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Volumn 167, Issue 1, 2011, Pages 96-112

Nitric oxide and redox regulation in the liver: Part II. Redox biology in pathologic hepatocytes and implications for intervention

Author keywords

ethanol induced hepatitis; hepatitis; hepatocytes; nitric oxide; oxidative stress; reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ALLOPURINOL; ALPHA TOCOPHEROL; AMINOGUANIDINE; ANTIOXIDANT; APOLIPOPROTEIN A1; ASCORBIC ACID; BUCILLAMINE; CYANIDIN 3 GLUCOSIDE; DEFEROXAMINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GRANULOCYTE COLONY STIMULATING FACTOR; GREEN TEA EXTRACT; IDEBENONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LONG CHAIN FATTY ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PARACETAMOL; QUERCETIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; TRIMETAZIDINE; TUMOR NECROSIS FACTOR ALPHA; UBIQUINONE; UNINDEXED DRUG; VASCULOTROPIN;

EID: 79953036451     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.10.006     Document Type: Review
Times cited : (69)

References (185)
  • 1
    • 0028527530 scopus 로고
    • Glycolysis and energy metabolism in rat liver during warm and cold ischemia: Evidence of an activation of the regulatory enzyme phosphofructokinase
    • T.A. Churchill, K.M. Cheetham, and B.J. Fuller Glycolysis and energy metabolism in rat liver during warm and cold ischemia: evidence of an activation of the regulatory enzyme phosphofructokinase Cryobiology 31 1994 441
    • (1994) Cryobiology , vol.31 , pp. 441
    • Churchill, T.A.1    Cheetham, K.M.2    Fuller, B.J.3
  • 2
    • 0034776853 scopus 로고    scopus 로고
    • Effects of preoperative chemotherapy on liver function tests after hepatectomy
    • M. Pocard, A. Vincent-Salomon, and J. Girodet Effects of preoperative chemotherapy on liver function tests after hepatectomy Hepatogastroenterology 48 2001 1406
    • (2001) Hepatogastroenterology , vol.48 , pp. 1406
    • Pocard, M.1    Vincent-Salomon, A.2    Girodet, J.3
  • 3
    • 0032423221 scopus 로고    scopus 로고
    • Postischemic reperfusion injury and allograft arteriosclerosis
    • B. Fellstrom, L.M. Akuyrek, and U. Backman Postischemic reperfusion injury and allograft arteriosclerosis Transplant Proc 30 1998 4278
    • (1998) Transplant Proc , vol.30 , pp. 4278
    • Fellstrom, B.1    Akuyrek, L.M.2    Backman, U.3
  • 4
    • 0021984681 scopus 로고
    • Oxygen-derived free radicals in postischemic tissue injury
    • J.M. McCord Oxygen-derived free radicals in postischemic tissue injury N Engl J Med 312 1985 159
    • (1985) N Engl J Med , vol.312 , pp. 159
    • McCord, J.M.1
  • 5
    • 0025763349 scopus 로고
    • Sodium flux and bioenergetics in the ischemic rat liver
    • H. Blum, M.D. Osbakken, and R.G. Johnson Jr. Sodium flux and bioenergetics in the ischemic rat liver Magn Reson Med 18 1991 348
    • (1991) Magn Reson Med , vol.18 , pp. 348
    • Blum, H.1    Osbakken, M.D.2    Johnson Jr., R.G.3
  • 6
    • 0030038818 scopus 로고    scopus 로고
    • FK506 maintains cellular calcium homeostasis in ischemia-reperfusion injury of the canine liver
    • D.K. Dhar, Y. Takemoto, and N. Nagasue FK506 maintains cellular calcium homeostasis in ischemia-reperfusion injury of the canine liver J Surg Res 60 1996 142
    • (1996) J Surg Res , vol.60 , pp. 142
    • Dhar, D.K.1    Takemoto, Y.2    Nagasue, N.3
  • 7
    • 0019842034 scopus 로고
    • The role of calcium in cell death
    • J.L. Farber The role of calcium in cell death Life Sci 29 1981 1289
    • (1981) Life Sci , vol.29 , pp. 1289
    • Farber, J.L.1
  • 8
    • 0037427440 scopus 로고    scopus 로고
    • Mitochondrial permeability transition: A common pathway to necrosis and apoptosis
    • J.S. Kim, L. He, and J.J. Lemasters Mitochondrial permeability transition: a common pathway to necrosis and apoptosis Biochem Biophys Res Commun 304 2003 463
    • (2003) Biochem Biophys Res Commun , vol.304 , pp. 463
    • Kim, J.S.1    He, L.2    Lemasters, J.J.3
  • 9
    • 0029011918 scopus 로고
    • Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study
    • G. Zahrebelski, A.L. Nieminen, and K. al-Ghoul Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: a laser scanning confocal microscopic study Hepatology 21 1995 1361
    • (1995) Hepatology , vol.21 , pp. 1361
    • Zahrebelski, G.1    Nieminen, A.L.2    Al-Ghoul, K.3
  • 10
    • 0032881237 scopus 로고    scopus 로고
    • Therapeutic approaches for ischemia/reperfusion injury in the liver
    • C. Fan, R.M. Zwacka, and J.F. Engelhardt Therapeutic approaches for ischemia/reperfusion injury in the liver J Mol Med 77 1999 577
    • (1999) J Mol Med , vol.77 , pp. 577
    • Fan, C.1    Zwacka, R.M.2    Engelhardt, J.F.3
  • 11
    • 0025745032 scopus 로고
    • Reactive oxygen and ischemia/reperfusion injury of the liver
    • H. Jaeschke Reactive oxygen and ischemia/reperfusion injury of the liver Chem Biol Interact 79 1991 115
    • (1991) Chem Biol Interact , vol.79 , pp. 115
    • Jaeschke, H.1
  • 12
    • 0023256645 scopus 로고
    • Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues
    • T.D. Engerson, T.G. McKelvey, and D.B. Rhyne Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues J Clin Invest 79 1987 1564
    • (1987) J Clin Invest , vol.79 , pp. 1564
    • Engerson, T.D.1    McKelvey, T.G.2    Rhyne, D.B.3
  • 13
    • 0036618347 scopus 로고    scopus 로고
    • Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase
    • M. Ozaki, S. Suzuki, and K. Irani Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase FASEB J 16 2002 889
    • (2002) FASEB J , vol.16 , pp. 889
    • Ozaki, M.1    Suzuki, S.2    Irani, K.3
  • 14
    • 0024602827 scopus 로고
    • Tissue destruction by neutrophils
    • S.J. Weiss Tissue destruction by neutrophils N Engl J Med 320 1989 365
    • (1989) N Engl J Med , vol.320 , pp. 365
    • Weiss, S.J.1
  • 15
    • 0030836653 scopus 로고    scopus 로고
    • CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver
    • R.M. Zwacka, Y. Zhang, and J. Halldorson CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver J Clin Invest 100 1997 279
    • (1997) J Clin Invest , vol.100 , pp. 279
    • Zwacka, R.M.1    Zhang, Y.2    Halldorson, J.3
  • 16
    • 0033546733 scopus 로고    scopus 로고
    • Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-kappaB
    • G.M. Hur, Y.S. Ryu, and H.Y. Yun Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-kappaB Biochem Biophys Res Commun 261 1999 917
    • (1999) Biochem Biophys Res Commun , vol.261 , pp. 917
    • Hur, G.M.1    Ryu, Y.S.2    Yun, H.Y.3
  • 17
    • 0033610282 scopus 로고    scopus 로고
    • Beneficial effects of inducible nitric oxide synthase inhibitor on reperfusion injury in the pig liver
    • M. Isobe, T. Katsuramaki, and K. Hirata Beneficial effects of inducible nitric oxide synthase inhibitor on reperfusion injury in the pig liver Transplantation 68 1999 803
    • (1999) Transplantation , vol.68 , pp. 803
    • Isobe, M.1    Katsuramaki, T.2    Hirata, K.3
  • 18
    • 0026748407 scopus 로고
    • Ischemic injury in liver transplantation: Difference in injury sites between warm and cold ischemia in rats
    • T. Ikeda, K. Yanaga, and K. Kishikawa Ischemic injury in liver transplantation: difference in injury sites between warm and cold ischemia in rats Hepatology 16 1992 454
    • (1992) Hepatology , vol.16 , pp. 454
    • Ikeda, T.1    Yanaga, K.2    Kishikawa, K.3
  • 19
    • 0035512181 scopus 로고    scopus 로고
    • The roles of iNOS in liver ischemia-reperfusion injury
    • V.G. Lee, M.L. Johnson, and J. Baust The roles of iNOS in liver ischemia-reperfusion injury Shock 16 2001 355
    • (2001) Shock , vol.16 , pp. 355
    • Lee, V.G.1    Johnson, M.L.2    Baust, J.3
  • 20
    • 0029557231 scopus 로고
    • Role of endogenous nitric oxide in ischemia-reperfusion injury in rat liver
    • H. Kobayashi, T. Nonami, and T. Kurokawa Role of endogenous nitric oxide in ischemia-reperfusion injury in rat liver J Surg Res 59 1995 772
    • (1995) J Surg Res , vol.59 , pp. 772
    • Kobayashi, H.1    Nonami, T.2    Kurokawa, T.3
  • 21
    • 0029384468 scopus 로고
    • Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia
    • Y. Wang, W.R. Mathews, and D.M. Guido Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia Shock 4 1995 282
    • (1995) Shock , vol.4 , pp. 282
    • Wang, Y.1    Mathews, W.R.2    Guido, D.M.3
  • 22
    • 0037443905 scopus 로고    scopus 로고
    • Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714
    • M. Meguro, T. Katsuramaki, and H. Kimura Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714 Transplantation 75 2003 703
    • (2003) Transplantation , vol.75 , pp. 703
    • Meguro, M.1    Katsuramaki, T.2    Kimura, H.3
  • 23
    • 0037432615 scopus 로고    scopus 로고
    • Multiple pathways of peroxynitrite cytotoxicity
    • C. Szabo Multiple pathways of peroxynitrite cytotoxicity Toxicol Lett 140-141 2003 105
    • (2003) Toxicol Lett , vol.140-141 , pp. 105
    • Szabo, C.1
  • 24
    • 0035868469 scopus 로고    scopus 로고
    • SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay)
