IL-22: A critical mediator in mucosal host defense

Journal of Molecular Medicine

Volumn 87, Issue 5, 2009, Pages 451-454

  Aujla, S J ^a   Kolls, J K ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Autoimmunity; IL 22; Innate immunity

Indexed keywords

ETANERCEPT; ETRETIN; INTERLEUKIN 22;

ANTIMICROBIAL ACTIVITY; AUTOIMMUNE DISEASE; CELL LINEAGE; DIGESTIVE SYSTEM; ENTERITIS; EPITHELIUM CELL; GRAM NEGATIVE BACTERIUM; HOST RESISTANCE; HUMAN; INNATE IMMUNITY; KERATINOCYTE; MUCOSAL IMMUNITY; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSORIASIS; RESPIRATORY SYSTEM; REVIEW; SKIN; TARGET CELL; TH17 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; HUMANS; IMMUNITY, MUCOSAL; INTERLEUKIN-17; INTERLEUKINS; MODELS, BIOLOGICAL;

EID: 67349275024     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0448-1     Document Type: Review

References (22)

1. Dumoutier 2000 Cloning and characterization of IL-10-related T cell derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9 J Immunol 164 1814 1819 (Pubitemid 30108734)
2. K Wolk R Sabat 2006 Interleukin-22: a novel T and NK cell-derived cytokine that regulates the biology of tissue cells Cytokine Growth Factor Rev 17 367 380 (Pubitemid 44572879)
3. X Wolk 2004 IL-22 increases the innate immunity of tissues Immun 21 241 254 (Pubitemid 39094053)
4. T Wynn 2005 Th17: a giant step from Th1 and Th2 Nat Immunol 6 1069 1070
5. X Betteli 2007 Th17 cells in the circle of immunity and autoimmunity Nat Immunol 8 345 350 (Pubitemid 46745409)
6. X Liang 2006 Interleukin 22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides J Exp Med 203 2271 2279 (Pubitemid 44498362)
7. X Boniface 2005 IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes J Immunol 174 3695 3702 (Pubitemid 40354080)
8. X Wolk 2006 IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis Eur J Immunol 36 1309 1323
9. X Ma 2008 IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation J Clin Invest 118 597 607
10. Caproni X et al (2008) Serum levels of IL-17 and IL-22 are reduced by Etanercept, but not by Acitretin, in patients with psoriasis: a randomized controlled trial. J Clin Immunol. doi: 10.1007/s10875-008-9233-0
11. X Nagalakshmi 2004 Interleukin 22 activates STAT3 and induces IL-10 by colon epithelial cells Int Immunopharmacol 4 679 691 (Pubitemid 38553888)
12. X Brand 2006 IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration Am J Physiol Gastrointest Liver Physiol 290 G827 G838
13. X Sugimoto 2008 IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis J Clin Invest 118 534 544
14. X Zheng 2008 Interleukin 22 mediates early host defense against attaching and effacing bacterial pathogens Nat Med 14 282 289
15. X Whittington 2004 IL-22: a potential immunomodulatory molecule in the lung Am J Respir Cell Mol Biol 31 220 226 (Pubitemid 39095452)
16. X Aujla 2008 IL-22 mediates mucosal host defense against gram negative bacterial pneumonia Nat Med 14 275 281
17. X Andoh 2005 Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts Gastroenterol 129 969 984 (Pubitemid 41242688)
18. Cella X et al (2008) A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nat: Epub ahead of print
19. X Wolk 2007 IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease J Immunol 178 5973 5981 (Pubitemid 46674395)
20. X Zheng 2007 Interleukin-22, a Th17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis Nat 445 648 651 (Pubitemid 46232884)
21. K Malmberg H Ljunggren 2009 Spotlight on IL-22-producing NK cell receptor expressing mucosal lymphocytes Nat Immunol 10 11 12
22. + cells Nat Immunol 10 83 91