-
1
-
-
28144449739
-
Pathophysiological basis for antioxidant therapy in chronic liver disease
-
DOI 10.2165/00003495-200565170-00003
-
J. Medina, and R. Moreno-Otero Pathophysiological basis for antioxidant therapy in chronic liver disease Drugs 65 2005 2445 2461 (Pubitemid 41697314)
-
(2005)
Drugs
, vol.65
, Issue.17
, pp. 2445-2461
-
-
Medina, J.1
Moreno-Otero, R.2
-
2
-
-
77951771190
-
Redox control of liver function in health and disease
-
M. Mari, A. Colell, A. Morales, M.C. von, C. Garcia-Ruiz, and J.C. Fernandez-Checa Redox control of liver function in health and disease Antioxid. Redox Signaling 12 2010 1295 1331
-
(2010)
Antioxid. Redox Signaling
, vol.12
, pp. 1295-1331
-
-
Mari, M.1
Colell, A.2
Morales, A.3
Von, M.C.4
Garcia-Ruiz, C.5
Fernandez-Checa, J.C.6
-
3
-
-
73349136974
-
Role of free radicals in liver diseases
-
P. Muriel Role of free radicals in liver diseases Hepatol. Int. 3 2009 526 536
-
(2009)
Hepatol. Int.
, vol.3
, pp. 526-536
-
-
Muriel, P.1
-
4
-
-
77953293358
-
Nitric oxide and redox regulation in the liver. Part I. General considerations and redox biology in hepatitis
-
D.L. Diesen, and P.C. Kuo Nitric oxide and redox regulation in the liver. Part I. General considerations and redox biology in hepatitis J. Surg. Res. 162 2010 95 109
-
(2010)
J. Surg. Res.
, vol.162
, pp. 95-109
-
-
Diesen, D.L.1
Kuo, P.C.2
-
5
-
-
39749110624
-
Oxidative stress and iron homeostasis: Mechanistic and health aspects
-
DOI 10.1080/10408360701713104, PII 790776652
-
D. Galaris, and K. Pantopoulos Oxidative stress and iron homeostasis: mechanistic and health aspects Crit. Rev. Clin. Lab Sci. 45 2008 1 23 (Pubitemid 351299652)
-
(2008)
Critical Reviews in Clinical Laboratory Sciences
, vol.45
, Issue.1
, pp. 1-23
-
-
Galaris, D.1
Pantopoulos, K.2
-
6
-
-
10644220306
-
Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
-
DOI 10.1002/hep.20466
-
J.D. Browning, L.S. Szczepaniak, R. Dobbins, P. Nuremberg, J.D. Horton, J.C. Cohen, S.M. Grundy, and H.H. Hobbs Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity Hepatology 40 2004 1387 1395 (Pubitemid 39657013)
-
(2004)
Hepatology
, vol.40
, Issue.6
, pp. 1387-1395
-
-
Browning, J.D.1
Szczepaniak, L.S.2
Dobbins, R.3
Nuremberg, P.4
Horton, J.D.5
Cohen, J.C.6
Grundy, S.M.7
Hobbs, H.H.8
-
7
-
-
84655169624
-
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
-
A.P. Rolo, J.S. Teodoro, and C.M. Palmeira Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis Free Radic. Biol. Med. 52 2012 59 69
-
(2012)
Free Radic. Biol. Med.
, vol.52
, pp. 59-69
-
-
Rolo, A.P.1
Teodoro, J.S.2
Palmeira, C.M.3
-
8
-
-
0033198978
-
Mitochondrial abnormalities in non-alcoholic steatohepatitis
-
DOI 10.1016/S0168-8278(99)80033-6
-
S.H. Caldwell, R.H. Swerdlow, E.M. Khan, J.C. Iezzoni, E.E. Hespenheide, J.K. Parks, and W.D. Parker Jr. Mitochondrial abnormalities in non-alcoholic steatohepatitis J. Hepatol. 31 1999 430 434 (Pubitemid 29408724)
-
(1999)
Journal of Hepatology
, vol.31
, Issue.3
, pp. 430-434
-
-
Caldwell, S.H.1
Swerdlow, R.H.2
Khan, E.M.3
Iezzoni, J.C.4
Hespenheide, E.E.5
Parks, J.K.6
Parker Jr., W.D.7
-
9
-
-
0033520771
-
Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: A pilot study
-
DOI 10.1001/jama.282.17.1659
-
H. Cortez-Pinto, J. Chatham, V.P. Chacko, C. Arnold, A. Rashid, and A.M. Diehl Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study JAMA 282 1999 1659 1664 (Pubitemid 29513973)
-
(1999)
Journal of the American Medical Association
, vol.282
, Issue.17
, pp. 1659-1664
-
-
Cortez-Pinto, H.1
Chatham, J.2
Chacko, V.P.3
Arnold, C.4
Rashid, A.5
Diehl, A.M.6
-
10
-
-
40749091283
-
Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model
-
DOI 10.1111/j.1365-2362.2008.01936.x
-
G. Serviddio, F. Bellanti, R. Tamborra, T. Rollo, A.D. Romano, A.M. Giudetti, N. Capitanio, A. Petrella, G. Vendemiale, and E. Altomare Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model Eur. J. Clin. Invest. 38 2008 245 252 (Pubitemid 351389142)
-
(2008)
European Journal of Clinical Investigation
, vol.38
, Issue.4
, pp. 245-252
-
-
Serviddio, G.1
Bellanti, F.2
Tamborra, R.3
Rollo, T.4
Romano, A.D.5
Giudetti, A.M.6
Capitanio, N.7
Petrella, A.8
Vendemiale, G.9
Altomare, E.10
-
11
-
-
0034019329
-
2 generation in liver mitochondria
-
2 generation in liver mitochondria Carcinogenesis 21 2000 983 989 (Pubitemid 30265144)
-
(2000)
Carcinogenesis
, vol.21
, Issue.5
, pp. 983-989
-
-
Hensley, K.1
Kotake, Y.2
Sang, H.3
Pye, Q.N.4
Wallis, G.L.5
Kolker, L.M.6
Tabatabaie, T.7
Stewart, C.A.8
Konishi, Y.9
Nakae, D.10
Floyd, R.A.11
-
12
-
-
46349087273
-
Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury
-
DOI 10.1136/gut.2007.147496
-
G. Serviddio, F. Bellanti, R. Tamborra, T. Rollo, N. Capitanio, A.D. Romano, J. Sastre, G. Vendemiale, and E. Altomare Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury Gut 57 2008 957 965 (Pubitemid 351919530)
-
(2008)
Gut
, vol.57
, Issue.7
, pp. 957-965
-
-
Serviddio, G.1
Bellanti, F.2
Tamborra, R.3
Rollo, T.4
Capitanio, N.5
Romano, A.D.6
Sastre, J.7
Vendemiale, G.8
Altomare, E.9
-
13
-
-
69249233513
-
Role of hepatic iron in non-alcoholic steatohepatitis
-
Y. Sumida, T. Yoshikawa, and T. Okanoue Role of hepatic iron in non-alcoholic steatohepatitis Hepatol. Res. 39 2009 213 222
-
(2009)
Hepatol. Res.
, vol.39
, pp. 213-222
-
-
Sumida, Y.1
Yoshikawa, T.2
Okanoue, T.3
-
14
-
-
35448963836
-
Nonalcoholic Fatty Liver Disease as a Complication of Insulin Resistance
-
DOI 10.1016/j.mcna.2007.06.001, PII S0025712507000740, Metabolic Syndrome
-
Abdelmalek, M.F.; Diehl, A.M. Nonalcoholic fatty liver disease as a complication of insulin resistance. Med. Clin. North Am. 91:1125-1149, ix; 2007. (Pubitemid 47625434)
-
(2007)
Medical Clinics of North America
, vol.91
, Issue.6
, pp. 1125-1149
-
-
Abdelmalek, M.F.1
Diehl, A.M.2
-
16
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
-
DOI 10.1172/JCI34275
-
C. Postic, and J. Girard Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice J. Clin. Invest 118 2008 829 838 (Pubitemid 351364588)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.3
, pp. 829-838
-
-
Postic, C.1
Girard, J.2
-
17
-
-
84863143861
-
Oxidative stress and redox signaling mechanisms of alcoholic liver disease: Updated experimental and clinical evidence
-
H. Zhu, Z. Jia, H. Misra, and Y.R. Li Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence J. Dig. Dis. 13 2012 133 142
-
(2012)
J. Dig. Dis.
, vol.13
, pp. 133-142
-
-
Zhu, H.1
Jia, Z.2
Misra, H.3
Li, Y.R.4
-
18
-
-
0031035695
-
Ethanol metabolism, cirrhosis and alcoholism
-
DOI 10.1016/S0009-8981(96)06434-0, PII S0009898196064340
-
C.S. Lieber Ethanol metabolism, cirrhosis and alcoholism Clin. Chim. Acta 257 1997 59 84 (Pubitemid 27055895)
-
(1997)
Clinica Chimica Acta
, vol.257
, Issue.1
, pp. 59-84
-
-
Lieber, C.S.1
-
19
-
-
78649339034
-
Mechanisms and cell signaling in alcoholic liver disease
-
J.I. Beier, and C.J. McClain Mechanisms and cell signaling in alcoholic liver disease Biol. Chem. 391 2010 1249 1264
-
(2010)
Biol. Chem.
, vol.391
, pp. 1249-1264
-
-
Beier, J.I.1
McClain, C.J.2
-
20
-
-
77952574852
-
Pathogenesis of alcoholic liver disease: The role of nuclear receptors
-
M.A. Gyamfi, and Y.J. Wan Pathogenesis of alcoholic liver disease: the role of nuclear receptors Exp. Biol. Med. (Maywood) 235 2010 547 560
-
(2010)
Exp. Biol. Med. (Maywood)
, vol.235
, pp. 547-560
-
-
Gyamfi, M.A.1
Wan, Y.J.2
-
21
-
-
38849173251
-
Comparison of the natural history of alcoholic and nonalcoholic fatty liver disease
-
S.J. Mills, and S.A. Harrison Comparison of the natural history of alcoholic and nonalcoholic fatty liver disease Curr. Gastroenterol. Rep 7 2005 32 36
-
(2005)
Curr. Gastroenterol. Rep
, vol.7
, pp. 32-36
-
-
Mills, S.J.1
Harrison, S.A.2
-
22
-
-
79959501180
-
Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease
-
A.E. Feldstein, and S.M. Bailey Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease Antioxid. Redox Signaling 15 2011 421 424
-
(2011)
Antioxid. Redox Signaling
, vol.15
, pp. 421-424
-
-
Feldstein, A.E.1
Bailey, S.M.2
-
24
-
-
79959507760
-
Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease
-
C.L. Gentile, M. Frye, and M.J. Pagliassotti Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease Antioxid. Redox Signaling 15 2011 505 521
-
(2011)
Antioxid. Redox Signaling
, vol.15
, pp. 505-521
-
-
Gentile, C.L.1
Frye, M.2
Pagliassotti, M.J.3
-
25
-
-
79954558287
-
Adipokines and redox signaling: Impact on fatty liver disease
-
M. Parola, and F. Marra Adipokines and redox signaling: impact on fatty liver disease Antioxid. Redox Signaling 15 2011 461 483
-
(2011)
Antioxid. Redox Signaling
, vol.15
, pp. 461-483
-
-
Parola, M.1
Marra, F.2
-
26
-
-
79959497081
-
Redox signaling and the innate immune system in alcoholic liver disease
-
J.I. Cohen, X. Chen, and L.E. Nagy Redox signaling and the innate immune system in alcoholic liver disease Antioxid. Redox Signaling 15 2011 523 534
-
(2011)
Antioxid. Redox Signaling
, vol.15
, pp. 523-534
-
-
Cohen, J.I.1
Chen, X.2
Nagy, L.E.3
-
27
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
N. Houstis, E.D. Rosen, and E.S. Lander Reactive oxygen species have a causal role in multiple forms of insulin resistance Nature 440 2006 944 948
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
28
-
-
84870408095
-
Nuclear receptors and transcription factors in the development of fatty liver disease
-
A. Vluggens, and J.K. Reddy Nuclear receptors and transcription factors in the development of fatty liver disease Curr. Drug Metab. 13 2012 1422 1435
-
(2012)
Curr. Drug Metab.
, vol.13
, pp. 1422-1435
-
-
Vluggens, A.1
Reddy, J.K.2
-
29
-
-
77649250810
-
Nuclear redox signaling
-
M. Lukosz, S. Jakob, N. Buchner, T.C. Zschauer, J. Altschmied, and J. Haendeler Nuclear redox signaling Antioxid. Redox Signaling 12 2010 713 742
-
(2010)
Antioxid. Redox Signaling
, vol.12
, pp. 713-742
-
-
Lukosz, M.1
Jakob, S.2
Buchner, N.3
Zschauer, T.C.4
Altschmied, J.5
Haendeler, J.6
-
30
-
-
0035371184
-
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
-
DOI 10.1016/S0891-5849(01)00480-4, PII S0891584901004804
-
F.Q. Schafer, and G.R. Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radic. Biol. Med 30 2001 1191 1212 (Pubitemid 32463931)
-
(2001)
Free Radical Biology and Medicine
, vol.30
, Issue.11
, pp. 1191-1212
-
-
Schafer, F.Q.1
Buettner, G.R.2
-
31
-
-
37549068090
-
+/NADPH in cellular functions and cell death: Regulation and biological consequences
-
+/NADPH in cellular functions and cell death: regulation and biological consequences Antioxid. Redox Signaling 10 2008 179 206
-
(2008)
Antioxid. Redox Signaling
, vol.10
, pp. 179-206
-
-
Ying, W.1
-
32
-
-
0028181364
-
Redox control of beta-oxidation in rat liver mitochondria
-
S. Eaton, D.M. Turnbull, and K. Bartlett Redox control of beta-oxidation in rat liver mitochondria Eur. J. Biochem. 220 1994 671 681
-
(1994)
Eur. J. Biochem.
, vol.220
, pp. 671-681
-
-
Eaton, S.1
Turnbull, D.M.2
Bartlett, K.3
-
33
-
-
0036154857
-
Control of mitochondrial beta-oxidation flux
-
S. Eaton Control of mitochondrial beta-oxidation flux Prog. Lipid Res. 41 2002 197 239
-
(2002)
Prog. Lipid Res.
, vol.41
, pp. 197-239
-
-
Eaton, S.1
-
34
-
-
13744263104
-
Temporal pattern of de novo lipogenesis in the postprandial state in healthy men
-
M.T. Timlin, and E.J. Parks Temporal pattern of de novo lipogenesis in the postprandial state in healthy men Am. J. Clin. Nutr. 81 2005 35 42 (Pubitemid 43073373)
-
(2005)
American Journal of Clinical Nutrition
, vol.81
, Issue.1
, pp. 35-42
-
-
Timlin, M.T.1
Parks, E.J.2
-
35
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
DOI 10.1172/JCI200523621
-
K.L. Donnelly, C.I. Smith, S.J. Schwarzenberg, J. Jessurun, M.D. Boldt, and E.J. Parks Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J. Clin. Invest. 115 2005 1343 1351 (Pubitemid 40629054)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.5
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
36
-
-
2342509057
-
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
-
DOI 10.1038/nm995
-
J. An, D.M. Muoio, M. Shiota, Y. Fujimoto, G.W. Cline, G.I. Shulman, T.R. Koves, R. Stevens, D. Millington, and C.B. Newgard Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance Nat. Med 10 2004 268 274 (Pubitemid 38667617)
-
(2004)
Nature Medicine
, vol.10
, Issue.3
, pp. 268-274
-
-
An, J.1
Muoio, D.M.2
Shiota, M.3
Fujimoto, Y.4
Cline, G.W.5
Shulman, G.I.6
Koves, T.R.7
Stevens, R.8
Millington, D.9
Newgard, C.B.10
-
37
-
-
33644654777
-
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
-
DOI 10.1172/JCI27300
-
D.B. Savage, C.S. Choi, V.T. Samuel, Z.X. Liu, D. Zhang, A. Wang, X.M. Zhang, G.W. Cline, X.X. Yu, J.G. Geisler, S. Bhanot, B.P. Monia, and G.I. Shulman Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2 J. Clin. Invest. 116 2006 817 824 (Pubitemid 43326891)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.3
, pp. 817-824
-
-
Savage, D.B.1
Cheol, S.C.2
Samuel, V.T.3
Liu, Z.-X.4
Zhang, D.5
Wang, A.6
Zhang, X.-M.7
Cline, G.W.8
Xing, X.Y.9
Geisler, J.G.10
Bhanot, S.11
Monia, B.P.12
Shulman, G.I.13
-
38
-
-
82955239838
-
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
-
N.E. Sunny, E.J. Parks, J.D. Browning, and S.C. Burgess Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease Cell Metab. 14 2011 804 810
-
(2011)
Cell Metab.
