Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-binding proteins

Alcohol

Volumn 34, Issue 1, 2004, Pages 39-43

  You, Min ^a   Crabb, David W ^a  

^a NONE

Author keywords

Alcoholic fatty liver; AMP activated protein kinase; Sterol regulatory element binding proteins

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARBOXYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER PROTEIN; PROTEIN DERIVATIVE; STEROL DERIVATIVE;

ALCOHOL METABOLISM; ALCOHOL OXIDATION; ALCOHOLIC FATTY LIVER; CONFERENCE PAPER; ENZYME INHIBITION; GENE CONTROL; GENE EXPRESSION; HEPATOMA CELL; HUMAN; LIPOGENESIS; MOLECULAR MECHANICS; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; TRANSCRIPTION INITIATION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; FATTY LIVER, ALCOHOLIC; HUMANS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

EID: 12744267804     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2004.07.004     Document Type: Conference Paper

References (36)

1. M. Arakawa, S. Taketomi, K. Furuno, T. Matsuo, and H. Iwatsuka Metabolic studies on the development of ethanol-induced fatty liver in KK-Ay mice J Nutr 105 1975 1500 1508
2. F. Bardag-Gorce, Q.X. Yuan, J. Li, B.A. French, C. Fang, M. Ingelman-Sundberg, and S.W. French The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol Biochem Biophys Res Commun 279 2000 23 29
3. M.S. Brown, and J.L. Goldstein A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc Natl Acad Sci U S A 96 1999 11041 11048
4. M.P. Carrasco, C. Marco, and J.L. Segovia Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes Life Sci 68 2001 1295 1304
5. M. Fischer, M. You, M. Matsumoto, and D.W. Crabb Peroxisome proliferator-activated receptor α (PPARα) agonist treatment reverses PPARα dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice J Biol Chem 278 2003 27997 28004
6. A. Galli, D. Price, and D. Crabb High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells Hepatology 29 1999 1164 1170
7. D.G. Hardie, and D.A. Pan Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase Biochem Soc Trans 30 2002 1064 1070
8. K. Higashi, M. Hoshino, T. Nomura, K. Saso, M. Ito, and J.B. Hoek Interaction of protein phosphatases and ethanol on phospholipase C-mediated intracellular signal transduction processes in rat hepatocytes: role of protein kinase A Alcohol Clin Exp Res 20 1996 320A 324A
9. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 2002 1125 1131
10. C. Ji, and N. Kaplowitz Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice Gastroenterology 124 2003 1488 1499
11. J.-G. Joly, L. Feinman, H. Ishii, and C.S. Lieber Effect of chronic ethanol feeding on hepatic microsomal glycerophosphate acyltransferase activity J Lipid Res 14 1973 337 343
12. S. Kovacic, C.-L.M. Soltys, A.J. Barr, I. Shiojima, K. Walsh, and J.R.B. Dyck Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart J Biol Chem 278 2003 39422 39427
13. C.S. Lieber, N. Spritz, and L.M. DeCarli Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver J Clin Invest 45 1966 51 62
14. H.Z. Lin, S.Q. Yang, C. Chuckaree, F. Kuhajda, G. Ronnet, and A.M. Diehl Metformin reverses fatty liver disease in obese, leptin-deficient mice Nat Med 6 2000 998 1003
15. J.M. Lluis, A. Colell, C. García-Ruiz, N. Kaplowitz, and J.C. Fernández-Checa Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress Gastroenterology 124 2003 708 724
16. M. Muramatsu, K. Kuriyama, T. Yuki, and S. Ohkuma Hepatic lipogenesis and mobilization of peripheral fats in the formation of alcoholic fatty liver Jpn J Pharmacol 31 1981 931 940
17. N. Ouchi, H. Kobayashi, S. Kihara, M. Kumada, K. Sato, T. Inoue, T. Funahashi, and K. Walsh Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells J Biol Chem 279 2004 1304 1309
18. J.J. Repa, G. Liang, J. Ou, Y. Bashmakov, J.-M.A. Lobaccaro, I. Shimomura, B. Shan, M.S. Brown, J.L. Goldstein, and D.J. Mangelsdorf Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ Genes Dev 14 2000 2819 2830
19. J. Sakai, R.B. Rawson, P.J. Espenshade, D. Cheng, A.C. Seegmiller, J.L. Goldstein, and M.S. Brown Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells Mol Cell 2 1998 505 514
20. H.K. Seitz, B. Kuhn, E. von Hodenberg, W. Fiehn, C. Conradt, and U.A. Simanowski Increased messenger RNA levels for low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat liver after long-term ethanol ingestion Hepatology 20 1994 487 493
21. H. Shimano, J.D. Horton, R.E. Hammer, I. Shimomura, M.S. Brown, and J.L. Goldstein Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a J Clin Invest 98 1996 1575 1584
22. I. Shimomura, Y. Bashmakov, and J.D. Horton Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus J Biol Chem 274 1999 30028 30032
23. I. Shimomura, R.E. Hammer, S. Ikemoto, M.S. Brown, and J.L. Goldstein Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401 1999 73 76
24. I. Shimomura, M. Matsuda, R.E. Hammer, Y. Bashmakov, M.S. Brown, and J.L. Goldstein Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice Mol Cell 6 2000 77 86
25. I. Shimomura, H. Shimano, J.D. Horton, J.L. Goldstein, and M.S. Brown Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells J Clin Invest 99 1997 838 845
26. S. Shklyaev, G. Aslanidi, M. Tennant, V. Prima, E. Kohlbrenner, V. Kroutov, M. Campbell-Thompson, J. Crawford, E.W. Shek, P.J. Scarpace, and S. Zolotukhin Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats Proc Natl Acad Sci U S A 100 2003 14217 14222
27. S.Q. Siler, R.A. Neese, and M.K. Hellerstein De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption Am J Clin Nutr 70 1999 928 936
28. W.W. Winder, and D.G. Hardie AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes Am J Physiol 277 1999 E1 E10
29. A. Xu, Y. Wang, H. Keshaw, L.Y. Xu, K.S.L. Lam, and G.J.S. Cooper The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice J Clin Invest 112 2003 91 100
30. T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, S. Uchida, S. Yamashita, M. Noda, S. Kita, K. Ueki, K. Eto, Y. Akanuma, P. Froguel, F. Foufelle, P. Ferre, D. Carling, S. Kimura, R. Nagai, B.B. Kahn, and T. Kadowaki Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nat Med 8 2002 1288 1295
31. J.E. Yeon, S. Califano, J. Xu, J.R. Wands, and S.M. De La Monte Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver Hepatology 38 2003 703 714
32. M. You, M. Fischer, M.A. Deeg, and D.W. Crabb Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP) J Biol Chem 277 2002 29342 29347
33. You, M., Matsumoto, M., Pacold, C. M., Cho, W. K., & Crabb, D. W. (In press). The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology.
34. G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M.F. Hirshman, L.J. Goodyear, and D.E. Moller Role of AMP-activated protein kinase in mechanism of metformin action J Clin Invest 108 2001 1167 1174
35. H.-Z. Zhou, J.S. Karliner, and M.O. Gray Moderate alcohol consumption induces sustained cardiac protection by activating PKC-εand Akt Am J Physiol Heart Circ Physiol 283 2002 H165 H174
36. 1179 phosphorylation of endothelial nitric oxide synthase J Biol Chem 277 2002 32552 32557