
    • Wang, X.; Wang, N.; Cheung, F.; Lao, L.; Li, C.; Feng, Y. Chinese medicines for prevention and treatment of human hepatocellular carcinoma: Current progress on pharmacological actions and mechanisms. J. Integr. Med. 2015, 13, 142-164
    • (2015) J. Integr. Med. , vol.13 , pp. 142-164
    • Wang, X.1    Wang, N.2    Cheung, F.3    Lao, L.4    Li, C.5    Feng, Y.6
  • 20
    • 84655169624 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of nonalcoholicsteatohepatitis
    • Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic. Biol. Med. 2012, 52, 59-69
    • (2012) Free Radic. Biol. Med , vol.52 , pp. 59-69
    • Rolo, A.P.1    Teodoro, J.S.2    Palmeira, C.M.3
  • 21
    • 84884414173 scopus 로고    scopus 로고
    • Chinese herbal medicine-derived compoundsfor cancer therapy: A focus on hepatocellular carcinoma
    • Hu, Y.; Wang, S.; Wu, X.; Zhang, J.; Chen, R.; Chen, M.; Wang, Y. Chinese herbal medicine-derived compounds for cancer therapy: A focus on hepatocellular carcinoma. J. Ethnopharmacol. 2013, 149, 601-612
    • (2013) J. Ethnopharmacol , vol.149 , pp. 601-612
    • Hu, Y.1    Wang, S.2    Wu, X.3    Zhang, J.4    Chen, R.5    Chen, M.6    Wang, Y.7
  • 22
    • 84920733357 scopus 로고    scopus 로고
    • An overview of effective therapies and recent advances in biomarkers for chronicliver diseases and associated liver cancer
    • Chatterjee, R.; Mitra, A. An overview of effective therapies and recent advances in biomarkers for chronic liver diseases and associated liver cancer. Int. Immunopharmacol. 2015, 24, 335-345
    • (2015) Int. Immunopharmacol , vol.24 , pp. 335-345
    • Chatterjee, R.1    Mitra, A.2
  • 23
    • 84887318014 scopus 로고    scopus 로고
    • The gordian knot of dysbiosis, obesity and nafld
    • Mehal, W.Z. The gordian knot of dysbiosis, obesity and nafld. Nat. Rev. Gastroenterol. Hepatol. 2013, 10, 637-644
    • (2013) Nat. Rev. Gastroenterol. Hepatol , vol.10 , pp. 637-644
    • Mehal, W.Z.1
  • 24
    • 84936775786 scopus 로고    scopus 로고
    • Epigenetic modifications by histone deacetylases: Biologicalimplications and therapeutic potential in liver fibrosis
    • Chen, P.J.; Huang, C.; Meng, X.M.; Li, J. Epigenetic modifications by histone deacetylases: Biological implications and therapeutic potential in liver fibrosis. Biochimie 2015, 116, 61-69
    • (2015) Biochimie , vol.116 , pp. 61-69
    • Chen, P.J.1    Huang, C.2    Meng, X.M.3    Li, J.4
  • 25
    • 84923054566 scopus 로고    scopus 로고
    • Protectivemechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
    • Duval, F.; Moreno-Cuevas, J.E.; Gonzalez-Garza, M.T.; Rodriguez-Montalvo, C.; Cruz-Vega, D.E. Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis. Chin. Med. 2014, 9
    • (2014) Chin. Med , vol.9
    • Duval, F.1    Moreno-Cuevas, J.E.2    Gonzalez-Garza, M.T.3    Rodriguez-Montalvo, C.4    Cruz-Vega, D.E.5
  • 26
    • 79953036451 scopus 로고    scopus 로고
    • Nitric oxide and redox regulation in the liver: Part II. Redox biology in pathologichepatocytes and implications for intervention
    • Diesen, D.L.; Kuo, P.C. Nitric oxide and redox regulation in the liver: Part II. Redox biology in pathologic hepatocytes and implications for intervention. J. Surg. Res. 2011, 167, 96-112
    • (2011) J. Surg. Res , vol.167 , pp. 96-112
    • Diesen, D.L.1    Kuo, P.C.2
  • 27
    • 84885093994 scopus 로고    scopus 로고
    • Development of nonalcoholichepatopathy: Contributions of oxidative stress and advanced glycation end products
    • Santos, J.C.; Valentim, I.B.; de Araujo, O.R.; Ataide Tda, R.; Goulart, M.O. Development of nonalcoholic hepatopathy: Contributions of oxidative stress and advanced glycation end products. Int. J. Mol. Sci. 2013, 14, 19846-19866
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 19846-19866
    • Santos, J.C.1    Valentim, I.B.2    De Araujo, O.R.3    Ataide Tda, R.4    Goulart, M.O.5
  • 31
  • 32
    • 0742288763 scopus 로고    scopus 로고
    • Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the managementof hepatobiliary disorders
    • Center, S.A. Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the management of hepatobiliary disorders. Vet. Clin. N. Am. Small Anim. Pract. 2004, 34, 67-172
    • (2004) Vet. Clin. N. Am. Small Anim. Pract , vol.34 , pp. 67-172
    • Center, S.A.1
  • 33
    • 84937523554 scopus 로고    scopus 로고
    • Micrornas in liver tissue engineering-New promisesfor failing organs
    • Raschzok, N.; Sallmon, H.; Pratschke, J.; Sauer, I.M. Micrornas in liver tissue engineering-New promises for failing organs. Adv. Drug Deliv. Rev. 2015, 88, 67-77
    • (2015) Adv. Drug Deliv. Rev , vol.88 , pp. 67-77
    • Raschzok, N.1    Sallmon, H.2    Pratschke, J.3    Sauer, I.M.4
  • 36
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signalling molecules: Mechanisms that generate specificity in ROShomeostasis
    • Benoît, D.A.; Michel, B.T. ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell Biol. 2007, 8, 813-824.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 813-824
    • Benoît, D.A.1    Michel, B.T.2
  • 38
    • 84872422812 scopus 로고    scopus 로고
    • Alterations in the redox state and liver damage: Hints from the easl basicschool of hepatology
    • Tell, G.; Vascotto, C.; Tiribelli, C. Alterations in the redox state and liver damage: Hints from the easl basic school of hepatology. J. Hepatol. 2013, 58, 365-374
    • (2013) J. Hepatol , vol.58 , pp. 365-374
    • Tell, G.1    Vascotto, C.2    Tiribelli, C.3
  • 39
    • 78349265397 scopus 로고    scopus 로고
    • Reactive oxygen species mediatehuman hepatocyte injury during hypoxia/reoxygenation
    • Bhogal, R.H.; Curbishley, S.M.; Weston, C.J.; Adams, D.H.; Afford, S.C. Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation. Liver Transplant. 2010, 16, 1303-1313
    • (2010) Liver Transplant , vol.16 , pp. 1303-1313
    • Bhogal, R.H.1    Curbishley, S.M.2    Weston, C.J.3    Adams, D.H.4    Afford, S.C.5
  • 40
    • 56149115918 scopus 로고    scopus 로고
    • Virus-induced oxidative stresssuppresses hepcidin expression through increased histone deacetylase activity
    • Miura, K.; Taura, K.; Kodama, Y.; Schnabl, B.; Brenner, D.A. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 2008, 48, 1420-1429
    • (2008) Hepatology , vol.48 , pp. 1420-1429
    • Miura, K.1    Taura, K.2    Kodama, Y.3    Schnabl, B.4    Brenner, D.A.5    Hepatitis, C.6
  • 41
    • 84928999912 scopus 로고    scopus 로고
    • Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful?
    • Takaki, A.; Yamamoto, K. Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful? World J. Hepatol. 2015, 7, 968-979
    • (2015) World J. Hepatol , vol.7 , pp. 968-979
    • Takaki, A.1    Yamamoto, K.2
  • 42
    • 66149088854 scopus 로고    scopus 로고
    • 8-hydroxy-21-deoxyguanosine (8-OHdG): A critical biomarkerof oxidative stress and carcinogenesis
    • Valavanidis, A.; Vlachogianni, T.; Fiotakis, C. 8-hydroxy-21-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J. Environ. Sci. Health Part C 2009, 27, 120-139
    • (2009) J. Environ. Sci. Health Part C , vol.27 , pp. 120-139
    • Valavanidis, A.1    Vlachogianni, T.2    Fiotakis, C.3
  • 44
    • 84884520213 scopus 로고    scopus 로고
    • Free radical biology for medicine: Learning from nonalcoholicfatty liver disease
    • Serviddio, G.; Bellanti, F.; Vendemiale, G. Free radical biology for medicine: Learning from nonalcoholic fatty liver disease. Free Radic. Biol. Med. 2013, 65, 952-968
    • (2013) Free Radic. Biol. Med , vol.65 , pp. 952-968
    • Serviddio, G.1    Bellanti, F.2    Vendemiale, G.3
  • 45
    • 36148931348 scopus 로고    scopus 로고
    • Espéciesreativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: Principais métodos analíticos para sua determinação
    • Vasconcelos, S.M.L.; Goulart, M.O.F.; Moura, J. d. F.; Manfredini, V.; Benfato, M.d.S.; Kubota, L.T. Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: Principais métodos analíticos para sua determinação. Quim. Nova 2007, 30, 1323-1338
    • (2007) Quim. Nova , vol.30 , pp. 1323-1338
    • Vasconcelos, S.M.L.1    Goulart, M.O.F.2    Moura, J.D.F.3    Manfredini, V.4    Benfato, M.D.S.5    Kubota, L.T.6
  • 47
    • 67349205002 scopus 로고    scopus 로고
    • Kupffer cells in non-alcoholic fatty liver disease: The emerging view
    • Baffy, G. Kupffer cells in non-alcoholic fatty liver disease: The emerging view. J. Hepatol. 2009, 51, 212-223
    • (2009) J. Hepatol , vol.51 , pp. 212-223
    • Baffy, G.1
  • 49
    • 84896826716 scopus 로고    scopus 로고
    • Hepatic inflammation and progressive liver fibrosis in chronic liver disease
    • Czaja, A.J. Hepatic inflammation and progressive liver fibrosis in chronic liver disease. World J. Gastroenterol. 2014, 20, 2515-2532
    • (2014) World J. Gastroenterol , vol.20 , pp. 2515-2532
    • Czaja, A.J.1
  • 52
    • 80052707667 scopus 로고    scopus 로고
    • Molecular pathogenesis of hepatic fibrosis and current therapeuticapproaches
    • Mormone, E.; George, J.; Nieto, N. Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches. Chem. Biol. Interact. 2011, 193, 225-231
    • (2011) Chem. Biol. Interact. , vol.193 , pp. 225-231
    • Mormone, E.1    George, J.2    Nieto, N.3
  • 53
    • 0035996583 scopus 로고    scopus 로고
    • Oxygen homeostasis, thiol equilibrium and redox regulation of signalling transcription factorsin the alveolar epithelium
    • Haddad, J.J. Oxygen homeostasis, thiol equilibrium and redox regulation of signalling transcription factors in the alveolar epithelium. Cell Signal. 2002, 14, 799-810
    • (2002) Cell Signal , vol.14 , pp. 799-810
    • Haddad, J.J.1
  • 54
    • 84922753298 scopus 로고    scopus 로고
    • The importance of theinteraction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation
    • Giraudi, P.J.; Becerra, V.J.B.; Marin, V.; Chavez-Tapia, N.C.; Tiribelli, C.; Rosso, N. The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation. Exp. Mol. Pathol. 2015, 98, 85-92
    • (2015) Exp. Mol. Pathol , vol.98 , pp. 85-92
    • Giraudi, P.J.1    Becerra, V.J.B.2    Marin, V.3    Chavez-Tapia, N.C.4    Tiribelli, C.5    Rosso, N.6
  • 55
    • 84987802508 scopus 로고    scopus 로고
    • Role of toll-like receptors in immune activation and tolerance in the liver
    • Nakamoto, N.; Kanai, T. Role of toll-like receptors in immune activation and tolerance in the liver. Front. Immunol. 2014, 5
    • (2014) Front.Immunol , vol.5
    • Nakamoto, N.1    Kanai, T.2
  • 56
    • 84855860915 scopus 로고    scopus 로고
    • A methionine-choline-deficient diet elicits NASH in theimmunodeficient mouse featuring a model for hepatic cell transplantation
    • Pelz, S.; Stock, P.; Brückner, S.; Christ, B. A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation. Exp. Cell Res. 2012, 318, 276-287
    • (2012) Exp. Cell Res , vol.318 , pp. 276-287
    • Pelz, S.1    Stock, P.2    Brückner, S.3    Christ, B.4
  • 57
    • 84875103455 scopus 로고    scopus 로고
    • Balancing reactive oxygen species in the epigenome: NADPH oxidases as target andperpetrator
    • Hayes, P.; Knaus, U.G. Balancing reactive oxygen species in the epigenome: NADPH oxidases as target and perpetrator. Antioxid. Redox Signal. 2013, 18, 1937-1945
    • (2013) Antioxid. Redox Signal. , vol.18 , pp. 1937-1945
    • Hayes, P.1    Knaus, U.G.2
  • 58
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16, 6-21
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 60
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • Jones, P.A.; Takai, D. The role of DNA methylation in mammalian epigenetics. Science 2001, 293, 1068-1070
    • (2001) Science , vol.293 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 61
    • 0026742792 scopus 로고
    • CpG islands as gene markers in the human genome
    • Larsen, F.; Gundersen, G.; Lopez, R.; Prydz, H. CpG islands as gene markers in the human genome. Genomics 1992, 13, 1095-1107
    • (1992) Genomics , vol.13 , pp. 1095-1107
    • Larsen, F.1    Gundersen, G.2    Lopez, R.3    Prydz, H.4
  • 62
    • 44049120882 scopus 로고
    • CpG islands in mammalian gene promoters areinherently resistant to de novo methylation
    • Bestor, T.H.; Gundersen, G.; Kolstø, A.-B.; Prydz, H. CpG islands in mammalian gene promoters are inherently resistant to de novo methylation. Genet. Anal. Biomol. Eng. 1992, 9, 48-53
    • (1992) Genet. Anal. Biomol. Eng , vol.9 , pp. 48-53
    • Bestor, T.H.1    Gundersen, G.2    Kolstø, A.-B.3    Prydz, H.4
  • 63
    • 0032722062 scopus 로고    scopus 로고
    • Recombinant human DNA (Cytosine-5) methyltransferase.I. Expression, purification, and comparison of novo and maintenance methylation
    • Pradhan, S.; Bacolla, A.; Wells, R.D.; Roberts, R.J. Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of novo and maintenance methylation. J. Biol. Chem. 1999, 274, 33002-33010
    • (1999) J. Biol. Chem , vol.274 , pp. 33002-33010
    • Pradhan, S.1    Bacolla, A.2    Wells, R.D.3    Roberts, R.J.4
  • 64
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • En, L.; Caroline, B.; Rudolf, J. Role for DNA methylation in genomic imprinting. Nature 1993, 366, 362-365.
    • (1993) Nature , vol.366 , pp. 362-365
    • En, L.1    Caroline, B.2    Rudolf, J.3
  • 65
    • 0028786951 scopus 로고
    • Loss of methylation activates xist in somatic but not in embryonic cells
    • Beard, C.; Jaenisch, R.; Li, E. Loss of methylation activates xist in somatic but not in embryonic cells. Genes Dev. 1995, 9, 2325-2334
    • (1995) Genes Dev , vol.9 , pp. 2325-2334
    • Beard, C.1    Jaenisch, R.2    Li, E.3
  • 66
    • 85016326735 scopus 로고    scopus 로고
    • New nucleophilic mechanisms of ROS-dependent epigenetic modifications: Comparison ofaging and cancer
    • Afanas’Ev, I. New nucleophilic mechanisms of ROS-dependent epigenetic modifications: Comparison of aging and cancer. Aging Dis. 2014, 5, 52-62
    • (2014) Aging Dis , vol.5 , pp. 52-62
    • Afanas’Ev, I.1
  • 67
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA(Cytosine-5) methyltransferases
    • Masaki, O.; Shaoping, X.; En, L. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet. 1998, 19, 219-220.