    • P.T. Doulias, A. Barbouti, and D. Galaris SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay) Free Radic Biol Med 30 2001 679
    • (2001) Free Radic Biol Med , vol.30 , pp. 679
    • Doulias, P.T.1    Barbouti, A.2    Galaris, D.3
  • 25
    • 0033951191 scopus 로고    scopus 로고
    • Morphological mechanisms for regulating blood flow through hepatic sinusoids
    • R.S. McCuskey Morphological mechanisms for regulating blood flow through hepatic sinusoids Liver 20 2000 3
    • (2000) Liver , vol.20 , pp. 3
    • McCuskey, R.S.1
  • 26
    • 0033383893 scopus 로고    scopus 로고
    • Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction
    • Z. Ming, C. Han, and W.W. Lautt Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction Am J Physiol 277 1999 G1200
    • (1999) Am J Physiol , vol.277 , pp. 1200
    • Ming, Z.1    Han, C.2    Lautt, W.W.3
  • 27
    • 0028034751 scopus 로고
    • Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion
    • T.W. Gauthier, K.L. Davenpeck, and A.M. Lefer Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion Am J Physiol 267 1994 G562
    • (1994) Am J Physiol , vol.267 , pp. 562
    • Gauthier, T.W.1    Davenpeck, K.L.2    Lefer, A.M.3
  • 28
    • 0028011371 scopus 로고
    • Nitric oxide modulates hepatic vascular tone in normal rat liver
    • M.K. Mittal, T.K. Gupta, and F.Y. Lee Nitric oxide modulates hepatic vascular tone in normal rat liver Am J Physiol 267 1994 G416
    • (1994) Am J Physiol , vol.267 , pp. 416
    • Mittal, M.K.1    Gupta, T.K.2    Lee, F.Y.3
  • 29
    • 0023200487 scopus 로고
    • Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium
    • M.W. Radomski, R.M. Palmer, and S. Moncada Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium Lancet 2 1987 1057
    • (1987) Lancet , vol.2 , pp. 1057
    • Radomski, M.W.1    Palmer, R.M.2    Moncada, S.3
  • 30
    • 0025731835 scopus 로고
    • Nitric oxide: An endogenous modulator of leukocyte adhesion
    • P. Kubes, M. Suzuki, and D.N. Granger Nitric oxide: an endogenous modulator of leukocyte adhesion Proc Natl Acad Sci USA 88 1991 4651
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4651
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 31
    • 0028349209 scopus 로고
    • Time course of nitric oxide production and epithelial dysfunction during ischemia/reperfusion of the feline small intestine
    • S. Kanwar, B.L. Tepperman, and D. Payne Time course of nitric oxide production and epithelial dysfunction during ischemia/reperfusion of the feline small intestine Circ Shock 42 1994 135
    • (1994) Circ Shock , vol.42 , pp. 135
    • Kanwar, S.1    Tepperman, B.L.2    Payne, D.3
  • 32
    • 4243978473 scopus 로고    scopus 로고
    • Role of nitric oxide in liver ischemia and reperfusion injury
    • I.N. Hines, S. Kawachi, and H. Harada Role of nitric oxide in liver ischemia and reperfusion injury Mol Cell Biochem 234-235 2002 229
    • (2002) Mol Cell Biochem , vol.234-235 , pp. 229
    • Hines, I.N.1    Kawachi, S.2    Harada, H.3
  • 33
    • 33845438092 scopus 로고    scopus 로고
    • Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury
    • M.R. Duranski, J.W. Elrod, and J.W. Calvert Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury Am J Physiol Heart Circ Physiol 291 2006 H2980
    • (2006) Am J Physiol Heart Circ Physiol , vol.291 , pp. 2980
    • Duranski, M.R.1    Elrod, J.W.2    Calvert, J.W.3
  • 34
    • 9144252563 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury
    • S.P. Jones, J.J. Greer, and A.K. Kakkar Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury Am J Physiol Heart Circ Physiol 286 2004 H276
    • (2004) Am J Physiol Heart Circ Physiol , vol.286 , pp. 276
    • Jones, S.P.1    Greer, J.J.2    Kakkar, A.K.3
  • 35
    • 33746234766 scopus 로고    scopus 로고
    • ENOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: A role for eNOS uncoupling
    • J.W. Elrod, M.R. Duranski, and W. Langston eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling Circ Res 99 2006 78
    • (2006) Circ Res , vol.99 , pp. 78
    • Elrod, J.W.1    Duranski, M.R.2    Langston, W.3
  • 36
    • 3943106192 scopus 로고    scopus 로고
    • Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation
    • R. Varadarajan, L. Golden-Mason, and L. Young Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation Transplantation 78 2004 250
    • (2004) Transplantation , vol.78 , pp. 250
    • Varadarajan, R.1    Golden-Mason, L.2    Young, L.3
  • 37
    • 34848888949 scopus 로고    scopus 로고
    • Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
    • J.D. Lang Jr., X. Teng, and P. Chumley Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation J Clin Invest 117 2007 2583
    • (2007) J Clin Invest , vol.117 , pp. 2583
    • Lang Jr., J.D.1    Teng, X.2    Chumley, P.3
  • 38
    • 0033744385 scopus 로고    scopus 로고
    • Endothelin/nitric oxide balance influences hepatic ischemia-reperfusion injury
    • D. Uhlmann, S. Uhlmann, and H.U. Spiegel Endothelin/nitric oxide balance influences hepatic ischemia-reperfusion injury J Cardiovasc Pharmacol 36 2000 S212
    • (2000) J Cardiovasc Pharmacol , vol.36 , pp. 212
    • Uhlmann, D.1    Uhlmann, S.2    Spiegel, H.U.3
  • 39
    • 0031944387 scopus 로고    scopus 로고
    • Exogenous L-arginine protects liver microcirculation from ischemia reperfusion injury
    • D. Uhlmann, S. Scommotau, and H. Witzigmann Exogenous L-arginine protects liver microcirculation from ischemia reperfusion injury Eur Surg Res 30 1998 175
    • (1998) Eur Surg Res , vol.30 , pp. 175
    • Uhlmann, D.1    Scommotau, S.2    Witzigmann, H.3
  • 40
    • 38549101065 scopus 로고    scopus 로고
    • Prevention of hepatic ischemia/reperfusion injury by prolonged delivery of nitric oxide to the circulating blood in mice
    • H. Katsumi, M. Nishikawa, and F. Yamashita Prevention of hepatic ischemia/reperfusion injury by prolonged delivery of nitric oxide to the circulating blood in mice Transplantation 85 2008 264
    • (2008) Transplantation , vol.85 , pp. 264
    • Katsumi, H.1    Nishikawa, M.2    Yamashita, F.3
  • 41
    • 0035033402 scopus 로고    scopus 로고
    • Protective role of the L-arginine-nitric oxide synthase pathway on preservation injury after rat liver transplantation
    • D.A. Geller, S.H. Chia, and Y. Takahashi Protective role of the L-arginine-nitric oxide synthase pathway on preservation injury after rat liver transplantation JPEN J Parenter Enteral Nutr 25 2001 142
    • (2001) JPEN J Parenter Enteral Nutr , vol.25 , pp. 142
    • Geller, D.A.1    Chia, S.H.2    Takahashi, Y.3
  • 42
    • 0033405614 scopus 로고    scopus 로고
    • Role of sodium nitroprusside in the improvement of rat liver preservation in University of Wisconsin solution: A study in the isolated perfused liver model
    • J.V. Rodriguez, E.E. Guibert, and A. Quintana Role of sodium nitroprusside in the improvement of rat liver preservation in University of Wisconsin solution: A study in the isolated perfused liver model J Surg Res 87 1999 201
    • (1999) J Surg Res , vol.87 , pp. 201
    • Rodriguez, J.V.1    Guibert, E.E.2    Quintana, A.3
  • 43
    • 0035084074 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock
    • C. Hierholzer, B.G. Harbrecht, and T.R. Billiar Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock Arch Orthop Trauma Surg 121 2001 219
    • (2001) Arch Orthop Trauma Surg , vol.121 , pp. 219
    • Hierholzer, C.1    Harbrecht, B.G.2    Billiar, T.R.3
  • 44
    • 0034929133 scopus 로고    scopus 로고
    • Molecular mechanisms in the early phase of hemorrhagic shock
    • C. Hierholzer, and T.R. Billiar Molecular mechanisms in the early phase of hemorrhagic shock Langenbecks Arch Surg 386 2001 302
    • (2001) Langenbecks Arch Surg , vol.386 , pp. 302
    • Hierholzer, C.1    Billiar, T.R.2
  • 45
    • 0030963616 scopus 로고    scopus 로고
    • The hypoxic response: Huffing and HIFing
    • K. Guillemin, and M.A. Krasnow The hypoxic response: huffing and HIFing Cell 89 1997 9
    • (1997) Cell , vol.89 , pp. 9
    • Guillemin, K.1    Krasnow, M.A.2
  • 46
    • 0031052886 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase
    • C. Hierholzer, E. Kelly, and T.R. Billiar Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase Arch Orthop Trauma Surg 116 1997 173
    • (1997) Arch Orthop Trauma Surg , vol.116 , pp. 173
    • Hierholzer, C.1    Kelly, E.2    Billiar, T.R.3
  • 47
    • 0031711449 scopus 로고    scopus 로고
    • Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury
    • C. Hierholzer, J.C. Kalff, and L. Omert Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury Am J Physiol 275 1998 L611
    • (1998) Am J Physiol , vol.275 , pp. 611
    • Hierholzer, C.1    Kalff, J.C.2    Omert, L.3
  • 48
    • 0032536875 scopus 로고    scopus 로고
    • Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock
    • C. Hierholzer, B. Harbrecht, and J.M. Menezes Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock J Exp Med 187 1998 917
    • (1998) J Exp Med , vol.187 , pp. 917
    • Hierholzer, C.1    Harbrecht, B.2    Menezes, J.M.3
  • 49
    • 18844463672 scopus 로고    scopus 로고
    • Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile
    • DOI 10.1016/S0041-1345(98)00771-4, PII S0041134598007714
    • C. Hierholzer, J.C. Kalff, and T.R. Billiar Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile Transplant Proc 30 1998 2647 (Pubitemid 28459784)
    • (1998) Transplantation Proceedings , vol.30 , Issue.6 , pp. 2647
    • Hierholzer, C.1    Kalff, J.C.2    Billiar, T.R.3    Bauer, A.4    Tweardy, D.J.5
  • 50
    • 0032607311 scopus 로고    scopus 로고
    • Influence of L-arginine, aminoguanidine, and NG-nitro-L-arginine methyl ester (L-name) on the survival rate in a rat model of hemorrhagic shock
    • T.C. Hua, and S.M. Moochhala Influence of L-arginine, aminoguanidine, and NG-nitro-L-arginine methyl ester (L-name) on the survival rate in a rat model of hemorrhagic shock Shock 11 1999 51
    • (1999) Shock , vol.11 , pp. 51
    • Hua, T.C.1    Moochhala, S.M.2
  • 51
    • 0036908191 scopus 로고    scopus 로고
    • A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock
    • M.C. McDonald, M. Izumi, and S. Cuzzocrea A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock J Physiol Pharmacol 53 2002 555
    • (2002) J Physiol Pharmacol , vol.53 , pp. 555
    • McDonald, M.C.1    Izumi, M.2    Cuzzocrea, S.3
  • 52
    • 0036365190 scopus 로고    scopus 로고
    • The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock
    • J.M. Menezes, C. Hierholzer, and S.C. Watkins The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock Shock 17 2002 13
    • (2002) Shock , vol.17 , pp. 13
    • Menezes, J.M.1    Hierholzer, C.2    Watkins, S.C.3
  • 53
    • 0029881769 scopus 로고    scopus 로고
    • Increasing nitric oxide production improves survival in experimental hemorrhagic shock
    • K. Daughters, K. Waxman, and H. Nguyen Increasing nitric oxide production improves survival in experimental hemorrhagic shock Resuscitation 31 1996 141
    • (1996) Resuscitation , vol.31 , pp. 141
    • Daughters, K.1    Waxman, K.2    Nguyen, H.3
  • 54
    • 0032801941 scopus 로고    scopus 로고
    • A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock
    • J. Menezes, C. Hierholzer, and S.C. Watkins A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock Am J Physiol 277 1999 G144
    • (1999) Am J Physiol , vol.277 , pp. 144
    • Menezes, J.1    Hierholzer, C.2    Watkins, S.C.3
  • 55
    • 0036479542 scopus 로고    scopus 로고
    • A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock
    • C. Hierholzer, J.M. Menezes, and A. Ungeheuer A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock Shock 17 2002 98
    • (2002) Shock , vol.17 , pp. 98
    • Hierholzer, C.1    Menezes, J.M.2    Ungeheuer, A.3
  • 56
    • 4644301611 scopus 로고    scopus 로고
    • The attenuation of hepatic microcirculatory alterations by exogenous substitution of nitric oxide by s-nitroso-human albumin after hemorrhagic shock in the rat
    • C. Bauer, W. Kuntz, and F. Ohnsmann The attenuation of hepatic microcirculatory alterations by exogenous substitution of nitric oxide by s-nitroso-human albumin after hemorrhagic shock in the rat Shock 21 2004 165
    • (2004) Shock , vol.21 , pp. 165
    • Bauer, C.1    Kuntz, W.2    Ohnsmann, F.3
  • 57
    • 0032111014 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase in the liver: Regulation and function
    • B.S. Taylor, L.H. Alarcon, and T.R. Billiar Inducible nitric oxide synthase in the liver: regulation and function Biochemistry (Mosc) 63 1998 766
    • (1998) Biochemistry (Mosc) , vol.63 , pp. 766
    • Taylor, B.S.1    Alarcon, L.H.2    Billiar, T.R.3
  • 58
    • 0032531047 scopus 로고    scopus 로고
    • Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride
    • P. Muriel Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride Biochem Pharmacol 56 1998 773
    • (1998) Biochem Pharmacol , vol.56 , pp. 773
    • Muriel, P.1
  • 59
    • 0025761982 scopus 로고
    • IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism
    • S. Mellouk, S.J. Green, and C.A. Nacy IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism J Immunol 146 1991 3971
    • (1991) J Immunol , vol.146 , pp. 3971
    • Mellouk, S.1    Green, S.J.2    Nacy, C.A.3
  • 60
    • 0026065305 scopus 로고
    • L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation
    • A. Nussler, J.C. Drapier, and L. Renia L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation Eur J Immunol 21 1991 227
    • (1991) Eur J Immunol , vol.21 , pp. 227
    • Nussler, A.1    Drapier, J.C.2    Renia, L.3
  • 61
    • 0025200266 scopus 로고
    • Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage
    • T.R. Billiar, R.D. Curran, and B.G. Harbrecht Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage J Leukoc Biol 48 1990 565
    • (1990) J Leukoc Biol , vol.48 , pp. 565
    • Billiar, T.R.1    Curran, R.D.2    Harbrecht, B.G.3
  • 62
    • 0026666826 scopus 로고
    • Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury
    • B.G. Harbrecht, T.R. Billiar, and J. Stadler Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury J Leukoc Biol 52 1992 390
    • (1992) J Leukoc Biol , vol.52 , pp. 390
    • Harbrecht, B.G.1    Billiar, T.R.2    Stadler, J.3
  • 63
    • 0026447191 scopus 로고
    • Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia
    • B.G. Harbrecht, T.R. Billiar, and J. Stadler Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia Crit Care Med 20 1992 1568
    • (1992) Crit Care Med , vol.20 , pp. 1568
    • Harbrecht, B.G.1    Billiar, T.R.2    Stadler, J.3
  • 64
    • 0030752217 scopus 로고    scopus 로고
    • Role of nitric oxide in oxygen transport in rat liver sinusoids during endotoxemia
    • T.P. Huang, T. Nishida, and W. Kamike Role of nitric oxide in oxygen transport in rat liver sinusoids during endotoxemia Hepatology 26 1997 336
    • (1997) Hepatology , vol.26 , pp. 336
    • Huang, T.P.1    Nishida, T.2    Kamike, W.3
  • 65
    • 0034241882 scopus 로고    scopus 로고
    • The cytoprotective role of lipopolysaccharide-induced nitric oxide against liver damage during early phase of endotoxemia in rats
    • K. Kamiya, T. Kono, and J. Iwamoto The cytoprotective role of lipopolysaccharide-induced nitric oxide against liver damage during early phase of endotoxemia in rats Shock 14 2000 229
    • (2000) Shock , vol.14 , pp. 229
    • Kamiya, K.1    Kono, T.2    Iwamoto, J.3
  • 66
    • 0031431194 scopus 로고    scopus 로고
    • Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia
    • J. Ou, T.M. Carlos, and S.C. Watkins Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia Nitric Oxide 1 1997 404
    • (1997) Nitric Oxide , vol.1 , pp. 404
    • Ou, J.1    Carlos, T.M.2    Watkins, S.C.3
  • 67
    • 0030803656 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia
    • M.J. Hickey, K.A. Sharkey, and E.G. Sihota Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia FASEB J 11 1997 955
    • (1997) FASEB J , vol.11 , pp. 955
    • Hickey, M.J.1    Sharkey, K.A.2    Sihota, E.G.3
  • 68
    • 0035110655 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice
    • G. Sass, K. Koerber, and R. Bang Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice J Clin Invest 107 2001 439
    • (2001) J Clin Invest , vol.107 , pp. 439
    • Sass, G.1    Koerber, K.2    Bang, R.3
  • 70
    • 0042405194 scopus 로고    scopus 로고
    • LINCS: L-NAME (a NO synthase inhibitor) in the treatment of refractory cardiogenic shock: A prospective randomized study
    • G. Cotter, E. Kaluski, and O. Milo LINCS: L-NAME (a NO synthase inhibitor) in the treatment of refractory cardiogenic shock: a prospective randomized study Eur Heart J 24 2003 1287
    • (2003) Eur Heart J , vol.24 , pp. 1287
    • Cotter, G.1    Kaluski, E.2    Milo, O.3
  • 71
    • 0028155913 scopus 로고
    • Effects of a nitric oxide synthase inhibitor in humans with septic shock
    • A. Petros, G. Lamb, and A. Leone Effects of a nitric oxide synthase inhibitor in humans with septic shock Cardiovasc Res 28 1994 34
    • (1994) Cardiovasc Res , vol.28 , pp. 34
    • Petros, A.1    Lamb, G.2    Leone, A.3
  • 72
    • 4444273012 scopus 로고    scopus 로고
    • Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock
    • A. Lopez, J.A. Lorente, and J. Steingrub Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock Crit Care Med 32 2004 21
    • (2004) Crit Care Med , vol.32 , pp. 21
    • Lopez, A.1    Lorente, J.A.2    Steingrub, J.3
  • 73
    • 34247392754 scopus 로고    scopus 로고
    • Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: The TRIUMPH randomized controlled trial
    • J.H. Alexander, H.R. Reynolds, and A.L. Stebbins Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial JAMA 297 2007 1657
    • (2007) JAMA , vol.297 , pp. 1657
    • Alexander, J.H.1    Reynolds, H.R.2    Stebbins, A.L.3
  • 74
    • 12644291219 scopus 로고    scopus 로고
    • Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication
    • I. Kurose, H. Higuchi, and S. Miura Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication Hepatology 25 1997 368
    • (1997) Hepatology , vol.25 , pp. 368
    • Kurose, I.1    Higuchi, H.2    Miura, S.3
  • 75
