Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress

Experimental Biology and Medicine

Volumn 227, Issue 3, 2002, Pages 214-222

  Zhou, Zhanxiang ^a   Sun, Xiuhua ^a   James Kang, Y ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Alcohol; Hepatotoxicity; Metallothionein; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ANTIOXIDANT; CYSTEINE; CYTOCHROME P450 2E1; FAT; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLYCOGEN; METALLOTHIONEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUPEROXIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER CIRRHOSIS; ALCOHOL METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; FATTY LIVER; LIPID PEROXIDATION; LIVER CELL; LIVER NECROSIS; LIVER TOXICITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN MODIFICATION; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANIMALIA; MUS MUSCULUS;

EID: 0036521544     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020222700310     Document Type: Article

References (40)

1. Kingham JGC. Clinical hepatology: alcohol liver disease, not viral hepatitis, predominates in south Wales. Hepatology 24:1297, 1996.
2. National Institute on Alcohol Abuse and Alcoholism. The economic costs of alcohol abuse. In: 10th Special Report to the U.S. Congress on Alcohol and Health. pp339-370, 2000.
3. Noedmann R. Alcohol and antioxidant system. Alcohol Alcohol 29:513-522. 1994.
4. Wieland P, Lauterburg BH. Oxidation of mitochondrial proteins and DNA following administration of ethanol. Biochem Biophys Res Commun 213:815-819, 1995.
5. Kurose I, Higuchi H, Kato S, Miura S, Watanabe N, Kamegaya Y, Tomita K, Takashi M, Horie Y, Fukuda M, Mizukami K, Ishii H. Oxidative stress on mitochondrial and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol. Gastroenterology 112:1331-1343, 1997.
6. Rouach H, Fataccioli V, Gentil M, French SW, Mirimoto M, Nordmann R. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology 25:351-355, 1997.
7. Speisky H, MacDonald A, Griles G, Orrego H, Israel L. Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Biochem J 225:565-572, 1985.
8. Trenti T, Sternieri E, Ceccarelli D, Gallesi D, Masini A. Production of lipid hydroperoxides and depletion of reduced glutathione in liver mitochondria after acute ethanol administration to rats. Toxicol Lett 64/65:751-755, 1992.
9. Masini A, Ceccarelli D, Gallesi D, Giovannini F, Trenti T. Lipid hydroperoxide induced mitochondrial dysfunction following acute ethanol intoxication in rats: the critical role for mitochondrial reduced glutathione. Biochem Pharmacol 47:217-224, 1994.
10. Videla LA, Valenzuela A. Alcohol ingestion, liver glutathione and lipoperoxidation: metabolic interrelations and pathological implication. Life Sci 31:2395-2407, 1982.
11. Fermandez-Checa JC, Morales A, Colell A, Bellesta A, Rodes J. Kaplowitz N. S-adenosyl-L-methionine prevents both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology 21:207-214, 1995.
12. Iimuro Y, Bradford BU, Yamashita S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W. Forman D, Brenner D, Thurman RG. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology 31:391-398, 2000.
13. Sato M, Bremner I. Oxygen free radicals and metallothionein. Free Radic Biol Med 14:325-337, 1993.
14. Kang YJ. The antioxidant function of metallothionein in the heart. Proc Soc Exp Biol Med 222:263-273, 1999.
15. Thornalley PJ, Vasak M. Possible role for metallothionein in protection against radiation-induced oxidative stress: kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim Biophys Acta 827:36-44, 1985.
16. Abel J, de Ruiter N, Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein. Toxicol Lett 47:191-196, 1989.
17. Bauman J, Liu YP, Andrews GK, Klaassen CD. Examination of potential mechanism(s) of metallothionein induction by diethyl maleate. Toxicol Appl Pharmacol 117:226-232, 1992.
18. Haidara K, Moffatt P, Denizeau F. Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes. Toxicol Sci 49:297-305, 1999.
19. Palmiter RD, Sandgren EP, Koeller DM, Brinster RL, Distal regulatory elements from the metallothionein locus stimulate gene expression in transgenic mice. Mol Cell Biol 13:5266-5275, 1993.
20. Iszard MB, Liu J, Liu Y, Dalton T, Andrews GK, Palmiter RD, Klaassen CD. Characterization of metallothionein-I-transgenic mice. Toxicol Appl Pharmacol 133:305-312, 1995.
21. Carson EJ, Pruett SB. Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol, Alcohol Clin Exp Res 20:132-138, 1996.
22. Kang YJ, Chen Y, Yu A, Voss-McCowan M, Epstein PN. Over-expression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. J Clin Invest 100:1501-1506, 1997.
23. Williamson DH, Lund P, Krebs HA. The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103:514-527, 1967.
24. Koop DR. Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozymes 3a. Mol Pharmacol 29:399-404, 1986.
25. Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27:502-522, 1969.
26. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 44:276-278, 1979.
27. Reznick AA, Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol 233:357-363, 1994.
28. Ingelman-Sundberg M, Johansson I. Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450. J Biol Chem 259:6447-6458, 1984.
29. Iimuro Y, Frankenberg MV, Arteel GA, Bradford BU, Wall CA. Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males. Am J Physiol 272 (Gastrointest Liver Physiol 35):G1186-G1194, 1997.
30. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 106:867-872, 2000.
31. Lane BP, Lieber CS. Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets. Am J Pathol 49:593-604, 1966.
32. Benedetti A. Brunelli E, Risicato R, Cilliffo T, Jezequel AM. Subcellular changes and apoptosis induced by ethanol in rat liver. J Hepatol 6:137-143, 1988.
33. Sanchez-Amate MC, Marco C, Segovia JL. Comparative study of the effect of ethanol on the fluidity of subcellular hepatic membranes. Biochem Int 27:535-543, 1982.
34. Waring AJ, Rottenberg H, Ohnishi T, Rubin E. Membrane and phospholipids of liver mitochondria from chronic alcoholic rats are resistant to membrane disordering by alcohol. Proc Natl Acad Sci U S A 78:2582-2586, 1981.
35. Gordon ER, Rochman J, Arai M, Lieber CS. Lack of correlation between hepatic mitochondrial membrane structure and functions in ethanol-fed rats. Science 216:1319-1321, 1982.
36. Guerri C, Grisolia S. Changes in glutathione in acute and chronic alcohol intoxication. Pharmacol Biochem Behav 13(Suppl 1):53-61, 1980.
37. Vedila LA, Valenzuela A. Alcohol ingestion, liver glutathione and lipoperoxidation: metabolic interrelations and pathological implications. Life Sci 31:2395-2407, 1982.
38. Mira L, Maia L, Barreira L, Manso CF. Evidence for radical generation due to NADH oxidation by aldehyde oxidase during ethanol metabolism. Arch Biochem Biophys 318:53-58, 1995.
39. Lieber CS. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 77:517-544, 1997.
40. Mullen KD, Dasarathy S. Potential new therapies for alcoholic liver disease. Clin Liver Dis 2:851-881, 1998.