    • (1998) Nat. Genet , vol.19 , pp. 219-220
    • Masaki, O.1    Shaoping, X.2    En, L.3
  • 68
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases DNMT3a and DNMT3b are essential forde novo methylation and mammalian development
    • Okano, M.; Bell, D.W.; Haber, D.A.; Li, E. DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian development. Cell 1999, 99, 247-257
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 69
    • 0033499867 scopus 로고    scopus 로고
    • In vivo activity of murine de novo methyltransferases, DNMT3a and DNMT3b
    • Hsieh, C.-L. In vivo activity of murine de novo methyltransferases, DNMT3a and DNMT3b. Mol. Cell. Biol. 1999, 19, 8211-8218
    • (1999) Mol. Cell. Biol , vol.19 , pp. 8211-8218
    • Hsieh, C.-L.1
  • 70
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor, T.H. The DNA methyltransferases of mammals. Hum. Mol. Genet. 2000, 9, 2395-2402
    • (2000) Hum. Mol. Genet , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 72
    • 0036415141 scopus 로고    scopus 로고
    • DNMT3a and DNMT1 functionally cooperate duringde novo methylation of DNA
    • Fatemi, M.; Hermann, A.; Gowher, H.; Jeltsch, A. DNMT3a and DNMT1 functionally cooperate during de novo methylation of DNA. Eur. J. Biochem. 2002, 269, 4981-4984
    • (2002) Eur. J. Biochem , vol.269 , pp. 4981-4984
    • Fatemi, M.1    Hermann, A.2    Gowher, H.3    Jeltsch, A.4
  • 73
    • 0036683055 scopus 로고    scopus 로고
    • Co-operation and communication betweenthe human maintenance and de novo DNA (Cytosine-5) methyltransferases
    • Kim, G.D.; Ni, J.; Kelesoglu, N.; Roberts, R.J.; Pradhan, S. Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J. 2002, 21, 4183-4195
    • (2002) EMBO J , vol.21 , pp. 4183-4195
    • Kim, G.D.1    Ni, J.2    Kelesoglu, N.3    Roberts, R.J.4    Pradhan, S.5
  • 74
    • 0026583975 scopus 로고
    • Repression of genes by DNA methylation depends on CPG density and promoter strength:Evidence for involvement of a methyl-CPG binding protein
    • Boyes, J.; Bird, A. Repression of genes by DNA methylation depends on CPG density and promoter strength: Evidence for involvement of a methyl-CPG binding protein. EMBO J. 1992, 11, 327-333
    • (1992) EMBO J , vol.11 , pp. 327-333
    • Boyes, J.1    Bird, A.2
  • 75
    • 0028106737 scopus 로고
    • Dependence of transcriptional repression on CPG methylation density
    • Hsieh, C.L. Dependence of transcriptional repression on CPG methylation density. Mol. Cell. Biol. 1994, 14, 5487-5494
    • (1994) Mol. Cell. Biol , vol.14 , pp. 5487-5494
    • Hsieh, C.L.1
  • 76
    • 0031104930 scopus 로고    scopus 로고
    • DNA methylation directs a time-dependent repression oftranscription initiation
    • Kass, S.U.; Landsberger, N.; Wolffe, A.P. DNA methylation directs a time-dependent repression of transcription initiation. Curr. Biol. 1997, 7, 157-165
    • (1997) Curr. Biol , vol.7 , pp. 157-165
    • Kass, S.U.1    Landsberger, N.2    Wolffe, A.P.3
  • 77
    • 23844547591 scopus 로고    scopus 로고
    • Epigenetic deregulation of genomic imprinting in human disorders and following assistedreproduction
    • Arnaud, P.; Feil, R. Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction. Birth Defects Res. Part C Embryo Today Rev. 2005, 75, 81-97
    • (2005) Birth Defects Res. Part C Embryo Today Rev , vol.75 , pp. 81-97
    • Arnaud, P.1    Feil, R.2
  • 78
    • 0020436347 scopus 로고
    • 5-Azacytidine-induced re-expression of alleles on the inactive X chromosome in a hybrid mousecell line
    • Graves, J.A. 5-Azacytidine-induced re-expression of alleles on the inactive X chromosome in a hybrid mouse cell line. Exp. Cell Res. 1982, 141, 99-105
    • (1982) Exp. Cell Res , vol.141 , pp. 99-105
    • Graves, J.A.1
  • 80
    • 0019510628 scopus 로고
    • Reactivation of an inactive human X chromosome: Evidence for Xinactivation by DNA methylation
    • Mohandas, T.; Sparkes, R.S.; Shapiro, L.J. Reactivation of an inactive human X chromosome: Evidence for X inactivation by DNA methylation. Science 1981, 211, 393-396
    • (1981) Science , vol.211 , pp. 393-396
    • Mohandas, T.1    Sparkes, R.S.2    Shapiro, L.J.3
  • 81
    • 0034665756 scopus 로고    scopus 로고
    • X inactivation in the mouse embryo deficient forDNMT1: Distinct effect of hypomethylation on imprinted and random X inactivation
    • Sado, T.; Fenner, M.H.; Tan, S.-S.; Tam, P.; Shioda, T.; Li, E. X inactivation in the mouse embryo deficient for DNMT1: Distinct effect of hypomethylation on imprinted and random X inactivation. Dev. Biol. 2000, 225, 294-303
    • (2000) Dev. Biol , vol.225 , pp. 294-303
    • Sado, T.1    Fenner, M.H.2    Tan, S.-S.3    Tam, P.4    Shioda, T.5    Li, E.6
  • 82
    • 34848911647 scopus 로고    scopus 로고
    • DNA methylation: The nuts and bolts of repression
    • Miranda, T.B.; Jones, P.A. DNA methylation: The nuts and bolts of repression. J. Cell. Physiol. 2007, 213, 384-390
    • (2007) J. Cell. Physiol , vol.213 , pp. 384-390
    • Miranda, T.B.1    Jones, P.A.2
  • 85
    • 34548140496 scopus 로고    scopus 로고
    • An epigenetic perspective on the free radical theory of development
    • Hitchler, M.J.; Domann, F.E. An epigenetic perspective on the free radical theory of development. Free Radic. Biol. Med. 2007, 43, 1023-1036
    • (2007) Free Radic.Biol. Med , vol.43 , pp. 1023-1036
    • Hitchler, M.J.1    Domann, F.E.2
  • 86
    • 84882656834 scopus 로고    scopus 로고
    • Oxidative stressinduces hypomethylation of line-1 and hypermethylation of the RUNX3 promoter in a bladder cancer cell line
    • Wongpaiboonwattana, W.; Tosukhowong, P.; Dissayabutra, T.; Mutirangura, A.; Boonla, C. Oxidative stress induces hypomethylation of line-1 and hypermethylation of the RUNX3 promoter in a bladder cancer cell line. Asian Pac. J. Cancer Prev. 2013, 14, 3773-3778
    • (2013) Asian Pac. J. Cancer Prev , vol.14 , pp. 3773-3778
    • Wongpaiboonwattana, W.1    Tosukhowong, P.2    Dissayabutra, T.3    Mutirangura, A.4    Boonla, C.5
  • 87
    • 84876105336 scopus 로고    scopus 로고
    • Regulation of SOD2 in cancer by histone modifications and CPGmethylation: Closing the loop between redox biology and epigenetics
    • Cyr, A.; Hitchler, M.; Domann, F. Regulation of SOD2 in cancer by histone modifications and CPG methylation: Closing the loop between redox biology and epigenetics. Antioxid. Redox Signal. 2013, 18, 1946-1955
    • (2013) Antioxid. Redox Signal , vol.18 , pp. 1946-1955
    • Cyr, A.1    Hitchler, M.2    Domann, F.3
  • 88
    • 84878660136 scopus 로고    scopus 로고
    • Oxidative stresscauses epigenetic alteration of CDX1 expression in colorectal cancer cells
    • Zhang, R.; Kang, K.A.; Kim, K.C.; Na, S.-Y.; Chang, W.Y.; Kim, G.Y.; Kim, H.S.; Hyun, J.W. Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells. Gene 2013, 524, 214-219
    • (2013) Gene , vol.524 , pp. 214-219
    • Zhang, R.1    Kang, K.A.2    Kim, K.C.3    Na, S.-Y.4    Chang, W.Y.5    Kim, G.Y.6    Kim, H.S.7    Hyun, J.W.8
  • 89
    • 84863206202 scopus 로고    scopus 로고
    • Norepinephrine causes epigenetic repression of PKCε gene in rodent hearts byactivating NOX1-dependent reactive oxygen species production
    • Xiong, F.; Xiao, D.; Zhang, L. Norepinephrine causes epigenetic repression of PKCε gene in rodent hearts by activating NOX1-dependent reactive oxygen species production. FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol. 2012, 26, 2753-2763.
    • (2012) FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol , vol.26 , pp. 2753-2763
    • Xiong, F.1    Xiao, D.2    Zhang, L.3
  • 90
    • 25144453808 scopus 로고    scopus 로고
    • Epigeneticsilencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation
    • Hodge, D.R.; Peng, B.; Pompeia, C.; Thomas, S.; Cho, E.; Clausen, P.A.; Marquez, V.E.; Farrar, W.L. Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation. Cancer Biol. Ther. 2005, 4, 585-592
    • (2005) Cancer Biol. Ther , vol.4 , pp. 585-592
    • Hodge, D.R.1    Peng, B.2    Pompeia, C.3    Thomas, S.4    Cho, E.5    Clausen, P.A.6    Marquez, V.E.7    Farrar, W.L.8
  • 92
    • 77249099223 scopus 로고    scopus 로고
    • CpG methylation attenuates Sp1 and Sp3 binding to the humanextracellular superoxide dismutase promoter and regulates its cell-specific expression
    • Zelko, I.N.; Mueller, M.R.; Folz, R.J. CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression. Free Radic. Biol. Med. 2010, 48, 895-904
    • (2010) Free Radic. Biol. Med , vol.48 , pp. 895-904
    • Zelko, I.N.1    Mueller, M.R.2    Folz, R.J.3
  • 93
    • 79959838676 scopus 로고    scopus 로고
    • GPX3 promoter hypermethylationis a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response
    • Chen, B.; Rao, X.; House, M.G.; Nephew, K.P.; Cullen, K.J.; Guo, Z. GPX3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response. Cancer Lett. 2011, 309, 37-45
    • (2011) Cancer Lett , vol.309 , pp. 37-45
    • Chen, B.1    Rao, X.2    House, M.G.3    Nephew, K.P.4    Cullen, K.J.5    Guo, Z.6
  • 96
    • 58249084836 scopus 로고    scopus 로고
    • DNAhypermethylation regulates the expression of members of the mu-class glutathione-transferases and glutathione peroxidases in Barrett’s adenocarcinoma
    • Peng, D.F.; Razvi, M.; Chen, H.; Washington, K.; Roessner, A.; Schneider-Stock, R.; El-Rifai, W. DNA hypermethylation regulates the expression of members of the mu-class glutathione-transferases and glutathione peroxidases in Barrett’s adenocarcinoma. Gut 2009, 58, 5-15
    • (2009) Gut , vol.58 , pp. 5-15
    • Peng, D.F.1    Razvi, M.2    Chen, H.3    Washington, K.4    Roessner, A.5    Schneider-Stock, R.6    El-Rifai, W.7
  • 97
    • 80053978389 scopus 로고    scopus 로고
    • Pharmacodynamics of curcumin asDNA hypomethylation agent in restoring the expression of NRF2 via promoter CPGs demethylation. Biochem
    • Khor, T.O.; Huang, Y.; Wu, T.-Y.; Shu, L.; Lee, J.; Kong, A.-N.T. Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of NRF2 via promoter CPGs demethylation. Biochem. Pharmacol. 2011, 82, 1073-1078
    • (2011) Pharmacol , vol.82 , pp. 1073-1078
    • Khor, T.O.1    Huang, Y.2    Wu, T.-Y.3    Shu, L.4    Lee, J.5    Kong, A.-N.T.6
  • 98
    • 77952959173 scopus 로고    scopus 로고
    • Downregulation of catalase by reactive oxygen species via hypermethylationof CPG island ii on the catalase promoter
    • Min, J.Y.; Lim, S.-O.; Jung, G. Downregulation of catalase by reactive oxygen species via hypermethylation of CPG island ii on the catalase promoter. FEBS Lett. 2010, 584, 2427-2432
    • (2010) FEBS Lett , vol.584 , pp. 2427-2432
    • Min, J.Y.1    Lim, S.-O.2    Jung, G.3
  • 99
    • 33845969839 scopus 로고    scopus 로고
    • Dietary polyphenols may affect DNA methylation
    • Fang, M.; Chen, D.; Yang, C.S. Dietary polyphenols may affect DNA methylation. J. Nutr. 2007, 137, 223S-228S
    • (2007) J. Nutr , vol.137 , pp. 223S-228S
    • Fang, M.1    Chen, D.2    Yang, C.S.3
  • 100
    • 48349116871 scopus 로고    scopus 로고
    • Reversal of hypermethylation and reactivation ofgenes by dietary polyphenolic compounds
    • Yang, C.S.; Fang, M.; Lambert, J.D.; Yan, P.; Huang, T.H.M. Reversal of hypermethylation and reactivation of genes by dietary polyphenolic compounds. Nutr. Rev. 2008, 66, S18-S20
    • (2008) Nutr. Rev , vol.66 , pp. S18-S20
    • Yang, C.S.1    Fang, M.2    Lambert, J.D.3    Yan, P.4    Huang, T.5
  • 101
    • 26444451123 scopus 로고    scopus 로고
    • Reversal of hypermethylation andreactivation of p16 INK4a, RARβ, and MGMT genes by genistein and other isoflavones from SOY
    • Fang, M.Z.; Chen, D.; Sun, Y.; Jin, Z.; Yang, C.S.; Christman, J.K. Reversal of hypermethylation and reactivation of p16 INK4a, RARβ, and MGMT genes by genistein and other isoflavones from SOY. Clin. Cancer Res. 2005, 11, 7033-7041
    • (2005) Clin. Cancer Res , vol.11 , pp. 7033-7041
    • Fang, M.Z.1    Chen, D.2    Sun, Y.3    Jin, Z.4    Yang, C.S.5    Christman, J.K.6
  • 102
    • 80054758173 scopus 로고    scopus 로고
    • Current status of novel antifibrotic therapies in patients with chronic liverdisease
    • Cohen-Naftaly, M.; Friedman, S.L. Current status of novel antifibrotic therapies in patients with chronic liver disease. Ther. Adv. Gastroenterol. 2011, 137, 391-417
    • (2011) Ther. Adv. Gastroenterol , vol.137 , pp. 391-417
    • Cohen-Naftaly, M.1    Friedman, S.L.2
  • 103
    • 84926361584 scopus 로고    scopus 로고
    • As2O3 induces apoptosisin human hepatocellular carcinoma HEPG2 cells through a ROS-mediated mitochondrial pathway and activation of caspases
    • Jiang, L.; Wang, L.; Chen, L.; Cai, G.-H.; Ren, Q.-Y.; Chen, J.-Z.; Shi, H.-J.; Xie, Y.-H. As2O3 induces apoptosis in human hepatocellular carcinoma HEPG2 cells through a ROS-mediated mitochondrial pathway and activation of caspases. Int. J. Clin. Exp. Med. 2015, 8, 2190-2196
    • (2015) Int. J. Clin. Exp. Med , vol.8 , pp. 2190-2196
    • Jiang, L.1    Wang, L.2    Chen, L.3    Cai, G.-H.4    Ren, Q.-Y.5    Chen, J.-Z.6    Shi, H.-J.7    Xie, Y.-H.8
  • 104
    • 84959372783 scopus 로고    scopus 로고
    • Liver disease and hepatocellular carcinoma in alcoholics: The role ofanticraving therapy
    • Borro, P.; Leone, S.; Testino, G. Liver disease and hepatocellular carcinoma in alcoholics: The role of anticraving therapy. Curr. Drug Targets 2015, 17, 239-251
    • (2015) Curr. Drug Targets , vol.17 , pp. 239-251
    • Borro, P.1    Leone, S.2    Testino, G.3
  • 106
    • 34948823454 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates oxidativestress and liver pathology in rats with non-alcoholic steatohepatitis
    • Thong-Ngam, D.; Samuhasaneeto, S.; Kulaputana, O.; Klaikeaw, N. N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis. World J. Gastroenterol. 2007, 13, 5127-5132
    • (2007) World J. Gastroenterol , vol.13 , pp. 5127-5132
    • Thong-Ngam, D.1    Samuhasaneeto, S.2    Kulaputana, O.3    Klaikeaw, N.4
  • 109
  • 110
    • 84876149257 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virusinfection: New estimates of age-specific antibody to HCV seroprevalence
    • Mohd Hanafiah, K.; Groeger, J.; Flaxman, A.D.; Wiersma, S.T. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013, 57, 1333-1342
    • (2013) Hepatology , vol.57 , pp. 1333-1342
    • Mohd Hanafiah, K.1    Groeger, J.2    Flaxman, A.D.3    Wiersma, S.T.4
  • 111
    • 0033869778 scopus 로고    scopus 로고
    • Pathogenesis of liver fibrosis: Role of oxidative stress
    • Poli, G. Pathogenesis of liver fibrosis: Role of oxidative stress. Mol. Asp. Med. 2000, 21, 49-98
    • (2000) Mol. Asp. Med , vol.21 , pp. 49-98
    • Poli, G.1
  • 114
    • 84928956747 scopus 로고    scopus 로고
    • Prevention of hepatocellular carcinoma: Focusing on antioxidanttherapy
    • Miyanishi, K.; Hoki, T.; Tanaka, S.; Kato, J. Prevention of hepatocellular carcinoma: Focusing on antioxidant therapy. World J. Hepatol. 2015, 7, 593-599
    • (2015) World J. Hepatol , vol.7 , pp. 593-599
    • Miyanishi, K.1    Hoki, T.2    Tanaka, S.3    Kato, J.4
  • 117
    • 0031980673 scopus 로고    scopus 로고
    • Role of iron in the natural history and clinical course of hepatitis C disease
    • Shedlofsky, S. Role of iron in the natural history and clinical course of hepatitis C disease. Hepato-Gastroenterology 1997, 45, 349-355.