    • 0347949728 scopus 로고    scopus 로고
    • 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells
    • E. Zamara, E. Novo, and F. Marra 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells J Hepatol 40 2004 60
    • (2004) J Hepatol , vol.40 , pp. 60
    • Zamara, E.1    Novo, E.2    Marra, F.3
  • 76
    • 0033427390 scopus 로고    scopus 로고
    • Liver microvascular architecture: An insight into the pathophysiology of portal hypertension
    • W. Ekataksin, and K. Kaneda Liver microvascular architecture: an insight into the pathophysiology of portal hypertension Semin Liver Dis 19 1999 359
    • (1999) Semin Liver Dis , vol.19 , pp. 359
    • Ekataksin, W.1    Kaneda, K.2
  • 77
    • 0032482952 scopus 로고    scopus 로고
    • Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis
    • V. Ratziu, A. Lalazar, and L. Wong Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis Proc Natl Acad Sci U S A 95 1998 9500
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9500
    • Ratziu, V.1    Lalazar, A.2    Wong, L.3
  • 78
    • 0035179839 scopus 로고    scopus 로고
    • DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells
    • E. Olaso, K. Ikeda, and F.J. Eng DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells J Clin Invest 108 2001 1369
    • (2001) J Clin Invest , vol.108 , pp. 1369
    • Olaso, E.1    Ikeda, K.2    Eng, F.J.3
  • 79
    • 18244431128 scopus 로고    scopus 로고
    • Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation
    • O. Vinas, R. Bataller, and P. Sancho-Bru Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation Hepatology 38 2003 919
    • (2003) Hepatology , vol.38 , pp. 919
    • Vinas, O.1    Bataller, R.2    Sancho-Bru, P.3
  • 80
    • 0032738990 scopus 로고    scopus 로고
    • Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat
    • V. Shah, M. Toruner, and F. Haddad Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat Gastroenterology 117 1999 1222
    • (1999) Gastroenterology , vol.117 , pp. 1222
    • Shah, V.1    Toruner, M.2    Haddad, F.3
  • 81
    • 42249111199 scopus 로고    scopus 로고
    • Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability
    • J. Gracia-Sancho, B. Lavina, and A. Rodriguez-Vilarrupla Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability Hepatology 47 2008 1248
    • (2008) Hepatology , vol.47 , pp. 1248
    • Gracia-Sancho, J.1    Lavina, B.2    Rodriguez-Vilarrupla, A.3
  • 82
    • 0036022305 scopus 로고    scopus 로고
    • Antioxidant capacity and nitric oxide in patients with hepatic cirrhosis
    • M. Koruk, H. Aksoy, and F. Akcay Antioxidant capacity and nitric oxide in patients with hepatic cirrhosis Ann Clin Lab Sci 32 2002 252
    • (2002) Ann Clin Lab Sci , vol.32 , pp. 252
    • Koruk, M.1    Aksoy, H.2    Akcay, F.3
  • 83
    • 0025157647 scopus 로고
    • The pathology of hepatic iron overload: A free radical-mediated process?
    • B.R. Bacon, and R.S. Britton The pathology of hepatic iron overload: a free radical-mediated process? Hepatology 11 1990 127
    • (1990) Hepatology , vol.11 , pp. 127
    • Bacon, B.R.1    Britton, R.S.2
  • 84
    • 0029160569 scopus 로고
    • Experimental liver cirrhosis induced by alcohol and iron
    • H. Tsukamoto, W. Horne, and S. Kamimura Experimental liver cirrhosis induced by alcohol and iron J Clin Invest 96 1995 620
    • (1995) J Clin Invest , vol.96 , pp. 620
    • Tsukamoto, H.1    Horne, W.2    Kamimura, S.3
  • 85
    • 0021842533 scopus 로고
    • Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions
    • G. Poli, M.U. Dianzani, and K.H. Cheeseman Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions Biochem J 227 1985 629
    • (1985) Biochem J , vol.227 , pp. 629
    • Poli, G.1    Dianzani, M.U.2    Cheeseman, K.H.3
  • 86
    • 0033134774 scopus 로고    scopus 로고
    • Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury
    • O. Niemela, S. Parkkila, and R.S. Britton Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury J Lab Clin Med 133 1999 451
    • (1999) J Lab Clin Med , vol.133 , pp. 451
    • Niemela, O.1    Parkkila, S.2    Britton, R.S.3
  • 87
    • 0000707647 scopus 로고    scopus 로고
    • Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: Oxyradical overload diseases
    • S.P. Hussain, K. Raja, and P.A. Amstad Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases Proc Natl Acad Sci USA 97 2000 12770
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12770
    • Hussain, S.P.1    Raja, K.2    Amstad, P.A.3
  • 88
    • 0032065356 scopus 로고    scopus 로고
    • Immunohistochemical detection of 4-hydroxy-2-nonenal-modified-protein adducts in human alcoholic liver diseases
    • M. Ohhira, T. Ohtake, and A. Matsumoto Immunohistochemical detection of 4-hydroxy-2-nonenal-modified-protein adducts in human alcoholic liver diseases Alcohol Clin Exp Res 22 1998 145S
    • (1998) Alcohol Clin Exp Res , vol.22
    • Ohhira, M.1    Ohtake, T.2    Matsumoto, A.3
  • 89
    • 0027234615 scopus 로고
    • Hepatic mitochondrial energy production in rats with chronic iron overload
    • B.R. Bacon, R. O'Neill, and R.S. Britton Hepatic mitochondrial energy production in rats with chronic iron overload Gastroenterology 105 1993 1134
    • (1993) Gastroenterology , vol.105 , pp. 1134
    • Bacon, B.R.1    O'Neill, R.2    Britton, R.S.3
  • 90
    • 0037321181 scopus 로고    scopus 로고
    • Protective effect of desferrioxamine during canine liver transplantation: Significance of peritransplant liver biopsy
    • K. Park, K.Y. Chung, and S.H. Sung Protective effect of desferrioxamine during canine liver transplantation: significance of peritransplant liver biopsy Transplant Proc 35 2003 117
    • (2003) Transplant Proc , vol.35 , pp. 117
    • Park, K.1    Chung, K.Y.2    Sung, S.H.3
  • 91
    • 0025296596 scopus 로고
    • Liver gene expression during chronic dietary iron overload in rats
    • A. Pietrangelo, E. Rocchi, and L. Schiaffonati Liver gene expression during chronic dietary iron overload in rats Hepatology 11 1990 798
    • (1990) Hepatology , vol.11 , pp. 798
    • Pietrangelo, A.1    Rocchi, E.2    Schiaffonati, L.3
  • 92
    • 0028347059 scopus 로고
    • Antioxidant status and lipid peroxidation in hereditary haemochromatosis
    • I.S. Young, T.G. Trouton, and J.J. Torney Antioxidant status and lipid peroxidation in hereditary haemochromatosis Free Radic Biol Med 16 1994 393
    • (1994) Free Radic Biol Med , vol.16 , pp. 393
    • Young, I.S.1    Trouton, T.G.2    Torney, J.J.3
  • 93
    • 0028792178 scopus 로고
    • Antioxidant activity of silybin in vivo during long-term iron overload in rats
    • A. Pietrangelo, F. Borella, and G. Casalgrandi Antioxidant activity of silybin in vivo during long-term iron overload in rats Gastroenterology 109 1995 1941
    • (1995) Gastroenterology , vol.109 , pp. 1941
    • Pietrangelo, A.1    Borella, F.2    Casalgrandi, G.3
  • 94
    • 0027974170 scopus 로고
    • TGF-beta and collagen-alpha 1 (I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload
    • K. Houglum, P. Bedossa, and M. Chojkier TGF-beta and collagen-alpha 1 (I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload Am J Physiol 267 1994 G908
    • (1994) Am J Physiol , vol.267 , pp. 908
    • Houglum, K.1    Bedossa, P.2    Chojkier, M.3
  • 95
    • 0022368621 scopus 로고
    • Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis
    • C. Niederau, R. Fischer, and A. Sonnenberg Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis N Engl J Med 313 1985 1256
    • (1985) N Engl J Med , vol.313 , pp. 1256
    • Niederau, C.1    Fischer, R.2    Sonnenberg, A.3
  • 96
    • 0035824070 scopus 로고    scopus 로고
    • Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma
    • A.J. Marrogi, M.A. Khan, and H.E. van Gijssel Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma J Natl Cancer Inst 93 2001 1652
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1652
    • Marrogi, A.J.1    Khan, M.A.2    Van Gijssel, H.E.3
  • 97
    • 0028888151 scopus 로고
    • Plasma copper and antioxidant status in Wilson's disease
    • H. Ogihara, T. Ogihara, and M. Miki Plasma copper and antioxidant status in Wilson's disease Pediatr Res 37 1995 219
    • (1995) Pediatr Res , vol.37 , pp. 219
    • Ogihara, H.1    Ogihara, T.2    Miki, M.3
  • 98
    • 0027943858 scopus 로고
    • Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis
    • R.J. Sokol, D. Twedt, and J.M. McKim Jr. Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis Gastroenterology 107 1994 1788
    • (1994) Gastroenterology , vol.107 , pp. 1788
    • Sokol, R.J.1    Twedt, D.2    McKim Jr., J.M.3
  • 99
    • 0031948085 scopus 로고    scopus 로고
    • Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis
    • J. Nair, P.L. Carmichael, and R.C. Fernando Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis Cancer Epidemiol Biomarkers Prev 7 1998 435
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , pp. 435
    • Nair, J.1    Carmichael, P.L.2    Fernando, R.C.3
  • 100
    • 0036304261 scopus 로고    scopus 로고
    • Mode of cell death after acetaminophen overdose in mice: Apoptosis or oncotic necrosis?