, vol.14
, pp. 804-810
-
-
Sunny, N.E.1
Parks, E.J.2
Browning, J.D.3
Burgess, S.C.4
-
39
-
-
0018356140
-
Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats
-
G.P. Mannaerts, L.J. Debeer, J. Thomas, and P.J. De Schepper Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats J. Biol. Chem. 254 1979 4585 4595 (Pubitemid 9203487)
-
(1979)
Journal of Biological Chemistry
, vol.254
, Issue.11
, pp. 4585-4595
-
-
Mannaerts, G.P.1
Debeer, L.J.2
Thomas, J.3
De Schepper, P.J.4
-
41
-
-
0029128915
-
Alterations of peroxisomes in steatosis of the human liver: A quantitative study
-
C.D. De, M. Pauwels, and C. Van den Branden Alterations of peroxisomes in steatosis of the human liver: a quantitative study Hepatology 22 1995 744 752
-
(1995)
Hepatology
, vol.22
, pp. 744-752
-
-
De, C.D.1
Pauwels, M.2
Van Den Branden, C.3
-
42
-
-
0037369729
-
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
-
DOI 10.1053/jhep.2003.50095
-
N. Chalasani, J.C. Gorski, M.S. Asghar, A. Asghar, B. Foresman, S.D. Hall, and D.W. Crabb Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis Hepatology 37 2003 544 550 (Pubitemid 36258775)
-
(2003)
Hepatology
, vol.37
, Issue.3
, pp. 544-550
-
-
Chalasani, N.1
Christopher Gorski, J.2
Asghar, M.S.3
Asghar, A.4
Foresman, B.5
Hall, S.D.6
Crabb, D.W.7
-
43
-
-
33745844419
-
Oxidative stress in experimental liver microvesicular steatosis: Role of mitochondria and peroxisomes
-
DOI 10.1111/j.1440-1746.2006.04313.x
-
S.K. Natarajan, C.E. Eapen, A.B. Pullimood, and K.A. Balasubramanian Oxidative stress in experimental liver microvesicular steatosis: role of mitochondria and peroxisomes J. Gastroenterol. Hepatol. 21 2006 1240 1249 (Pubitemid 44034335)
-
(2006)
Journal of Gastroenterology and Hepatology
, vol.21
, Issue.8
, pp. 1240-1249
-
-
Natarajan, S.K.1
Eapen, C.E.2
Pullimood, A.B.3
Balasubramanian, K.A.4
-
44
-
-
77958501463
-
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase
-
J.W. Zmijewski, S. Banerjee, H. Bae, A. Friggeri, E.R. Lazarowski, and E. Abraham Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase J. Biol. Chem. 285 2010 33154 33164
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 33154-33164
-
-
Zmijewski, J.W.1
Banerjee, S.2
Bae, H.3
Friggeri, A.4
Lazarowski, E.R.5
Abraham, E.6
-
45
-
-
32844458032
-
Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it
-
K. Begriche, A. Igoudjil, D. Pessayre, and B. Fromenty Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it Mitochondrion 6 2006 1 28
-
(2006)
Mitochondrion
, vol.6
, pp. 1-28
-
-
Begriche, K.1
Igoudjil, A.2
Pessayre, D.3
Fromenty, B.4
-
46
-
-
1442282934
-
New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments
-
C.S. Lieber New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments Curr. Gastroenterol. Rep 6 2004 60 65 (Pubitemid 39359586)
-
(2004)
Current Gastroenterology Reports
, vol.6
, Issue.1
, pp. 60-65
-
-
Lieber, C.S.1
-
47
-
-
10344219509
-
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase
-
DOI 10.1074/jbc.M407120200
-
S.C. Burgess, N. Hausler, M. Merritt, F.M. Jeffrey, C. Storey, A. Milde, S. Koshy, J. Lindner, M.A. Magnuson, C.R. Malloy, and A.D. Sherry Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase J. Biol. Chem. 279 2004 48941 48949 (Pubitemid 39625775)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.47
, pp. 48941-48949
-
-
Burgess, S.C.1
Hausler, N.2
Merritt, M.3
Jeffrey, F.M.H.4
Storey, C.5
Milde, A.6
Koshy, S.7
Lindner, J.8
Magnuson, M.A.9
Malloy, C.R.10
Sherry, A.D.11
-
48
-
-
70450248387
-
Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis
-
Y. Noguchi, J.D. Young, J.O. Aleman, M.E. Hansen, J.K. Kelleher, and G. Stephanopoulos Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis J. Biol. Chem. 284 2009 33425 33436
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 33425-33436
-
-
Noguchi, Y.1
Young, J.D.2
Aleman, J.O.3
Hansen, M.E.4
Kelleher, J.K.5
Stephanopoulos, G.6
-
49
-
-
33745828301
-
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
-
Y. Wei, D. Wang, F. Topczewski, and M.J. Pagliassotti Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells Am. J. Physiol Endocrinol. Metab. 291 2006 E275 E281
-
(2006)
Am. J. Physiol Endocrinol. Metab.
, vol.291
-
-
Wei, Y.1
Wang, D.2
Topczewski, F.3
Pagliassotti, M.J.4
-
50
-
-
84867637301
-
N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis
-
R. Valenzuela, A. Espinosa, D. Gonzalez-Manan, A. D'Espessailles, V. Fernandez, L.A. Videla, and G. Tapia N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis PLoS One 7 2012 e46400
-
(2012)
PLoS One
, vol.7
, pp. 46400
-
-
Valenzuela, R.1
Espinosa, A.2
Gonzalez-Manan, D.3
D'Espessailles, A.4
Fernandez, V.5
Videla, L.A.6
Tapia, G.7
-
51
-
-
84870755708
-
High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet
-
G. Silbernagel, M. Kovarova, A. Cegan, J. Machann, F. Schick, and R. Lehmann Haring, H.U.; Stefan, N.; Schleicher, E.; Fritsche, A.; Peter, A. High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet J. Clin. Endocrinol. Metab. 97 2012 E2288 E2292
-
(2012)
J. Clin. Endocrinol. Metab.
, vol.97
-
-
Silbernagel, G.1
Kovarova, M.2
Cegan, A.3
Machann, J.4
Schick, F.5
Lehmann, R.6
Haring, H.U.7
Stefan, N.8
Schleicher, E.9
Fritsche, A.10
Peter, A.11
-
52
-
-
79956336707
-
Transcriptional profile of genes involved in oxidative stress and antioxidant defense in a dietary murine model of steatohepatitis
-
A. Gornicka, G. Morris-Stiff, S. Thapaliya, B.G. Papouchado, M. Berk, and A.E. Feldstein Transcriptional profile of genes involved in oxidative stress and antioxidant defense in a dietary murine model of steatohepatitis Antioxid. Redox Signaling 15 2011 437 445
-
(2011)
Antioxid. Redox Signaling
, vol.15
, pp. 437-445
-
-
Gornicka, A.1
Morris-Stiff, G.2
Thapaliya, S.3
Papouchado, B.G.4
Berk, M.5
Feldstein, A.E.6
-
53
-
-
36349024819
-
A lipidomic analysis of nonalcoholic fatty liver disease
-
DOI 10.1002/hep.21763
-
P. Puri, R.A. Baillie, M.M. Wiest, F. Mirshahi, J. Choudhury, O. Cheung, C. Sargeant, M.J. Contos, and A.J. Sanyal A lipidomic analysis of nonalcoholic fatty liver disease Hepatology 46 2007 1081 1090 (Pubitemid 350144772)
-
(2007)
Hepatology
, vol.46
, Issue.4
, pp. 1081-1090
-
-
Puri, P.1
Baillie, R.A.2
Wiest, M.M.3
Mirshahi, F.4
Choudhury, J.5
Cheung, O.6
Sargeant, C.7
Contos, M.J.8
Sanyal, A.J.9
-
54
-
-
61849095626
-
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH
-
F. Caballero, A. Fernandez, A.M. De Lacy, J.C. Fernandez-Checa, J. Caballeria, and C. Garcia-Ruiz Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH J. Hepatol. 50 2009 789 796
-
(2009)
J. Hepatol.
, vol.50
, pp. 789-796
-
-
Caballero, F.1
Fernandez, A.2
De Lacy, A.M.3
Fernandez-Checa, J.C.4
Caballeria, J.5
Garcia-Ruiz, C.6
-
55
-
-
78649632998
-
Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity
-
P. Simonen, A. Kotronen, M. Hallikainen, K. Sevastianova, J. Makkonen, A. Hakkarainen, N. Lundbom, T.A. Miettinen, H. Gylling, and H. Yki-Jarvinen Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity J. Hepatol. 54 2011 153 159
-
(2011)
J. Hepatol.
, vol.54
, pp. 153-159
-
-
Simonen, P.1
Kotronen, A.2
Hallikainen, M.3
Sevastianova, K.4
Makkonen, J.5
Hakkarainen, A.6
Lundbom, N.7
Miettinen, T.A.8
Gylling, H.9
Yki-Jarvinen, H.10
-
56
-
-
33747626511
-
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
-
DOI 10.1016/j.cmet.2006.07.006, PII S1550413106002658
-
M. Mari, F. Caballero, A. Colell, A. Morales, J. Caballeria, A. Fernandez, C. Enrich, J.C. Fernandez-Checa, and C. Garcia-Ruiz Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis Cell Metab. 4 2006 185 198 (Pubitemid 44307975)
-
(2006)
Cell Metabolism
, vol.4
, Issue.3
, pp. 185-198
-
-
Mari, M.1
Caballero, F.2
Colell, A.3
Morales, A.4
Caballeria, J.5
Fernandez, A.6
Enrich, C.7
Fernandez-Checa, J.C.8
Garcia-Ruiz, C.9
-
57
-
-
0022383292
-
Sulfhydryl/disulfide forms of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase
-
G.C. Ness, M.J. McCreery, C.E. Sample, M. Smith, and L.C. Pendleton Sulfhydryl/disulfide forms of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Biol. Chem. 260 1985 16395 16399 (Pubitemid 16172359)
-
(1985)
Journal of Biological Chemistry
, vol.260
, Issue.30
, pp. 16395-16399
-
-
Ness, G.C.1
McCreery, M.J.2
Sample, C.E.3
-
58
-
-
0034093374
-
Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: The concept of cholesterol buffering capacity (44508)
-
G.C. Ness, and C.M. Chambers Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity Proc. Soc. Exp. Biol. Med. 224 2000 8 19 (Pubitemid 30230413)
-
(2000)
Proceedings of the Society for Experimental Biology and Medicine
, vol.224
, Issue.1
, pp. 8-19
-
-
Ness, G.C.1
Chambers, C.M.2
-
59
-
-
52049088770
-
Oxidative stress and covalent modification of protein with bioactive aldehydes
-
P.A. Grimsrud, H. Xie, T.J. Griffin, and D.A. Bernlohr Oxidative stress and covalent modification of protein with bioactive aldehydes J. Biol. Chem. 283 2008 21837 21841
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 21837-21841
-
-
Grimsrud, P.A.1
Xie, H.2
Griffin, T.J.3
Bernlohr, D.A.4
-
60
-
-
33846853515
-
Chemical nature of stochastic generation of protein-based carbonyls: Metal-catalyzed oxidation versus modification by products of lipid oxidation
-
DOI 10.1021/tx600270f
-
Q. Yuan, X. Zhu, and L.M. Sayre Chemical nature of stochastic generation of protein-based carbonyls: metal-catalyzed oxidation versus modification by products of lipid oxidation Chem. Res. Toxicol 20 2007 129 139 (Pubitemid 46220163)
-
(2007)
Chemical Research in Toxicology
, vol.20
, Issue.1
, pp. 129-139
-
-
Yuan, Q.1
Zhu, X.2
Sayre, L.M.3
-
61
-
-
33845390864
-
Protein adducts generated from products of lipid oxidation: Focus on HNE and ONE
-
DOI 10.1080/03602530600959508, PII X078211547323X23
-
L.M. Sayre, D. Lin, Q. Yuan, X. Zhu, and X. Tang Protein adducts generated from products of lipid oxidation: focus on HNE and ONE Drug Metab. Rev. 38 2006 651 675 (Pubitemid 44903261)
-
(2006)
Drug Metabolism Reviews
, vol.38
, Issue.4
, pp. 651-675
-
-
Sayre, L.M.1
Lin, D.2
Yuan, Q.3
Zhu, X.4
Tang, X.5
-
62
-
-
4043077961
-
Molecular mediators of hepatic steatosis and liver injury
-
DOI 10.1172/JCI200422422
-
J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J. Clin. Invest. 114 2004 147 152 (Pubitemid 39071617)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.2
, pp. 147-152
-
-
Browning, J.D.1
Horton, J.D.2
-
64
-
-
48649100200
-
Protein glutathionylation increases in the liver of patients with non-alcoholic fatty liver disease
-
F. Piemonte, S. Petrini, L.M. Gaeta, G. Tozzi, E. Bertini, R. Devito, R. Boldrini, M. Marcellini, E. Ciacco, and V. Nobili Protein glutathionylation increases in the liver of patients with non-alcoholic fatty liver disease J. Gastroenterol. Hepatol. 23 2008 e457 e464
-
(2008)
J. Gastroenterol. Hepatol.
, vol.23
-
-
Piemonte, F.1
Petrini, S.2
Gaeta, L.M.3
Tozzi, G.4
Bertini, E.5
Devito, R.6
Boldrini, R.7
Marcellini, M.8
Ciacco, E.9
Nobili, V.10
-
65
-
-
80052356803
-
Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet
-
G. Serviddio, A.M. Giudetti, F. Bellanti, P. Priore, T. Rollo, R. Tamborra, L. Siculella, G. Vendemiale, E. Altomare, and G.V. Gnoni Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet PLoS One 6 2011 e24084
-
(2011)
PLoS One
, vol.6
, pp. 24084
-
-
Serviddio, G.1
Giudetti, A.M.2
Bellanti, F.3
Priore, P.4
Rollo, T.5
Tamborra, R.6
Siculella, L.7
Vendemiale, G.8
Altomare, E.9
Gnoni, G.V.10
-
66
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
DOI 10.1038/414799a
-
A.R. Saltiel, and C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 2001 799 806 (Pubitemid 34000783)
-
(2001)
Nature
, vol.414
, Issue.6865
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
67
-
-
0142027805
-
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
-
DOI 10.1073/pnas.1534923100
-
J.D. Horton, N.A. Shah, J.A. Warrington, N.N. Anderson, S.W. Park, M.S. Brown, and J.L. Goldstein Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes Proc. Natl. Acad. Sci. USA 100 2003 12027 12032 (Pubitemid 37271509)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.21
, pp. 12027-12032
-
-
Horton, J.D.1
Shah, N.A.2
Warrington, J.A.3
Anderson, N.N.4
Park, S.W.5
Brown, M.S.6
Goldstein, J.L.7
-
68
-
-
43649094366
-
Carbohydrate responsive element binding protein and lipid homeostasis
-
DOI 10.1097/MOL.0b013e3282ffafaa, PII 0004143320080600000014
-
P.D. Denechaud, J. Girard, and C. Postic Carbohydrate responsive element binding protein and lipid homeostasis Curr. Opin. Lipidol. 19 2008 301 306 (Pubitemid 351681558)
-
(2008)
Current Opinion in Lipidology
, vol.19
, Issue.3
, pp. 301-306
-
-
Denechaud, P.-D.1
Girard, J.2
Postic, C.3
-
69
-
-
0023442337
-
Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide
-
G.R. Hayes, and D.H. Lockwood Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide Proc. Natl. Acad. Sci. USA 84 1987 8115 8119
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 8115-8119
-
-
Hayes, G.R.1
Lockwood, D.H.2
-
70
-
-
0025193521
-
2 and vanadate stimulate protein tyrosine phosphorylation in intact cells
-
2 and vanadate stimulate protein tyrosine phosphorylation in intact cells J. Biol. Chem. 265 1990 2896 2902
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 2896-2902
-
-
Heffetz, D.1
Bushkin, I.2
Dror, R.3
Zick, Y.4
-
71
-
-
13544268735
-
Interdependent regulation of insulin receptor kinase activity by ADP and hydrogen peroxide
-
DOI 10.1074/jbc.M410352200
-
T.L. Schmitt, A. Hotz-Wagenblatt, H. Klein, and W. Droge Interdependent regulation of insulin receptor kinase activity by ADP and hydrogen peroxide J. Biol. Chem. 280 2005 3795 3801 (Pubitemid 40223848)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.5
, pp. 3795-3801
-
-
Schmitt, T.L.1
Hotz-Wagenblatt, A.2
Klein, H.3
Droge, W.4
-
72
-
-
0036366424
-
Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: Detecting sulfenic acid intermediates and examining reversible inactivation
-
DOI 10.1016/S0076-6879(02)48648-X, 29, Part B: Protein Sensors and Reactive Oxygen Species
-
J.M. Denu, and K.G. Tanner Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: detecting sulfenic acid intermediates and examining reversible inactivation Methods Enzymol 348 2002 297 305 (Pubitemid 41103120)
-
(2002)
Methods in Enzymology
, vol.348
, pp. 297-305
-
-
Denu, J.M.1
Tanner, K.G.2
-
73
-
-
0142137134
-
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
-
DOI 10.1093/emboj/cdg513
-
N.R. Leslie, D. Bennett, Y.E. Lindsay, H. Stewart, A. Gray, and C.P. Downes Redox regulation of PI 3-kinase signalling via inactivation of PTEN EMBO J. 22 2003 5501 5510 (Pubitemid 37279959)
-
(2003)
EMBO Journal
, vol.22
, Issue.20
, pp. 5501-5510
-
-
Leslie, N.R.1
Bennett, D.2
Lindsay, Y.E.3
Stewart, H.4
Gray, A.5
Downes, C.P.6
-
74
-
-
4544314719
-
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes
-
DOI 10.1128/MCB.24.19.8778-8789.2004
-
S. Ugi, T. Imamura, H. Maegawa, K. Egawa, T. Yoshizaki, K. Shi, T. Obata, Y. Ebina, A. Kashiwagi, and J.M. Olefsky Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes Mol. Cell. Biol. 24 2004 8778 8789 (Pubitemid 39245095)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.19
, pp. 8778-8789
-
-
Ugi, S.1
Imamura, T.2
Maegawa, H.3
Egawa, K.4
Yoshizaki, T.5
Shi, K.6
Obata, T.7
Ebina, Y.8
Kashiwagi, A.9
Olefsky, J.M.10
-
75
-
-
4444233558
-
Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B
-
DOI 10.1074/jbc.M404606200
-
T.C. Meng, D.A. Buckley, S. Galic, T. Tiganis, and N.K. Tonks Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B J. Biol. Chem. 279 2004 37716 37725 (Pubitemid 39195485)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.36
, pp. 37716-37725
-
-
Meng, T.-C.1
Buckley, D.A.2
Galic, S.3
Tiganis, T.4
Tonks, N.K.5
-
76
-
-
0031750534
-
Redox priming of the insulin receptor β-chain associated with altered tyrosine kinase activity and insulin responsiveness in the absence of tyrosine autophosphorylation
-
E. Schmid, B.J. El, D. Galter, G. Klein, and W. Droge Redox priming of the insulin receptor beta-chain associated with altered tyrosine kinase activity and insulin responsiveness in the absence of tyrosine autophosphorylation FASEB J 12 1998 863 870 (Pubitemid 28294676)
-
(1998)
FASEB Journal
, vol.12
, Issue.10
, pp. 863-870
-
-
Schmid, E.1
El Benna, J.2
Galter, D.3
Klein, G.4
Droge, W.5
-
77
-
-
0032867462
-
Phosphorylation of the insulin receptor kinase by phosphocreatine in combination with hydrogen peroxide: The structural basis of redox priming
-
E. Schmid, A. Hotz-Wagenblatt, V. Hacj, and W. Droge Phosphorylation of the insulin receptor kinase by phosphocreatine in combination with hydrogen peroxide: the structural basis of redox priming FASEB J 13 1999 1491 1500 (Pubitemid 29411781)
-
(1999)
FASEB Journal
, vol.13
, Issue.12
, pp. 1491-1500
-
-
Schmid, E.1
Hotz-Wagenblatt, A.2
Hack, V.3
Droge, W.4
-
78
-
-
79952935338
-
Redox regulation of insulin degradation by insulin-degrading enzyme
-
C.M. Cordes, R.G. Bennett, G.L. Siford, and F.G. Hamel Redox regulation of insulin degradation by insulin-degrading enzyme PLoS One 6 2011 e18138
-
(2011)
PLoS One
, vol.6
, pp. 18138
-
-
Cordes, C.M.1
Bennett, R.G.2
Siford, G.L.3
Hamel, F.G.4
-
79
-
-
84860455885
-
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
-
R.V. Farese Jr, R. Zechner, C.B. Newgard, and T.C. Walther The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance Cell Metab. 15 2012 570 573
-
(2012)
Cell Metab.