    • (1997) Hepato-Gastroenterology , vol.45 , pp. 349-355
    • Shedlofsky, S.1
  • 118
    • 1442350427 scopus 로고    scopus 로고
    • Clinical significance of hepatic iron deposition and serum iron valuesin patients with chronic hepatitis C infection
    • Metwally, M.A.; Zein, C.O.; Zein, N.N. Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection. Am. J. Gastroenterol. 2004, 99, 286-291
    • (2004) Am. J. Gastroenterol. , vol.99 , pp. 286-291
    • Metwally, M.A.1    Zein, C.O.2    Zein, N.N.3
  • 120
    • 14944342277 scopus 로고    scopus 로고
    • Association of hepatitis C virus infection with serum iron status:Analysis of data from the third national health and nutrition examination survey
    • Shan, Y.; Lambrecht, R.W.; Bonkovsky, H.L. Association of hepatitis C virus infection with serum iron status: Analysis of data from the third national health and nutrition examination survey. Clin. Infect. Dis. 2005, 40, 834-841
    • (2005) Clin. Infect. Dis , vol.40 , pp. 834-841
    • Shan, Y.1    Lambrecht, R.W.2    Bonkovsky, H.L.3
  • 122
    • 84941079687 scopus 로고    scopus 로고
    • Prediction of fibrosis in hepatitis C patients: Assessment using hydroxyprolineand oxidative stress biomarkers
    • Gabr, S.A.; Alghadir, A.H. Prediction of fibrosis in hepatitis C patients: Assessment using hydroxyproline and oxidative stress biomarkers. Virusdisease 2014, 25, 91-100
    • (2014) Virusdisease , vol.25 , pp. 91-100
    • Gabr, S.A.1    Alghadir, A.H.2
  • 123
    • 84919848147 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Trépo, C.; Chan, H.L.; Lok, A. Hepatitis B virus infection. Lancet 2014, 384, 2053-2063
    • (2014) Lancet , vol.384 , pp. 2053-2063
    • Trépo, C.1    Chan, H.L.2    Lok, A.3
  • 124
    • 77954650414 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B
    • McMahon, B.J. Natural history of chronic hepatitis B. Clin. Liver Dis. 2010, 14, 381-396
    • (2010) Clin. Liver Dis , vol.14 , pp. 381-396
    • McMahon, B.J.1
  • 126
    • 44649161902 scopus 로고    scopus 로고
    • Proteomicanalysis of cellular protein alterations using a hepatitis B virus-producing cellular model
    • Tong, A.; Wu, L.; Lin, Q.; Lau, Q.C.; Zhao, X.; Li, J.; Chen, P.; Chen, L.; Tang, H.; Huang, C. Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model. Proteomics 2008, 8, 2012-2023
    • (2008) Proteomics , vol.8 , pp. 2012-2023
    • Tong, A.1    Wu, L.2    Lin, Q.3    Lau, Q.C.4    Zhao, X.5    Li, J.6    Chen, P.7    Chen, L.8    Tang, H.9    Huang, C.10
  • 127
    • 23044439383 scopus 로고    scopus 로고
    • CDNA microarray analysis ofHBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV
    • Hajjou, M.; Norel, R.; Carver, R.; Marion, P.; Cullen, J.; Rogler, L.E.; Rogler, C.E. cDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV. J. Med. Virol. 2005, 77, 57-65
    • (2005) J. Med. Virol. , vol.77 , pp. 57-65
    • Hajjou, M.1    Norel, R.2    Carver, R.3    Marion, P.4    Cullen, J.5    Rogler, L.E.6    Rogler, C.E.7
  • 128
    • 84922688324 scopus 로고    scopus 로고
    • Reactive oxygen species promote heat shock protein 90-mediated hbv capsidassembly
    • Kim, Y.S.; Seo, H.W.; Jung, G. Reactive oxygen species promote heat shock protein 90-mediated hbv capsid assembly. Biochem. Biophys. Res. Commun. 2015, 457, 328-333
    • (2015) Biochem. Biophys. Res. Commun , vol.457 , pp. 328-333
    • Kim, Y.S.1    Seo, H.W.2    Jung, G.3
  • 129
    • 29144475091 scopus 로고    scopus 로고
    • Investigation of oxidative stress and someantioxidants in patients with acute and chronic viral hepatitis B and the effect of interferon-α treatment
    • Dikici, I.; Mehmetoglu, I.; Dikici, N.; Bitirgen, M.; Kurban, S. Investigation of oxidative stress and some antioxidants in patients with acute and chronic viral hepatitis B and the effect of interferon-α treatment. Clin. Biochem. 2005, 38, 1141-1144
    • (2005) Clin. Biochem , vol.38 , pp. 1141-1144
    • Dikici, I.1    Mehmetoglu, I.2    Dikici, N.3    Bitirgen, M.4    Kurban, S.5
  • 130
    • 84923009315 scopus 로고    scopus 로고
    • The metabolic responsesto hepatitis B virus infection shed new light on pathogenesis and targets for treatment
    • Li, H.; Zhu, W.; Zhang, L.; Lei, H.; Wu, X.; Guo, L.; Chen, X.; Wang, Y.; Tang, H. The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment. Sci. Rep. 2015, 5
    • (2015) Sci. Rep , vol.5
    • Li, H.1    Zhu, W.2    Zhang, L.3    Lei, H.4    Wu, X.5    Guo, L.6    Chen, X.7    Wang, Y.8    Tang, H.9
  • 131
    • 84859183283 scopus 로고    scopus 로고
    • Relationship of oxidative stress in hepatitis B infection activitywith hbv DNA and fibrosis
    • Duygu, F.; Karsen, H.; Aksoy, N.; Taskin, A. Relationship of oxidative stress in hepatitis B infection activity with hbv DNA and fibrosis. Ann. Lab. Med. 2012, 32, 113-118
    • (2012) Ann. Lab. Med. , vol.32 , pp. 113-118
    • Duygu, F.1    Karsen, H.2    Aksoy, N.3    Taskin, A.4
  • 132
    • 67649116613 scopus 로고    scopus 로고
    • Global burden ofdisease and injury and economic cost attributable to alcohol use and alcohol-use disorders
    • Rehm, J.; Mathers, C.; Popova, S.; Thavorncharoensap, M.; Teerawattananon, Y.; Patra, J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 2009, 373, 2223-2233
    • (2009) Lancet , vol.373 , pp. 2223-2233
    • Rehm, J.1    Mathers, C.2    Popova, S.3    Thavorncharoensap, M.4    Teerawattananon, Y.5    Patra, J.6
  • 134
    • 77955663457 scopus 로고    scopus 로고
    • Caffeine protects against alcoholic liver injuryby attenuating inflammatory response and oxidative stress
    • Lv, X.; Chen, Z.; Li, J.; Zhang, L.; Liu, H.; Huang, C.; Zhu, P. Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. Inflamm. Res. 2010, 59, 635-645
    • (2010) Inflamm. Res , vol.59 , pp. 635-645
    • Lv, X.1    Chen, Z.2    Li, J.3    Zhang, L.4    Liu, H.5    Huang, C.6    Zhu, P.7
  • 135
    • 39749090649 scopus 로고    scopus 로고
    • Oxidative mechanisms in the pathogenesis of alcoholic liver disease
    • Albano, E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol. Asp. Med. 2008, 29, 9-16
    • (2008) Mol. Asp. Med , vol.29 , pp. 9-16
    • Albano, E.1
  • 136
    • 79953719985 scopus 로고    scopus 로고
    • Further studies on the hepatoprotectiveeffect of antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats
    • Lu, Z.-M.; Tao, W.-Y.; Xu, H.-Y.; Ao, Z.-H.; Zhang, X.-M.; Xu, Z.-H. Further studies on the hepatoprotective effect of antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats. Nat. Prod. Res. 2011, 25, 684-695
    • (2011) Nat. Prod. Res , vol.25 , pp. 684-695
    • Lu, Z.-M.1    Tao, W.-Y.2    Xu, H.-Y.3    Ao, Z.-H.4    Zhang, X.-M.5    Xu, Z.-H.6
  • 137
    • 67649968443 scopus 로고    scopus 로고
    • Oxidative stress and alcoholic liver disease
    • Wu, D.I.; Cederbaum, A.I. Oxidative stress and alcoholic liver disease. Semin. Liver Dis. 2009, 29, 141-154
    • (2009) Semin. Liver Dis , vol.29 , pp. 141-154
    • Wu, D.I.1    Cederbaum, A.I.2
  • 138
    • 33747099988 scopus 로고    scopus 로고
    • CYP2E1-dependent oxidative stress and toxicity: Role inethanol-induced liver injury
    • Jimenez-Lopez, J.M.; Cederbaum, A.I. CYP2E1-dependent oxidative stress and toxicity: Role in ethanol-induced liver injury. Expert Opin. Drug Metab. Toxicol. 2005, 1, 671-685
    • (2005) Expert Opin. Drug Metab. Toxicol , vol.1 , pp. 671-685
    • Jimenez-Lopez, J.M.1    Cederbaum, A.I.2
  • 139
    • 34347366351 scopus 로고    scopus 로고
    • Protective effects of platycodi radix on alcohol-induced fatty liver
    • Kim, H.K.; Kim, D.-S.; Cho, H.-Y. Protective effects of platycodi radix on alcohol-induced fatty liver. Biosci. Biotechnol. Biochem. 2007, 71, 1550-1552
    • (2007) Biosci. Biotechnol. Biochem , vol.71 , pp. 1550-1552
    • Kim, H.K.1    Kim, D.-S.2    Cho, H.-Y.3
  • 140
    • 78650355363 scopus 로고    scopus 로고
    • Gentianamanshurica kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation
    • Lian, L.-H.; Wu, Y.-L.; Song, S.-Z.; Wan, Y.; Xie, W.-X.; Li, X.; Bai, T.; Ouyang, B.-Q.; Nan, J.-X. Gentiana manshurica kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation. J. Agric. Food Chem. 2010, 58, 13013-13019
    • (2010) J. Agric. Food Chem , vol.58 , pp. 13013-13019
    • Lian, L.-H.1    Wu, Y.-L.2    Song, S.-Z.3    Wan, Y.4    Xie, W.-X.5    Li, X.6    Bai, T.7    Ouyang, B.-Q.8    Nan, J.-X.9
  • 141
    • 34447134884 scopus 로고    scopus 로고
    • Heme oxygenase-1 upregulated by ginkgo biloba extract: Potential protection against ethanol-induced oxidative liver damage
    • Yao, P.; Li, K.; Song, F.; Zhou, S.; Sun, X.; Zhang, X.; Nüssler, A.K.; Liu, L. Heme oxygenase-1 upregulated by ginkgo biloba extract: Potential protection against ethanol-induced oxidative liver damage. Food Chem. Toxicol. 2007, 45, 1333-1342
    • (2007) Food Chem. Toxicol , vol.45 , pp. 1333-1342
    • Yao, P.1    Li, K.2    Song, F.3    Zhou, S.4    Sun, X.5    Zhang, X.6    Nüssler, A.K.7    Liu, L.8
  • 142
    • 77953220373 scopus 로고    scopus 로고
    • The role of oxidative stress in alcoholic liver injury
    • Radosavljević, T.; Mladenović, D.; Vučević, D. The role of oxidative stress in alcoholic liver injury. Med. Pregled 2009, 62, 547-553
    • (2009) Med.Pregled , vol.62 , pp. 547-553
    • Radosavljević, T.1    Mladenović, D.2    Vučević, D.3
  • 143
    • 50249097286 scopus 로고    scopus 로고
    • Protective action of fenugreek (Trigonella foenum graecum)seed polyphenols against alcohol-induced protein and lipid damage in rat liver
    • Kaviarasan, S.; Sundarapandiyan, R.; Anuradha, C. Protective action of fenugreek (Trigonella foenum graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver. Cell Biol. Toxicol. 2008, 24, 391-400
    • (2008) Cell Biol. Toxicol , vol.24 , pp. 391-400
    • Kaviarasan, S.1    Sundarapandiyan, R.2    Anuradha, C.3
  • 144
    • 77951668368 scopus 로고    scopus 로고
    • Protective effect of puerarin on acute alcoholic liver injury
    • Zhao, M.; Du, Y.-Q.; Yuan, L.; Wang, N.-N. Protective effect of puerarin on acute alcoholic liver injury. Am. J. Chin. Med. 2010, 38, 241-249
    • (2010) Am. J.Chin. Med , vol.38 , pp. 241-249
    • Zhao, M.1    Du, Y.-Q.2    Yuan, L.3    Wang, N.-N.4
  • 145
    • 33947603510 scopus 로고    scopus 로고
    • Ginkgo biloba extract protects against alcohol-induced liver injury in rats
    • Yuan, G.; Gong, Z.; Li, J.; Li, X. Ginkgo biloba extract protects against alcohol-induced liver injury in rats. Phytother. Res. 2007, 21, 234-238
    • (2007) Phytother. Res , vol.21 , pp. 234-238
    • Yuan, G.1    Gong, Z.2    Li, J.3    Li, X.4
  • 146
    • 68949132656 scopus 로고    scopus 로고
    • Curcumin decreasedoxidative stress, inhibited NF-κB activation, and improved liver pathology in ethanol-induced liver injury in rats
    • Samuhasaneeto, S.; Thong-Ngam, D.; Kulaputana, O.; Suyasunanont, D.; Klaikeaw, N. Curcumin decreased oxidative stress, inhibited NF-κB activation, and improved liver pathology in ethanol-induced liver injury in rats. J. Biomed. Biotechnol. 2009, 2009
    • (2009) J. Biomed. Biotechnol , vol.2009
    • Samuhasaneeto, S.1    Thong-Ngam, D.2    Kulaputana, O.3    Suyasunanont, D.4    Klaikeaw, N.5
  • 147
    • 79958043464 scopus 로고    scopus 로고
    • Catechin suppresses an array of signalling moleculesand modulates alcohol-induced endotoxin mediated liver injury in a rat model
    • Bharrhan, S.; Koul, A.; Chopra, K.; Rishi, P.; Lee, T. Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. PLoS ONE 2011, 6, e20635
    • (2011) Plos ONE , vol.6
    • Bharrhan, S.1    Koul, A.2    Chopra, K.3    Rishi, P.4    Lee, T.5
  • 148
    • 2642553874 scopus 로고    scopus 로고
    • Recent advances in alcoholic liver disease. I. Role of intestinalpermeability and endotoxemia in alcoholic liver disease
    • Rao, R.K.; Seth, A.; Sheth, P.; Rao, P. Recent advances in alcoholic liver disease. I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286, G881-G884
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.286 , pp. G881-G884
    • Rao, R.K.1    Seth, A.2    Sheth, P.3    Rao, P.4
  • 149
    • 70350302336 scopus 로고    scopus 로고
    • Effects of puerariae radix extract on the increasing intestinal permeabilityin rat with alcohol-induced liver injury
    • Zhang, R.; Hu, Y.; Yuan, J.; Wu, D. Effects of puerariae radix extract on the increasing intestinal permeability in rat with alcohol-induced liver injury. J. Ethnopharmacol. 2009, 126, 207-214
    • (2009) J. Ethnopharmacol , vol.126 , pp. 207-214
    • Zhang, R.1    Hu, Y.2    Yuan, J.3    Wu, D.4
  • 153
    • 62749162644 scopus 로고    scopus 로고
    • Cinnamon extract protects againstacute alcohol-induced liver steatosis in mice
    • Kanuri, G.; Weber, S.; Volynets, V.; Spruss, A.; Bischoff, S.C.; Bergheim, I. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. J. Nutr. 2009, 139, 482-487
    • (2009) J. Nutr , vol.139 , pp. 482-487
    • Kanuri, G.1    Weber, S.2    Volynets, V.3    Spruss, A.4    Bischoff, S.C.5    Bergheim, I.6
  • 154
    • 84855440646 scopus 로고    scopus 로고
    • Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatoryresponses in alcoholic fatty liver condition
    • Kim, S.-J.; Lee, S.-M. Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition. Toxicol. Appl. Pharmacol. 2012, 258, 43-50
    • (2012) Toxicol. Appl. Pharmacol , vol.258 , pp. 43-50
    • Kim, S.-J.1    Lee, S.-M.2
  • 157
    • 0032185432 scopus 로고    scopus 로고
    • Mechanisms of hepatic toxicity II. Alcoholic liver injury involves activation of Kupffer cellsby endotoxin
    • Thurman, R.G. Mechanisms of hepatic toxicity II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am. J. Physiol. Gastrointest. Liver Physiol. 1998, 38, G605-G611.