    • J.S. Gujral, T.R. Knight, and A. Farhood Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci 67 2002 322
    • (2002) Toxicol Sci , vol.67 , pp. 322
    • Gujral, J.S.1    Knight, T.R.2    Farhood, A.3
  • 101
    • 0021308996 scopus 로고
    • Acetaminophen hepatotoxicity
    • M. Black Acetaminophen hepatotoxicity Annu Rev Med 35 1984 577
    • (1984) Annu Rev Med , vol.35 , pp. 577
    • Black, M.1
  • 103
    • 0032504193 scopus 로고    scopus 로고
    • Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry
    • Y. Qiu, L.Z. Benet, and A.L. Burlingame Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry J Biol Chem 273 1998 17940
    • (1998) J Biol Chem , vol.273 , pp. 17940
    • Qiu, Y.1    Benet, L.Z.2    Burlingame, A.L.3
  • 104
    • 0023037216 scopus 로고
    • Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver
    • D.L. Laskin, and A.M. Pilaro Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver Toxicol Appl Pharmacol 86 1986 204
    • (1986) Toxicol Appl Pharmacol , vol.86 , pp. 204
    • Laskin, D.L.1    Pilaro, A.M.2
  • 105
    • 0022968021 scopus 로고
    • Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation
    • D.L. Laskin, A.M. Pilaro, and S. Ji Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation Toxicol Appl Pharmacol 86 1986 216
    • (1986) Toxicol Appl Pharmacol , vol.86 , pp. 216
    • Laskin, D.L.1    Pilaro, A.M.2    Ji, S.3
  • 106
    • 0031802829 scopus 로고    scopus 로고
    • Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice
    • J.A. Hinson, S.L. Pike, and N.R. Pumford Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice Chem Res Toxicol 11 1998 604
    • (1998) Chem Res Toxicol , vol.11 , pp. 604
    • Hinson, J.A.1    Pike, S.L.2    Pumford, N.R.3
  • 107
    • 0033974969 scopus 로고    scopus 로고
    • Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice
    • J.A. Hinson, S.L. Michael, and S.G. Ault Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice Toxicol Sci 53 2000 467
    • (2000) Toxicol Sci , vol.53 , pp. 467
    • Hinson, J.A.1    Michael, S.L.2    Ault, S.G.3
  • 108
    • 0033000310 scopus 로고    scopus 로고
    • Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species
    • S.L. Michael, N.R. Pumford, and P.R. Mayeux Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species Hepatology 30 1999 186
    • (1999) Hepatology , vol.30 , pp. 186
    • Michael, S.L.1    Pumford, N.R.2    Mayeux, P.R.3
  • 109
    • 0034894722 scopus 로고    scopus 로고
    • Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: Role of mitochondrial oxidant stress
    • T.R. Knight, A. Kurtz, and M.L. Bajt Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress Toxicol Sci 62 2001 212
    • (2001) Toxicol Sci , vol.62 , pp. 212
    • Knight, T.R.1    Kurtz, A.2    Bajt, M.L.3
  • 110
    • 0031890184 scopus 로고    scopus 로고
    • Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat
    • C.R. Gardner, D.E. Heck, and C.S. Yang Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat Hepatology 27 1998 748
    • (1998) Hepatology , vol.27 , pp. 748
    • Gardner, C.R.1    Heck, D.E.2    Yang, C.S.3
  • 111
    • 0036408857 scopus 로고    scopus 로고
    • Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: Potential role of tumor necrosis factor-alpha and interleukin-10
    • C.R. Gardner, J.D. Laskin, and D.M. Dambach Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10 Toxicol Appl Pharmacol 184 2002 27
    • (2002) Toxicol Appl Pharmacol , vol.184 , pp. 27
    • Gardner, C.R.1    Laskin, J.D.2    Dambach, D.M.3
  • 112
    • 0037308128 scopus 로고    scopus 로고
    • The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen- induced hepatotoxicity in mice
    • J. Liu, C. Li, and M.P. Waalkes The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice Hepatology 37 2003 324
    • (2003) Hepatology , vol.37 , pp. 324
    • Liu, J.1    Li, C.2    Waalkes, M.P.3
  • 113
    • 0021224354 scopus 로고
    • Mechanism of action of paracetamol protective agents in mice in vivo
    • J.O. Miners, R. Drew, and D.J. Birkett Mechanism of action of paracetamol protective agents in mice in vivo Biochem Pharmacol 33 1984 2995
    • (1984) Biochem Pharmacol , vol.33 , pp. 2995
    • Miners, J.O.1    Drew, R.2    Birkett, D.J.3
  • 114
    • 0018713564 scopus 로고
    • Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation
    • A.R. Buckpitt, D.E. Rollins, and J.R. Mitchell Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation Biochem Pharmacol 28 1979 2941
    • (1979) Biochem Pharmacol , vol.28 , pp. 2941
    • Buckpitt, A.R.1    Rollins, D.E.2    Mitchell, J.R.3
  • 115
    • 0019388365 scopus 로고
    • Sulfate depletion after acetaminophen administration and replenishment by infusion of sodium sulfate or N-acetylcysteine in rats
    • J.H. Lin, and G. Levy Sulfate depletion after acetaminophen administration and replenishment by infusion of sodium sulfate or N-acetylcysteine in rats Biochem Pharmacol 30 1981 2723
    • (1981) Biochem Pharmacol , vol.30 , pp. 2723
    • Lin, J.H.1    Levy, G.2
  • 116
    • 0025291687 scopus 로고
    • Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine
    • P.M. Harrison, R. Keays, and G.P. Bray Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine Lancet 335 1990 1572
    • (1990) Lancet , vol.335 , pp. 1572
    • Harrison, P.M.1    Keays, R.2    Bray, G.P.3
  • 117
    • 0025946778 scopus 로고
    • Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: A prospective controlled trial
    • R. Keays, P.M. Harrison, and J.A. Wendon Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial BMJ 303 1991 1026
    • (1991) BMJ , vol.303 , pp. 1026
    • Keays, R.1    Harrison, P.M.2    Wendon, J.A.3
  • 118
    • 0026432652 scopus 로고
    • Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure
    • P.M. Harrison, J.A. Wendon, and A.E. Gimson Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure N Engl J Med 324 1991 1852
    • (1991) N Engl J Med , vol.324 , pp. 1852
    • Harrison, P.M.1    Wendon, J.A.2    Gimson, A.E.3
  • 119
    • 0038580372 scopus 로고    scopus 로고
    • Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling
    • M.J. Czaja, H. Liu, and Y. Wang Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling Hepatology 37 2003 1405
    • (2003) Hepatology , vol.37 , pp. 1405
    • Czaja, M.J.1    Liu, H.2    Wang, Y.3
  • 120
    • 0030995732 scopus 로고    scopus 로고
    • Differential activation of heat shock and nuclear factor kappaB transcription factors in postischemic reperfused rat liver
    • L. Tacchini, L. Radice, and G. Pogliaghi Differential activation of heat shock and nuclear factor kappaB transcription factors in postischemic reperfused rat liver Hepatology 26 1997 186
    • (1997) Hepatology , vol.26 , pp. 186
    • Tacchini, L.1    Radice, L.2    Pogliaghi, G.3
  • 121
    • 0036628949 scopus 로고    scopus 로고
    • Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells
    • K.T. Morgan, H. Ni, and H.R. Brown Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells Toxicol Pathol 30 2002 435
    • (2002) Toxicol Pathol , vol.30 , pp. 435
    • Morgan, K.T.1    Ni, H.2    Brown, H.R.3
  • 122
    • 1642464018 scopus 로고    scopus 로고
    • A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells
    • I. Paron, A. D'Elia, and C. D'Ambrosio A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells Biochem J 378 2004 929
    • (2004) Biochem J , vol.378 , pp. 929
    • Paron, I.1    D'Elia, A.2    D'Ambrosio, C.3