, vol.15
, pp. 570-573
-
-
Farese, Jr.R.V.1
Zechner, R.2
Newgard, C.B.3
Walther, T.C.4
-
80
-
-
67649304876
-
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria
-
S. Nakamura, T. Takamura, N. Matsuzawa-Nagata, H. Takayama, H. Misu, H. Noda, S. Nabemoto, S. Kurita, T. Ota, H. Ando, K. Miyamoto, and S. Kaneko Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria J. Biol. Chem. 284 2009 14809 14818
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 14809-14818
-
-
Nakamura, S.1
Takamura, T.2
Matsuzawa-Nagata, N.3
Takayama, H.4
Misu, H.5
Noda, H.6
Nabemoto, S.7
Kurita, S.8
Ota, T.9
Ando, H.10
Miyamoto, K.11
Kaneko, S.12
-
81
-
-
77951632831
-
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
-
R.S. Rector, J.P. Thyfault, G.M. Uptergrove, E.M. Morris, S.P. Naples, S.J. Borengasser, C.R. Mikus, M.J. Laye, M.H. Laughlin, F.W. Booth, and J.A. Ibdah Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model J. Hepatol. 52 2010 727 736
-
(2010)
J. Hepatol.
, vol.52
, pp. 727-736
-
-
Rector, R.S.1
Thyfault, J.P.2
Uptergrove, G.M.3
Morris, E.M.4
Naples, S.P.5
Borengasser, S.J.6
Mikus, C.R.7
Laye, M.J.8
Laughlin, M.H.9
Booth, F.W.10
Ibdah, J.A.11
-
82
-
-
84867892916
-
Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease
-
E.H. Kim, J.S. Bae, K.B. Hahm, and J.Y. Cha Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease Biochem. Pharmacol. 84 2012 1359 1365
-
(2012)
Biochem. Pharmacol.
, vol.84
, pp. 1359-1365
-
-
Kim, E.H.1
Bae, J.S.2
Hahm, K.B.3
Cha, J.Y.4
-
83
-
-
36348935003
-
Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
-
DOI 10.1002/hep.21874
-
N. Matsuzawa, T. Takamura, S. Kurita, H. Misu, T. Ota, H. Ando, M. Yokoyama, M. Honda, Y. Zen, Y. Nakanuma, K. Miyamoto, and S. Kaneko Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet Hepatology 46 2007 1392 1403 (Pubitemid 350155521)
-
(2007)
Hepatology
, vol.46
, Issue.5
, pp. 1392-1403
-
-
Matsuzawa, N.1
Takamura, T.2
Kurita, S.3
Misu, H.4
Ota, T.5
Ando, H.6
Yokoyama, M.7
Honda, M.8
Zen, Y.9
Nakanuma, Y.10
Miyamoto, K.-I.11
Kaneko, S.12
-
84
-
-
79960910228
-
Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia
-
M.E. Visser, N.M. Lammers, A.J. Nederveen, M. van der Graaf, A. Heerschap, M.T. Ackermans, H.P. Sauerwein, E.S. Stroes, and M.J. Serlie Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia Diabetologia 54 2011 2113 2121
-
(2011)
Diabetologia
, vol.54
, pp. 2113-2121
-
-
Visser, M.E.1
Lammers, N.M.2
Nederveen, A.J.3
Van Der Graaf, M.4
Heerschap, A.5
Ackermans, M.T.6
Sauerwein, H.P.7
Stroes, E.S.8
Serlie, M.J.9
-
85
-
-
70350449644
-
Fat and cholesterol diet induced lipid metabolic disorders and insulin resistance in rabbit
-
H. Zheng, C. Zhang, W. Yang, Y. Wang, Y. Lin, P. Yang, Q. Yu, J. Fan, and E. Liu Fat and cholesterol diet induced lipid metabolic disorders and insulin resistance in rabbit Exp. Clin. Endocrinol. Diabetes 117 2009 400 405
-
(2009)
Exp. Clin. Endocrinol. Diabetes
, vol.117
, pp. 400-405
-
-
Zheng, H.1
Zhang, C.2
Yang, W.3
Wang, Y.4
Lin, Y.5
Yang, P.6
Yu, Q.7
Fan, J.8
Liu, E.9
-
86
-
-
84872271480
-
Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease
-
T. Ikegami, H. Hyogo, A. Honda, T. Miyazaki, K. Tokushige, E. Hashimoto, K. Inui, Y. Matsuzaki, and S. Tazuma Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease J. Gastroenterol. 47 2012 1257 1266
-
(2012)
J. Gastroenterol.
, vol.47
, pp. 1257-1266
-
-
Ikegami, T.1
Hyogo, H.2
Honda, A.3
Miyazaki, T.4
Tokushige, K.5
Hashimoto, E.6
Inui, K.7
Matsuzaki, Y.8
Tazuma, S.9
-
87
-
-
77949875356
-
Nuclear receptors, inflammation, and liver disease: Insights for cholestatic and fatty liver diseases
-
M. Arrese, and S.J. Karpen Nuclear receptors, inflammation, and liver disease: insights for cholestatic and fatty liver diseases Clin. Pharmacol. Ther. 87 2010 473 478
-
(2010)
Clin. Pharmacol. Ther.
, vol.87
, pp. 473-478
-
-
Arrese, M.1
Karpen, S.J.2
-
88
-
-
79952227694
-
Nuclear receptors in liver disease
-
M. Wagner, G. Zollner, and M. Trauner Nuclear receptors in liver disease Hepatology 53 2011 1023 1034
-
(2011)
Hepatology
, vol.53
, pp. 1023-1034
-
-
Wagner, M.1
Zollner, G.2
Trauner, M.3
-
89
-
-
0028355391
-
Peroxisome proliferator-activated receptors: Finding the orphan a home
-
DOI 10.1016/0303-7207(94)90294-1
-
S. Green, and W. Wahli Peroxisome proliferator-activated receptors: finding the orphan a home Mol. Cell. Endocrinol. 100 1994 149 153 (Pubitemid 24109542)
-
(1994)
Molecular and Cellular Endocrinology
, vol.100
, Issue.1-2
, pp. 149-153
-
-
Green, S.1
Wahli, W.2
-
90
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
I. Issemann, and S. Green Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 347 1990 645 650
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
91
-
-
0033305213
-
Peroxisome proliferator-activated receptors: Nuclear control of metabolism
-
B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptors: nuclear control of metabolism Endocr. Rev. 20 1999 649 688 (Pubitemid 30650602)
-
(1999)
Endocrine Reviews
, vol.20
, Issue.5
, pp. 649-688
-
-
Desvergne, B.1
Wahli, W.2
-
92
-
-
0034666132
-
Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
-
T. Hashimoto, W.S. Cook, C. Qi, A.V. Yeldandi, J.K. Reddy, and M.S. Rao Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting J. Biol. Chem. 275 2000 28918 28928
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28918-28928
-
-
Hashimoto, T.1
Cook, W.S.2
Qi, C.3
Yeldandi, A.V.4
Reddy, J.K.5
Rao, M.S.6
-
94
-
-
0029562554
-
The RXR heterodimers and orphan receptors
-
DOI 10.1016/0092-8674(95)90200-7
-
D.J. Mangelsdorf, and R.M. Evans The RXR heterodimers and orphan receptors Cell 83 1995 841 850 (Pubitemid 26006526)
-
(1995)
Cell
, vol.83
, Issue.6
, pp. 841-850
-
-
Mangelsdorf, D.J.1
Evans, R.M.2
-
95
-
-
3242795074
-
Reduced expression of peroxisome proliferator-activated receptor-alpha may have an important role in the development of non-alcoholic fatty liver disease
-
J.E. Yeon, K.M. Choi, S.H. Baik, K.O. Kim, H.J. Lim, K.H. Park, J.Y. Kim, J.J. Park, J.S. Kim, Y.T. Bak, K.S. Byun, and C.H. Lee Reduced expression of peroxisome proliferator-activated receptor-alpha may have an important role in the development of non-alcoholic fatty liver disease J. Gastroenterol. Hepatol. 19 2004 799 804
-
(2004)
J. Gastroenterol. Hepatol.
, vol.19
, pp. 799-804
-
-
Yeon, J.E.1
Choi, K.M.2
Baik, S.H.3
Kim, K.O.4
Lim, H.J.5
Park, K.H.6
Kim, J.Y.7
Park, J.J.8
Kim, J.S.9
Bak, Y.T.10
Byun, K.S.11
Lee, C.H.12
-
96
-
-
37249059359
-
PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes
-
DOI 10.1111/j.1440-1746.2006.04819.x
-
Y.S. Seo, J.H. Kim, N.Y. Jo, K.M. Choi, S.H. Baik, J.J. Park, J.S. Kim, K.S. Byun, Y.T. Bak, C.H. Lee, A. Kim, and J.E. Yeon PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes J. Gastroenterol. Hepatol. 23 2008 102 109 (Pubitemid 350265194)
-
(2008)
Journal of Gastroenterology and Hepatology
, vol.23
, Issue.1
, pp. 102-109
-
-
Seo, Y.S.1
Kim, J.H.2
Jo, N.Y.3
Choi, K.M.4
Baik, S.H.5
Park, J.-J.6
Kim, J.S.7
Byun, K.S.8
Bak, Y.-T.9
Lee, C.H.10
Kim, A.11
Yeon, J.E.12
-
97
-
-
0032699670
-
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
-
S. Kersten, J. Seydoux, J.M. Peters, F.J. Gonzalez, B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting J. Clin. Invest. 103 1999 1489 1498
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 1489-1498
-
-
Kersten, S.1
Seydoux, J.2
Peters, J.M.3
Gonzalez, F.J.4
Desvergne, B.5
Wahli, W.6
-
98
-
-
0033594980
-
A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
-
DOI 10.1073/pnas.96.13.7473
-
T.C. Leone, C.J. Weinheimer, and D.P. Kelly A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders Proc. Natl. Acad. Sci. USA 96 1999 7473 7478 (Pubitemid 29299686)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.13
, pp. 7473-7478
-
-
Leone, T.C.1
Weinheimer, C.J.2
Kelly, D.P.3
-
99
-
-
35148881190
-
Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
-
M. Kohjima, M. Enjoji, N. Higuchi, M. Kato, K. Kotoh, T. Yoshimoto, T. Fujino, M. Yada, R. Yada, N. Harada, R. Takayanagi, and M. Nakamuta Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease Int. J. Mol. Med. 20 2007 351 358
-
(2007)
Int. J. Mol. Med.
, vol.20
, pp. 351-358
-
-
Kohjima, M.1
Enjoji, M.2
Higuchi, N.3
Kato, M.4
Kotoh, K.5
Yoshimoto, T.6
Fujino, T.7
Yada, M.8
Yada, R.9
Harada, N.10
Takayanagi, R.11
Nakamuta, M.12
-
100
-
-
49849093922
-
A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio
-
S. Chen, Y. Li, S. Li, and C. Yu A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio J. Gastroenterol. Hepatol 23 2008 1415 1418
-
(2008)
J. Gastroenterol. Hepatol
, vol.23
, pp. 1415-1418
-
-
Chen, S.1
Li, Y.2
Li, S.3
Yu, C.4
-
101
-
-
84862817269
-
Effects of L-carnitine against oxidative stress in human hepatocytes: Involvement of peroxisome proliferator-activated receptor alpha
-
J.L. Li, Q.Y. Wang, H.Y. Luan, Z.C. Kang, and C.B. Wang Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha J. Biomed. Sci. 19 2012 32
-
(2012)
J. Biomed. Sci.
, vol.19
, pp. 32
-
-
Li, J.L.1
Wang, Q.Y.2
Luan, H.Y.3
Kang, Z.C.4
Wang, C.B.5
-
102
-
-
0032486173
-
2+-superoxide dismutase in the liver
-
DOI 10.1016/S0024-3205(98)00249-5, PII S0024320598002495
-
2+-superoxide dismutase in the liver Life Sci. 63 1998 135 144 (Pubitemid 28298667)
-
(1998)
Life Sciences
, vol.63
, Issue.2
, pp. 135-144
-
-
Inoue, I.1
Noji, S.2
Awata, T.3
Takahashi, K.4
Nakajima, T.5
Sonoda, M.6
Komoda, T.7
Katayama, S.8
-
103
-
-
0036908619
-
Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter
-
DOI 10.1210/me.2002-0020
-
G.D. Girnun, F.E. Domann, S.A. Moore, and M.E. Robbins Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter Mol. Endocrinol. 16 2002 2793 2801 (Pubitemid 36020658)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.12
, pp. 2793-2801
-
-
Girnun, G.D.1
Domann, F.E.2
Moore, S.A.3
Robbins, M.E.C.4
-
104
-
-
68349131724
-
Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress
-
M.A. Abdelmegeed, K.H. Moon, J.P. Hardwick, F.J. Gonzalez, and B.J. Song Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress Free Radic. Biol. Med. 47 2009 767 778
-
(2009)
Free Radic. Biol. Med.