    • (1998) Am. J. Physiol. Gastrointest. Liver Physiol , vol.38 , pp. G605-G611
    • Thurman, R.G.1
  • 158
    • 58849156556 scopus 로고    scopus 로고
    • Molecular mechanisms of alcoholic fatty liver
    • Purohit, V.; Gao, B.; Song, B.J. Molecular mechanisms of alcoholic fatty liver. Alcohol. Clin. Exp. Res. 2009, 33, 191-205
    • (2009) Alcohol. Clin. Exp. Res , vol.33 , pp. 191-205
    • Purohit, V.1    Gao, B.2    Song, B.J.3
  • 159
    • 12744267804 scopus 로고    scopus 로고
    • Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-bindingproteins
    • You, M.; Crabb, D.W. Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-binding proteins. Alcohol 2004, 34, 39-43
    • (2004) Alcohol , vol.34 , pp. 39-43
    • You, M.1    Crabb, D.W.2
  • 160
    • 0036251153 scopus 로고    scopus 로고
    • Srebps: Activators of the complete program of cholesterol and fattyacid synthesis in the liver
    • Horton, J.D.; Goldstein, J.; Brown, M.S. Srebps: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Investig. 2002, 109, 1125-1131
    • (2002) J. Clin. Investig , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.2    Brown, M.S.3
  • 161
    • 61849111204 scopus 로고    scopus 로고
    • Honokiol reverses alcoholic fatty liverby inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes
    • Yin, H.Q.; Kim, Y.C.; Chuang, Y.S.; Kim, Y.C.; Shin, Y.K.; Lee, B.H. Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes. Toxicol. Appl. Pharmacol. 2009, 236, 124-130
    • (2009) Toxicol. Appl. Pharmacol , vol.236 , pp. 124-130
    • Yin, H.Q.1    Kim, Y.C.2    Chuang, Y.S.3    Kim, Y.C.4    Shin, Y.K.5    Lee, B.H.6
  • 162
    • 80053167253 scopus 로고    scopus 로고
    • Depression by a green tea extract of alcohol-induced oxidative stress and lipogenesis in rat liver
    • Chen, K.-H.; Li, P.-C.; Lin, W.-H.; Chien, C.-T.; Low, B.-H. Depression by a green tea extract of alcohol-induced oxidative stress and lipogenesis in rat liver. Biosci. Biotechnol. Biochem. 2011, 75, 1668-1676
    • (2011) Biosci. Biotechnol. Biochem. , vol.75 , pp. 1668-1676
    • Chen, K.-H.1    Li, P.-C.2    Lin, W.-H.3    Chien, C.-T.4    Low, B.-H.5
  • 164
    • 66249124259 scopus 로고    scopus 로고
    • Magnoliaofficinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c
    • Yin, H.-Q.; Je, Y.-T.; Kim, Y.-C.; Shin, Y.-K.; Sung, S.; Lee, K.; Lee, B.-H.; Jeong, G.-S.; Kim, Y.-C. Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c. J. Pharmacol. Sci. 2009, 109, 486-495
    • (2009) J. Pharmacol. Sci , vol.109 , pp. 486-495
    • Yin, H.-Q.1    Je, Y.-T.2    Kim, Y.-C.3    Shin, Y.-K.4    Sung, S.5    Lee, K.6    Lee, B.-H.7    Jeong, G.-S.8    Kim, Y.-C.9
  • 165
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • Long, Y.C.; Zierath, J.R. AMP-activated protein kinase signaling in metabolic regulation. J. Clin. Investig. 2006, 116, 1776-1783
    • (2006) J. Clin. Investig , vol.116 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 166
    • 34247604581 scopus 로고    scopus 로고
    • TNF-α induces hepatic steatosis in mice by enhancing geneexpression of sterol regulatory element binding protein-1c (SREBP-1c)
    • Endo, M.; Masaki, T.; Seike, M.; Yoshimatsu, H. TNF-α induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c). Exp. Biol. Med. 2007, 232, 614-621.
    • (2007) Exp. Biol. Med , vol.232 , pp. 614-621
    • Endo, M.1    Masaki, T.2    Seike, M.3    Yoshimatsu, H.4
  • 167
    • 0032570828 scopus 로고    scopus 로고
    • Tumor necrosis factor-α stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase
    • Lawler, J.F., Jr.; Yin, M.; Diehl, A.M.; Chatterjee, S.; Roberts, E. Tumor necrosis factor-α stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. J. Biol. Chem. 1998, 273, 5053-5059
    • (1998) J. Biol. Chem , vol.273 , pp. 5053-5059
    • Lawler, J.F.1    Yin, M.2    Diehl, A.M.3    Chatterjee, S.4    Roberts, E.5
  • 169
    • 48449089518 scopus 로고    scopus 로고
    • Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice
    • Wada, S.; Yamazaki, T.; Kawano, Y.; Miura, S.; Ezaki, O. Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice. J. Hepatol. 2008, 49, 441-450
    • (2008) J. Hepatol , vol.49 , pp. 441-450
    • Wada, S.1    Yamazaki, T.2    Kawano, Y.3    Miura, S.4    Ezaki, O.5
  • 171
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon, G.; Baranova, A.; Younossi, Z. Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 2011, 34, 274-285
    • (2011) Aliment. Pharmacol. Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.3
  • 172
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "HITS"?
    • Day, C.P.; James, O.F. Steatohepatitis: A tale of two "HITS"? Gastroenterology 1998, 114, 842-845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 173
    • 84944358185 scopus 로고    scopus 로고
    • Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liverdisease?-A mechanistic hypothesis
    • de Medeiros, I.C.; de Lima, J.G. Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease?-A mechanistic hypothesis. Med. Hypotheses 2015, 85, 148-152
    • (2015) Med. Hypotheses , vol.85 , pp. 148-152
    • De Medeiros, I.C.1    De Lima, J.G.2
  • 174
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulinresistance
    • Houstis, N.; Rosen, E.D.; Lander, E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440, 944-948
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 175
    • 84925507275 scopus 로고    scopus 로고
    • The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, withsystemic inflammation and subclinical atherosclerosis: The multi-ethnic study of atherosclerosis (MESA)
    • Al Rifai, M.; Silverman, M.G.; Nasir, K.; Budoff, M.J.; Blankstein, R.; Szklo, M.; Katz, R.; Blumenthal, R.S.; Blaha, M.J. The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: The multi-ethnic study of atherosclerosis (MESA). Atherosclerosis 2015, 239, 629-633
    • (2015) Atherosclerosis , vol.239 , pp. 629-633
    • Al Rifai, M.1    Silverman, M.G.2    Nasir, K.3    Budoff, M.J.4    Blankstein, R.5    Szklo, M.6    Katz, R.7    Blumenthal, R.S.8    Blaha, M.J.9
  • 176
    • 84893903196 scopus 로고    scopus 로고
    • Therelationship between advanced oxidation protein products (AOPP) and biochemical and histopathological findings in patients with nonalcoholic steatohepatitis
    • Ozenirler, S.; Erkan, G.; Konca Degertekin, C.; Ercin, U.; Cengiz, M.; Bilgihan, A.; Yilmaz, G.; Akyol, G. The relationship between advanced oxidation protein products (AOPP) and biochemical and histopathological findings in patients with nonalcoholic steatohepatitis. J. Dig. Dis. 2014, 15, 131-136
    • (2014) J. Dig. Dis , vol.15 , pp. 131-136
    • Ozenirler, S.1    Erkan, G.2    Konca Degertekin, C.3    Ercin, U.4    Cengiz, M.5    Bilgihan, A.6    Yilmaz, G.7    Akyol, G.8
  • 177
    • 33845390864 scopus 로고    scopus 로고
    • Protein adducts generated from products of lipid oxidation: Focus on hne and one*
    • Sayre, L.M.; Lin, D.; Yuan, Q.; Zhu, X.; Tang, X. Protein adducts generated from products of lipid oxidation: Focus on hne and one*. Drug Metab. Rev. 2006, 38, 651-675
    • (2006) Drug Metab. Rev. , vol.38 , pp. 651-675
    • Sayre, L.M.1    Lin, D.2    Yuan, Q.3    Zhu, X.4    Tang, X.5
  • 178
    • 84915803580 scopus 로고    scopus 로고
    • Oral coenzyme q10 supplementation in patientswith nonalcoholic fatty liver disease: Effects on serum vaspin, chemerin, pentraxin 3, insulin resistance and oxidative stress
    • Farhangi, M.A.; Alipour, B.; Jafarvand, E.; Khoshbaten, M. Oral coenzyme q10 supplementation in patients with nonalcoholic fatty liver disease: Effects on serum vaspin, chemerin, pentraxin 3, insulin resistance and oxidative stress. Arch. Med. Res. 2014, 45, 589-595
    • (2014) Arch. Med. Res , vol.45 , pp. 589-595
    • Farhangi, M.A.1    Alipour, B.2    Jafarvand, E.3    Khoshbaten, M.4
  • 180
    • 1442300220 scopus 로고    scopus 로고
    • Oxidative stress and enzymaticantioxidant status in patients with nonalcoholic steatohepatitis
    • Koruk, M.; Taysi, S.; Savas, M.C.; Yilmaz, O.; Akcay, F.; Karakok, M. Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis. Ann. Clin. Lab. Sci. 2004, 34, 57-62
    • (2004) Ann. Clin. Lab. Sci , vol.34 , pp. 57-62
    • Koruk, M.1    Taysi, S.2    Savas, M.C.3    Yilmaz, O.4    Akcay, F.5    Karakok, M.6
  • 181
    • 84942821013 scopus 로고    scopus 로고
    • Drug-induced liver injury: Interactions betweendrug properties and host factors
    • Chen, M.; Suzuki, A.; Borlak, J.; Andrade, R.J.; Lucena, M.I. Drug-induced liver injury: Interactions between drug properties and host factors. J. Hepatol. 2015, 63, 503-514
    • (2015) J. Hepatol , vol.63 , pp. 503-514
    • Chen, M.1    Suzuki, A.2    Borlak, J.3    Andrade, R.J.4    Lucena, M.I.5
  • 182
    • 84921874747 scopus 로고    scopus 로고
    • Comparative hepatoprotective effects of tocotrienol analogs againstdrug-induced liver injury
    • Tan, C.Y.; Saw, T.Y.; Fong, C.W.; Ho, H.K. Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury. Redox Biol. 2015, 4, 308-320
    • (2015) Redox Biol , vol.4 , pp. 308-320
    • Tan, C.Y.1    Saw, T.Y.2    Fong, C.W.3    Ho, H.K.4
  • 184
    • 0025087535 scopus 로고
    • Do corticosteroids reduce mortality from alcoholic hepatitis?:A meta-analysis of the randomized trials
    • Imperiale, T.F.; McCullough, A.J. Do corticosteroids reduce mortality from alcoholic hepatitis?: A meta-analysis of the randomized trials. Ann. Intern. Med. 1990, 113, 299-307
    • (1990) Ann. Intern. Med , vol.113 , pp. 299-307
    • Imperiale, T.F.1    McCullough, A.J.2
  • 187
    • 64549087112 scopus 로고    scopus 로고
    • Pentoxifylline versus prednisolone for severe alcoholic hepatitis: A randomized controlled trial
    • De, B.K.; Gangopadhyay, S.; Dutta, D.; Baksi, S.D.; Pani, A.; Ghosh, P. Pentoxifylline versus prednisolone for severe alcoholic hepatitis: A randomized controlled trial. World J. Gastroenterol. 2009, 15, 1613-1619
    • (2009) World J. Gastroenterol , vol.15 , pp. 1613-1619
    • De, B.K.1    Gangopadhyay, S.2    Dutta, D.3    Baksi, S.D.4    Pani, A.5    Ghosh, P.6
  • 188
    • 84856948223 scopus 로고    scopus 로고
    • Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease
    • Gao, B. Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease. J. Gastroenterol. Hepatol. 2012, 27, 89-93
    • (2012) J. Gastroenterol. Hepatol , vol.27 , pp. 89-93
    • Gao, B.1
  • 189
    • 79955776494 scopus 로고    scopus 로고
    • In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression
    • Park, O.; Wang, H.; Weng, H.; Feigenbaum, L.; Li, H.; Yin, S.; Ki, S.H.; Yoo, S.H.; Dooley, S.; Wang, F.S. In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression. Hepatology 2011, 54, 252-261
    • (2011) Hepatology , vol.54 , pp. 252-261
    • Park, O.1    Wang, H.2    Weng, H.3    Feigenbaum, L.4    Li, H.5    Yin, S.6    Ki, S.H.7    Yoo, S.H.8    Dooley, S.9    Wang, F.S.10
  • 191
    • 67349275024 scopus 로고    scopus 로고
    • IL-22: A critical mediator in mucosal host defense
    • Aujla, S.; Kolls, J. IL-22: A critical mediator in mucosal host defense. J. Mol. Med. 2009, 87, 451-454
    • (2009) J. Mol. Med , vol.87 , pp. 451-454
    • Aujla, S.1    Kolls, J.2
  • 193
    • 84883036665 scopus 로고    scopus 로고
    • Oxidative stress and the paradoxical effects of antioxidants
    • Rafieian-Kopaei, M.; Baradaran, A.; Rafieian, M. Oxidative stress and the paradoxical effects of antioxidants. J. Res. Med. Sci. 2013, 18, 628
    • (2013) J. Res. Med. Sci , vol.18 , pp. 628
    • Rafieian-Kopaei, M.1    Baradaran, A.2    Rafieian, M.3
  • 195
    • 62149087766 scopus 로고    scopus 로고
    • Weaknesses of bayesian model averaging for meta-analysis in the study of vitamin E andmortality
    • Greenland, S. Weaknesses of bayesian model averaging for meta-analysis in the study of vitamin E and mortality. Clin. Trials 2009, 6, 42-46
    • (2009) Clin. Trials , vol.6 , pp. 42-46
    • Greenland, S.1
  • 196
    • 84894639624 scopus 로고    scopus 로고
    • Medicinal plants and antioxidants: Why they are not always beneficial? Iran
    • Nasri, H.; Rafieian-Kopaei, M. Medicinal plants and antioxidants: Why they are not always beneficial? Iran. J. Public Health 2014, 43, 255-257
    • (2014) J. Public Health , vol.43 , pp. 255-257
    • Nasri, H.1    Rafieian-Kopaei, M.2
  • 197
    • 84933533842 scopus 로고    scopus 로고
    • Renoprotective effects of antioxidants against cisplatinnephrotoxicity
    • Hajian, S.; Rafieian-Kopaei, M.; Nasri, H. Renoprotective effects of antioxidants against cisplatin nephrotoxicity. J. Nephropharmacol. 2015, 3, 39-42.
    • (2015) J. Nephropharmacol , vol.3 , pp. 39-42
    • Hajian, S.1    Rafieian-Kopaei, M.2    Nasri, H.3
  • 201
    • 84897906802 scopus 로고    scopus 로고
    • World kidney day 2014: Kidney disease and elderly
    • Hajivandi, A.; Amiri, M. World kidney day 2014: Kidney disease and elderly. J. Parathyr. Dis. 2015, 2, 3-4.
    • (2015) J. Parathyr. Dis , vol.2 , pp. 3-4
    • Hajivandi, A.1    Amiri, M.2
  • 203
    • 84900332421 scopus 로고    scopus 로고
    • World kidney day 2013; acute renal injury; a global healthwarning
    • Tamadon, M.-R.; Ardalan, M.-R.; Nasri, H. World kidney day 2013; acute renal injury; a global health warning. J. Parathyr. Dis. 2015, 1, 27-28.