  • 123
    • 33745065775 scopus 로고    scopus 로고
    • Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation
    • C. Vascotto, L. Cesaratto, and C. D'Ambrosio Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation Proteomics 6 2006 3455
    • (2006) Proteomics , vol.6 , pp. 3455
    • Vascotto, C.1    Cesaratto, L.2    D'Ambrosio, C.3
  • 124
    • 34547556622 scopus 로고    scopus 로고
    • Redox proteomics and immunohistology to study molecular events during ischemia-reperfusion in human liver
    • C. Avellini, U. Baccarani, and G. Trevisan Redox proteomics and immunohistology to study molecular events during ischemia-reperfusion in human liver Transplant Proc 39 2007 1755
    • (2007) Transplant Proc , vol.39 , pp. 1755
    • Avellini, C.1    Baccarani, U.2    Trevisan, G.3
  • 125
    • 25144463539 scopus 로고    scopus 로고
    • The contemporary role of antioxidant therapy in attenuating liver ischemia-reperfusion injury: A review
    • G.K. Glantzounis, H.J. Salacinski, and W. Yang The contemporary role of antioxidant therapy in attenuating liver ischemia-reperfusion injury: a review Liver Transpl 11 2005 1031
    • (2005) Liver Transpl , vol.11 , pp. 1031
    • Glantzounis, G.K.1    Salacinski, H.J.2    Yang, W.3
  • 126
    • 0027490562 scopus 로고
    • Alcohol-induced toxic hepatitis-a "free radical" associated disease. Lowering fatality by adjuvant antioxidant therapy
    • G. Wenzel, B. Kuklinski, and C. Ruhlmann [Alcohol-induced toxic hepatitis-a "free radical" associated disease. Lowering fatality by adjuvant antioxidant therapy] Z Gesamte Inn Med 48 1993 490
    • (1993) Z Gesamte Inn Med , vol.48 , pp. 490
    • Wenzel, G.1    Kuklinski, B.2    Ruhlmann, C.3
  • 127
    • 33644882812 scopus 로고    scopus 로고
    • Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis-a randomised clinical trial
    • M. Phillips, H. Curtis, and B. Portmann Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis-a randomised clinical trial J Hepatol 44 2006 784
    • (2006) J Hepatol , vol.44 , pp. 784
    • Phillips, M.1    Curtis, H.2    Portmann, B.3
  • 128
    • 34347401402 scopus 로고    scopus 로고
    • A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis
    • S. Stewart, M. Prince, and M. Bassendine A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis J Hepatol 47 2007 277
    • (2007) J Hepatol , vol.47 , pp. 277
    • Stewart, S.1    Prince, M.2    Bassendine, M.3
  • 129
    • 0028916565 scopus 로고
    • Effects of long-term vitamin e supplementation in alcoholic cirrhotics
    • M.P. de la Maza, M. Petermann, and D. Bunout Effects of long-term vitamin E supplementation in alcoholic cirrhotics J Am Coll Nutr 14 1995 192
    • (1995) J Am Coll Nutr , vol.14 , pp. 192
    • De La Maza, M.P.1    Petermann, M.2    Bunout, D.3
  • 130
    • 0347950972 scopus 로고    scopus 로고
    • A randomized placebo controlled trial of vitamin e for alcoholic hepatitis
    • E. Mezey, J.J. Potter, and L. Rennie-Tankersley A randomized placebo controlled trial of vitamin E for alcoholic hepatitis J Hepatol 40 2004 40
    • (2004) J Hepatol , vol.40 , pp. 40
    • Mezey, E.1    Potter, J.J.2    Rennie-Tankersley, L.3
  • 131
    • 19944427642 scopus 로고    scopus 로고
    • Meta-analysis: High-dosage vitamin e supplementation may increase all-cause mortality
    • E.R. Miller 3rd, R. Pastor-Barriuso, and D. Dalal Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality Ann Intern Med 142 2005 37
    • (2005) Ann Intern Med , vol.142 , pp. 37
    • Miller III, E.R.1    Pastor-Barriuso, R.2    Dalal, D.3
  • 132
    • 0344867846 scopus 로고    scopus 로고
    • S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multicenter clinical trial
    • J.M. Mato, J. Camara, and J. Fernandez de Paz S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial J Hepatol 30 1999 1081
    • (1999) J Hepatol , vol.30 , pp. 1081
    • Mato, J.M.1    Camara, J.2    Fernandez De Paz, J.3
  • 133
    • 0242487635 scopus 로고    scopus 로고
    • N-acetylcysteine in the treatment of non-alcoholic steatohepatitis
    • G.E. Pamuk, and A. Sonsuz N-acetylcysteine in the treatment of non-alcoholic steatohepatitis J Gastroenterol Hepatol 18 2003 1220
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1220
    • Pamuk, G.E.1    Sonsuz, A.2
  • 134
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin e treatment of nonalcoholic steatohepatitis in children: A pilot study
    • J.E. Lavine Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study J Pediatr 136 2000 734
    • (2000) J Pediatr , vol.136 , pp. 734
    • Lavine, J.E.1
  • 135
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin e and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • S.A. Harrison, S. Torgerson, and P. Hayashi Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis Am J Gastroenterol 98 2003 2485
    • (2003) Am J Gastroenterol , vol.98 , pp. 2485
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3
  • 136
    • 14944359845 scopus 로고    scopus 로고
    • A pilot study of vitamin e versus vitamin e and pioglitazone for the treatment of nonalcoholic steatohepatitis
    • A.J. Sanyal, P.S. Mofrad, and M.J. Contos A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis Clin Gastroenterol Hepatol 2 2004 1107
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 1107
    • Sanyal, A.J.1    Mofrad, P.S.2    Contos, M.J.3
  • 137
    • 3142634597 scopus 로고    scopus 로고
    • Vitamin e treatment in pediatric obesity-related liver disease: A randomized study
    • P. Vajro, C. Mandato, and A. Franzese Vitamin E treatment in pediatric obesity-related liver disease: a randomized study J Pediatr Gastroenterol Nutr 38 2004 48
    • (2004) J Pediatr Gastroenterol Nutr , vol.38 , pp. 48
    • Vajro, P.1    Mandato, C.2    Franzese, A.3
  • 138
    • 34249053143 scopus 로고    scopus 로고
    • Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis
    • F. Lirussi, L. Azzalini, and S. Orando Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis Cochrane Database Syst Rev 2007 CD004996
    • (2007) Cochrane Database Syst Rev
    • Lirussi, F.1    Azzalini, L.2    Orando, S.3
  • 139
    • 0031460937 scopus 로고    scopus 로고
    • Vitamin e improves the aminotransferase status of patients suffering from viral hepatitis C: A randomized, double-blind, placebo-controlled study
    • A. von Herbay, W. Stahl, and C. Niederau Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C: a randomized, double-blind, placebo-controlled study Free Radic Res 27 1997 599
    • (1997) Free Radic Res , vol.27 , pp. 599
    • Von Herbay, A.1    Stahl, W.2    Niederau, C.3
  • 140
    • 0032832659 scopus 로고    scopus 로고
    • Interferon/antioxidant combination therapy for chronic hepatitis C-a controlled pilot trial
    • M.P. Look, A. Gerard, and G.S. Rao Interferon/antioxidant combination therapy for chronic hepatitis C-a controlled pilot trial Antiviral Res 43 1999 113
    • (1999) Antiviral Res , vol.43 , pp. 113
    • Look, M.P.1    Gerard, A.2    Rao, G.S.3
  • 141
    • 23844479925 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C virus infection via antioxidants: Results of a phase i clinical trial
    • A. Melhem, M. Stern, and O. Shibolet Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial J Clin Gastroenterol 39 2005 737
    • (2005) J Clin Gastroenterol , vol.39 , pp. 737
    • Melhem, A.1    Stern, M.2    Shibolet, O.3
  • 142
    • 35248848237 scopus 로고    scopus 로고