, vol.47
, pp. 767-778
-
-
Abdelmegeed, M.A.1
Moon, K.H.2
Hardwick, J.P.3
Gonzalez, F.J.4
Song, B.J.5
-
105
-
-
0033087317
-
Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans
-
A. Vidal-Puig, M. Rosenbaum, R.C. Considine, R.L. Leibel, G.L. Dohm, and B.B. Lowell Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans Obes. Res. 7 1999 133 140 (Pubitemid 129710570)
-
(1999)
Obesity Research
, vol.7
, Issue.2
, pp. 133-140
-
-
Vidal-Puig, A.1
Rosenbaum, M.2
Considine, R.C.3
Leibel, R.L.4
Dohm, G.L.5
Lowell, B.B.6
-
107
-
-
0036145372
-
Toxicological consequences of altered peroxisome proliferator-activated receptor γ (PPARγ) expression in the liver: Insights from models of obesity and type 2 diabetes
-
DOI 10.1016/S0006-2952(01)00817-6, PII S0006295201008176
-
U.A. Boelsterli, and M. Bedoucha Toxicological consequences of altered peroxisome proliferator-activated receptor gamma (PPARgamma) expression in the liver: insights from models of obesity and type 2 diabetes Biochem. Pharmacol 63 2002 1 10 (Pubitemid 34075287)
-
(2002)
Biochemical Pharmacology
, vol.63
, Issue.1
, pp. 1-10
-
-
Boelsterli, U.A.1
Bedoucha, M.2
-
108
-
-
46149098344
-
LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response
-
DOI 10.1016/j.cell.2008.04.052, PII S0092867408006946
-
S.J. Bensinger, M.N. Bradley, S.B. Joseph, N. Zelcer, E.M. Janssen, M.A. Hausner, R. Shih, J.S. Parks, P.A. Edwards, B.D. Jamieson, and P. Tontonoz LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell 134 2008 97 111 (Pubitemid 351905740)
-
(2008)
Cell
, vol.134
, Issue.1
, pp. 97-111
-
-
Bensinger, S.J.1
Bradley, M.N.2
Joseph, S.B.3
Zelcer, N.4
Janssen, E.M.5
Hausner, M.A.6
Shih, R.7
Parks, J.S.8
Edwards, P.A.9
Jamieson, B.D.10
Tontonoz, P.11
-
109
-
-
33645027391
-
Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients
-
M. Lemoine, V. Barbu, P.M. Girard, M. Kim, J.P. Bastard, D. Wendum, F. Paye, C. Housset, J. Capeau, and L. Serfaty Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients AIDS 20 2006 387 395
-
(2006)
AIDS
, vol.20
, pp. 387-395
-
-
Lemoine, M.1
Barbu, V.2
Girard, P.M.3
Kim, M.4
Bastard, J.P.5
Wendum, D.6
Paye, F.7
Housset, C.8
Capeau, J.9
Serfaty, L.10
-
110
-
-
79955650290
-
Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: An additional reinforcing lipogenic mechanism to SREBP-1c induction
-
P. Pettinelli, and L.A. Videla Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction J. Clin. Endocrinol. Metab 96 2011 1424 1430
-
(2011)
J. Clin. Endocrinol. Metab
, vol.96
, pp. 1424-1430
-
-
Pettinelli, P.1
Videla, L.A.2
-
111
-
-
0141532275
-
Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
-
DOI 10.1053/jhep.2003.50420
-
B.A. Neuschwander-Tetri, E.M. Brunt, K.R. Wehmeier, D. Oliver, and B.R. Bacon Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone Hepatology 38 2003 1008 1017 (Pubitemid 37221684)
-
(2003)
Hepatology
, vol.38
, Issue.4
, pp. 1008-1017
-
-
Neuschwander-Tetri, B.A.1
Brunt, E.M.2
Wehmeier, K.R.3
Oliver, D.4
Bacon, B.R.5
-
112
-
-
33751545838
-
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
-
DOI 10.1056/NEJMoa060326
-
R. Belfort, S.A. Harrison, K. Brown, C. Darland, J. Finch, J. Hardies, B. Balas, A. Gastaldelli, F. Tio, J. Pulcini, R. Berria, J.Z. Ma, S. Dwivedi, R. Havranek, C. Fincke, R. DeFronzo, G.A. Bannayan, S. Schenker, and K. Cusi A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis N. Engl. J. Med. 355 2006 2297 2307 (Pubitemid 44837778)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.22
, pp. 2297-2307
-
-
Belfort, R.1
Harrison, S.A.2
Brown, K.3
Darland, C.4
Finch, J.5
Hardies, J.6
Balas, B.7
Gastaldelli, A.8
Tio, F.9
Pulcini, J.10
Berria, R.11
Ma, J.Z.12
Dwivedi, S.13
Havranek, R.14
Fincke, C.15
DeFronzo, R.16
Bannayan, G.A.17
Schenker, S.18
Cusi, K.19
-
113
-
-
34548306770
-
The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis
-
DOI 10.1002/hep.21661
-
G. Lutchman, A. Modi, D.E. Kleiner, K. Promrat, T. Heller, M. Ghany, B. Borg, R. Loomba, T.J. Liang, A. Premkumar, and J.H. Hoofnagle The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis Hepatology 46 2007 424 429 (Pubitemid 47344777)
-
(2007)
Hepatology
, vol.46
, Issue.2
, pp. 424-429
-
-
Lutchman, G.1
Modi, A.2
Kleiner, D.E.3
Promrat, K.4
Heller, T.5
Ghany, M.6
Borg, B.7
Loomba, R.8
Liang, T.J.9
Premkumar, A.10
Hoofnagle, J.H.11
-
114
-
-
84863413790
-
Improved insulin sensitivity after treatment with PPARgamma and PPARalpha ligands is mediated by genetically modulated transcripts
-
N. Rasouli, P.A. Kern, S.C. Elbein, N.K. Sharma, and S.K. Das Improved insulin sensitivity after treatment with PPARgamma and PPARalpha ligands is mediated by genetically modulated transcripts Pharmacogenet. Genomics 22 2012 484 497
-
(2012)
Pharmacogenet. Genomics
, vol.22
, pp. 484-497
-
-
Rasouli, N.1
Kern, P.A.2
Elbein, S.C.3
Sharma, N.K.4
Das, S.K.5
-
115
-
-
80053904684
-
Mitochondrial complex III ROS regulate adipocyte differentiation
-
K.V. Tormos, E. Anso, R.B. Hamanaka, J. Eisenbart, J. Joseph, B. Kalyanaraman, and N.S. Chandel Mitochondrial complex III ROS regulate adipocyte differentiation Cell Metab. 14 2011 537 544
-
(2011)
Cell Metab.
, vol.14
, pp. 537-544
-
-
Tormos, K.V.1
Anso, E.2
Hamanaka, R.B.3
Eisenbart, J.4
Joseph, J.5
Kalyanaraman, B.6
Chandel, N.S.7
-
116
-
-
77952674282
-
Oxidative stress modulates PPAR gamma in vascular endothelial cells
-
C. Blanquicett, B.Y. Kang, J.D. Ritzenthaler, D.P. Jones, and C.M. Hart Oxidative stress modulates PPAR gamma in vascular endothelial cells Free Radic. Biol. Med. 48 2010 1618 1625
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 1618-1625
-
-
Blanquicett, C.1
Kang, B.Y.2
Ritzenthaler, J.D.3
Jones, D.P.4
Hart, C.M.5
-
117
-
-
0036468883
-
Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation
-
DOI 10.1016/S0891-5849(01)00798-5, PII S0891584901007985
-
S. Pizzimenti, S. Laurora, F. Briatore, C. Ferretti, M.U. Dianzani, and G. Barrera Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation Free Radic. Biol. Med. 32 2002 233 245 (Pubitemid 34119402)
-
(2002)
Free Radical Biology and Medicine
, vol.32
, Issue.3
, pp. 233-245
-
-
Pizzimenti, S.1
Laurora, S.2
Briatore, F.3
Ferretti, C.4
Dianzani, M.U.5
Barrera, G.6
-
118
-
-
0037417726
-
PPARδ is a very low-density lipoprotein sensor in macrophages
-
DOI 10.1073/pnas.0337331100
-
A. Chawla, C.H. Lee, Y. Barak, W. He, J. Rosenfeld, D. Liao, J. Han, H. Kang, and R.M. Evans PPARdelta is a very low-density lipoprotein sensor in macrophages Proc. Natl. Acad. Sci. USA 100 2003 1268 1273 (Pubitemid 36183991)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.3
, pp. 1268-1273
-
-
Chawla, A.1
Lee, C.-H.2
Barak, Y.3
He, W.4
Rosenfeld, J.5
Liao, D.6
Han, J.7
Kang, H.8
Evans, R.M.9
-
119
-
-
0037453718
-
Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
-
DOI 10.1016/S0092-8674(03)00269-1
-
Y.X. Wang, C.H. Lee, S. Tiep, R.T. Yu, J. Ham, H. Kang, and R.M. Evans Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity Cell 113 2003 159 170 (Pubitemid 36514968)
-
(2003)
Cell
, vol.113
, Issue.2
, pp. 159-170
-
-
Wang, Y.-X.1
Lee, C.-H.2
Tiep, S.3
Yu, R.T.4
Ham, J.5
Kang, H.6
Evans, R.M.7
-
120
-
-
0642303113
-
Peroxisome proliferator-activated receptor δ controls muscle development and oxidative capability
-
DOI 10.1096/fj.03-0269fje
-
S. Luquet, J. Lopez-Soriano, D. Holst, A. Fredenrich, J. Melki, M. Rassoulzadegan, and P.A. Grimaldi Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability FASEB J 17 2003 2299 2301 (Pubitemid 39561472)
-
(2003)
FASEB Journal
, vol.17
, Issue.15
, pp. 2299-2301
-
-
Luquet, S.1
Lopez-Soriano, J.2
Holst, D.3
Fredenrich, A.4
Melki, J.5
Rassoulzadegan, M.6
Grimaldi, P.A.7
-
121
-
-
33644766913
-
PPARδ regulates glucose metabolism and insulin sensitivity
-
DOI 10.1073/pnas.0511253103
-
C.H. Lee, P. Olson, A. Hevener, I. Mehl, L.W. Chong, J.M. Olefsky, F.J. Gonzalez, J. Ham, H. Kang, J.M. Peters, and R.M. Evans PPARdelta regulates glucose metabolism and insulin sensitivity Proc. Natl. Acad. Sci. USA 103 2006 3444 3449 (Pubitemid 43346488)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.9
, pp. 3444-3449
-
-
Lee, C.-H.1
Olson, P.2
Hevener, A.3
Mehl, I.4
Chong, L.-W.5
Olefsky, J.M.6
Gonzalez, F.J.7
Ham, J.8
Kang, H.9
Peters, J.M.10
Evans, R.M.11
-
122
-
-
0035942162
-
A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport
-
DOI 10.1073/pnas.091021198
-
W.R. Oliver Jr, J.L. Shenk, M.R. Snaith, C.S. Russell, K.D. Plunket, N.L. Bodkin, M.C. Lewis, D.A. Winegar, M.L. Sznaidman, M.H. Lambert, H.E. Xu, D.D. Sternbach, S.A. Kliewer, B.C. Hansen, and T.M. Willson A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport Proc. Natl. Acad. Sci. USA 98 2001 5306 5311 (Pubitemid 32397124)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.9
, pp. 5306-5311
-
-
Oliver Jr., W.R.1
Shenk, J.L.2
Snaith, M.R.3
Russell, C.S.4
Plunket, K.D.5
Bodkin, N.L.6
Lewis, M.C.7
Winegar, D.A.8
Sznaidman, M.L.9
Lambert, M.H.10
Xu, H.E.11
Sternbach, D.D.12
Kliewer, S.A.13
Hansen, B.C.14
Willson, T.M.15
-
124
-
-
37349007681
-
PPARδ as a therapeutic target in metabolic disease
-
DOI 10.1016/j.febslet.2007.11.040, PII S0014579307011842
-
S.M. Reilly, and C.H. Lee PPAR delta as a therapeutic target in metabolic disease FEBS Lett. 582 2008 26 31 (Pubitemid 350297247)
-
(2008)
FEBS Letters
, vol.582
, Issue.1
, pp. 26-31
-
-
Reilly, S.M.1
Lee, C.-H.2
-
125
-
-
33645891166
-
Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet
-
T. Nagasawa, Y. Inada, S. Nakano, T. Tamura, T. Takahashi, K. Maruyama, Y. Yamazaki, J. Kuroda, and N. Shibata Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet Eur. J. Pharmacol. 536 2006 182 191
-
(2006)
Eur. J. Pharmacol.
, vol.536
, pp. 182-191
-
-
Nagasawa, T.1
Inada, Y.2
Nakano, S.3
Tamura, T.4
Takahashi, T.5
Maruyama, K.6
Yamazaki, Y.7
Kuroda, J.8
Shibata, N.9
-
126
-
-
78651384181
-
Role of peroxisome proliferator-activated receptor δ/β in hepatic metabolic regulation
-
S. Liu, B. Hatano, M. Zhao, C.C. Yen, K. Kang, S.M. Reilly, M.R. Gangl, C. Gorgun, J.A. Balschi, J.M. Ntambi, and C.H. Lee Role of peroxisome proliferator-activated receptor δ/β in hepatic metabolic regulation J. Biol. Chem. 286 2011 1237 1247
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 1237-1247
-
-
Liu, S.1
Hatano, B.2
Zhao, M.3
Yen, C.C.4
Kang, K.5
Reilly, S.M.6
Gangl, M.R.7
Gorgun, C.8
Balschi, J.A.9
Ntambi, J.M.10
Lee, C.H.11
-
127
-
-
13444273562
-
Recognizing drug-induced liver injury: Current problems, possible solutions
-
DOI 10.1080/01926230590522356
-
W.M. Lee, and J.R. Senior Recognizing drug-induced liver injury: current problems, possible solutions Toxicol. Pathol. 33 2005 155 164 (Pubitemid 40216814)
-
(2005)
Toxicologic Pathology
, vol.33
, Issue.1
, pp. 155-164
-
-
Lee, W.M.1
Senior, J.R.2
-
128
-
-
33947241783
-
The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)
-
DOI 10.1016/j.freeradbiomed.2007.01.003, PII S089158490700010X
-
J.D. Coleman, K.S. Prabhu, J.T. Thompson, P.S. Reddy, J.M. Peters, B.R. Peterson, C.C. Reddy, and J.P. Vanden Heuvel The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) Free Radic. Biol. Med. 42 2007 1155 1164 (Pubitemid 46428510)
-
(2007)
Free Radical Biology and Medicine
, vol.42
, Issue.8
, pp. 1155-1164
-
-
Coleman, J.D.1
Prabhu, K.S.2
Thompson, J.T.3
Reddy, P.S.4
Peters, J.M.5
Peterson, B.R.6
Reddy, C.C.7
Vanden Heuvel, J.P.8
-
129
-
-
0035813090
-
Coregulator codes of transcriptional regulation by nuclear receptors
-
M.G. Rosenfeld, and C.K. Glass Coregulator codes of transcriptional regulation by nuclear receptors J. Biol. Chem. 276 2001 36865 36868
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 36865-36868
-
-
Rosenfeld, M.G.1
Glass, C.K.2
-
130
-
-
79953186142
-
PGC-1 coactivators in the control of energy metabolism
-
C. Liu, and J.D. Lin PGC-1 coactivators in the control of energy metabolism Acta Biochim. Biophys. Sin. (Shanghai) 43 2011 248 257
-
(2011)
Acta Biochim. Biophys. Sin. (Shanghai)
, vol.43
, pp. 248-257
-
-
Liu, C.1
Lin, J.D.2
-
131
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
DOI 10.1016/S0092-8674(00)80611-X
-
Z. Wu, P. Puigserver, U. Andersson, C. Zhang, G. Adelmant, V. Mootha, A. Troy, S. Cinti, B. Lowell, R.C. Scarpulla, and B.M. Spiegelman Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 Cell 98 1999 115 124 (Pubitemid 29331201)
-
(1999)
Cell
, vol.98
, Issue.1
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
Zhang, C.4
Adelmant, G.5
Mootha, V.6
Troy, A.7
Cinti, S.8
Lowell, B.9
Scarpulla, R.C.10
Spiegelman, B.M.11
-
132
-
-
2342477730
-
Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
-
DOI 10.1073/pnas.0401401101
-
V.K. Mootha, C. Handschin, D. Arlow, X. Xie St, P.J. Sihag, S. Yang, W. Altshuler, D. Puigserver, P. Patterson, N. Willy, P.J. Schulman, I.G. Heyman, R.A. Lander, E.S. Spiegelman, and B.M. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle Proc. Natl. Acad. Sci. USA 101 2004 6570 6575 (Pubitemid 38586015)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.17
, pp. 6570-6575
-
-
Mootha, V.K.1
Handschin, C.2
Arlow, D.3
Xie, X.4
St. Pierre, J.5
Sihag, S.6
Yang, W.7
Altshuler, D.8
Puigserver, P.9
Patterson, N.10
Willy, P.J.11
Schulman, I.G.12
Heyman, R.A.13
Lander, E.S.14
Spiegelman, B.M.15
-
133
-
-
2342592545
-
The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis
-
DOI 10.1073/pnas.0308686101
-
S.N. Schreiber, R. Emter, M.B. Hock, D. Knutti, J. Cardenas, M. Podvinec, E.J. Oakeley, and A. Kralli The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis Proc. Natl. Acad. Sci. USA 101 2004 6472 6477 (Pubitemid 38585998)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.17
, pp. 6472-6477
-
-
Schreiber, S.N.1
Emter, R.2
Hock, M.B.3
Knutti, D.4
Cardenas, J.5
Podvinec, M.6
Oakeley, E.J.7
Kralli, A.8
-
134
-
-
57649148823
-
Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator
-
R.C. Scarpulla Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator Ann. N. Y. Acad. Sci 1147 2008 321 334
-
(2008)
Ann. N. Y. Acad. Sci
, vol.1147
, pp. 321-334
-
-
Scarpulla, R.C.1
-
135
-
-
0031930319
-
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
-
DOI 10.1038/ng0398-231
-
N.G. Larsson, J. Wang, H. Wilhelmsson, A. Oldfors, P. Rustin, M. Lewandoski, G.S. Barsh, and D.A. Clayton Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice Nat. Genet. 18 1998 231 236 (Pubitemid 28117260)
-
(1998)
Nature Genetics
, vol.18
, Issue.3
, pp. 231-236
-
-
Larsson, N.-G.1
Wang, J.2
Wilhelmsson, H.3
Oldfors, A.4
Rustin, P.5
Lewandoski, M.6
Barsh, G.S.7
Clayton, D.A.8
-
136
-
-
24144463983
-
Metabolic control through the PGC-1 family of transcription coactivators
-
DOI 10.1016/j.cmet.2005.05.004, PII S1550413105001427
-
J. Lin, C. Handschin, and B.M. Spiegelman Metabolic control through the PGC-1 family of transcription coactivators Cell Metab. 1 2005 361 370 (Pubitemid 43960626)
-
(2005)
Cell Metabolism
, vol.1
, Issue.6
, pp. 361-370
-
-
Lin, J.1
Handschin, C.2
Spiegelman, B.M.3
-
137
-
-
78649568544
-
Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor gamma coactivator 1alpha promoter
-
S. Sookoian, M.S. Rosselli, C. Gemma, A.L. Burgueno, G.T. Fernandez, G.O. Castano, and C.J. Pirola Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor gamma coactivator 1alpha promoter Hepatology 52 2010 1992 2000
-
(2010)
Hepatology
, vol.52
, pp. 1992-2000
-
-
Sookoian, S.1
Rosselli, M.S.2
Gemma, C.3
Burgueno, A.L.4
Fernandez, G.T.5
Castano, G.O.6
Pirola, C.J.7
-
138
-
-
33845670719
-
Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1alpha
-
S. Borniquel, I. Valle, S. Cadenas, S. Lamas, and M. Monsalve Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1alpha FASEB J 20 2006 1889 1891
-
(2006)
FASEB J
, vol.20
, pp. 1889-1891
-
-
Borniquel, S.1
Valle, I.2
Cadenas, S.3
Lamas, S.4
Monsalve, M.5
-
139
-
-
70350020773
-
Exercise activation of muscle peroxisome proliferator-activated receptor-γ coactivator-1α signaling is redox sensitive
-
C. Kang, K.M. O'Moore, J.R. Dickman, and L.L. Ji Exercise activation of muscle peroxisome proliferator-activated receptor-γ coactivator-1α signaling is redox sensitive Free Radic. Biol. Med. 47 2009 1394 1400
-
(2009)
Free Radic. Biol. Med.
