Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes

Toxicology and Applied Pharmacology

Volumn 236, Issue 1, 2009, Pages 124-130

  Yin, Hu Quan ^a   Kim, Youn Chul ^b   Chung, Young Suk ^a   Kim, Young Chul ^a   Shin, Young Kee ^a   Lee, Byung Hoon ^a  

^a Seoul National University   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

Ethanol; Fatty acid synthesis; Fatty liver; Honokiol; SREBP (sterol regulatory element binding protein)

Indexed keywords

ALCOHOL; FAT DROPLET; GLUTATHIONE; HONOKIOL; MAGNOLOL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; DRUG SCREENING; FATTY ACID SYNTHESIS; GENE EXPRESSION REGULATION; GENE SEQUENCE; HEPATOMA CELL; LIPID LIVER LEVEL; LIPID STORAGE; LIPOGENESIS; LIVER LEVEL; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN TRANSPORT; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIGENS, CD95; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FATTY ACIDS; FATTY LIVER, ALCOHOLIC; GENES, REPORTER; GLUTATHIONE; LIGNANS; LIPOGENESIS; LIVER; MALE; PROMOTER REGIONS, GENETIC; PROTECTIVE AGENTS; RATS; RATS, WISTAR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION, GENETIC; TRANSFECTION; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS; RATTUS NORVEGICUS;

EID: 61849111204     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.12.030     Document Type: Article

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