Inhibition of TNF-α-mediated NF-κB transcriptional activity in HepG2 cells by dammarane-type saponins from Panax ginseng leaves

Journal of Ginseng Research

Volumn 36, Issue 2, 2012, Pages 146-152

  Song, Seok Bean ^a   Tung, Nguyen Huu ^a   Quang, Tran Hong ^a   Ngan, Nguyen Thi Thanh ^a   Kim, Kyoon Eon ^a   Kim, Young Ho ^a  

^a Chungnam National University   (South Korea)

Author keywords

Anti inflammation; Cyclooxygenase 2; Inducible nitric oxide synthase; Nuclear factor B; Panax ginseng; Panax ginseng leaves

Indexed keywords

PANAX GINSENG;

EID: 84859615207     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2012.36.2.146     Document Type: Article

References (32)

1. Berasain C, Castillo J, Perugorria MJ, Latasa MU, Prieto J, Avila MA. Inflammation and liver cancer: new molecular links. Ann N Y Acad Sci 2009;1155:206-221.
2. Kawanishi S, Hiraku Y, Pinlaor S, Ma N. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem 2006;387:365-372.
3. Yamashita T, Kaneko S. Molecular pathogenesis of hepatocellular carcinoma. Gan To Kagaku Ryoho 2010;37:14-17.
4. Elsharkawy AM, Mann DA. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 2007;46:590-597.
5. Farinati F, Piciocchi M, Lavezzo E, Bortolami M, Cardin R. Oxidative stress and inducible nitric oxide synthase induction in carcinogenesis. Dig Dis 2010;28:579-584.
6. Holt AP, Salmon M, Buckley CD, Adams DH. Immune interactions in hepatic fibrosis. Clin Liver Dis 2008;12:861-882.
7. Lentsch AB, Ward PA. The NFkappaBb/IkappaB system in acute inflammation. Arch Immunol Ther Exp (Warsz) 2000;48:59-63.
8. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 2001;480-481:243-268.
9. Tsatsanis C, Androulidaki A, Venihaki M, Margioris AN. Signalling networks regulating cyclooxygenase-2. Int J Biochem Cell Biol 2006;38:1654-1661.
10. Luqman S, Pezzuto JM. NFkappaB: a promising target for natural products in cancer chemoprevention. Phytother Res 2010;24:949-963.
11. Nam NH. Naturally occurring NF-kappaB inhibitors. Mini Rev Med Chem 2006;6:945-951.
12. Ernst E. Panax ginseng: an overview of the clinical evidence. J Ginseng Res 2010;34:259-263.
13. Hofseth LJ, Wargovich MJ. Inflammation, cancer, and targets of ginseng. J Nutr 2007;137(1 Suppl):183S-185S.
14. Vuksan V, Sievenpipper J, Jovanovski E, Jenkins AL. Current clinical evidence for Korean red ginseng in management of diabetes and vascular disease: a Toronto's ginseng clinical testing program. J Ginseng Res 2010;34:264-273.
15. Liu GY, Li XW, Wang NB, Zhou HY, Wei W, Gui MY, Yang B, Jin YR. Three new dammarane-type triterpene saponins from the leaves of Panax ginseng C.A. Meyer. J Asian Nat Prod Res 2010;12:865-873.
16. Tung NH, Song GY, Park YJ, Kim YH. Two new dammarane- type saponins from the leaves of Panax ginseng. Chem Pharm Bull (Tokyo) 2009;57:1412-1414.
17. Tung NH, Song GY, Minh CV, Kiem PV, Jin LG, Boo HJ, Kang HK, Kim YH. Steamed ginseng-leaf components enhance cytotoxic effects on human leukemia HL-60 cells. Chem Pharm Bull (Tokyo) 2010;58:1111-1115.
18. Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009;55:1-99.
19. Wang H, Peng D, Xie J. Ginseng leaf-stem: bioactive constituents and pharmacological functions. Chin Med 2009;4:20.
20. Baek NI, Kim DS, Lee YH, Park JD, Lee CB, Kim SI. Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng. Planta Med 1996;62:86-87.
21. Kim KK, Park KS, Song SB, Kim KE. Up regulation of GW112 Gene by NF kappaB promotes an antiapoptotic property in gastric cancer cells. Mol Carcinog 2010;49:259-270.
22. Ye R, Yang Q, Kong X, Han J, Zhang X, Zhang Y, Li P, Liu J, Shi M, Xiong L, Zhao G. Ginsenoside Rd attenuates early oxidative damage and sequential inflamatory response after transient focal ischemia in rats. Neurochem Int 2011;58:391-398.
23. Lee DC, Lau AS. Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: a mini-review. Molecules 2011;16:2802-2816.
24. Chang SH, Choi Y, Park JA, Jung DS, Shin J, Yang JH, Ko SY, Kim SW, Kim JK. Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model. Clin Nutr 2007;26:785-791.
25. Son HY, Han HS, Jung HW, Park YK. Panax notoginseng attenuates the infarct volume in rat ischemic brain and the inflammatory response of microglia. J Pharmacol Sci 2009;109:368-379.
26. Ahn JY, Choi IS, Shim JY, Yun EK, Yun YS, Jeong G, Song JY. The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals. Eur J Immunol 2006;36:37-45.
27. Ahn JY, Song JY, Yun YS, Jeong G, Choi IS. Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunol Med Microbiol 2006;46:187-197.
28. 1 inhibits tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Biol Pharm Bull 2008;31:2050-2056.
29. 3 inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells. Pharmazie 2010;65:699-701.
30. Wu CF, Bi XL, Yang JY, Zhan JY, Dong YX, Wang JH, Wang JM, Zhang R, Li X. Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia. Int Immunopharmacol 2007;7:313-320.
31. Nguyen MD, Kasai R, Ohtani K, Ito A, Nguyen TN, Yamasaki K, Tanaka O. Saponins from Vietnamese ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II. Chem Pharm Bull (Tokyo) 1994;42:115-122.
32. Lee EH, Cho SY, Kim SJ, Shin ES, Chang HK, Kim DH, Yeom MH, Woe KS, Lee J, Sim YC et al. Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolet-Binduced apoptosis by maintaining constant levels of Bcl-2. J Invest Dermatol 2003;121:607-613.