, vol.47
, pp. 1394-1400
-
-
Kang, C.1
O'Moore, K.M.2
Dickman, J.R.3
Ji, L.L.4
-
140
-
-
50949102655
-
Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance
-
N. Kumashiro, Y. Tamura, T. Uchida, T. Ogihara, Y. Fujitani, T. Hirose, H. Mochizuki, R. Kawamori, and H. Watada Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance Diabetes 57 2008 2083 2091
-
(2008)
Diabetes
, vol.57
, pp. 2083-2091
-
-
Kumashiro, N.1
Tamura, Y.2
Uchida, T.3
Ogihara, T.4
Fujitani, Y.5
Hirose, T.6
Mochizuki, H.7
Kawamori, R.8
Watada, H.9
-
141
-
-
32444451567
-
Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion
-
C. Wolfrum, and M. Stoffel Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion Cell Metab 3 2006 99 110
-
(2006)
Cell Metab
, vol.3
, pp. 99-110
-
-
Wolfrum, C.1
Stoffel, M.2
-
142
-
-
24644463295
-
Schoenheimer effect explained - Feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
-
DOI 10.1172/JCI25614
-
L.J. Engelking, G. Liang, R.E. Hammer, K. Takaishi, H. Kuriyama, B.M. Evers, W.P. Li, J.D. Horton, J.L. Goldstein, and M.S. Brown Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins J. Clin. Invest. 115 2005 2489 2498 (Pubitemid 41266211)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.9
, pp. 2489-2498
-
-
Engelking, L.J.1
Liang, G.2
Hammer, R.E.3
Takaishi, K.4
Kuriyama, H.5
Evers, B.M.6
Li, W.-P.7
Horton, J.D.8
Goldstein, J.L.9
Brown, M.S.10
-
143
-
-
66349134748
-
Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL
-
M.S. Brown, and J.L. Goldstein Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL J. Lipid Res. 50 Suppl 2009 S15 S27
-
(2009)
J. Lipid Res.
, vol.50
, Issue.SUPPL.
-
-
Brown, M.S.1
Goldstein, J.L.2
-
144
-
-
39849083646
-
SREBPs: The crossroads of physiological and pathological lipid homeostasis
-
DOI 10.1016/j.tem.2007.10.009, PII S1043276008000040
-
R. Raghow, C. Yellaturu, X. Deng, E.A. Park, and M.B. Elam SREBPs: the crossroads of physiological and pathological lipid homeostasis Trends Endocrinol. Metab. 19 2008 65 73 (Pubitemid 351317897)
-
(2008)
Trends in Endocrinology and Metabolism
, vol.19
, Issue.2
, pp. 65-73
-
-
Raghow, R.1
Yellaturu, C.2
Deng, X.3
Park, E.A.4
Elam, M.B.5
-
145
-
-
77952567958
-
Haring, H.U.; Stefan, N. Environmental and genetic determinants of fatty liver in humans
-
K. Kantartzis, and F. Schick Haring, H.U.; Stefan, N. Environmental and genetic determinants of fatty liver in humans Dig. Dis. 28 2010 169 178
-
(2010)
Dig. Dis.
, vol.28
, pp. 169-178
-
-
Kantartzis, K.1
Schick, F.2
-
146
-
-
0034693259
-
Sterol regulatory element-binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
-
T.F. Osborne Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action J. Biol. Chem. 275 2000 32379 32382
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32379-32382
-
-
Osborne, T.F.1
-
147
-
-
10744228031
-
Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice
-
DOI 10.2337/diabetes.53.3.560
-
T. Matsuzaka, H. Shimano, N. Yahagi, M. Amemiya-Kudo, H. Okazaki, Y. Tamura, Y. Iizuka, K. Ohashi, S. Tomita, M. Sekiya, A. Hasty, Y. Nakagawa, H. Sone, H. Toyoshima, S. Ishibashi, J. Osuga, and N. Yamada Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice Diabetes 53 2004 560 569 (Pubitemid 38270623)
-
(2004)
Diabetes
, vol.53
, Issue.3
, pp. 560-569
-
-
Matsuzaka, T.1
Shimano, H.2
Yahagi, N.3
Amemiya-Kudo, M.4
Okazaki, H.5
Tamura, Y.6
Iizuka, Y.7
Ohashi, K.8
Tomita, S.9
Sekiya, M.10
Hasty, A.11
Nakagawa, Y.12
Sone, H.13
Toyoshima, H.14
Ishibashi, S.15
Osuga, J.-I.16
Yamada, N.17
-
148
-
-
11144244418
-
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
-
DOI 10.1038/nature03047
-
C. Wolfrum, E. Asilmaz, E. Luca, J.M. Friedman, and M. Stoffel Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes Nature 432 2004 1027 1032 (Pubitemid 40052233)
-
(2004)
Nature
, vol.432
, Issue.7020
, pp. 1027-1032
-
-
Wolfrum, C.1
Asilmaz, E.2
Luca, E.3
Friedman, J.M.4
Stoffel, M.5
-
149
-
-
29244465372
-
Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
-
M. Nakamuta, M. Kohjima, S. Morizono, K. Kotoh, T. Yoshimoto, I. Miyagi, and M. Enjoji Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease Int. J. Mol. Med. 16 2005 631 635
-
(2005)
Int. J. Mol. Med.
, vol.16
, pp. 631-635
-
-
Nakamuta, M.1
Kohjima, M.2
Morizono, S.3
Kotoh, K.4
Yoshimoto, T.5
Miyagi, I.6
Enjoji, M.7
-
150
-
-
44649111219
-
SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease
-
M. Kohjima, N. Higuchi, M. Kato, K. Kotoh, T. Yoshimoto, T. Fujino, M. Yada, R. Yada, N. Harada, M. Enjoji, R. Takayanagi, and M. Nakamuta SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease Int. J. Mol. Med. 21 2008 507 511 (Pubitemid 351802646)
-
(2008)
International Journal of Molecular Medicine
, vol.21
, Issue.4
, pp. 507-511
-
-
Kohjima, M.1
Higuchi, N.2
Kato, M.3
Kotoh, K.4
Yoshimoto, T.5
Fujino, T.6
Yada, M.7
Yada, R.8
Harada, N.9
Enjoji, M.10
Takayanagi, R.11
Nakamuta, M.12
-
151
-
-
84857383028
-
Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass
-
B. Knebel, J. Haas, S. Hartwig, S. Jacob, C. Kollmer, U. Nitzgen, D. Muller-Wieland, and J. Kotzka Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass PLoS One 7 2012 e31812
-
(2012)
PLoS One
, vol.7
, pp. 31812
-
-
Knebel, B.1
Haas, J.2
Hartwig, S.3
Jacob, S.4
Kollmer, C.5
Nitzgen, U.6
Muller-Wieland, D.7
Kotzka, J.8
-
152
-
-
84857548618
-
Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity
-
J. Kotzka, B. Knebel, J. Haas, L. Kremer, S. Jacob, S. Hartwig, U. Nitzgen, and D. Muller-Wieland Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity PLoS One 7 2012 e32609
-
(2012)
PLoS One
, vol.7
, pp. 32609
-
-
Kotzka, J.1
Knebel, B.2
Haas, J.3
Kremer, L.4
Jacob, S.5
Hartwig, S.6
Nitzgen, U.7
Muller-Wieland, D.8
-
153
-
-
79954527279
-
SREBP-2: A link between insulin resistance, hepatic cholesterol, and inflammation in NASH
-
D.M. Van Rooyen, and G.C. Farrell SREBP-2: a link between insulin resistance, hepatic cholesterol, and inflammation in NASH J. Gastroenterol. Hepatol. 26 2011 789 792
-
(2011)
J. Gastroenterol. Hepatol.
, vol.26
, pp. 789-792
-
-
Van Rooyen, D.M.1
Farrell, G.C.2
-
154
-
-
84860469242
-
Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
-
H.K. Min, A. Kapoor, M. Fuchs, F. Mirshahi, H. Zhou, J. Maher, J. Kellum, R. Warnick, M.J. Contos, and A.J. Sanyal Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease Cell Metab. 15 2012 665 674
-
(2012)
Cell Metab.
, vol.15
, pp. 665-674
-
-
Min, H.K.1
Kapoor, A.2
Fuchs, M.3
Mirshahi, F.4
Zhou, H.5
Maher, J.6
Kellum, J.7
Warnick, R.8
Contos, M.J.9
Sanyal, A.J.10
-
155
-
-
39549117982
-
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
-
DOI 10.1158/0008-5472.CAN-07-2489
-
E. Furuta, S.K. Pai, R. Zhan, S. Bandyopadhyay, M. Watabe, Y.Y. Mo, S. Hirota, S. Hosobe, T. Tsukada, K. Miura, S. Kamada, K. Saito, M. Iiizumi, W. Liu, J. Ericsson, and K. Watabe Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1 Cancer Res. 68 2008 1003 1011 (Pubitemid 351278386)
-
(2008)
Cancer Research
, vol.68
, Issue.4
, pp. 1003-1011
-
-
Furuta, E.1
Pai, S.K.2
Zhan, R.3
Bandyopadhyay, S.4
Watabe, M.5
Mo, Y.-Y.6
Hirota, S.7
Hosobe, S.8
Tsukada, T.9
Miura, K.10
Kamada, S.11
Saito, K.12
Iiizumi, M.13
Liu, W.14
Ericsson, J.15
Watabe, K.16
-
157
-
-
34548488370
-
Oxidative stress and the JNK pathway in diabetes
-
H. Kaneto, T.A. Matsuoka, Y. Nakatani, D. Kawamori, M. Matsuhisa, and Y. Yamasaki Oxidative stress and the JNK pathway in diabetes Curr. Diabetes Rev. 1 2005 65 72
-
(2005)
Curr. Diabetes Rev.
, vol.1
, pp. 65-72
-
-
Kaneto, H.1
Matsuoka, T.A.2
Nakatani, Y.3
Kawamori, D.4
Matsuhisa, M.5
Yamasaki, Y.6
-
158
-
-
26244456414
-
ER stress and SREBP-1 activation are implicated in B-cell glucolipotoxicity
-
DOI 10.1242/jcs.02513
-
H. Wang, G. Kouri, and C.B. Wollheim ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity J. Cell Sci. 118 2005 3905 3915 (Pubitemid 41410274)
-
(2005)
Journal of Cell Science
, vol.118
, Issue.17
, pp. 3905-3915
-
-
Wang, H.1
Kouri, G.2
Wollheim, C.B.3
-
159
-
-
34548220998
-
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2
-
DOI 10.1016/j.biocel.2007.05.002, PII S1357272507001458
-
S.M. Colgan, D. Tang, G.H. Werstuck, and R.C. Austin Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2 Int. J. Biochem. Cell Biol. 39 2007 1843 1851 (Pubitemid 47321345)
-
(2007)
International Journal of Biochemistry and Cell Biology
, vol.39
, Issue.10
, pp. 1843-1851
-
-
Colgan, S.M.1
Tang, D.2
Werstuck, G.H.3
Austin, R.C.4
-
160
-
-
78650762536
-
Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice
-
T. Murase, K. Misawa, Y. Minegishi, M. Aoki, H. Ominami, Y. Suzuki, Y. Shibuya, and T. Hase Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice Am. J. Physiol. Endocrinol. Metab. 300 2011 E122 E133
-
(2011)
Am. J. Physiol. Endocrinol. Metab.
, vol.300
-
-
Murase, T.1
Misawa, K.2
Minegishi, Y.3
Aoki, M.4
Ominami, H.5
Suzuki, Y.6
Shibuya, Y.7
Hase, T.8
-
161
-
-
0029910018
-
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
-
DOI 10.1074/jbc.271.44.27879
-
S.A. Hawley, M. Davison, A. Woods, S.P. Davies, R.K. Beri, D. Carling, and D.G. Hardie Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase J. Biol. Chem. 271 1996 27879 27887 (Pubitemid 26367365)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.44
, pp. 27879-27887
-
-
Hawley, S.A.1
Davison, M.2
Woods, A.3
Davies, S.P.4
Beri, R.K.5
Carling, D.6
Hardie, D.G.7
-
162
-
-
0028406897
-
Role of the AMP-activated protein kinase in the cellular stress response
-
J.M. Corton, J.G. Gillespie, and D.G. Hardie Role of the AMP-activated protein kinase in the cellular stress response Curr. Biol. 4 1994 315 324
-
(1994)
Curr. Biol.
, vol.4
, pp. 315-324
-
-
Corton, J.M.1
Gillespie, J.G.2
Hardie, D.G.3
-
163
-
-
0030688924
-
Regulation of lipid metabolism by the AMP-activated protein kinase
-
D.G. Hardie, J. Corton, Y.P. Ching, S.P. Davies, and S. Hawley Regulation of lipid metabolism by the AMP-activated protein kinase Biochem. Soc. Trans. 25 1997 1229 1231 (Pubitemid 27528568)
-
(1997)
Biochemical Society Transactions
, vol.25
, Issue.4
, pp. 1229-1231
-
-
Hardie, D.G.1
Corton, J.2
Ching, Y.P.3
Davies, S.P.4
Hawley, S.5
-
164
-
-
9644290860
-
The role of AMP-activated protein kinase in the action of ethanol in the liver
-
DOI 10.1053/j.gastro.2004.09.049, PII S0016508504016282
-
M. You, M. Matsumoto, C.M. Pacold, W.K. Cho, and D.W. Crabb The role of AMP-activated protein kinase in the action of ethanol in the liver Gastroenterology 127 2004 1798 1808 (Pubitemid 39575858)
-
(2004)
Gastroenterology
, vol.127
, Issue.6
, pp. 1798-1808
-
-
You, M.1
Matsumoto, M.2
Pacold, C.M.3
Cho, W.K.4
Crabb, D.W.5
-
165
-
-
33847080728
-
AMP-activated protein kinase in metabolic control and insulin signaling
-
M.C. Towler, and D.G. Hardie AMP-activated protein kinase in metabolic control and insulin signaling Circ. Res. 100 2007 328 341
-
(2007)
Circ. Res.
, vol.100
, pp. 328-341
-
-
Towler, M.C.1
Hardie, D.G.2
-
166
-
-
33745196745
-
Activation of AMP-activated protein kinase in the liver: A new strategy for the management of metabolic hepatic disorders
-
DOI 10.1113/jphysiol.2006.108506
-
B. Viollet, M. Foretz, B. Guigas, S. Horman, R. Dentin, L. Bertrand, L. Hue, and F. Andreelli Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders J. Physiol. 574 2006 41 53 (Pubitemid 43905795)
-
(2006)
Journal of Physiology
, vol.574
, Issue.1
, pp. 41-53
-
-
Viollet, B.1
Foretz, M.2
Guigas, B.3
Horman, S.4
Dentin, R.5
Bertrand, L.6
Hue, L.7
Andreelli, F.8
-
167
-
-
63849206613
-
AMP-activated protein kinase in the regulation of hepatic energy metabolism: From physiology to therapeutic perspectives
-
B. Viollet, B. Guigas, J. Leclerc, S. Hebrard, L. Lantier, R. Mounier, F. Andreelli, and M. Foretz AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives Acta Physiol. (Oxford) 196 2009 81 98
-
(2009)
Acta Physiol. (Oxford)
, vol.196
, pp. 81-98
-
-
Viollet, B.1
Guigas, B.2
Leclerc, J.3
Hebrard, S.4
Lantier, L.5
Mounier, R.6
Andreelli, F.7
Foretz, M.8
-
168
-
-
3843061127
-
Central role for liver X receptor in insulin-mediated activation of SREBP-1c transcription and stimulation of fatty acid synthesis in liver
-
DOI 10.1073/pnas.0404297101
-
G. Chen, G. Liang, J. Ou, J.L. Goldstein, and M.S. Brown Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver Proc. Natl. Acad. Sci. USA 101 2004 11245 11250 (Pubitemid 39038332)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.31
, pp. 11245-11250
-
-
Chen, G.1
Liang, G.2
Ou, J.3
Goldstein, J.L.4
Brown, M.S.5
-
169
-
-
0023896220
-
The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase
-
A.T. Sim, and D.G. Hardie The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase FEBS Lett 233 1988 294 298
-
(1988)
FEBS Lett
, vol.233
, pp. 294-298
-
-
Sim, A.T.1
Hardie, D.G.2
-
170
-
-
79960131362
-
Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription
-
F. Yap, L. Craddock, and J. Yang Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription Int. J. Biol. Sci. 7 2011 645 650
-
(2011)
Int. J. Biol. Sci.