    • (2015) J. Parathyr. Dis. , vol.1 , pp. 27-28
    • Tamadon, M.-R.1    Ardalan, M.-R.2    Nasri, H.3
  • 204
    • 13444280225 scopus 로고    scopus 로고
    • Dietary fats and membrane function: Implications formetabolism and disease
    • Hulbert, A.J.; Turner, N.; Storlien, L.; Else, P. Dietary fats and membrane function: Implications for metabolism and disease. Biol. Rev. 2005, 80, 155-169
    • (2005) Biol. Rev , vol.80 , pp. 155-169
    • Hulbert, A.J.1    Turner, N.2    Storlien, L.3    Else, P.4
  • 205
    • 84895101265 scopus 로고    scopus 로고
    • Antioxidant activity and preventive effectof aqueous leaf extract of aloe vera on gentamicin-induced nephrotoxicity in male wistar rats
    • Baradaran, A.; Nasri, H.; Nematbakhsh, M.; Rafieian-Kopaei, M. Antioxidant activity and preventive effect of aqueous leaf extract of aloe vera on gentamicin-induced nephrotoxicity in male wistar rats. La Clin. Ter. 2013, 165, 7-11.
    • (2013) La Clin. Ter , vol.165 , pp. 7-11
    • Baradaran, A.1    Nasri, H.2    Nematbakhsh, M.3    Rafieian-Kopaei, M.4
  • 207
    • 84894619288 scopus 로고    scopus 로고
    • Toxicity and safety of medicinal plants
    • Nasri, H.; Shirzad, H. Toxicity and safety of medicinal plants. J. HerbMed Plarmacol. 2013, 2, 21-22.
    • (2013) J. Herbmed Plarmacol , vol.2 , pp. 21-22
    • Nasri, H.1    Shirzad, H.2
  • 208
    • 84894281562 scopus 로고    scopus 로고
    • Safety concerns to application of graphene compounds inpharmacy and medicine
    • Mogharabi, M.; Abdollahi, M.; Faramarzi, M.A. Safety concerns to application of graphene compounds in pharmacy and medicine. Daru 2014, 22(1), 22-23
    • (2014) Daru , vol.22 , Issue.1 , pp. 22-23
    • Mogharabi, M.1    Abdollahi, M.2    Faramarzi, M.A.3
  • 211
    • 24344466882 scopus 로고    scopus 로고
    • DNA methylation and histone modifications: Teaming up to silence genes
    • Fuks, F. DNA methylation and histone modifications: Teaming up to silence genes. Curr. Opin. Genet. Dev. 2005, 15, 490-495
    • (2005) Curr. Opin. Genet. Dev , vol.15 , pp. 490-495
    • Fuks, F.1
  • 212
    • 55849135596 scopus 로고    scopus 로고
    • MicroRNA-directed transcriptional gene silencing in mammaliancells
    • Kim, D.H.; Saetrom, P.; Snøve, O.; Rossi, J.J. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc. Natl. Acad. Sci. USA 2008, 105, 16230-16235
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16230-16235
    • Kim, D.H.1    Saetrom, P.2    Snøve, O.3    Rossi, J.J.4
  • 213
    • 67749129297 scopus 로고    scopus 로고
    • Epigenetics and environmental chemicals
    • Baccarelli, A.; Bollati, V. Epigenetics and environmental chemicals. Curr. Opin. Pediatr. 2009, 21, 243-251
    • (2009) Curr. Opin. Pediatr , vol.21 , pp. 243-251
    • Baccarelli, A.1    Bollati, V.2
  • 214
    • 43349090926 scopus 로고    scopus 로고
    • Mirnas: Effectors of environmental influences on gene expression and disease
    • Hudder, A.; Novak, R.F. Mirnas: Effectors of environmental influences on gene expression and disease. Toxicol. Sci. 2008, 103, 228-240
    • (2008) Toxicol. Sci , vol.103 , pp. 228-240
    • Hudder, A.1    Novak, R.F.2
  • 215
    • 67349236051 scopus 로고    scopus 로고
    • The genetics and epigenetics of autoimmune diseases
    • Hewagama, A.; Richardson, B. The genetics and epigenetics of autoimmune diseases. J. Autoimmun. 2009, 33, 3-11
    • (2009) J. Autoimmun , vol.33 , pp. 3-11
    • Hewagama, A.1    Richardson, B.2
  • 216
    • 34147095310 scopus 로고    scopus 로고
    • The muscle-specificmicrorna miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    • Yang, B.; Lin, H.; Xiao, J.; Lu, Y.; Luo, X.; Li, B.; Zhang, Y.; Xu, C.; Bai, Y.; Wang, H.; et al. The muscle-specific microrna miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat. Med. 2007, 13, 486-491
    • (2007) Nat. Med , vol.13 , pp. 486-491
    • Yang, B.1    Lin, H.2    Xiao, J.3    Lu, Y.4    Luo, X.5    Li, B.6    Zhang, Y.7    Xu, C.8    Bai, Y.9    Wang, H.10
  • 217
    • 49949108971 scopus 로고    scopus 로고
    • Age-specific epigenetic drift in late-onset Alzheimer’s disease
    • Wang, S.-C.; Oelze, B.; Schumacher, A. Age-specific epigenetic drift in late-onset Alzheimer’s disease. PLoS ONE 2008, 3, e2698
    • (2008) Plosone , vol.3
    • Wang, S.-C.1    Oelze, B.2    Schumacher, A.3
  • 218
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Andrew, P.F.; Rolf, O.; Steven, H. The epigenetic progenitor origin of human cancer. Nat. Rev. Genet. 2006, 7, 21-33.
    • (2006) Nat. Rev. Genet , vol.7 , pp. 21-33
    • Andrew, P.F.1    Rolf, O.2    Steven, H.3
  • 219
    • 42549085238 scopus 로고    scopus 로고
    • The epigenetic landscape of plants
    • Zhang, X. The epigenetic landscape of plants. Science 2008, 320, 489-492
    • (2008) Science , vol.320 , pp. 489-492
    • Zhang, X.1
  • 220
    • 67650684993 scopus 로고    scopus 로고
    • Review Article: Epigenetics in the Placenta
    • Maccani, M.A.; Marsit, C.J. Review Article: Epigenetics in the Placenta. Am. J. Reprod. Immunol. 2009, 62, 78-89
    • (2009) Am. J. Reprod. Immunol , vol.62 , pp. 78-89
    • Maccani, M.A.1    Marsit, C.J.2
  • 221
    • 39149091066 scopus 로고    scopus 로고
    • Environment, diet and CPG island methylation: Epigenetic signals ingastrointestinal neoplasia
    • Johnson, I.T.; Belshaw, N.J. Environment, diet and CPG island methylation: Epigenetic signals in gastrointestinal neoplasia. Food Chem. Toxicol. 2008, 46, 1346-1359
    • (2008) Food Chem. Toxicol , vol.46 , pp. 1346-1359
    • Johnson, I.T.1    Belshaw, N.J.2
  • 222
    • 0033988813 scopus 로고    scopus 로고
    • DNA methyltransferase DNMT1 associateswith histone deacetylase activity
    • François, F.; Wendy, A.B.; Alexander, B.; Luke, H.-D.; Tony, K. DNA methyltransferase DNMT1 associates with histone deacetylase activity. Nat. Genet. 2000, 24, 88-91.
    • (2000) Nat. Genet , vol.24 , pp. 88-91
    • François, F.1    Wendy, A.B.2    Alexander, B.3    Luke, H.-D.4    Tony, K.5
  • 223
    • 79955104996 scopus 로고    scopus 로고
    • Epigenetics in traditional chinese pharmacy: A bioinformatic study atpharmacopoeia scale
    • Hsieh, H.-Y.; Chiu, P.-H.; Wang, S.-C. Epigenetics in traditional chinese pharmacy: A bioinformatic study at pharmacopoeia scale. Evid. Based Complement. Altern. Med. 2011, 2011
    • (2011) Evid. Based Complement. Altern. Med , pp. 2011
    • Hsieh, H.-Y.1    Chiu, P.-H.2    Wang, S.-C.3
  • 224
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • Veerle, R.; Anders, M.N. MicroRNAs in metabolism and metabolic disorders. Nat. Rev. Mol. Cell Biol. 2012, 13, 239-250.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 239-250
    • Veerle, R.1    Anders, M.N.2
  • 225
    • 84863983719 scopus 로고    scopus 로고
    • MicroRNA silencing and the development of novel therapies for liver disease
    • Szabo, G.; Sarnow, P.; Bala, S. MicroRNA silencing and the development of novel therapies for liver disease. J. Hepatol. 2012, 57, 462-466
    • (2012) J. Hepatol , vol.57 , pp. 462-466
    • Szabo, G.1    Sarnow, P.2    Bala, S.3
  • 226
    • 84864568279 scopus 로고    scopus 로고
    • Combating hepatitis C virus by targeting microrna-122 using lockednucleic acids
    • Machlin, E.; Sarnow, P.; Sagan, S.M. Combating hepatitis C virus by targeting microrna-122 using locked nucleic acids. Curr. Gene Ther. 2012, 12, 301-306
    • (2012) Curr. Gene Ther , vol.12 , pp. 301-306
    • Machlin, E.1    Sarnow, P.2    Sagan, S.M.3
  • 228
    • 79952529158 scopus 로고    scopus 로고
    • A circadian rhythmorchestrated by histone deacetylase 3 controls hepatic lipid metabolism
    • Feng, D.; Liu, T.; Sun, Z.; Bugge, A.; Mullican, S.E.; Alenghat, T.; Liu, X.S.; Lazar, M.A. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 2011, 331, 1315-1319
    • (2011) Science , vol.331 , pp. 1315-1319
    • Feng, D.1    Liu, T.2    Sun, Z.3    Bugge, A.4    Mullican, S.E.5    Alenghat, T.6    Liu, X.S.7    Lazar, M.A.8
  • 230
    • 84862800165 scopus 로고    scopus 로고
    • Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect
    • Yang, M.D.; Chiang, Y.M.; Higashiyama, R.; Asahina, K.; Mann, D.A.; Mann, J.; Wang, C.C.; Tsukamoto, H. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect. Hepatology 2012, 55, 1271-1281
    • (2012) Hepatology , vol.55 , pp. 1271-1281
    • Yang, M.D.1    Chiang, Y.M.2    Higashiyama, R.3    Asahina, K.4    Mann, D.A.5    Mann, J.6    Wang, C.C.7    Tsukamoto, H.8
  • 231
    • 79955667793 scopus 로고    scopus 로고
    • Andrographis paniculata: A review of pharmacological activities and clinical effects
    • Akbar, S. Andrographis paniculata: A review of pharmacological activities and clinical effects. Altern. Med. Rev. 2011, 16, 66-77
    • (2011) Altern. Med. Rev , vol.16 , pp. 66-77
    • Akbar, S.1
  • 233
    • 70349085432 scopus 로고    scopus 로고
    • Hepatoprotective activity of six polyherbalformulations in paracetamol induced liver toxicity in mice
    • Girish, C.; Koner, B.; Jayanthi, S.; Rao, K.; Rajesh, B.; Pradhan, S. Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice. Indian J. Med. Res. 2009, 129, 569-578
    • (2009) Indian J. Med. Res , vol.129 , pp. 569-578
    • Girish, C.1    Koner, B.2    Jayanthi, S.3    Rao, K.4    Rajesh, B.5    Pradhan, S.6
  • 234
    • 0022869536 scopus 로고
    • Natural products and plants as liver protecting drugs
    • Handa, S.; Sharma, A.; Chakraborti, K. Natural products and plants as liver protecting drugs. Fitoterapia 1986, 57, 307-351.
    • (1986) Fitoterapia , vol.57 , pp. 307-351
    • Handa, S.1    Sharma, A.2    Chakraborti, K.3
  • 235
    • 0027337678 scopus 로고
    • Antihepatotoxic effects of major diterpenoid constituents ofAndrographis paniculata
    • Kapil, A.; Koul, I.; Banerjee, S.; Gupta, B. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem. Pharmacol. 1993, 46, 182-185
    • (1993) Biochem. Pharmacol , vol.46 , pp. 182-185
    • Kapil, A.1    Koul, I.2    Banerjee, S.3    Gupta, B.4
  • 236
    • 48749133288 scopus 로고    scopus 로고
    • Pharmacological aspects of Andrographis paniculata on health and its majorditerpenoid constituent andrographolide
    • Jarukamjorn, K.; Nemoto, N. Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolide. J. Health Sci. 2008, 54, 370-381
    • (2008) J. Health Sci. , vol.54 , pp. 370-381
    • Jarukamjorn, K.1    Nemoto, N.2
  • 237
    • 84873492852 scopus 로고    scopus 로고
    • Hepatoprotective activity of Andrographispaniculata in ethanol induced hepatotoxicity in albino wistar rats
    • Vetriselvan, S.; Subasini, U.; Rajamanickam, C.; Thirumurugu, S. Hepatoprotective activity of Andrographis paniculata in ethanol induced hepatotoxicity in albino wistar rats. Pharm. Glob. 2011, 2, 1-4.
    • (2011) Pharm. Glob , vol.2 , pp. 1-4
    • Vetriselvan, S.1    Subasini, U.2    Rajamanickam, C.3    Thirumurugu, S.4
  • 238
    • 0033767367 scopus 로고    scopus 로고
    • Hepatoprotective and toxicological evaluation of Andrographis paniculata on severeliver damage
    • Trivedi, N.; Rawal, U. Hepatoprotective and toxicological evaluation of Andrographis paniculata on severe liver damage. Indian J. Pharmacol. 2000, 32, 288-293.
    • (2000) Indian J. Pharmacol , vol.32 , pp. 288-293
    • Trivedi, N.1    Rawal, U.2
  • 239
    • 15944409586 scopus 로고    scopus 로고
    • Andrographolideinterferes with binding of nuclear factor-κB to DNA in HL-60-derived neutrophilic cells
    • Hidalgo, M.A.; Romero, A.; Figueroa, J.; Cortés, P.; Concha, I.I.; Hancke, J.L.; Burgos, R.A. Andrographolide interferes with binding of nuclear factor-κB to DNA in HL-60-derived neutrophilic cells. Br. J. Pharmacol. 2005, 144, 680-686
    • (2005) Br. J. Pharmacol , vol.144 , pp. 680-686
    • Hidalgo, M.A.1    Romero, A.2    Figueroa, J.3    Cortés, P.4    Concha, I.I.5    Hancke, J.L.6    Burgos, R.A.7
  • 240
    • 0036181416 scopus 로고    scopus 로고
    • Andrographolide prevents oxygen radical production by humanneutrophils: Possible mechanism(s) involved in its anti-inflammatory effect
    • Shen, Y.C.; Chen, C.F.; Chiou, W.F. Andrographolide prevents oxygen radical production by human neutrophils: Possible mechanism(s) involved in its anti-inflammatory effect. Br. J. Pharmacol. 2002, 135, 399-406
    • (2002) Br. J. Pharmacol , vol.135 , pp. 399-406
    • Shen, Y.C.1    Chen, C.F.2    Chiou, W.F.3
  • 241
    • 36749046966 scopus 로고    scopus 로고
    • Effect of andrographolide on monkey hepatocytes againstgalactosamine induced cell toxicity: An in vitro study
    • Visen, P.K.; Saraswat, B.; Vuksan, V.; Dhawan, B. Effect of andrographolide on monkey hepatocytes against galactosamine induced cell toxicity: An in vitro study. J. Complement. Integr. Med. 2007, 4
    • (2007) J. Complement. Integr. Med , vol.4
    • Visen, P.K.1    Saraswat, B.2    Vuksan, V.3    Dhawan, B.4
  • 242
    • 0036363437 scopus 로고    scopus 로고
    • Hepatoprotective and antioxidativeproperties of salacia reticulata: Preventive effects of phenolic constituents on CCL4-induced liver injury in mice
    • Yoshikawa, M.; Ninomiya, K.; Shimoda, H.; Nishida, N.; Matsuda, H. Hepatoprotective and antioxidative properties of salacia reticulata: Preventive effects of phenolic constituents on CCL4-induced liver injury in mice. Biol. Pharm. Bull. 2002, 25, 72-76
    • (2002) Biol. Pharm. Bull , vol.25 , pp. 72-76
    • Yoshikawa, M.1    Ninomiya, K.2    Shimoda, H.3    Nishida, N.4    Matsuda, H.5
  • 243
    • 79955537221 scopus 로고    scopus 로고
    • Evaluation of in vitro antioxidant activity of leaf extract of Andrographis paniculata
    • Prakash, E.L. Evaluation of in vitro antioxidant activity of leaf extract of Andrographis paniculata. Res. J. Pharm. Biol. Chem. Sci. 2011, 2, 891-895.