    • Antioxidant therapy for chronic hepatitis C after failure of interferon: Results of phase II randomized, double-blind placebo controlled clinical trial
    • E. Gabbay, E. Zigmond, and O. Pappo Antioxidant therapy for chronic hepatitis C after failure of interferon: results of phase II randomized, double-blind placebo controlled clinical trial World J Gastroenterol 13 2007 5317
    • (2007) World J Gastroenterol , vol.13 , pp. 5317
    • Gabbay, E.1    Zigmond, E.2    Pappo, O.3
  • 143
    • 0036784399 scopus 로고    scopus 로고
    • The European perspective on vitamin E: Current knowledge and future research
    • R. Brigelius-Flohe, F.J. Kelly, and J.T. Salonen The European perspective on vitamin E: current knowledge and future research Am J Clin Nutr 76 2002 703
    • (2002) Am J Clin Nutr , vol.76 , pp. 703
    • Brigelius-Flohe, R.1    Kelly, F.J.2    Salonen, J.T.3
  • 144
    • 0036791126 scopus 로고    scopus 로고
    • Vitamin e inhibits hepatic NF-kappaB activation in rats administered the hepatic tumor promoter, phenobarbital
    • K.G. Calfee-Mason, B.T. Spear, and H.P. Glauert Vitamin E inhibits hepatic NF-kappaB activation in rats administered the hepatic tumor promoter, phenobarbital J Nutr 132 2002 3178
    • (2002) J Nutr , vol.132 , pp. 3178
    • Calfee-Mason, K.G.1    Spear, B.T.2    Glauert, H.P.3
  • 145
    • 0036244669 scopus 로고    scopus 로고
    • The 80th anniversary of vitamin E: Beyond its antioxidant properties
    • R. Ricciarelli, J.M. Zingg, and A. Azzi The 80th anniversary of vitamin E: beyond its antioxidant properties Biol Chem 383 2002 457
    • (2002) Biol Chem , vol.383 , pp. 457
    • Ricciarelli, R.1    Zingg, J.M.2    Azzi, A.3
  • 146
    • 0036605547 scopus 로고    scopus 로고
    • Alpha-tocopherol increases the intracellular glutathione level in HaCaT keratinocytes
    • H. Masaki, Y. Okano, and Y. Ochiai alpha-tocopherol increases the intracellular glutathione level in HaCaT keratinocytes Free Radic Res 36 2002 705
    • (2002) Free Radic Res , vol.36 , pp. 705
    • Masaki, H.1    Okano, Y.2    Ochiai, Y.3
  • 147
    • 0021338370 scopus 로고
    • Changes in the levels of endogenous coenzyme Q homologs, alpha-tocopherol, and glutathione in rat liver after hepatic ischemia and reperfusion, and the effect of pretreatment with coenzyme Q10
    • S. Marubayashi, K. Dohi, and K. Yamada Changes in the levels of endogenous coenzyme Q homologs, alpha-tocopherol, and glutathione in rat liver after hepatic ischemia and reperfusion, and the effect of pretreatment with coenzyme Q10 Biochim Biophys Acta 797 1984 1
    • (1984) Biochim Biophys Acta , vol.797 , pp. 1
    • Marubayashi, S.1    Dohi, K.2    Yamada, K.3
  • 148
    • 0034959502 scopus 로고    scopus 로고
    • Oxidative stress in fatty livers of obese Zucker rats: Rapid amelioration and improved tolerance to warm ischemia with tocopherol
    • K. Soltys, G. Dikdan, and B. Koneru Oxidative stress in fatty livers of obese Zucker rats: rapid amelioration and improved tolerance to warm ischemia with tocopherol Hepatology 34 2001 13
    • (2001) Hepatology , vol.34 , pp. 13
    • Soltys, K.1    Dikdan, G.2    Koneru, B.3
  • 149
    • 0035998984 scopus 로고    scopus 로고
    • Reduction of ischemia-reperfusion injury in parenchymal and nonparenchymal liver cells by donor treatment with DL-alpha-tocopherol prior to organ harvest
    • G.E. Gondolesi, N. Lausada, and G. Schinella Reduction of ischemia-reperfusion injury in parenchymal and nonparenchymal liver cells by donor treatment with DL-alpha-tocopherol prior to organ harvest Transplant Proc 34 2002 1086
    • (2002) Transplant Proc , vol.34 , pp. 1086
    • Gondolesi, G.E.1    Lausada, N.2    Schinella, G.3
  • 150
    • 0038680423 scopus 로고    scopus 로고
    • Trolox C ameliorates hepatic drug metabolizing dysfunction after ischemia/reperfusion
    • H.A. Eum, S.H. Lee, and S.M. Lee Trolox C ameliorates hepatic drug metabolizing dysfunction after ischemia/reperfusion Arch Pharm Res 25 2002 940
    • (2002) Arch Pharm Res , vol.25 , pp. 940
    • Eum, H.A.1    Lee, S.H.2    Lee, S.M.3
  • 151
    • 0031736037 scopus 로고    scopus 로고
    • The effect of alpha-tocopherol and pentoxyfilline on ischemia-reperfusion induced liver injury in rats
    • E. Vardareli, T. Saricam, and T. Koken The effect of alpha-tocopherol and pentoxyfilline on ischemia-reperfusion induced liver injury in rats Hepatogastroenterology 45 1998 1505
    • (1998) Hepatogastroenterology , vol.45 , pp. 1505
    • Vardareli, E.1    Saricam, T.2    Koken, T.3
  • 152
    • 0036128306 scopus 로고    scopus 로고
    • Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats
    • M.Y. Seo, and S.M. Lee Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats J Hepatol 36 2002 72
    • (2002) J Hepatol , vol.36 , pp. 72
    • Seo, M.Y.1    Lee, S.M.2
  • 153
    • 0032768157 scopus 로고    scopus 로고
    • Normothermic liver ischemia and antioxidant treatment during hepatic resections
    • H. Cerwenka, G. Khoschsorur, and H. Bacher Normothermic liver ischemia and antioxidant treatment during hepatic resections Free Radic Res 30 1999 463
    • (1999) Free Radic Res , vol.30 , pp. 463
    • Cerwenka, H.1    Khoschsorur, G.2    Bacher, H.3
  • 154
    • 0034781638 scopus 로고    scopus 로고
    • Effect of exogenous melatonin on hepatic energetic status during ischemia/reperfusion: Possible role of tumor necrosis factor-alpha and nitric oxide
    • S. Rodriguez-Reynoso, C. Leal, and E. Portilla Effect of exogenous melatonin on hepatic energetic status during ischemia/reperfusion: possible role of tumor necrosis factor-alpha and nitric oxide J Surg Res 100 2001 141
    • (2001) J Surg Res , vol.100 , pp. 141
    • Rodriguez-Reynoso, S.1    Leal, C.2    Portilla, E.3
  • 155
    • 0037404928 scopus 로고    scopus 로고
    • Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion
    • J.C. Chen, C.J. Ng, and T.F. Chiu Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion J Pineal Res 34 2003 260
    • (2003) J Pineal Res , vol.34 , pp. 260
    • Chen, J.C.1    Ng, C.J.2    Chiu, T.F.3
  • 156
    • 0025142530 scopus 로고
    • Comparison of superoxide dismutase, allopurinol, coenzyme Q10, and glutathione for the prevention of warm ischemic injury
    • W.H. Cho, D.G. Kim, and N. Murase Comparison of superoxide dismutase, allopurinol, coenzyme Q10, and glutathione for the prevention of warm ischemic injury Transplantation 50 1990 353
    • (1990) Transplantation , vol.50 , pp. 353
    • Cho, W.H.1    Kim, D.G.2    Murase, N.3
  • 157
    • 1842535023 scopus 로고    scopus 로고
    • Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation
    • R.J. Schauer, S. Kalmuk, and A.L. Gerbes Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation World J Gastroenterol 10 2004 864
    • (2004) World J Gastroenterol , vol.10 , pp. 864
    • Schauer, R.J.1    Kalmuk, S.2    Gerbes, A.L.3
  • 158
    • 0842305753 scopus 로고    scopus 로고
    • Glutathione protects the rat liver against reperfusion injury after prolonged warm ischemia
    • R.J. Schauer, A.L. Gerbes, and D. Vonier Glutathione protects the rat liver against reperfusion injury after prolonged warm ischemia Ann Surg 239 2004 220
    • (2004) Ann Surg , vol.239 , pp. 220
    • Schauer, R.J.1    Gerbes, A.L.2    Vonier, D.3
  • 159
    • 0032973296 scopus 로고    scopus 로고
    • Free radical scavengers to prevent reperfusion injury following experimental warm liver ischaemia. Is there a real physiological benefit?