, vol.7
, pp. 645-650
-
-
Yap, F.1
Craddock, L.2
Yang, J.3
-
171
-
-
77957349477
-
AMP-activated protein kinase and its downstream transcriptional pathways
-
C. Canto, and J. Auwerx AMP-activated protein kinase and its downstream transcriptional pathways Cell. Mol. Life Sci. 67 2010 3407 3423
-
(2010)
Cell. Mol. Life Sci.
, vol.67
, pp. 3407-3423
-
-
Canto, C.1
Auwerx, J.2
-
172
-
-
80053198203
-
Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells
-
M.S. Sozio, C. Lu, Y. Zeng, S. Liangpunsakul, and D.W. Crabb Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells Am. J. Physiol Gastrointest. Liver Physiol. 301 2011 G739 G747
-
(2011)
Am. J. Physiol Gastrointest. Liver Physiol.
, vol.301
-
-
Sozio, M.S.1
Lu, C.2
Zeng, Y.3
Liangpunsakul, S.4
Crabb, D.W.5
-
173
-
-
53349153430
-
Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
-
N. Higuchi, M. Kato, Y. Shundo, H. Tajiri, M. Tanaka, N. Yamashita, M. Kohjima, K. Kotoh, M. Nakamuta, R. Takayanagi, and M. Enjoji Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease Hepatol. Res. 38 2008 1122 1129
-
(2008)
Hepatol. Res.
, vol.38
, pp. 1122-1129
-
-
Higuchi, N.1
Kato, M.2
Shundo, Y.3
Tajiri, H.4
Tanaka, M.5
Yamashita, N.6
Kohjima, M.7
Kotoh, K.8
Nakamuta, M.9
Takayanagi, R.10
Enjoji, M.11
-
174
-
-
74149092293
-
Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis
-
Y.W. Kim, Y.M. Kim, Y.M. Yang, T.H. Kim, S.J. Hwang, J.R. Lee, S.C. Kim, and S.G. Kim Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis Free Radic. Biol. Med. 48 2010 567 578
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 567-578
-
-
Kim, Y.W.1
Kim, Y.M.2
Yang, Y.M.3
Kim, T.H.4
Hwang, S.J.5
Lee, J.R.6
Kim, S.C.7
Kim, S.G.8
-
175
-
-
79953755370
-
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
-
Y. Li, S. Xu, M.M. Mihaylova, B. Zheng, X. Hou, B. Jiang, O. Park, Z. Luo, E. Lefai, J.Y. Shyy, B. Gao, M. Wierzbicki, T.J. Verbeuren, R.J. Shaw, R.A. Cohen, and M. Zang AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice Cell Metab. 13 2011 376 388
-
(2011)
Cell Metab.
, vol.13
, pp. 376-388
-
-
Li, Y.1
Xu, S.2
Mihaylova, M.M.3
Zheng, B.4
Hou, X.5
Jiang, B.6
Park, O.7
Luo, Z.8
Lefai, E.9
Shyy, J.Y.10
Gao, B.11
Wierzbicki, M.12
Verbeuren, T.J.13
Shaw, R.J.14
Cohen, R.A.15
Zang, M.16
-
176
-
-
0035860237
-
2
-
DOI 10.1006/bbrc.2001.5544
-
2 Biochem. Biophys. Res. Commun. 287 2001 92 97 (Pubitemid 32912467)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.287
, Issue.1
, pp. 92-97
-
-
Choi, S.-L.1
Kim, S.-J.2
Lee, K.-T.3
Kim, J.4
Mu, J.5
Birnbaum, M.J.6
Soo Kim, S.7
Ha, J.8
-
178
-
-
64449087671
-
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio
-
B.M. Emerling, F. Weinberg, C. Snyder, Z. Burgess, G.M. Mutlu, B. Viollet, G.R. Budinger, and N.S. Chandel Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio Free Radic. Biol. Med. 46 2009 1386 1391
-
(2009)
Free Radic. Biol. Med.
, vol.46
, pp. 1386-1391
-
-
Emerling, B.M.1
Weinberg, F.2
Snyder, C.3
Burgess, Z.4
Mutlu, G.M.5
Viollet, B.6
Budinger, G.R.7
Chandel, N.S.8
-
179
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
S.M. Jeon, N.S. Chandel, and N. Hay AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress Nature 485 2012 661 665
-
(2012)
Nature
, vol.485
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
180
-
-
79953220498
-
Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress
-
J.F. Liu, Y. Ma, Y. Wang, Z.Y. Du, J.K. Shen, and H.L. Peng Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress Phytother. Res. 25 2011 588 596
-
(2011)
Phytother. Res.
, vol.25
, pp. 588-596
-
-
Liu, J.F.1
Ma, Y.2
Wang, Y.3
Du, Z.Y.4
Shen, J.K.5
Peng, H.L.6
-
181
-
-
0029805887
-
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
-
DOI 10.1038/383728a0
-
B.A. Janowski, P.J. Willy, T.R. Devi, J.R. Falck, and D.J. Mangelsdorf An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha Nature 383 1996 728 731 (Pubitemid 26360651)
-
(1996)
Nature
, vol.383
, Issue.6602
, pp. 728-731
-
-
Janowski, B.A.1
Willy, P.J.2
Devi, T.R.3
Falck, J.R.4
Mangelsdorf, D.J.5
-
182
-
-
0029035278
-
LXR, a nuclear receptor that defines a distinct retinoid response pathway
-
P.J. Willy, K. Umesono, E.S. Ong, R.M. Evans, R.A. Heyman, and D.J. Mangelsdorf LXR, a nuclear receptor that defines a distinct retinoid response pathway Genes Dev. 9 1995 1033 1045
-
(1995)
Genes Dev.
, vol.9
, pp. 1033-1045
-
-
Willy, P.J.1
Umesono, K.2
Ong, E.S.3
Evans, R.M.4
Heyman, R.A.5
Mangelsdorf, D.J.6
-
183
-
-
33646204900
-
A novel principle for partial agonism of liver X receptor ligands: Competitive recruitment of activators and repressors
-
DOI 10.1074/jbc.M510101200
-
M. Albers, B. Blume, T. Schlueter, M.B. Wright, I. Kober, C. Kremoser, U. Deuschle, and M. Koegl A novel principle for partial agonism of liver X receptor ligands: competitive recruitment of activators and repressors J. Biol. Chem. 281 2006 4920 4930 (Pubitemid 43847754)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.8
, pp. 4920-4930
-
-
Albers, M.1
Blume, B.2
Schlueter, T.3
Wright, M.B.4
Kober, I.5
Kremoser, C.6
Deuschle, U.7
Koegl, M.8
-
184
-
-
0035851188
-
Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism
-
T.T. Lu, J.J. Repa, and D.J. Mangelsdorf Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism J. Biol. Chem. 276 2001 37735 37738
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37735-37738
-
-
Lu, T.T.1
Repa, J.J.2
Mangelsdorf, D.J.3
-
185
-
-
64749108682
-
Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia
-
A. Kratzer, M. Buchebner, T. Pfeifer, T.M. Becker, G. Uray, M. Miyazaki, S. Miyazaki-Anzai, B. Ebner, P.G. Chandak, R.S. Kadam, E. Calayir, N. Rathke, H. Ahammer, B. Radovic, M. Trauner, G. Hoefler, U.B. Kompella, G. Fauler, M. Levi, S. Levak-Frank, G.M. Kostner, and D. Kratky Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia J. Lipid Res. 50 2009 312 326
-
(2009)
J. Lipid Res.
, vol.50
, pp. 312-326
-
-
Kratzer, A.1
Buchebner, M.2
Pfeifer, T.3
Becker, T.M.4
Uray, G.5
Miyazaki, M.6
Miyazaki-Anzai, S.7
Ebner, B.8
Chandak, P.G.9
Kadam, R.S.10
Calayir, E.11
Rathke, N.12
Ahammer, H.13
Radovic, B.14
Trauner, M.15
Hoefler, G.16
Kompella, U.B.17
Fauler, G.18
Levi, M.19
Levak-Frank, S.20
Kostner, G.M.21
Kratky, D.22
more..
-
186
-
-
0037192797
-
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
-
DOI 10.1074/jbc.M111041200
-
S.B. Joseph, B.A. Laffitte, P.H. Patel, M.A. Watson, K.E. Matsukuma, R. Walczak, J.L. Collins, T.F. Osborne, and P. Tontonoz Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors J. Biol. Chem. 277 2002 11019 11025 (Pubitemid 34952859)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.13
, pp. 11019-11025
-
-
Joseph, S.B.1
Laffitte, B.A.2
Patel, P.H.3
Watson, M.A.4
Matsukuma, K.E.5
Walczak, R.6
Collins, J.L.7
Osborne, T.F.8
Tontonoz, P.9
-
187
-
-
67649429268
-
Impact of cholesterol metabolism and the LXRalpha-SREBP-1c pathway on nonalcoholic fatty liver disease
-
M. Nakamuta, T. Fujino, R. Yada, M. Yada, K. Yasutake, T. Yoshimoto, N. Harada, N. Higuchi, M. Kato, M. Kohjima, A. Taketomi, Y. Maehara, M. Nakashima, K. Kotoh, and M. Enjoji Impact of cholesterol metabolism and the LXRalpha-SREBP-1c pathway on nonalcoholic fatty liver disease Int. J. Mol. Med. 23 2009 603 608
-
(2009)
Int. J. Mol. Med.
, vol.23
, pp. 603-608
-
-
Nakamuta, M.1
Fujino, T.2
Yada, R.3
Yada, M.4
Yasutake, K.5
Yoshimoto, T.6
Harada, N.7
Higuchi, N.8
Kato, M.9
Kohjima, M.10
Taketomi, A.11
Maehara, Y.12
Nakashima, M.13
Kotoh, K.14
Enjoji, M.15
-
188
-
-
0037790917
-
The enzymes, regulation, and genetics of bile acid synthesis
-
DOI 10.1146/annurev.biochem.72.121801.161712
-
D.W. Russell The enzymes, regulation, and genetics of bile acid synthesis Annu. Rev. Biochem. 72 2003 137 174 (Pubitemid 36930444)
-
(2003)
Annual Review of Biochemistry
, vol.72
, pp. 137-174
-
-
Russell, D.W.1
-
189
-
-
47049112744
-
Cholesterol, reactive oxygen species, and the formation of biologically active mediators
-
R.C. Murphy, and K.M. Johnson Cholesterol, reactive oxygen species, and the formation of biologically active mediators J. Biol. Chem. 283 2008 15521 15525
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 15521-15525
-
-
Murphy, R.C.1
Johnson, K.M.2
-
190
-
-
67349262029
-
Interactions of oxysterols with membranes and proteins
-
V.M. Olkkonen, and R. Hynynen Interactions of oxysterols with membranes and proteins Mol. Aspects Med. 30 2009 123 133
-
(2009)
Mol. Aspects Med.
, vol.30
, pp. 123-133
-
-
Olkkonen, V.M.1
Hynynen, R.2
-
191
-
-
71649098891
-
Oxysterols in biological systems: The gastrointestinal tract, liver, vascular wall and central nervous system
-
C. Garenc, P. Julien, and E. Levy Oxysterols in biological systems: the gastrointestinal tract, liver, vascular wall and central nervous system Free Radic. Res. 44 2010 47 73
-
(2010)
Free Radic. Res.
, vol.44
, pp. 47-73
-
-
Garenc, C.1
Julien, P.2
Levy, E.3
-
192
-
-
67349268463
-
Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
-
A.J. Brown, and W. Jessup Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis Mol. Aspects Med. 30 2009 111 122
-
(2009)
Mol. Aspects Med.
, vol.30
, pp. 111-122
-
-
Brown, A.J.1
Jessup, W.2
-
194
-
-
33751069000
-
Oxidative stress influences cholesterol efflux in THP-1 macrophages: Role of ATP-binding cassette A1 and nuclear factors
-
DOI 10.1016/j.cardiores.2006.08.024, PII S0008636306003993
-
V. Marcil, E. Delvin, A.T. Sane, A. Tremblay, and E. Levy Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors Cardiovasc. Res. 72 2006 473 482 (Pubitemid 44755054)
-
(2006)
Cardiovascular Research
, vol.72
, Issue.3
, pp. 473-482
-
-
Marcil, V.1
Delvin, E.2
Sane, A.T.3
Tremblay, A.4
Levy, E.5
-
195
-
-
23944465934
-
Genomic effect of vitamin 'C' and statins within human mononuclear cells involved in atherogenic process
-
DOI 10.1038/sj.ejcn.1602203
-
D. Kaul, and M.I. Baba Genomic effect of vitamin 'C' and statins within human mononuclear cells involved in atherogenic process Eur. J. Clin. Nutr. 59 2005 978 981 (Pubitemid 41195215)
-
(2005)
European Journal of Clinical Nutrition
, vol.59
, Issue.8
, pp. 978-981
-
-
Kaul, D.1
Baba, M.I.2
-
196
-
-
84867570924
-
Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet
-
K. Okada, E. Warabi, H. Sugimoto, M. Horie, N. Gotoh, K. Tokushige, E. Hashimoto, H. Utsunomiya, H. Takahashi, T. Ishii, M. Yamamoto, and J. Shoda Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet J. Gastroenterol. 47 2012 924 935
-
(2012)
J. Gastroenterol.
, vol.47
, pp. 924-935
-
-
Okada, K.1
Warabi, E.2
Sugimoto, H.3
Horie, M.4
Gotoh, N.5
Tokushige, K.6
Hashimoto, E.7
Utsunomiya, H.8
Takahashi, H.9
Ishii, T.10
Yamamoto, M.11
Shoda, J.12
-
197
-
-
80052600141
-
Nrf2 inhibits LXRalpha-dependent hepatic lipogenesis by competing with FXR for acetylase binding
-
H.Y. Kay, W.D. Kim, S.J. Hwang, H.S. Choi, R.K. Gilroy, Y.J. Wan, and S.G. Kim Nrf2 inhibits LXRalpha-dependent hepatic lipogenesis by competing with FXR for acetylase binding Antioxid. Redox Signaling 15 2011 2135 2146
-
(2011)
Antioxid. Redox Signaling
, vol.15
, pp. 2135-2146
-
-
Kay, H.Y.1
Kim, W.D.2
Hwang, S.J.3
Choi, H.S.4
Gilroy, R.K.5
Wan, Y.J.6
Kim, S.G.7
-
198
-
-
27944474377
-
Redox-dependent transcriptional regulation
-
DOI 10.1161/01.RES.0000188210.72062.10
-
H. Liu, R. Colavitti, I.I. Rovira, and T. Finkel Redox-dependent transcriptional regulation Circ. Res. 97 2005 967 974 (Pubitemid 41668909)
-
(2005)
Circulation Research
, vol.97
, Issue.10
, pp. 967-974
-
-
Liu, H.1
Colavitti, R.2
Rovira, I.I.3
Finkel, T.4
-
199
-
-
58249110568
-
Role of bile acids and bile acid receptors in metabolic regulation
-
P. Lefebvre, B. Cariou, F. Lien, F. Kuipers, and B. Staels Role of bile acids and bile acid receptors in metabolic regulation Physiol. Rev. 89 2009 147 191
-
(2009)
Physiol. Rev.
, vol.89
, pp. 147-191
-
-
Lefebvre, P.1
Cariou, B.2
Lien, F.3
Kuipers, F.4
Staels, B.5
-
200
-
-
0041845334
-
Farnesoid X receptor regulates bile acid-amino acid conjugation
-
DOI 10.1074/jbc.M302128200
-
P.C. Pircher, J.L. Kitto, M.L. Petrowski, R.K. Tangirala, E.D. Bischoff, I.G. Schulman, and S.K. Westin Farnesoid X receptor regulates bile acid-amino acid conjugation J. Biol. Chem. 278 2003 27703 27711 (Pubitemid 36899959)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.30
, pp. 27703-27711
-
-
Pircher, P.C.1
Kitto, J.L.2
Petrowski, M.L.3
Tangirala, R.K.4
Bischoff, E.D.5
Schulman, I.G.6
Westin, S.K.7
-
201
-
-
84858796689
-
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
-
A.C. Calkin, and P. Tontonoz Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nat. Rev. Mol. Cell Biol. 13 2012 213 224
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 213-224
-
-
Calkin, A.C.1
Tontonoz, P.2
-
202
-
-
33748950271
-
FXR, a multipurpose nuclear receptor
-
DOI 10.1016/j.tibs.2006.08.002, PII S096800040600209X
-
F.Y. Lee, H. Lee, M.L. Hubbert, P.A. Edwards, and Y. Zhang FXR, a multipurpose nuclear receptor Trends Biochem. Sci. 31 2006 572 580 (Pubitemid 44436939)
-
(2006)
Trends in Biochemical Sciences
, vol.31
, Issue.10
, pp. 572-580
-
-
Lee, F.Y.1
Lee, H.2
Hubbert, M.L.3
Edwards, P.A.4
Zhang, Y.5
-
203
-
-
33749344968
-
Nuclear bile acid receptor FXR as pharmacological target: Are we there yet?