    • (2011) Res. J. Pharm.Biol. Chem. Sci , vol.2 , pp. 891-895
    • Prakash, E.L.1
  • 244
    • 77958152946 scopus 로고    scopus 로고
    • Study of anti-inflammatory activitiesof the pure compounds from Andrographis paniculata (Burm. F.) nees and their effects on gene expression
    • Parichatikanond, W.; Suthisisang, C.; Dhepakson, P.; Herunsalee, A. Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (Burm. F.) nees and their effects on gene expression. Int. Immunopharmacol. 2010, 10, 1361-1373
    • (2010) Int. Immunopharmacol. , vol.10 , pp. 1361-1373
    • Parichatikanond, W.1    Suthisisang, C.2    Dhepakson, P.3    Herunsalee, A.4
  • 245
    • 84857381831 scopus 로고    scopus 로고
    • Andrographolide and its analogues:Versatile bioactive molecules for combating inflammation and cancer
    • Lim, J.C.W.; Chan, T.K.; Ng, D.S.; Sagineedu, S.R.; Stanslas, J.; Wong, W. Andrographolide and its analogues: Versatile bioactive molecules for combating inflammation and cancer. Clin. Exp. Pharmacol. Physiol. 2012, 39, 300-310
    • (2012) Clin. Exp. Pharmacol. Physiol , vol.39 , pp. 300-310
    • Lim, J.C.W.1    Chan, T.K.2    Ng, D.S.3    Sagineedu, S.R.4    Stanslas, J.5    Wong, W.6
  • 246
    • 0036813343 scopus 로고    scopus 로고
    • Effect of andrographolide and Kan Jang-Fixed combination of extract SHA-10 and extract SHE-3-Onproliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture
    • Panossian, A.; Davtyan, T.; Gukassyan, N.; Gukasova, G.; Mamikonyan, G.; Gabrielian, E.; Wikman, G. Effect of andrographolide and Kan Jang-Fixed combination of extract SHA-10 and extract SHE-3-On proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture. Phytomedicine 2002, 9, 598-605
    • (2002) Phytomedicine , vol.9 , pp. 598-605
    • Panossian, A.1    Davtyan, T.2    Gukassyan, N.3    Gukasova, G.4    Mamikonyan, G.5    Gabrielian, E.6    Wikman, G.7
  • 247
    • 0035997402 scopus 로고    scopus 로고
    • Increased tumor necrosis factor α (TNF-α) and natural killer cell (NK) functionusing an integrative approach in late stage cancers
    • See, D.; Mason, S.; Roshan, R. Increased tumor necrosis factor α (TNF-α) and natural killer cell (NK) function using an integrative approach in late stage cancers. Immunol. Investig. 2002, 31, 137-153
    • (2002) Immunol. Investig , vol.31 , pp. 137-153
    • See, D.1    Mason, S.2    Roshan, R.3
  • 248
    • 4644241127 scopus 로고    scopus 로고
    • Andrographolide attenuates inflammation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50
    • Xia, Y.-F.; Ye, B.-Q.; Li, Y.-D.; Wang, J.-G.; He, X.-J.; Lin, X.; Yao, X.; Ma, D.; Slungaard, A.; Hebbel, R.P. Andrographolide attenuates inflammation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50. J. Immunol. 2004, 173, 4207-4217
    • (2004) J. Immunol , vol.173 , pp. 4207-4217
    • Xia, Y.-F.1    Ye, B.-Q.2    Li, Y.-D.3    Wang, J.-G.4    He, X.-J.5    Lin, X.6    Yao, X.7    Ma, D.8    Slungaard, A.9    Hebbel, R.P.10
  • 249
    • 65249122527 scopus 로고    scopus 로고
    • A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-κB pathway
    • Bao, Z.; Guan, S.; Cheng, C.; Wu, S.; Wong, S.H.; Kemeny, D.M.; Leung, B.P.; Wong, W.F. A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-κB pathway. Am. J. Respir. Crit. Care Med. 2009, 179, 657-665
    • (2009) Am. J. Respir. Crit. Care Med , vol.179 , pp. 657-665
    • Bao, Z.1    Guan, S.2    Cheng, C.3    Wu, S.4    Wong, S.H.5    Kemeny, D.M.6    Leung, B.P.7    Wong, W.F.8
  • 250
    • 59849084324 scopus 로고    scopus 로고
    • The production of nitric oxide and prostaglandin E2 in peritonealmacrophages is inhibited by Andrographis paniculata, angelica sinensis and morus alba ethyl acetate fractions
    • Chao, W.-W.; Kuo, Y.-H.; Li, W.-C.; Lin, B.-F. The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, angelica sinensis and morus alba ethyl acetate fractions. J. Ethnopharmacol. 2009, 122, 68-75
    • (2009) J. Ethnopharmacol , vol.122 , pp. 68-75
    • Chao, W.-W.1    Kuo, Y.-H.2    Li, W.-C.3    Lin, B.-F.4
  • 251
    • 84974811338 scopus 로고    scopus 로고
    • Review isolation and identification of bioactive compounds in Andrographis paniculata(Chuanxinlian)
    • Chao, W.-W.; Lin, B.-F. Review isolation and identification of bioactive compounds in Andrographis paniculata (chuanxinlian). Growth 2010, 10
    • (2010) Growth , vol.10
    • Chao, W.-W.1    Lin, B.-F.2
  • 252
    • 79953273783 scopus 로고    scopus 로고
    • Inhibitory effects of ethyl acetate extract of Andrographispaniculata on NF-κB trans-activation activity and LPS-induced acute inflammation in mice
    • Chao, W.-W.; Kuo, Y.-H.; Hsieh, S.-L.; Lin, B.-F. Inhibitory effects of ethyl acetate extract of Andrographis paniculata on NF-κB trans-activation activity and LPS-induced acute inflammation in mice. Evid. Based Complement. Altern. Med. 2011, 2011
    • (2011) Evid. Based Complement. Altern. Med , vol.2011
    • Chao, W.-W.1    Kuo, Y.-H.2    Hsieh, S.-L.3    Lin, B.-F.4
  • 253
    • 84886301449 scopus 로고    scopus 로고
    • Mechanismsof andrographolide-induced platelet apoptosis in human platelets: Regulatory roles of the extrinsic apoptotic pathway
    • Lien, L.M.; Su, C.C.; Hsu, W.H.; Lu, W.J.; Chung, C.L.; Yen, T.L.; Chiu, H.C.; Sheu, J.R.; Lin, K.H. Mechanisms of andrographolide-induced platelet apoptosis in human platelets: Regulatory roles of the extrinsic apoptotic pathway. Phytother. Res. 2013, 27, 1671-1677
    • (2013) Phytother. Res. , vol.27 , pp. 1671-1677
    • Lien, L.M.1    Su, C.C.2    Hsu, W.H.3    Lu, W.J.4    Chung, C.L.5    Yen, T.L.6    Chiu, H.C.7    Sheu, J.R.8    Lin, K.H.9
  • 254
    • 0034001308 scopus 로고    scopus 로고
    • Mechanisms of suppression of inducible nitric oxide synthase (INOS)expression in RAW 264.7 cells by andrographolide
    • Chiou, W.F.; Chen, C.F.; Lin, J.J. Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide. Br. J. Pharmacol. 2000, 129, 1553-1560
    • (2000) Br. J. Pharmacol , vol.129 , pp. 1553-1560
    • Chiou, W.F.1    Chen, C.F.2    Lin, J.J.3
  • 255
    • 1342323332 scopus 로고    scopus 로고
    • Andrographolide reduces inflammation-mediateddopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation
    • Wang, T.; Liu, B.; Zhang, W.; Wilson, B.; Hong, J.-S. Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation. J. Pharmacol. Exp. Ther. 2004, 308, 975-983
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , pp. 975-983
    • Wang, T.1    Liu, B.2    Zhang, W.3    Wilson, B.4    Hong, J.-S.5
  • 256
    • 0031670451 scopus 로고    scopus 로고
    • Andrographolide suppresses the expression of inducible nitric oxide synthasein macrophage and restores the vasoconstriction in rat aorta treated with lipopolysaccharide
    • Chiou, W.F.; Lin, J.J.; Chen, C.F. Andrographolide suppresses the expression of inducible nitric oxide synthase in macrophage and restores the vasoconstriction in rat aorta treated with lipopolysaccharide. Br. J. Pharmacol. 1998, 125, 327-334
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 327-334
    • Chiou, W.F.1    Lin, J.J.2    Chen, C.F.3
  • 257
    • 0035124051 scopus 로고    scopus 로고
    • Induction of catalase, α, and microsomal glutathione s-transferase in CYP2E1overexpressing HepG2 cells and protection against short-term oxidative stress
    • Marı, M.; Cederbaum, A.I. Induction of catalase, α, and microsomal glutathione s-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress. Hepatology 2001, 33, 652-661
    • (2001) Hepatology , vol.33 , pp. 652-661
    • Marı, M.1    Cederbaum, A.I.2
  • 258
    • 0036521544 scopus 로고    scopus 로고
    • Metallothionein protection against alcoholic liver injury through inhibitionof oxidative stress
    • Zhou, Z.; Sun, X.; James Kang, Y. Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress. Exp. Biol. Med. 2002, 227, 214-222.
    • (2002) Exp. Biol. Med , vol.227 , pp. 214-222
    • Zhou, Z.1    Sun, X.2    James Kang, Y.3
  • 260
    • 11244356693 scopus 로고    scopus 로고
    • Green tea modulation of the biochemical and electric properties of rat liver cells that were affected by ethanol and aging
    • Dobrzy nska, I.; Figaszewski, Z.; Snieci nska, A.; Skrzydlewska, E. Green tea modulation of the biochemical and electric properties of rat liver cells that were affected by ethanol and aging. Cell. Mol. Biol. Lett. 2004, 9, 709-721
    • (2004) Cell. Mol. Biol. Lett , vol.9 , pp. 709-721
    • Dobrzy Nska, I.1    Figaszewski, Z.2    Snieci Nska, A.3    Skrzydlewska, E.4
  • 261
    • 1542436560 scopus 로고    scopus 로고
    • Quercetin, a flavonoid antioxidant, prevents and protectsagainst ethanol-induced oxidative stress in mouse liver
    • Molina, M.F.; Iglesias, I.; Benedi, J.; Sanchez-Reus, I. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol. Pharm. Bull. 2003, 26, 1398-1402
    • (2003) Biol. Pharm. Bull , vol.26 , pp. 1398-1402
    • Molina, M.F.1    Iglesias, I.2    Benedi, J.3    Sanchez-Reus, I.4
  • 264
    • 66149088090 scopus 로고    scopus 로고
    • Oxidative stress in the brain of nicotine-induced toxicity:Protective role of Andrographis paniculata nees and vitamin e
    • Das, S.; Gautam, N.; Dey, S.K.; Maiti, T.; Roy, S. Oxidative stress in the brain of nicotine-induced toxicity: Protective role of Andrographis paniculata nees and vitamin e. Appl. Physiol. Nutr. Metab. 2009, 34, 124-135
    • (2009) Appl. Physiol. Nutr. Metab , vol.34 , pp. 124-135
    • Das, S.1    Gautam, N.2    Dey, S.K.3    Maiti, T.4    Roy, S.5
  • 265
    • 67650133615 scopus 로고    scopus 로고
    • Antioxidant, antioedema and analgesic activities of Andrographis paniculataextracts and their active constituent andrographolide
    • Lin, F.; Wu, S.; Lee, S.; Ng, L. Antioxidant, antioedema and analgesic activities of Andrographis paniculata extracts and their active constituent andrographolide. Phytother. Res. 2009, 23, 958-964
    • (2009) Phytother. Res , vol.23 , pp. 958-964
    • Lin, F.1    Wu, S.2    Lee, S.3    Ng, L.4
  • 268
    • 84876296042 scopus 로고    scopus 로고
    • Hypolipidemic effects of andrographolide andneoandrographolide in mice and rats
    • Yang, T.; Shi, H.X.; Wang, Z.T.; Wang, C.H. Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats. Phytother. Res. 2013, 27, 618-623
    • (2013) Phytother. Res , vol.27 , pp. 618-623
    • Yang, T.1    Shi, H.X.2    Wang, Z.T.3    Wang, C.H.4
  • 269
    • 0037532629 scopus 로고    scopus 로고
    • Effect of azadirachta indica onparacetamol-induced hepatic damage in albino rats
    • Yanpallewar, S.U.; Sen, S.; Tapas, S.; Kumar, M.; Raju, S.S.; Acharya, S.B. Effect of azadirachta indica on paracetamol-induced hepatic damage in albino rats. Phytomedicine 2003, 10, 391-396
    • (2003) Phytomedicine , vol.10 , pp. 391-396
    • Yanpallewar, S.U.1    Sen, S.2    Tapas, S.3    Kumar, M.4    Raju, S.S.5    Acharya, S.B.6
  • 270
    • 1942488165 scopus 로고    scopus 로고
    • Further studies on the antihepatotoxic activity of phyllanthus maderaspatensis LINN
    • Asha, V.V.; Akhila, S.; Wills, P.J.; Subramoniam, A. Further studies on the antihepatotoxic activity of phyllanthus maderaspatensis LINN. J. Ethnopharmacol. 2004, 92, 67-70
    • (2004) J. Ethnopharmacol , vol.92 , pp. 67-70
    • Asha, V.V.1    Akhila, S.2    Wills, P.J.3    Subramoniam, A.4
  • 271
    • 70449974645 scopus 로고    scopus 로고
    • Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome
    • Maiti, K.; Mukherjee, K.; Murugan, V.; Saha, B.P.; Mukherjee, P.K. Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome. J. Sci. Food Agric. 2010, 90, 43-51
    • (2010) J. Sci. Food Agric , vol.90 , pp. 43-51
    • Maiti, K.1    Mukherjee, K.2    Murugan, V.3    Saha, B.P.4    Mukherjee, P.K.5
  • 272
    • 33750580411 scopus 로고    scopus 로고
    • The use of selected nutrition supplements andcomplementary and alternative medicine in liver disease
    • Hanje, A.J.; Fortune, B.; Song, M.; Hill, D.; McClain, C. The use of selected nutrition supplements and complementary and alternative medicine in liver disease. Nutr. Clin. Pract. 2006, 21, 255-272
    • (2006) Nutr. Clin. Pract , vol.21 , pp. 255-272
    • Hanje, A.J.1    Fortune, B.2    Song, M.3    Hill, D.4    McClain, C.5
  • 274
    • 79960605124 scopus 로고    scopus 로고
    • Glycyrrhizic acid and 18β-glycyrrhetinic acid modulatelipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions
    • Wang, C.-Y.; Kao, T.-C.; Lo, W.-H.; Yen, G.-C. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. J. Agric. Food Chem. 2011, 59, 7726-7733
    • (2011) J. Agric. Food Chem , vol.59 , pp. 7726-7733
    • Wang, C.-Y.1    Kao, T.-C.2    Lo, W.-H.3    Yen, G.-C.4
  • 275
    • 79960236561 scopus 로고    scopus 로고
    • Modulation of lipopolysaccharide-inducedpro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents
    • Thiyagarajan, P.; Chandrasekaran, C.; Deepak, H.; Agarwal, A. Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. Inflammopharmacology 2011, 19, 235-241
    • (2011) Inflammopharmacology , vol.19 , pp. 235-241
    • Thiyagarajan, P.1    Chandrasekaran, C.2    Deepak, H.3    Agarwal, A.4
  • 276
    • 84862952502 scopus 로고    scopus 로고
    • Evaluation of the immunity activity of glycyrrhizin in AR mice
    • Li, X.-L.; Zhou, A.-G. Evaluation of the immunity activity of glycyrrhizin in AR mice. Molecules 2012, 17, 716-727
    • (2012) Molecules , vol.17 , pp. 716-727
    • Li, X.-L.1    Zhou, A.-G.2
  • 277
    • 34547153231 scopus 로고    scopus 로고
    • Diammonium glycyrrhizinate, a component oftraditional Chinese medicine Gan-Cao, prevents murine T-cell-mediated fulminant hepatitis in IL-10-and IL-6-dependent manners
    • Feng, C.; Wang, H.; Yao, C.; Zhang, J.; Tian, Z. Diammonium glycyrrhizinate, a component of traditional Chinese medicine Gan-Cao, prevents murine T-cell-mediated fulminant hepatitis in IL-10-and IL-6-dependent manners. Int. Immunopharmacol. 2007, 7, 1292-1298
    • (2007) Int. Immunopharmacol , vol.7 , pp. 1292-1298
    • Feng, C.1    Wang, H.2    Yao, C.3    Zhang, J.4    Tian, Z.5
  • 278
    • 35348993141 scopus 로고    scopus 로고
    • Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice
    • Lee, C.-H.; Park, S.-W.; Kim, Y.S.; Kang, S.S.; Kim, J.A.; Lee, S.H.; Lee, S.-M. Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Biol. Pharm. Bull. 2007, 30, 1898-1904
    • (2007) Biol. Pharm. Bull , vol.30 , pp. 1898-1904
    • Lee, C.-H.1    Park, S.-W.2    Kim, Y.S.3    Kang, S.S.4    Kim, J.A.5    Lee, S.H.6    Lee, S.-M.7
  • 279
    • 70449370069 scopus 로고    scopus 로고
    • Long-termbaicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet
    • Guo, H.-X.; Liu, D.-H.; Ma, Y.; Liu, J.-F.; Wang, Y.; Du, Z.-Y.; Wang, X.; Shen, J.-K.; Peng, H.-L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol. Sin. 2009, 30, 1505-1512
    • (2009) Acta Pharmacol. Sin , vol.30 , pp. 1505-1512
    • Guo, H.-X.1    Liu, D.-H.2    Ma, Y.3    Liu, J.-F.4    Wang, Y.5    Du, Z.-Y.6    Wang, X.7    Shen, J.-K.8    Peng, H.-L.9
  • 281
    • 0033088938 scopus 로고    scopus 로고
    • [inhibitory effect of glycyrrhizin on NF-κB binding activity in CCL4 plusethanol induced liver cirrhosis in rats]. Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi= Chin
    • Wang, J.; Guo, J.; Liu, S. [inhibitory effect of glycyrrhizin on NF-κB binding activity in CCL4 plus ethanol induced liver cirrhosis in rats]. Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chin. J. Hepatol. 1999, 7, 42-43.