    • R. Chavez-Cartaya, N.V. Jamieson, and P. Ramirez Free radical scavengers to prevent reperfusion injury following experimental warm liver ischaemia. Is there a real physiological benefit? Transpl Int 12 1999 213
    • (1999) Transpl Int , vol.12 , pp. 213
    • Chavez-Cartaya, R.1    Jamieson, N.V.2    Ramirez, P.3
  • 160
    • 0029890763 scopus 로고    scopus 로고
    • Improvement of hepatic microhemodynamics by N-acetylcysteine after warm ischemia
    • T.A. Koeppel, J.C. Thies, and T. Lehmann Improvement of hepatic microhemodynamics by N-acetylcysteine after warm ischemia Eur Surg Res 28 1996 270
    • (1996) Eur Surg Res , vol.28 , pp. 270
    • Koeppel, T.A.1    Thies, J.C.2    Lehmann, T.3
  • 161
    • 0023029952 scopus 로고
    • Lung protection by a thiol-containing antioxidant: N-acetylcysteine
    • P. Moldeus, I.A. Cotgreave, and M. Berggren Lung protection by a thiol-containing antioxidant: N-acetylcysteine Respiration 1 50 Suppl 1986 31
    • (1986) Respiration , vol.1 , Issue.50 SUPPL. , pp. 31
    • Moldeus, P.1    Cotgreave, I.A.2    Berggren, M.3
  • 162
    • 4944231808 scopus 로고    scopus 로고
    • Continuous infusion of N-acetylcysteine reduces liver warm ischaemia-reperfusion injury
    • G.K. Glantzounis, W. Yang, and R.S. Koti Continuous infusion of N-acetylcysteine reduces liver warm ischaemia-reperfusion injury Br J Surg 91 2004 1330
    • (2004) Br J Surg , vol.91 , pp. 1330
    • Glantzounis, G.K.1    Yang, W.2    Koti, R.S.3
  • 163
    • 0031608982 scopus 로고    scopus 로고
    • The efficacy of N-acetylcysteine as a hepatoprotective agent in liver transplantation
    • J.C. Thies, J. Teklote, and U. Clauer The efficacy of N-acetylcysteine as a hepatoprotective agent in liver transplantation Transpl Int 1 11 Suppl 1998 S390
    • (1998) Transpl Int , vol.1 , Issue.11 SUPPL. , pp. 390
    • Thies, J.C.1    Teklote, J.2    Clauer, U.3
  • 164
    • 0034933440 scopus 로고    scopus 로고
    • Effect of treatment with prostaglandin E1 and N-acetylcysteine on pediatric liver transplant recipients: A single-center study
    • J.C. Bucuvalas, F.C. Ryckman, and S. Krug Effect of treatment with prostaglandin E1 and N-acetylcysteine on pediatric liver transplant recipients: a single-center study Pediatr Transplant 5 2001 274
    • (2001) Pediatr Transplant , vol.5 , pp. 274
    • Bucuvalas, J.C.1    Ryckman, F.C.2    Krug, S.3
  • 165
    • 0035959375 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates the increase in alpha-glutathione S-transferase and circulating ICAM-1 and VCAM-1 after reperfusion in humans undergoing liver transplantation
    • M.A. Weigand, J. Plachky, and J.C. Thies N-acetylcysteine attenuates the increase in alpha-glutathione S-transferase and circulating ICAM-1 and VCAM-1 after reperfusion in humans undergoing liver transplantation Transplantation 72 2001 694
    • (2001) Transplantation , vol.72 , pp. 694
    • Weigand, M.A.1    Plachky, J.2    Thies, J.C.3
  • 166
    • 0022405820 scopus 로고
    • Influence of oxygen-derived free radical scavengers on ischemic livers
    • S.L. Atalla, L.H. Toledo-Pereyra, and G.H. MacKenzie Influence of oxygen-derived free radical scavengers on ischemic livers Transplantation 40 1985 584
    • (1985) Transplantation , vol.40 , pp. 584
    • Atalla, S.L.1    Toledo-Pereyra, L.H.2    MacKenzie, G.H.3
  • 167
    • 0025061807 scopus 로고
    • Oxygen-derived free radicals in hepatic ischemia and reperfusion injury in the rat
    • R.J. Nauta, E. Tsimoyiannis, and M. Uribe Oxygen-derived free radicals in hepatic ischemia and reperfusion injury in the rat Surg Gynecol Obstet 171 1990 120
    • (1990) Surg Gynecol Obstet , vol.171 , pp. 120
    • Nauta, R.J.1    Tsimoyiannis, E.2    Uribe, M.3
  • 169
    • 0027051029 scopus 로고
    • Evaluation of antioxidant treatment with superoxide dismutase in rat liver transplantation after warm ischemia
    • T. Minor, C.W. Chung, and Y. Yamamoto Evaluation of antioxidant treatment with superoxide dismutase in rat liver transplantation after warm ischemia Eur Surg Res 24 1992 333
    • (1992) Eur Surg Res , vol.24 , pp. 333
    • Minor, T.1    Chung, C.W.2    Yamamoto, Y.3
  • 170
    • 0038047046 scopus 로고    scopus 로고
    • Role of inducible nitric oxide synthase in pig liver transplantation
    • H. Kimura, T. Katsuramaki, and M. Isobe Role of inducible nitric oxide synthase in pig liver transplantation J Surg Res 111 2003 28
    • (2003) J Surg Res , vol.111 , pp. 28
    • Kimura, H.1    Katsuramaki, T.2    Isobe, M.3
  • 171
    • 0032747347 scopus 로고    scopus 로고
    • Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury
    • O. Portakal, and M. Inal-Erden Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury Clin Biochem 32 1999 461
    • (1999) Clin Biochem , vol.32 , pp. 461
    • Portakal, O.1    Inal-Erden, M.2
  • 172
    • 0344836057 scopus 로고    scopus 로고
    • Suppression of leukocyte-enhanced cold ischemia/reperfusion injury of liver endothelium with the benzoquinone antioxidant idebenone
    • E. Schutz, E. Wieland, and A. Hensel Suppression of leukocyte-enhanced cold ischemia/reperfusion injury of liver endothelium with the benzoquinone antioxidant idebenone Clin Biochem 30 1997 619
    • (1997) Clin Biochem , vol.30 , pp. 619
    • Schutz, E.1    Wieland, E.2    Hensel, A.3
  • 173
    • 0141590207 scopus 로고    scopus 로고
    • Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway
    • C. Muller, F. Dunschede, and E. Koch Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway Am J Physiol Gastrointest Liver Physiol 285 2003 G769
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285 , pp. 769
    • Muller, C.1    Dunschede, F.2    Koch, E.3
  • 174
    • 0027545925 scopus 로고
    • Trimetazidine for prevention of hepatic injury induced by ischaemia and reperfusion in rats
    • E.C. Tsimoyiannis, K.J. Moutesidou, and C.M. Moschos Trimetazidine for prevention of hepatic injury induced by ischaemia and reperfusion in rats Eur J Surg 159 1993 89
    • (1993) Eur J Surg , vol.159 , pp. 89
    • Tsimoyiannis, E.C.1    Moutesidou, K.J.2    Moschos, C.M.3
  • 175
    • 0042845711 scopus 로고    scopus 로고
    • Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with quercetin
    • J.F. Su, C.J. Guo, and J.Y. Wei Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with quercetin Biomed Environ Sci 16 2003 1
    • (2003) Biomed Environ Sci , vol.16 , pp. 1
    • Su, J.F.1    Guo, C.J.2    Wei, J.Y.3
  • 176
    • 0036300243 scopus 로고    scopus 로고
    • Cyanidin 3-O-beta-D-glucoside attenuates the hepatic ischemia-reperfusion injury through a decrease in the neutrophil chemoattractant production in rats
    • T. Tsuda, F. Horio, and Y. Kato Cyanidin 3-O-beta-D-glucoside attenuates the hepatic ischemia-reperfusion injury through a decrease in the neutrophil chemoattractant production in rats J Nutr Sci Vitaminol (Tokyo) 48 2002 134
    • (2002) J Nutr Sci Vitaminol (Tokyo) , vol.48 , pp. 134
    • Tsuda, T.1    Horio, F.2    Kato, Y.3
  • 177
  • 178
    • 0037173011 scopus 로고    scopus 로고
    • Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury
    • F. Amersi, S.K. Nelson, and X.D. Shen Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury Proc Natl Acad Sci U S A 99 2002 8915
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8915
    • Amersi, F.1    Nelson, S.K.2    Shen, X.D.3
  • 179
    • 0032850003 scopus 로고    scopus 로고
    • Polyethylene glycol-superoxide dismutase inhibits lipid peroxidation in hepatic ischemia/reperfusion injury
    • W.D. Nguyen, D.H. Kim, and H.B. Alam Polyethylene glycol-superoxide dismutase inhibits lipid peroxidation in hepatic ischemia/reperfusion injury Crit Care 3 1999 127
    • (1999) Crit Care , vol.3 , pp. 127
    • Nguyen, W.D.1    Kim, D.H.2    Alam, H.B.3
  • 180
    • 0032902593 scopus 로고    scopus 로고
    • Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice
    • Y. Yabe, Y. Koyama, and M. Nishikawa Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice Free Radic Res 30 1999 265
    • (1999) Free Radic Res , vol.30 , pp. 265
    • Yabe, Y.1    Koyama, Y.2    Nishikawa, M.3
  • 181
    • 0035261453 scopus 로고    scopus 로고
    • Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver
    • B.R. Jeon, D.H. Yeom, and S.M. Lee Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver Shock 15 2001 112
    • (2001) Shock , vol.15 , pp. 112
    • Jeon, B.R.1    Yeom, D.H.2    Lee, S.M.3
  • 183
    • 0036635326 scopus 로고    scopus 로고
    • Intramuscular administration of very high dose of alpha-tocopherol protects liver from severe ischemia/reperfusion injury
    • D. Giakoustidis, G. Papageorgiou, and S. Iliadis Intramuscular administration of very high dose of alpha-tocopherol protects liver from severe ischemia/reperfusion injury World J Surg 26 2002 872
    • (2002) World J Surg , vol.26 , pp. 872
    • Giakoustidis, D.1    Papageorgiou, G.2    Iliadis, S.3
  • 184
    • 0344838587 scopus 로고    scopus 로고
    • Protective effect of Mangifera indica L. extract (Vimang) on the injury associated with hepatic ischaemia reperfusion
    • G.M. Sanchez, H.M. Rodriguez, and A. Giuliani Protective effect of Mangifera indica L. extract (Vimang) on the injury associated with hepatic ischaemia reperfusion Phytother Res 17 2003 197
    • (2003) Phytother Res , vol.17 , pp. 197
    • Sanchez, G.M.1    Rodriguez, H.M.2    Giuliani, A.3
  • 185
    • 0037414397 scopus 로고    scopus 로고
    • Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion
    • G. Sener, O. Tosun, and A.O. Sehirli Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion Life Sci 72 2003 2707
    • (2003) Life Sci , vol.72 , pp. 2707
    • Sener, G.1    Tosun, O.2    Sehirli, A.O.3


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