-
DOI 10.1016/j.febslet.2006.07.082, PII S0014579306009501
-
S. Modica, and A. Moschetta Nuclear bile acid receptor FXR as pharmacological target: are we there yet? FEBS Lett 580 2006 5492 5499 (Pubitemid 44488553)
-
(2006)
FEBS Letters
, vol.580
, Issue.23
, pp. 5492-5499
-
-
Modica, S.1
Moschetta, A.2
-
204
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
C.J. Sinal, M. Tohkin, M. Miyata, J.M. Ward, G. Lambert, and F.J. Gonzalez Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis Cell 102 2000 731 744
-
(2000)
Cell
, vol.102
, pp. 731-744
-
-
Sinal, C.J.1
Tohkin, M.2
Miyata, M.3
Ward, J.M.4
Lambert, G.5
Gonzalez, F.J.6
-
205
-
-
0037315190
-
Bile acids induce the expression of the human peroxisome proliferator-activated receptor α gene via activation of the farnesoid X receptor
-
DOI 10.1210/me.2002-0120
-
I. Pineda Torra, T. Claudel, C. Duval, V. Kosykh, J.C. Fruchart, and B. Staels Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor Mol. Endocrinol. 17 2003 259 272 (Pubitemid 36183149)
-
(2003)
Molecular Endocrinology
, vol.17
, Issue.2
, pp. 259-272
-
-
Torra, I.P.1
Claudel, T.2
Duval, C.3
Kosykh, V.4
Fruchart, J.-C.5
Staels, B.6
-
206
-
-
0942279602
-
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR
-
DOI 10.1101/gad.1138104
-
Y. Zhang, L.W. Castellani, C.J. Sinal, F.J. Gonzalez, and P.A. Edwards Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR Genes Dev. 18 2004 157 169 (Pubitemid 38141784)
-
(2004)
Genes and Development
, vol.18
, Issue.2
, pp. 157-169
-
-
Zhang, Y.1
Castellani, L.W.2
Sinal, C.J.3
Gonzalez, F.J.4
Edwards, P.A.5
-
207
-
-
78649475438
-
Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease
-
Z.X. Yang, W. Shen, and H. Sun Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease Hepatol. Int 4 2010 741 748
-
(2010)
Hepatol. Int
, vol.4
, pp. 741-748
-
-
Yang, Z.X.1
Shen, W.2
Sun, H.3
-
208
-
-
85047694456
-
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
-
DOI 10.1172/JCI200421025
-
M. Watanabe, S.M. Houten, L. Wang, A. Moschetta, D.J. Mangelsdorf, R.A. Heyman, D.D. Moore, and J. Auwerx Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c J. Clin. Invest. 113 2004 1408 1418 (Pubitemid 39071696)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.10
, pp. 1408-1418
-
-
Watanabe, M.1
Houten, S.M.2
Wang, L.3
Moschetta, A.4
Mangelsdorf, D.J.5
Heyman, R.A.6
Moore, D.D.7
Auwerx, J.8
-
210
-
-
33645127044
-
Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor
-
R. Deng, D. Yang, J. Yang, and B. Yan Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor J. Pharmacol. Exp. Ther 317 2006 317 325
-
(2006)
J. Pharmacol. Exp. Ther
, vol.317
, pp. 317-325
-
-
Deng, R.1
Yang, D.2
Yang, J.3
Yan, B.4
-
211
-
-
56649094325
-
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
-
H. Malhi, and G.J. Gores Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease Semin. Liver Dis. 28 2008 360 369
-
(2008)
Semin. Liver Dis.
, vol.28
, pp. 360-369
-
-
Malhi, H.1
Gores, G.J.2
-
213
-
-
83555176010
-
Lipotoxicity in NASH
-
M. Fuchs, and A.J. Sanyal Lipotoxicity in NASH J. Hepatol. 56 2012 291 293
-
(2012)
J. Hepatol.
, vol.56
, pp. 291-293
-
-
Fuchs, M.1
Sanyal, A.J.2
-
214
-
-
0035084699
-
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
-
A.J. Sanyal, C. Campbell-Sargent, F. Mirshahi, W.B. Rizzo, M.J. Contos, R.K. Sterling, V.A. Luketic, M.L. Shiffman, and J.N. Clore Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183 1192 (Pubitemid 32246672)
-
(2001)
Gastroenterology
, vol.120
, Issue.5
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
Sterling, R.K.6
Luketic, V.A.7
Shiffman, M.L.8
Clore, J.N.9
-
215
-
-
58149473989
-
Nutritional lipid-induced oxidative stress leads to mitochondrial dysfunction followed by necrotic death in FaO hepatocytes
-
O. Tirosh, E. Ilan, S. Anavi, G. Ramadori, and Z. Madar Nutritional lipid-induced oxidative stress leads to mitochondrial dysfunction followed by necrotic death in FaO hepatocytes Nutrition 25 2009 200 208
-
(2009)
Nutrition
, vol.25
, pp. 200-208
-
-
Tirosh, O.1
Ilan, E.2
Anavi, S.3
Ramadori, G.4
Madar, Z.5
-
216
-
-
78751678681
-
Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells
-
M.D. Mantzaris, E.V. Tsianos, and D. Galaris Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells FEBS J 278 2011 519 530
-
(2011)
FEBS J
, vol.278
, pp. 519-530
-
-
Mantzaris, M.D.1
Tsianos, E.V.2
Galaris, D.3
-
217
-
-
38649124615
-
Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
-
DOI 10.1053/j.gastro.2007.10.039, PII S0016508507019191
-
P. Puri, F. Mirshahi, O. Cheung, R. Natarajan, J.W. Maher, J.M. Kellum, and A.J. Sanyal Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease Gastroenterology 134 2008 568 576 (Pubitemid 351173040)
-
(2008)
Gastroenterology
, vol.134
, Issue.2
, pp. 568-576
-
-
Puri, P.1
Mirshahi, F.2
Cheung, O.3
Natarajan, R.4
Maher, J.W.5
Kellum, J.M.6
Sanyal, A.J.7
-
218
-
-
84864269699
-
Endoplasmic reticulum stress in nonalcoholic fatty liver disease
-
M.J. Pagliassotti Endoplasmic reticulum stress in nonalcoholic fatty liver disease Annu. Rev. Nutr. 32 2012 17 33
-
(2012)
Annu. Rev. Nutr.
, vol.32
, pp. 17-33
-
-
Pagliassotti, M.J.1
-
219
-
-
84861567265
-
Redox signaling loops in the unfolded protein response
-
A. Higa Chevet, E. Redox signaling loops in the unfolded protein response Cell. Signalling 24 2012 1548 1555
-
(2012)
Cell. Signalling
, vol.24
, pp. 1548-1555
-
-
Higa, A.1
Chevet, E.2
-
220
-
-
84872192695
-
An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases
-
B. Bhandary, A. Marahatta, H.R. Kim, and H.J. Chae An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases Int. J. Mol. Sci 14 2012 434 456
-
(2012)
Int. J. Mol. Sci
, vol.14
, pp. 434-456
-
-
Bhandary, B.1
Marahatta, A.2
Kim, H.R.3
Chae, H.J.4
-
221
-
-
35848957485
-
Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?
-
DOI 10.1089/ars.2007.1782
-
J.D. Malhotra, and R.J. Kaufman Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox Signaling 9 2007 2277 2293 (Pubitemid 350059010)
-
(2007)
Antioxidants and Redox Signaling
, vol.9
, Issue.12
, pp. 2277-2293
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
222
-
-
1642292288
-
Antioxidant defence mechanisms: New players in the pathogenesis of non-alcoholic steatohepatitis?
-
DOI 10.1042/CS20030368
-
I.A. Leclercq Antioxidant defence mechanisms: new players in the pathogenesis of non-alcoholic steatohepatitis? Clin. Sci. (London) 106 2004 235 237 (Pubitemid 38365828)
-
(2004)
Clinical Science
, vol.106
, Issue.3
, pp. 235-237
-
-
Leclercq, I.A.1
-
223
-
-
12144291550
-
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
-
DOI 10.1042/CS20030285
-
L.A. Videla, R. Rodrigo, M. Orellana, V. Fernandez, G. Tapia, L. Quinones, N. Varela, J. Contreras, R. Lazarte, A. Csendes, J. Rojas, F. Maluenda, P. Burdiles, J.C. Diaz, G. Smok, L. Thielemann, and J. Poniachik Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients Clin. Sci. (London) 106 2004 261 268 (Pubitemid 38365832)
-
(2004)
Clinical Science
, vol.106
, Issue.3
, pp. 261-268
-
-
Videla, L.A.1
Rodrigo, R.2
Orellana, M.3
Fernandez, V.4
Tapia, G.5
Quinones, L.6
Varela, N.7
Contreras, J.8
Lazarte, R.9
Csendes, A.10
Rojas, J.11
Maluenda, F.12
Burdiles, P.13
Diaz, J.C.14
Smok, G.15
Thielemann, L.16
Poniachik, J.17
-
224
-
-
11244348954
-
A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
-
DOI 10.1096/fj.04-2291fje
-
M. Carmiel-Haggai, A.I. Cederbaum, and N. Nieto A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats FASEB J 19 2005 136 138 (Pubitemid 40069943)
-
(2005)
FASEB Journal
, vol.19
, Issue.1
, pp. 136-138
-
-
Carmiel-Haggai, M.1
Cederbaum, A.I.2
Nieto, N.3
-
225
-
-
26044463449
-
Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease
-
DOI 10.1111/j.1478-3231.2005.01126.x
-
G. Perlemuter, A. Davit-Spraul, C. Cosson, M. Conti, A. Bigorgne, V. Paradis, M.P. Corre, L. Prat, V. Kuoch, A. Basdevant, G. Pelletier, J.M. Oppert, and C. Buffet Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease Liver Int. 25 2005 946 953 (Pubitemid 41404014)
-
(2005)
Liver International
, vol.25
, Issue.5
, pp. 946-953
-
-
Perlemuter, G.1
Davit-Spraul, A.2
Cosson, C.3
Conti, M.4
Bigorgne, A.5
Paradis, V.6
Corre, M.-P.7
Prat, L.8
Kuoch, V.9
Basdevant, A.10
Pelletier, G.11
Oppert, J.-M.12
Buffet, C.13
-
226
-
-
78649549021
-
Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease
-
R.N. Hardwick, C.D. Fisher, M.J. Canet, A.D. Lake, and N.J. Cherrington Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease Drug Metab. Dispos. 38 2010 2293 2301
-
(2010)
Drug Metab. Dispos.
, vol.38
, pp. 2293-2301
-
-
Hardwick, R.N.1
Fisher, C.D.2
Canet, M.J.3
Lake, A.D.4
Cherrington, N.J.5
-
227
-
-
16244385292
-
Antioxidant and cytoprotective responses to redox stress
-
J. Mathers, J.A. Fraser, M. McMahon, R.D. Saunders, J.D. Hayes, and L.I. McLellan Antioxidant and cytoprotective responses to redox stress Biochem. Soc. Symp. 71 2004 157 176 (Pubitemid 41185484)
-
(2004)
Biochemical Society Symposium
, vol.71
, pp. 157-176
-
-
Mathers, J.1
Fraser, J.A.2
McMahon, M.3
Saunders, R.D.C.4
Hayes, J.D.5
McLellan, L.I.6
-
228
-
-
14044254798
-
Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
-
DOI 10.1089/ars.2005.7.385
-
M. Kobayashi, and M. Yamamoto Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation Antioxid. Redox Signaling 7 2005 385 394 (Pubitemid 40279806)
-
(2005)
Antioxidants and Redox Signaling
, vol.7
, Issue.3-4
, pp. 385-394
-
-
Kobayashi, M.1
Yamamoto, M.2
-
229
-
-
66749112860
-
Genetic versus chemoprotective activation of Nrf2 signaling: Overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
-
M.S. Yates, Q.T. Tran, P.M. Dolan, W.O. Osburn, S. Shin, C.C. McCulloch, J.B. Silkworth, K. Taguchi, M. Yamamoto, C.R. Williams, K.T. Liby, M.B. Sporn, T.R. Sutter, and T.W. Kensler Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice Carcinogenesis 30 2009 1024 1031
-
(2009)
Carcinogenesis
, vol.30
, pp. 1024-1031
-
-
Yates, M.S.1
Tran, Q.T.2
Dolan, P.M.3
Osburn, W.O.4
Shin, S.5
McCulloch, C.C.6
Silkworth, J.B.7
Taguchi, K.8
Yamamoto, M.9
Williams, C.R.10
Liby, K.T.11
Sporn, M.B.12
Sutter, T.R.13
Kensler, T.W.14
-
230
-
-
84877276025
-
Hepatic gene expression profiling in nrf2 knockout mice after long-term high-fat diet-induced obesity
-
(2013)
-
D.V. Chartoumpekis, P.G. Ziros, A. Zaravinos, R.P. Iskrenova, A.I. Psyrogiannis, V.E. Kyriazopoulou, G.P. Sykiotis, and I.G. Habeos Hepatic gene expression profiling in nrf2 knockout mice after long-term high-fat diet-induced obesity Oxid. Med. Cell. Longevity 2013 340731 (2013)
-
(2013)
Oxid. Med. Cell. Longevity
, pp. 340731
-
-
Chartoumpekis, D.V.1
Ziros, P.G.2
Zaravinos, A.3
Iskrenova, R.P.4
Psyrogiannis, A.I.5
Kyriazopoulou, V.E.6
Sykiotis, G.P.7
Habeos, I.G.8
-
231
-
-
72649103895
-
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
-
S. Chowdhry, M.H. Nazmy, P.J. Meakin, A.T. Dinkova-Kostova, S.V. Walsh, T. Tsujita, J.F. Dillon, M.L. Ashford, and J.D. Hayes Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis Free Radic. Biol. Med. 48 2010 357 371
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 357-371
-
-
Chowdhry, S.1
Nazmy, M.H.2
Meakin, P.J.3
Dinkova-Kostova, A.T.4
Walsh, S.V.5
Tsujita, T.6
Dillon, J.F.7
Ashford, M.L.8
Hayes, J.D.9
-
232
-
-
77952952816
-
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet
-
Y.K. Zhang, R.L. Yeager, Y. Tanaka, and C.D. Klaassen Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet Toxicol. Appl. Pharmacol. 245 2010 326 334
-
(2010)
Toxicol. Appl. Pharmacol.
, vol.245
, pp. 326-334
-
-
Zhang, Y.K.1
Yeager, R.L.2
Tanaka, Y.3
Klaassen, C.D.4
-
233
-
-
70349140473
-
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide
-
S. Shin, J. Wakabayashi, M.S. Yates, N. Wakabayashi, P.M. Dolan, S. Aja, K.T. Liby, M.B. Sporn, M. Yamamoto, and T.W. Kensler Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide Eur. J. Pharmacol. 620 2009 138 144
-
(2009)
Eur. J. Pharmacol.
, vol.620
, pp. 138-144
-
-
Shin, S.1
Wakabayashi, J.2
Yates, M.S.3
Wakabayashi, N.4
Dolan, P.M.5
Aja, S.6
Liby, K.T.7
Sporn, M.B.8
Yamamoto, M.9
Kensler, T.W.10
-
234
-
-
35148823513
-
NRF2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis
-
DOI 10.1128/MCB.00915-07
-
S. Shin, N. Wakabayashi, V. Misra, S. Biswal, G.H. Lee, E.S. Agoston, M. Yamamoto, and T.W. Kensler NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis Mol. Cell. Biol. 27 2007 7188 7197 (Pubitemid 47549754)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.20
, pp. 7188-7197
-
-
Shin, S.1
Wakabayashi, N.2
Misra, V.3
Biswal, S.4
Gum, H.L.5
Agoston, E.S.6
Yamamoto, M.7
Kensler, T.W.8
-
235
-
-
77950553993
-
Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity
-
J. Pi, L. Leung, P. Xue, W. Wang, Y. Hou, D. Liu, E. Yehuda-Shnaidman, C. Lee, J. Lau, T.W. Kurtz, and J.Y. Chan Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity J. Biol. Chem. 285 2010 9292 9300
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 9292-9300
-
-
Pi, J.1
Leung, L.2
Xue, P.3
Wang, W.4
Hou, Y.5
Liu, D.6
Yehuda-Shnaidman, E.7
Lee, C.8
Lau, J.9
Kurtz, T.W.10
Chan, J.Y.11
-
236
-
-
84870361939
-
Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice
-
J. Xu, S.R. Kulkarni, A.C. Donepudi, V.R. More, and A.L. Slitt Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice Diabetes 61 2012 3208 3218
-
(2012)
Diabetes
, vol.61
, pp. 3208-3218
-
-
Xu, J.1
Kulkarni, S.R.2
Donepudi, A.C.3
More, V.R.4
Slitt, A.L.5
-
237
-
-
77955650026
-
Targeting mitochondria: A new promising approach for the treatment of liver diseases
-
G. Serviddio, F. Bellanti, J. Sastre, G. Vendemiale, and E. Altomare Targeting mitochondria: a new promising approach for the treatment of liver diseases Curr. Med. Chem. 17 2010 2325 2337
-
(2010)
Curr. Med. Chem.