    • (1999) J. Hepatol , vol.7 , pp. 42-43
    • Wang, J.1    Guo, J.2    Liu, S.3
  • 282
    • 0027268624 scopus 로고
    • A preliminary open trial on interferonstimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure
    • Acharya, S.K.; Dasarathy, S.; Tandon, A.; Joshi, Y.K.; Tandon, B.N. A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. Indian J. Med. Res. 1993, 98, 69-74
    • (1993) Indian J. Med. Res , vol.98 , pp. 69-74
    • Acharya, S.K.1    Dasarathy, S.2    Tandon, A.3    Joshi, Y.K.4    Tandon, B.N.5
  • 283
    • 0034886470 scopus 로고    scopus 로고
    • Glycyrrhizin-induced reduction of alt in europeanpatients with chronic hepatitis C
    • Tekla, G.J.V.R.; Arnold, G.V.; Wim, C.J.H.; Solko, W.S. Glycyrrhizin-induced reduction of alt in european patients with chronic hepatitis C. Am. J. Gastroenterol. 2001, 96, 2432-2437.
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 2432-2437
    • Tekla, G.J.V.R.1    Arnold, G.V.2    Wim, C.J.H.3    Solko, W.S.4
  • 284
    • 0025910503 scopus 로고
    • Renin-dependency of glycyrrhizin-induced pseudoaldosteronism
    • Kageyama, Y.; Suzuki, H.; Saruta, T. Renin-dependency of glycyrrhizin-induced pseudoaldosteronism. Endocrinol. Jpn. 1991, 38, 103-108
    • (1991) Endocrinol. Jpn , vol.38 , pp. 103-108
    • Kageyama, Y.1    Suzuki, H.2    Saruta, T.3
  • 285
    • 0028288963 scopus 로고
    • Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinicacid in humans and experimental animals
    • Krähenbühl, S.; Hasler, F.; Krapf, R. Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals. Steroids 1994, 59, 121-126
    • (1994) Steroids , vol.59 , pp. 121-126
    • Krähenbühl, S.1    Hasler, F.2    Krapf, R.3
  • 287
    • 34250697510 scopus 로고    scopus 로고
    • In vivo pharmacokinetic and metabolism studies of ginsenoside rd
    • Yang, L.; Deng, Y.; Xu, S.; Zeng, X. In vivo pharmacokinetic and metabolism studies of ginsenoside rd. J. Chromatogr. B 2007, 854, 77-84
    • (2007) J. Chromatogr. B , vol.854 , pp. 77-84
    • Yang, L.1    Deng, Y.2    Xu, S.3    Zeng, X.4
  • 288
    • 33749990092 scopus 로고    scopus 로고
    • Ginsenoside re of Panax ginsengpossesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats
    • Cho, W.C.; Chung, W.-S.; Lee, S.K.; Leung, A.W.; Cheng, C.H.; Yue, K.K. Ginsenoside re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 2006, 550, 173-179
    • (2006) Eur. J. Pharmacol. , vol.550 , pp. 173-179
    • Cho, W.C.1    Chung, W.-S.2    Lee, S.K.3    Leung, A.W.4    Cheng, C.H.5    Yue, K.K.6
  • 289
    • 0022357020 scopus 로고
    • Hyperlipemia-improving effects of ginsenoside-Rb2in streptozotocin-diabetic rats
    • Yokozawa, T.; Kobayashi, T.; Oura, H.; Kawashima, Y. Hyperlipemia-improving effects of ginsenoside-Rb2 in streptozotocin-diabetic rats. Chem. Pharm. Bull. 1985, 33, 3893-3898
    • (1985) Chem. Pharm. Bull , vol.33 , pp. 3893-3898
    • Yokozawa, T.1    Kobayashi, T.2    Oura, H.3    Kawashima, Y.4
  • 290
    • 84859615207 scopus 로고    scopus 로고
    • Inhibition of TNF-α-mediatedNF-κB transcriptional activity in HepG2 cells by dammarane-type saponins from Panax ginseng leaves
    • Song, S.B.; Tung, N.H.; Quang, T.H.; Ngan, N.T.T.; Kim, K.E.; Kim, Y.H. Inhibition of TNF-α-mediated NF-κB transcriptional activity in HepG2 cells by dammarane-type saponins from Panax ginseng leaves. J. Ginseng Res. 2012, 36, 146-152
    • (2012) J. Ginseng Res , vol.36 , pp. 146-152
    • Song, S.B.1    Tung, N.H.2    Quang, T.H.3    Ngan, N.T.T.4    Kim, K.E.5    Kim, Y.H.6
  • 291
    • 84856229622 scopus 로고    scopus 로고
    • Suppression of local inflammation contributes to theneuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia
    • Zhu, J.; Jiang, Y.; Wu, L.; Lu, T.; Xu, G.; Liu, X. Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia. Neuroscience 2012, 202, 342-351
    • (2012) Neuroscience , vol.202 , pp. 342-351
    • Zhu, J.1    Jiang, Y.2    Wu, L.3    Lu, T.4    Xu, G.5    Liu, X.6
  • 292
    • 1542376726 scopus 로고    scopus 로고
    • Ginsenoside Rh1 possesses antiallergic and anti-inflammatoryactivities
    • Park, E.-K.; Choo, M.-K.; Han, M.J.; Kim, D.-H. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int. Arch. Allergy Immunol. 2004, 133, 113-120
    • (2004) Int. Arch. Allergy Immunol , vol.133 , pp. 113-120
    • Park, E.-K.1    Choo, M.-K.2    Han, M.J.3    Kim, D.-H.4
  • 296
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginseng pharmacology: A nitric oxide link?
    • Gillis, C.N. Panax ginseng pharmacology: A nitric oxide link? Biochem. Pharmacol. 1997, 54, 1-8
    • (1997) Biochem. Pharmacol , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 297
    • 34548720473 scopus 로고    scopus 로고
    • Protective effects of ginsenoside Rb1 on human umbilical vein endothelial cells in vitro
    • He, F.; Guo, R.; Wu, S.-L.; Sun, M.; Li, M. Protective effects of ginsenoside Rb1 on human umbilical vein endothelial cells in vitro. J. Cardiovasc. Pharmacol. 2007, 50, 314-320
    • (2007) J. Cardiovasc. Pharmacol , vol.50 , pp. 314-320
    • He, F.1    Guo, R.2    Wu, S.-L.3    Sun, M.4    Li, M.5
  • 298
    • 34548651801 scopus 로고    scopus 로고
    • Water extract of korean red ginseng stimulates angiogenesis by activating the PI3k/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells
    • Kim, Y.-M.; Namkoong, S.; Yun, Y.-G.; Hong, H.-D.; Lee, Y.-C.; Ha, K.-S.; Lee, H.; Kwon, H.J.; Kwon, Y.-G.; Kim, Y.-M. Water extract of korean red ginseng stimulates angiogenesis by activating the PI3k/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells. Biol. Pharm. Bull. 2007, 30, 1674-1679
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 1674-1679
    • Kim, Y.-M.1    Namkoong, S.2    Yun, Y.-G.3    Hong, H.-D.4    Lee, Y.-C.5    Ha, K.-S.6    Lee, H.7    Kwon, H.J.8    Kwon, Y.-G.9    Kim, Y.-M.10
  • 299
    • 33846234714 scopus 로고    scopus 로고
    • Curcumin-phospholipid complex:Preparation, therapeutic evaluation and pharmacokinetic study in rats
    • Maiti, K.; Mukherjee, K.; Gantait, A.; Saha, B.P.; Mukherjee, P.K. Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. Int. J. Pharm. 2007, 330, 155-163
    • (2007) Int. J. Pharm , vol.330 , pp. 155-163
    • Maiti, K.1    Mukherjee, K.2    Gantait, A.3    Saha, B.P.4    Mukherjee, P.K.5
  • 300
    • 62849092266 scopus 로고    scopus 로고
    • NF-κB in liver diseases: A target for drug therapy
    • Muriel, P. NF-κB in liver diseases: A target for drug therapy. J. Appl. Toxicol. 2009, 29, 91-100
    • (2009) J. Appl. Toxicol , vol.29 , pp. 91-100
    • Muriel, P.1
  • 301
    • 84873722552 scopus 로고    scopus 로고
    • Acupuncture combined with curcumin disrupts platelet-derived growth factor β receptor/extracellular signal-regulated kinase signalling and stimulates extracellular matrix degradation in carbon tetrachloride-induced hepatic fibrosis in rats
    • Zhang, X.-P.; Zhang, F.; Zhang, Z.-L.; Ma, J.; Kong, D.-S.; Ni, G.-X.; Wang, A.-Y.; Chen, W.-X.; Lu, Y.; Zheng, S.-Z. Acupuncture combined with curcumin disrupts platelet-derived growth factor β receptor/extracellular signal-regulated kinase signalling and stimulates extracellular matrix degradation in carbon tetrachloride-induced hepatic fibrosis in rats. Acupunct. Med. 2012, 30, 324-330
    • (2012) Acupunct. Med , vol.30 , pp. 324-330
    • Zhang, X.-P.1    Zhang, F.2    Zhang, Z.-L.3    Ma, J.4    Kong, D.-S.5    Ni, G.-X.6    Wang, A.-Y.7    Chen, W.-X.8    Lu, Y.9    Zheng, S.-Z.10
  • 302
    • 84866146218 scopus 로고    scopus 로고
    • Inhibition by curcumin of multiple sites of the transforming growth factor-β1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats
    • Yao, Q.-Y.; Xu, B.-L.; Wang, J.-Y.; Liu, H.-C.; Zhang, S.-C.; Tu, C.-T. Inhibition by curcumin of multiple sites of the transforming growth factor-β1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. BMC Complement. Altern. Med. 2012, 12
    • (2012) BMC Complement. Altern. Med , vol.12
    • Yao, Q.-Y.1    Xu, B.-L.2    Wang, J.-Y.3    Liu, H.-C.4    Zhang, S.-C.5    Tu, C.-T.6
  • 303
    • 69949122086 scopus 로고    scopus 로고
    • Curcumin prevents liver fibrosis by inducing apoptosis andsuppressing activation of hepatic stellate cells
    • Shu, J.-C.; He, Y.-J.; Lv, X.; Ye, G.-R.; Wang, L.-X. Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells. J. Nat. Med. 2009, 63, 415-420
    • (2009) J. Nat. Med , vol.63 , pp. 415-420
    • Shu, J.-C.1    He, Y.-J.2    Lv, X.3    Ye, G.-R.4    Wang, L.-X.5
  • 304
    • 84858073258 scopus 로고    scopus 로고
    • Protective effects of curcumin, α-lipoicacid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats
    • Morsy, M.; Abdalla, A.; Mahmoud, A.; Abdelwahab, S.; Mahmoud, M. Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats. J. Physiol. Biochem. 2012, 68, 29-35
    • (2012) J. Physiol. Biochem. , vol.68 , pp. 29-35
    • Morsy, M.1    Abdalla, A.2    Mahmoud, A.3    Abdelwahab, S.4    Mahmoud, M.5
  • 305
    • 38549153486 scopus 로고    scopus 로고
    • Curcumin protects the rat liver from CCL4-caused injury andfibrogenesis by attenuating oxidative stress and suppressing inflammation
    • Fu, Y.; Zheng, S.; Lin, J.; Ryerse, J.; Chen, A. Curcumin protects the rat liver from CCL4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol. Pharmacol. 2008, 73, 399-409
    • (2008) Mol. Pharmacol , vol.73 , pp. 399-409
    • Fu, Y.1    Zheng, S.2    Lin, J.3    Ryerse, J.4    Chen, A.5
  • 306
    • 58149359848 scopus 로고    scopus 로고
    • Curcumin-induced recovery from hepatic injury involves induction of apoptosisof activated hepatic stellate cells
    • Priya, S.; Sudhakaran, P.R. Curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells. Indian J. Biochem. Biophys. 2008, 45, 317-325
    • (2008) Indian J. Biochem. Biophys , vol.45 , pp. 317-325
    • Priya, S.1    Sudhakaran, P.R.2
  • 307
    • 84874049409 scopus 로고    scopus 로고
    • Curcumin reorganizes mirna expression in a mouse model of liver fibrosis
    • Hassan, Z.K.; Al-Olayan, E.M. Curcumin reorganizes mirna expression in a mouse model of liver fibrosis. Asian Pac. J. Cancer Prev. 2012, 13, 5405-5408
    • (2012) Asian Pac. J. Cancer Prev , vol.13 , pp. 5405-5408
    • Hassan, Z.K.1    Al-Olayan, E.M.2
  • 308
    • 77951219887 scopus 로고    scopus 로고
    • Curcumin and saikosaponin a inhibitchemical-induced liver inflammation and fibrosis in rats
    • Wu, S.-J.; Tam, K.-W.; Tsai, Y.-H.; Chang, C.-C.; Chao, J.C.-J. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Am. J. Chin. Med. 2010, 38, 99-111
    • (2010) Am. J. Chin. Med , vol.38 , pp. 99-111
    • Wu, S.-J.1    Tam, K.-W.2    Tsai, Y.-H.3    Chang, C.-C.4    Chao, J.C.5
  • 309
    • 80052721903 scopus 로고    scopus 로고
    • Alteration of AP-endonuclease1 expression in curcumin-treatedfibrotic rats
    • Bassiouny, A.R.; Zaky, A.; Kandeel, K.M. Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats. Ann. Hepatol. 2011, 10, 516-530
    • (2011) Ann. Hepatol , vol.10 , pp. 516-530
    • Bassiouny, A.R.1    Zaky, A.2    Kandeel, K.M.3
  • 310
    • 67649641806 scopus 로고    scopus 로고
    • Curcumin eliminates leptin’s effects on hepatic stellate cell activation viainterrupting leptin signaling
    • Tang, Y.; Zheng, S.; Chen, A. Curcumin eliminates leptin’s effects on hepatic stellate cell activation via interrupting leptin signaling. Endocrinology 2009, 150, 3011-3020
    • (2009) Endocrinology , vol.150 , pp. 3011-3020
    • Tang, Y.1    Zheng, S.2    Chen, A.3
  • 311
    • 84899571370 scopus 로고    scopus 로고
    • Curcumin eliminates the effect of advanced glycation end-products (Ages) on thedivergent regulation of gene expression of receptors of ages by interrupting leptin signaling
    • Youcai, T.; Anping, C. Curcumin eliminates the effect of advanced glycation end-products (ages) on the divergent regulation of gene expression of receptors of ages by interrupting leptin signaling. Lab. Investig. 2014, 94, 503-516.