, vol.17
, pp. 2325-2337
-
-
Serviddio, G.1
Bellanti, F.2
Sastre, J.3
Vendemiale, G.4
Altomare, E.5
-
238
-
-
80052543705
-
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction
-
D.W. Jun, W.K. Cho, J.H. Jun, H.J. Kwon, K.S. Jang, H.J. Kim, H.J. Jeon, K.N. Lee, H.L. Lee, O.Y. Lee, B.C. Yoon, H.S. Choi, J.S. Hahm, and M.H. Lee Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction Liver Int. 31 2011 1315 1324
-
(2011)
Liver Int.
, vol.31
, pp. 1315-1324
-
-
Jun, D.W.1
Cho, W.K.2
Jun, J.H.3
Kwon, H.J.4
Jang, K.S.5
Kim, H.J.6
Jeon, H.J.7
Lee, K.N.8
Lee, H.L.9
Lee, O.Y.10
Yoon, B.C.11
Choi, H.S.12
Hahm, J.S.13
Lee, M.H.14
-
239
-
-
84865406937
-
Alpha-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
-
W.L. Chen, C.H. Kang, S.G. Wang, and H.M. Lee alpha-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase Diabetologia 55 2012 1824 1835
-
(2012)
Diabetologia
, vol.55
, pp. 1824-1835
-
-
Chen, W.L.1
Kang, C.H.2
Wang, S.G.3
Lee, H.M.4
-
240
-
-
84867097988
-
Alpha-Lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats
-
T.S. Jung, S.K. Kim, H.J. Shin, B.T. Jeon, J.R. Hahm, and G.S. Roh alpha-Lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats Liver Int. 32 2012 1565 1573
-
(2012)
Liver Int.
, vol.32
, pp. 1565-1573
-
-
Jung, T.S.1
Kim, S.K.2
Shin, H.J.3
Jeon, B.T.4
Hahm, J.R.5
Roh, G.S.6
-
241
-
-
77249113410
-
A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis
-
G. Serviddio, F. Bellanti, A.M. Giudetti, G.V. Gnoni, A. Petrella, R. Tamborra, A.D. Romano, T. Rollo, G. Vendemiale, and E. Altomare A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis J. Pharmacol. Exp. Ther. 332 2010 922 932
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.332
, pp. 922-932
-
-
Serviddio, G.1
Bellanti, F.2
Giudetti, A.M.3
Gnoni, G.V.4
Petrella, A.5
Tamborra, R.6
Romano, A.D.7
Rollo, T.8
Vendemiale, G.9
Altomare, E.10
-
242
-
-
84861603829
-
Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis
-
F. Salamone, F. Galvano, F. Cappello, A. Mangiameli, I. Barbagallo, and V.G. Li Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis Transl. Res. 159 2012 477 486
-
(2012)
Transl. Res.
, vol.159
, pp. 477-486
-
-
Salamone, F.1
Galvano, F.2
Cappello, F.3
Mangiameli, A.4
Barbagallo, I.5
Li, V.G.6
-
243
-
-
79952715994
-
Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis
-
T. Ma, C. Huang, G. Zong, D. Zha, X. Meng, J. Li, and W. Tang Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis J. Pharm. Pharmacol. 63 2011 587 593
-
(2011)
J. Pharm. Pharmacol.
, vol.63
, pp. 587-593
-
-
Ma, T.1
Huang, C.2
Zong, G.3
Zha, D.4
Meng, X.5
Li, J.6
Tang, W.7
-
244
-
-
52749094256
-
Resveratrol inhibits nonalcoholic fatty liver disease in rats
-
L. Bujanda, E. Hijona, M. Larzabal, M. Beraza, P. Aldazabal, N. Garcia-Urkia, C. Sarasqueta, A. Cosme, B. Irastorza, A. Gonzalez, and J.I. Arenas Jr. Resveratrol inhibits nonalcoholic fatty liver disease in rats BMC Gastroenterol. 8 2008 40
-
(2008)
BMC Gastroenterol.
, vol.8
, pp. 40
-
-
Bujanda, L.1
Hijona, E.2
Larzabal, M.3
Beraza, M.4
Aldazabal, P.5
Garcia-Urkia, N.6
Sarasqueta, C.7
Cosme, A.8
Irastorza, B.9
Gonzalez, A.10
Arenas, Jr.J.I.11
-
245
-
-
44849131936
-
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
-
DOI 10.1111/j.1745-7254.2008.00807.x
-
J. Shang, L.L. Chen, F.X. Xiao, H. Sun, H.C. Ding, and H. Xiao Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase Acta Pharmacol. Sin. 29 2008 698 706 (Pubitemid 351799479)
-
(2008)
Acta Pharmacologica Sinica
, vol.29
, Issue.6
, pp. 698-706
-
-
Shang, J.1
Chen, L.-L.2
Xiao, F.-X.3
Sun, H.4
Ding, H.-C.5
Xiao, H.6
-
246
-
-
38949165468
-
Green tea extract protects leptin-deficient, spontaneously obese mice from hepatic steatosis and injury
-
R.S. Bruno, C.E. Dugan, J.A. Smyth, D.A. DiNatale, and S.I. Koo Green tea extract protects leptin-deficient, spontaneously obese mice from hepatic steatosis and injury J. Nutr. 138 2008 323 331 (Pubitemid 351213647)
-
(2008)
Journal of Nutrition
, vol.138
, Issue.2
, pp. 323-331
-
-
Bruno, R.S.1
Dugan, C.E.2
Smyth, J.A.3
DiNatale, D.A.4
Koo, S.I.5
-
247
-
-
79952534308
-
Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice
-
H.J. Park, D.A. DiNatale, M.Y. Chung, Y.K. Park, J.Y. Lee, S.I. Koo, M. O'Connor, J.E. Manautou, and R.S. Bruno Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice J. Nutr. Biochem. 22 2011 393 400
-
(2011)
J. Nutr. Biochem.
, vol.22
, pp. 393-400
-
-
Park, H.J.1
Dinatale, D.A.2
Chung, M.Y.3
Park, Y.K.4
Lee, J.Y.5
Koo, S.I.6
O'Connor, M.7
Manautou, J.E.8
Bruno, R.S.9
-
248
-
-
65349093477
-
Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: Potential involvement of oxysterols
-
N. Ferre, M. Martinez-Clemente, M. Lopez-Parra, A. Gonzalez-Periz, R. Horrillo, A. Planaguma, J. Camps, J. Joven, A. Tres, F. Guardiola, R. Bataller, V. Arroyo, and J. Claria Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G553 G562
-
(2009)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.296
-
-
Ferre, N.1
Martinez-Clemente, M.2
Lopez-Parra, M.3
Gonzalez-Periz, A.4
Horrillo, R.5
Planaguma, A.6
Camps, J.7
Joven, J.8
Tres, A.9
Guardiola, F.10
Bataller, R.11
Arroyo, V.12
Claria, J.13
-
249
-
-
84871330823
-
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
-
V. Bieghs, T. Hendrikx, P.J. van Gorp, F. Verheyen, Y.D. Guichot, S.M. Walenbergh, M. Gijbels, S.S. Rensen, A. Bast, J. Plat, S.C. Kalhan, E. Leitersdorf, M. Hofker, D. Lutjohann, and R. Shiri-Sverdlov The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice Gastroenterology 144 2012 167 178
-
(2012)
Gastroenterology
, vol.144
, pp. 167-178
-
-
Bieghs, V.1
Hendrikx, T.2
Van Gorp, P.J.3
Verheyen, F.4
Guichot, Y.D.5
Walenbergh, S.M.6
Gijbels, M.7
Rensen, S.S.8
Bast, A.9
Plat, J.10
Kalhan, S.C.11
Leitersdorf, E.12
Hofker, M.13
Lutjohann, D.14
Shiri-Sverdlov, R.15
-
250
-
-
84861576789
-
Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease
-
Q. Bai, X. Zhang, L. Xu, G. Kakiyama, D. Heuman, A. Sanyal, W.M. Pandak, L. Yin, W. Xie, and S. Ren Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease Metabolism 61 2012 836 845
-
(2012)
Metabolism
, vol.61
, pp. 836-845
-
-
Bai, Q.1
Zhang, X.2
Xu, L.3
Kakiyama, G.4
Heuman, D.5
Sanyal, A.6
Pandak, W.M.7
Yin, L.8
Xie, W.9
Ren, S.10
-
251
-
-
84863427742
-
Non-alcoholic fatty liver disease: The bile acid-activated farnesoid X receptor as an emerging treatment target
-
(2012)
-
M. Fuchs Non-alcoholic fatty liver disease: the bile acid-activated farnesoid X receptor as an emerging treatment target J. Lipids 2012 934396 (2012)
-
(2012)
J. Lipids
, pp. 934396
-
-
Fuchs, M.1
-
252
-
-
77950613528
-
FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
-
S. Cipriani, A. Mencarelli, G. Palladino, and S. Fiorucci FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats J. Lipid Res 51 2010 771 784
-
(2010)
J. Lipid Res
, vol.51
, pp. 771-784
-
-
Cipriani, S.1
Mencarelli, A.2
Palladino, G.3
Fiorucci, S.4
-
253
-
-
0034126755
-
Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study
-
J.E. Lavine Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study J. Pediatr. 136 2000 734 738 (Pubitemid 30415645)
-
(2000)
Journal of Pediatrics
, vol.136
, Issue.6
, pp. 734-738
-
-
Lavine, J.E.1
-
254
-
-
0034799895
-
Plasma transforming growth factor-β1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: A pilot study
-
DOI 10.1046/j.1365-2036.2001.01083.x
-
T. Hasegawa, M. Yoneda, K. Nakamura, I. Makino, and A. Terano Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study Aliment. Pharmacol. Ther. 15 2001 1667 1672 (Pubitemid 32912411)
-
(2001)
Alimentary Pharmacology and Therapeutics
, vol.15
, Issue.10
, pp. 1667-1672
-
-
Hasegawa, T.1
Yoneda, M.2
Nakamura, K.3
Makino, I.4
Terano, A.5
-
255
-
-
0042265627
-
Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin E
-
DOI 10.1053/jhep.2003.50316
-
M. Kugelmas, and D.B. Hill Vivian, B.; Marsano, L.; McClain, C.J. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E Hepatology 38 2003 413 419 (Pubitemid 36919862)
-
(2003)
Hepatology
, vol.38
, Issue.2
, pp. 413-419
-
-
Kugelmas, M.1
Hill, D.B.2
Vivian, B.3
Marsano, L.4
McClain, C.J.5
-
257
-
-
73049090978
-
Treatment of nonalcoholic fatty liver disease in children: TONIC trial design
-
J.E. Lavine, J.B. Schwimmer, J.P. Molleston, A.O. Scheimann, K.F. Murray, S.H. Abrams, P. Rosenthal, A.J. Sanyal, P.R. Robuck, E.M. Brunt, A. Unalp, and J. Tonascia Treatment of nonalcoholic fatty liver disease in children: TONIC trial design Contemp. Clin. Trials 31 2010 62 70
-
(2010)
Contemp. Clin. Trials
, vol.31
, pp. 62-70
-
-
Lavine, J.E.1
Schwimmer, J.B.2
Molleston, J.P.3
Scheimann, A.O.4
Murray, K.F.5
Abrams, S.H.6
Rosenthal, P.7
Sanyal, A.J.8
Robuck, P.R.9
Brunt, E.M.10
Unalp, A.11
Tonascia, J.12
-
258
-
-
77951874018
-
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
-
A.J. Sanyal, N. Chalasani, K.V. Kowdley, A. McCullough, A.M. Diehl, N.M. Bass, B.A. Neuschwander-Tetri, J.E. Lavine, J. Tonascia, A. Unalp, N.M. Van, J. Clark, E.M. Brunt, D.E. Kleiner, J.H. Hoofnagle, and P.R. Robuck Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis N. Engl. J. Med. 362 2010 1675 1685
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 1675-1685
-
-
Sanyal, A.J.1
Chalasani, N.2
Kowdley, K.V.3
McCullough, A.4
Diehl, A.M.5
Bass, N.M.6
Neuschwander-Tetri, B.A.7
Lavine, J.E.8
Tonascia, J.9
Unalp, A.10
Van, N.M.11
Clark, J.12
Brunt, E.M.13
Kleiner, D.E.14
Hoofnagle, J.H.15
Robuck, P.R.16
-
260
-
-
0344742265
-
Vitamin E and Vitamin C Treatment Improves Fibrosis in Patients with Nonalcoholic Steatohepatitis
-
DOI 10.1111/j.1572-0241.2003.08699.x
-
S.A. Harrison, S. Torgerson, P. Hayashi, J. Ward, and S. Schenker Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis Am. J. Gastroenterol. 98 2003 2485 2490 (Pubitemid 37448761)
-
(2003)
American Journal of Gastroenterology
, vol.98
, Issue.11
, pp. 2485-2490
-
-
Harrison, S.A.1
Torgerson, S.2
Hayashi, P.3
Ward, J.4
Schenker, S.5
-
261
-
-
47149086771
-
Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial
-
DOI 10.1002/hep.22336
-
V. Nobili, M. Manco, R. Devito, C. Di, V Comparcola, D. Sartorelli, M.R. Piemonte, F. Marcellini, and M. Angulo P. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial Hepatology 48 2008 119 128 (Pubitemid 351975537)
-
(2008)
Hepatology
, vol.48
, Issue.1
, pp. 119-128
-
-
Nobili, V.1
Manco, M.2
Devito, R.3
Di Ciommo, V.4
Comparcola, D.5
Sartorelli, M.R.6
Piemonte, F.7
Marcellini, M.8
Angulo, P.9
-
262
-
-
84858959526
-
Silybin combined with phosphatidylcholine and vitamin e in patients with nonalcoholic fatty liver disease: A randomized controlled trial
-
C. Loguercio, P. Andreone, C. Brisc, M.C. Brisc, E. Bugianesi, M. Chiaramonte, C. Cursaro, M. Danila, S., I de, A. Floreani, M.A. Freni, A. Grieco, M. Groppo, R. Lazzari, S. Lobello, E. Lorefice, M. Margotti, L. Miele, S. Milani, L. Okolicsanyi, G. Palasciano, P. Portincasa, P. Saltarelli, A. Smedile, F. Somalvico, A. Spadaro, I. Sporea, P. Sorrentino, R. Vecchione, C. Tuccillo, B.C. Del Vecchio, and A. Federico Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial Free Radic. Biol. Med. 52 2012 1658 1665
-
(2012)
Free Radic. Biol. Med.
, vol.52
, pp. 1658-1665
-
-
Loguercio, C.1
Andreone, P.2
Brisc, C.3
Brisc, M.C.4
Bugianesi, E.5
Chiaramonte, M.6
Cursaro, C.7
Danila, M.8
De, S.I.9
Floreani, A.10
Freni, M.A.11
Grieco, A.12
Groppo, M.13
Lazzari, R.14
Lobello, S.15
Lorefice, E.16
Margotti, M.17
Miele, L.18
Milani, S.19
Okolicsanyi, L.20
Palasciano, G.21
Portincasa, P.22
Saltarelli, P.23
Smedile, A.24
Somalvico, F.25
Spadaro, A.26
Sporea, I.27
Sorrentino, P.28
Vecchione, R.29
Tuccillo, C.30
Del Vecchio, B.C.31
Federico, A.32
more..
-
263
-
-
58649089148
-
Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats
-
D.Y. Kwon, Y.S. Jung, S.J. Kim, H.K. Park, J.H. Park, and Y.C. Kim Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats J. Nutr. 139 2009 63 68
-
(2009)
J. Nutr.
, vol.139
, pp. 63-68
-
-
Kwon, D.Y.1
Jung, Y.S.2
Kim, S.J.3
Park, H.K.4
Park, J.H.5
Kim, Y.C.6
-
264
-
-
79953763871
-
Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease
-
W. Li, L. Zheng, C. Sheng, X. Cheng, L. Qing, and S. Qu Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease Lipids Health Dis. 10 2011 49
-
(2011)
Lipids Health Dis.
, vol.10
, pp. 49
-
-
Li, W.1
Zheng, L.2
Sheng, C.3
Cheng, X.4
Qing, L.5
Qu, S.6
-
265
-
-
79954764140
-
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis
-
V. Ratziu, V. de Ledinghen, F. Oberti, P. Mathurin, C. Wartelle-Bladou, C. Renou, P. Sogni, M. Maynard, D. Larrey, L. Serfaty, D. Bonnefont-Rousselot, J.P. Bastard, M. Riviere, and J. Spenard A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis J. Hepatol. 54 2011 1011 1019
-
(2011)
J. Hepatol.
, vol.54
, pp. 1011-1019
-
-
Ratziu, V.1
De Ledinghen, V.2
Oberti, F.3
Mathurin, P.4
Wartelle-Bladou, C.5
Renou, C.6
Sogni, P.7
Maynard, M.8
Larrey, D.9
Serfaty, L.10
Bonnefont-Rousselot, D.11
Bastard, J.P.12
Riviere, M.13
Spenard, J.14
-
266
-
-
34249053143
-
Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis
-
F. Lirussi, L. Azzalini, S. Orando, R. Orlando, and F. Angelico Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis Cochrane Database Syst. Rev. 2007 CD004996
-
(2007)
Cochrane Database Syst. Rev.
, pp. 004996
-
-
Lirussi, F.1
Azzalini, L.2
Orando, S.3
Orlando, R.4
Angelico, F.5
-
267
-
-
43049180323
-
Why have antioxidants failed in clinical trials?
-
S.R. Steinhubl Why have antioxidants failed in clinical trials? Am. J. Cardiol. 101 2008 14D 19D
-
(2008)
Am. J. Cardiol.
, vol.101
-
-
Steinhubl, S.R.1
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