    • (2014) Lab. Investig , vol.94 , pp. 503-516
    • Youcai, T.1    Anping, C.2
  • 312
    • 69149108872 scopus 로고    scopus 로고
    • Regulatory effect of the AMPK-COX-2 signaling pathway incurcumin-induced apoptosis in HT-29 colon cancer cells
    • Lee, Y.K.; Park, S.Y.; Kim, Y.M.; Park, O.J. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. Ann. N. Y. Acad. Sci. 2009, 11711, 489-494
    • (2009) Ann. N. Y. Acad. Sci , vol.11711 , pp. 489-494
    • Lee, Y.K.1    Park, S.Y.2    Kim, Y.M.3    Park, O.J.4
  • 313
    • 33749627688 scopus 로고    scopus 로고
    • Increased expression of Ob-Rb and itsrelationship with the overexpression of TGF-β1 and the stage of fibrosis in patients with nonalcoholicsteatohepatitis
    • Cayón, A.; Crespo, J.; Mayorga, M.; Guerra, A.; Pons-romero, F. Increased expression of Ob-Rb and its relationship with the overexpression of TGF-β1 and the stage of fibrosis in patients with nonalcoholic steatohepatitis. Liver Int. 2006, 26, 1065-1071
    • (2006) Liver Int , vol.26 , pp. 1065-1071
    • Cayón, A.1    Crespo, J.2    Mayorga, M.3    Guerra, A.4    Pons-Romero, F.5
  • 315
    • 46149090121 scopus 로고    scopus 로고
    • Use of anti-aging herbal medicine, Lycium barbarum, against aging-associateddiseases. What do we know so far
    • Chang, R.C.-C.; So, K.-F. Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell. Mol. Neurobiol. 2008, 28, 643-652
    • (2008) Cell. Mol. Neurobiol. , vol.28 , pp. 643-652
    • Chang, R.C.1    So, K.-F.2
  • 316
  • 317
    • 84896523087 scopus 로고    scopus 로고
    • Inhibitory effect of Lycium barbarum polysaccharides on cellapoptosis and senescence is potentially mediated by the p53 signaling pathway
    • Xia, G.; Xin, N.; Liu, W.; Yao, H.; Hou, Y.; Qi, J. Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway. Mol. Med. Rep. 2014, 9, 1237-1241
    • (2014) Mol. Med. Rep. , vol.9 , pp. 1237-1241
    • Xia, G.1    Xin, N.2    Liu, W.3    Yao, H.4    Hou, Y.5    Qi, J.6
  • 318
    • 34247259664 scopus 로고    scopus 로고
    • Effect of the Lycium barbarum polysaccharides on age-related oxidative stress inaged mice
    • Li, X.M.; Ma, Y.L.; Liu, X.J. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J. Ethnopharmacol. 2007, 111, 504-511
    • (2007) J. Ethnopharmacol , vol.111 , pp. 504-511
    • Li, X.M.1    Ma, Y.L.2    Liu, X.J.3
  • 319
    • 77952521247 scopus 로고    scopus 로고
    • Chemical characterization of Lycium barbarumpolysaccharides and its inhibition against liver oxidative injury of high-fat mice
    • Wu, H.-T.; He, X.-J.; Hong, Y.-K.; Ma, T.; Xu, Y.-P.; Li, H.-H. Chemical characterization of Lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice. Int. J. Biol. Macromol. 2010, 46, 540-543
    • (2010) Int. J. Biol. Macromol. , vol.46 , pp. 540-543
    • Wu, H.-T.1    He, X.-J.2    Hong, Y.-K.3    Ma, T.4    Xu, Y.-P.5    Li, H.-H.6
  • 320
    • 13844299309 scopus 로고    scopus 로고
    • Effect of Lycium barbarum polysaccharide on humanhepatoma QGY7703 cells: Inhibition of proliferation and induction of apoptosis
    • Zhang, M.; Chen, H.; Huang, J.; Li, Z.; Zhu, C.; Zhang, S. Effect of Lycium barbarum polysaccharide on human hepatoma QGY7703 cells: Inhibition of proliferation and induction of apoptosis. Life Sci. 2005, 76, 2115-2124
    • (2005) Life Sci. , vol.76 , pp. 2115-2124
    • Zhang, M.1    Chen, H.2    Huang, J.3    Li, Z.4    Zhu, C.5    Zhang, S.6
  • 321
    • 58649100911 scopus 로고    scopus 로고
    • Lycium barbarum (GOJI) juice improves in vivo antioxidant biomarkers inserum of healthy adults
    • Amagase, H.; Sun, B.; Borek, C. Lycium barbarum (GOJI) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr. Res. 2009, 29, 19-25
    • (2009) Nutr. Res , vol.29 , pp. 19-25
    • Amagase, H.1    Sun, B.2    Borek, C.3
  • 322
    • 19944374769 scopus 로고    scopus 로고
    • Berberine is a novelcholesterol-lowering drug working through a unique mechanism distinct from statins
    • Kong, W.; Wei, J.; Abidi, P.; Lin, M.; Inaba, S.; Li, C.; Wang, Y.; Wang, Z.; Si, S.; Pan, H. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat. Med. 2004, 10, 1344-1351
    • (2004) Nat. Med , vol.10 , pp. 1344-1351
    • Kong, W.1    Wei, J.2    Abidi, P.3    Lin, M.4    Inaba, S.5    Li, C.6    Wang, Y.7    Wang, Z.8    Si, S.9    Pan, H.10
  • 324
    • 27744437536 scopus 로고    scopus 로고
    • Acetaldehyde-induced interleukin-1β and tumor necrosisfactor-α production is inhibited by berberine through nuclear factor-κB signaling pathway in HEPG2 cells
    • Hsiang, C.-Y.; Wu, S.-L.; Cheng, S.-E.; Ho, T.-Y. Acetaldehyde-induced interleukin-1β and tumor necrosis factor-α production is inhibited by berberine through nuclear factor-κB signaling pathway in HEPG2 cells. J. Biomed. Sci. 2005, 12, 791-801
    • (2005) J. Biomed. Sci , vol.12 , pp. 791-801
    • Hsiang, C.-Y.1    Wu, S.-L.2    Cheng, S.-E.3    Ho, T.-Y.4
  • 325
    • 0027972604 scopus 로고
    • The herbalmedicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the g0/g1 phase
    • Yano, H.; Mizoguchi, A.; Fukuda, K.; Haramaki, M.; Ogasawara, S.; Momosaki, S.; Kojiro, M. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the g0/g1 phase. Cancer Res. 1994, 54, 448-454
    • (1994) Cancer Res , vol.54 , pp. 448-454
    • Yano, H.1    Mizoguchi, A.2    Fukuda, K.3    Haramaki, M.4    Ogasawara, S.5    Momosaki, S.6    Kojiro, M.7
  • 326
    • 84882766934 scopus 로고    scopus 로고
    • Berberine amelioratesexperimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of rhoa/rock signaling
    • Xie, X.; Chang, X.; Chen, L.; Huang, K.; Huang, J.; Wang, S.; Shen, X.; Liu, P.; Huang, H. Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of rhoa/rock signaling. Mol. Cell. Endocrinol. 2013, 381, 56-65
    • (2013) Mol. Cell. Endocrinol , vol.381 , pp. 56-65
    • Xie, X.1    Chang, X.2    Chen, L.3    Huang, K.4    Huang, J.5    Wang, S.6    Shen, X.7    Liu, P.8    Huang, H.9
  • 327
    • 79952758240 scopus 로고    scopus 로고
    • Protection ofcholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes
    • Bhutada, P.; Mundhada, Y.; Bansod, K.; Tawari, S.; Patil, S.; Dixit, P.; Umathe, S.; Mundhada, D. Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes. Behav. Brain Res. 2011, 220, 30-41
    • (2011) Behav. Brain Res , vol.220 , pp. 30-41
    • Bhutada, P.1    Mundhada, Y.2    Bansod, K.3    Tawari, S.4    Patil, S.5    Dixit, P.6    Umathe, S.7    Mundhada, D.8
  • 328
    • 79952362196 scopus 로고    scopus 로고
    • Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor B expression in diabetic rat liver
    • Zhou, J.-Y.; Zhou, S.-W. Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor B expression in diabetic rat liver. Fitoterapia 2011, 82, 184-189
    • (2011) Fitoterapia , vol.82 , pp. 184-189
    • Zhou, J.-Y.1    Zhou, S.-W.2
  • 329
    • 84863702559 scopus 로고    scopus 로고
    • Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine
    • Lao-Ong, T.; Chatuphonprasert, W.; Nemoto, N.; Jarukamjorn, K. Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine. Pharm. Biol. 2012, 50, 1007-1012
    • (2012) Pharm. Biol , vol.50 , pp. 1007-1012
    • Lao-Ong, T.1    Chatuphonprasert, W.2    Nemoto, N.3    Jarukamjorn, K.4
  • 330
    • 84924229346 scopus 로고    scopus 로고
    • Improvement of superoxide dismutase and catalase instreptozotocin-nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide
    • Chatuphonprasert, W.; Lao-Ong, T.; Jarukamjorn, K. Improvement of superoxide dismutase and catalase in streptozotocin-nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide. Pharm. Biol. 2014, 52, 419-427
    • (2014) Pharm. Biol , vol.52 , pp. 419-427
    • Chatuphonprasert, W.1    Lao-Ong, T.2    Jarukamjorn, K.3
  • 331
    • 84861829797 scopus 로고    scopus 로고
    • Ameliorative effect of berberineon renal damage in rats with diabetes induced by high-fat diet and streptozotocin
    • Wu, D.; Wen, W.; Qi, C.-L.; Zhao, R.-X.; Lü, J.-H.; Zhong, C.-Y.; Chen, Y.-Y. Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin. Phytomedicine 2012, 19, 712-718
    • (2012) Phytomedicine , vol.19 , pp. 712-718
    • Wu, D.1    Wen, W.2    Qi, C.-L.3    Zhao, R.-X.4    Lü, J.-H.5    Zhong, C.-Y.6    Chen, Y.-Y.7
  • 332
    • 60949108484 scopus 로고    scopus 로고
    • Protectiveeffect of berberine on β cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
    • Zhou, J.; Zhou, S.; Tang, J.; Zhang, K.; Guang, L.; Huang, Y.; Xu, Y.; Ying, Y.; Zhang, L.; Li, D. Protective effect of berberine on β cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Eur. J. Pharmacol. 2009, 606, 262-268
    • (2009) Eur. J. Pharmacol. , vol.606 , pp. 262-268
    • Zhou, J.1    Zhou, S.2    Tang, J.3    Zhang, K.4    Guang, L.5    Huang, Y.6    Xu, Y.7    Ying, Y.8    Zhang, L.9    Li, D.10
  • 333
    • 33749327046 scopus 로고    scopus 로고
    • Effects of berberine on diabetes induced by alloxan and ahigh-fat/high-cholesterol diet in rats
    • Tang, L.-Q.; Wei, W.; Chen, L.-M.; Liu, S. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J. Ethnopharmacol. 2006, 108, 109-115
    • (2006) J. Ethnopharmacol , vol.108 , pp. 109-115
    • Tang, L.-Q.1    Wei, W.2    Chen, L.-M.3    Liu, S.4
  • 335
    • 23944478990 scopus 로고    scopus 로고
    • A review of recent studies on malondialdehyde as toxic molecule andbiological marker of oxidative stress
    • Del Rio, D.; Stewart, A.J.; Pellegrini, N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr. Metab. Cardiovasc. Dis. 2005, 15, 316-328
    • (2005) Nutr. Metab. Cardiovasc. Dis. , vol.15 , pp. 316-328
    • Del Rio, D.1    Stewart, A.J.2    Pellegrini, N.3
  • 339
    • 82955235212 scopus 로고    scopus 로고
    • Berberine inhibits inflammatory response andameliorates insulin resistance in hepatocytes
    • Lou, T.; Zhang, Z.; Xi, Z.; Liu, K.; Li, L.; Liu, B.; Huang, F. Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. Inflammation 2011, 34, 659-667
    • (2011) Inflammation , vol.34 , pp. 659-667
    • Lou, T.1    Zhang, Z.2    Xi, Z.3    Liu, K.4    Li, L.5    Liu, B.6    Huang, F.7
  • 341
    • 84924596255 scopus 로고    scopus 로고
    • Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses inβ-cells via TLR4-independent JNK/NF-B pathway
    • Wang, Y. Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in β-cells via TLR4-independent JNK/NF-B pathway. Pharm. Biol. 2014, 52, 532-538
    • (2014) Pharm. Biol , vol.52 , pp. 532-538
    • Wang, Y.1
  • 342
    • 77956108839 scopus 로고    scopus 로고
    • [effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet]
    • Shang, W.; Liu, J.; Yu, X.; Zhao, J. [effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China J. Chin. Mater. Med. 2010, 35, 1474-1477.
    • (2010) Zhongguo Zhong Yao Za Zhi= Zhongguo Zhongyao Zazhi = China J. Chin. Mater. Med , vol.35 , pp. 1474-1477
    • Shang, W.1    Liu, J.2    Yu, X.3    Zhao, J.4
  • 343
    • 84962128497 scopus 로고    scopus 로고
    • Berberine improves glucose homeostasis instreptozotocin-induced diabetic rats in association with multiple factors of insulin resistance
    • Junzeng, Z.; Changhao, S.; Alfonso, L.; Yanwen, W.; Yanfeng, C. Berberine improves glucose homeostasis in streptozotocin-induced diabetic rats in association with multiple factors of insulin resistance. ISRN Endocrinol. 2011, 2011
    • (2011) ISRN Endocrinol , vol.2011
    • Junzeng, Z.1    Changhao, S.2    Alfonso, L.3    Yanwen, W.4    Yanfeng, C.5
  • 344
    • 78651085721 scopus 로고    scopus 로고
    • Five bitter compounds display different anti-inflammatory effects through modulatingcytokine secretion using mouse primary splenocytes in vitro
    • Lin, W.-C.; Lin, J.-Y. Five bitter compounds display different anti-inflammatory effects through modulating cytokine secretion using mouse primary splenocytes in vitro. J. Agric. Food Chem. 2011, 59, 184-192
    • (2011) J. Agric. Food Chem , vol.59 , pp. 184-192
    • Lin, W.-C.1    Lin, J.-Y.2
  • 345
    • 0033985502 scopus 로고    scopus 로고
    • Orally administered decoction of Kampo (Japaneseherbal) medicine,"Juzen-Taiho-To" modulates cytokine secretion and induces NKT cells in mouse liver
    • Matsumoto, T.; Sakurai, M.H.; Kiyohara, H.; Yamada, H. Orally administered decoction of Kampo (Japanese herbal) medicine,"Juzen-Taiho-To" modulates cytokine secretion and induces NKT cells in mouse liver. Immunopharmacology 2000, 46, 149-161
    • (2000) Immunopharmacology , vol.46 , pp. 149-161
    • Matsumoto, T.1    Sakurai, M.H.2    Kiyohara, H.3    Yamada, H.4
  • 347
    • 84899507684 scopus 로고    scopus 로고
    • Inhibitory effects of japaneseherbal medicines Sho-Saiko-To and Juzen-Taiho-To on nonalcoholic steatohepatitis in mice
    • Takahashi, Y.; Soejima, Y.; Kumagai, A.; Watanabe, M.; Uozaki, H.; Fukusato, T. Inhibitory effects of japanese herbal medicines Sho-Saiko-To and Juzen-Taiho-To on nonalcoholic steatohepatitis in mice. PLoS ONE 2014, 9, e87279
    • (2014) Plos ONE , vol.9
    • Takahashi, Y.1    Soejima, Y.2    Kumagai, A.3    Watanabe, M.4    Uozaki, H.5    Fukusato, T.6
  • 348
    • 0029586888 scopus 로고
    • [Five cases of drug-induced pneumonitis due toSho-Saiko-To or interferon-α or both]
    • Nakagawa, A.; Yamaguchi, T.; Takao, T.; Amano, H. [Five cases of drug-induced pneumonitis due to Sho-Saiko-To or interferon-α or both]. Nihon Kyobu Shikkan Gakkai Zasshi 1995, 33, 1361-1366
    • (1995) Nihon Kyobu Shikkan Gakkai Zasshi , vol.33 , pp. 1361-1366
    • Nakagawa, A.1    Yamaguchi, T.2    Takao, T.3    Amano, H.4
  • 350
    • 0035156416 scopus 로고    scopus 로고
    • Does the control of alanineaminotransferase levels lead to a regression of liver fibrosis in chronic hepatitis C patients?
    • Yagura, M.; Murai, S.; Kojima, H.; Tokita, H.; Kamitsukasa, H.; Harada, H. Does the control of alanine aminotransferase levels lead to a regression of liver fibrosis in chronic hepatitis C patients? Hepatol. Res. 2001, 19, 144-157
    • (2001) Hepatol. Res , vol.19 , pp. 144-157
    • Yagura, M.1    Murai, S.2    Kojima, H.3    Tokita, H.4    Kamitsukasa, H.5    Harada, H.6
  • 351
    • 0028110031 scopus 로고
    • Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma celllines
    • Motoo, Y.; Sawabu, N. Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines. Cancer Lett. 1994, 86, 91-95
    • (1994) Cancer Lett , vol.86 , pp. 91-95
    • Motoo, Y.1    Sawabu, N.2


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