메뉴 건너뛰기




Volumn 9, Issue 4, 2014, Pages 1237-1241

Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway

Author keywords

Cell apoptosis; Lycium barbarum polysaccharides; Senescence; Zebrafish

Indexed keywords

ACRIDINE ORANGE; BETA ACTIN; BETA GALACTOSIDASE; HERBACEOUS AGENT; LYCIUM BARBARUM POLYSACCHARIDE; POLYSACCHARIDE; PROTEIN BAX; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

EID: 84896523087     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.1964     Document Type: Article
Times cited : (45)

References (38)
  • 1
    • 0142213542 scopus 로고    scopus 로고
    • The free radical theory of aging
    • Harman D: The free radical theory of aging. Antioxid Redox Signal 5: 557-561, 2003.
    • (2003) Antioxid Redox Signal , vol.5 , pp. 557-561
    • Harman, D.1
  • 2
    • 40949149823 scopus 로고    scopus 로고
    • Signaling networks in aging
    • DOI 10.1242/jcs.021519
    • Greer EL and Brunet A: Signaling networks in aging. J Cell Sci 121: 407-412, 2008. (Pubitemid 351405048)
    • (2008) Journal of Cell Science , vol.121 , Issue.4 , pp. 407-412
    • Greer, E.L.1    Brunet, A.2
  • 3
    • 0036752553 scopus 로고    scopus 로고
    • Natural extracts as possible protective agents of brain aging
    • DOI 10.1016/S0197-4580(02)00024-6, PII S0197458002000246
    • Bastianetto S and Quirion R: Natural extracts as possible protective agents of brain aging. Neurobiol Aging 23: 891-897, 2002. (Pubitemid 35217714)
    • (2002) Neurobiology of Aging , vol.23 , Issue.5 , pp. 891-897
    • Bastianetto, S.1    Quirion, R.2
  • 4
    • 0035034887 scopus 로고    scopus 로고
    • Anti-aging and health-promoting constituents derived from traditional oriental herbal remedies: Information retrieval using the TradiMed 2000 DB
    • Chang IM: Anti-aging and health-promoting constituents derived from traditional oriental herbal remedies: information retrieval using the TradiMed 2000 DB. Ann NY Acad Sci 928: 281-286, 2001.
    • (2001) Ann NY Acad Sci , vol.928 , pp. 281-286
    • Chang, I.M.1
  • 5
    • 0037756826 scopus 로고    scopus 로고
    • A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells
    • DOI 10.1016/S0014-2999(03)01827-2
    • Gan L, Zhang SH, Liu Q and Xu HB: A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells. Eur J Pharmacol 471: 217-222, 2003. (Pubitemid 36776417)
    • (2003) European Journal of Pharmacology , vol.471 , Issue.3 , pp. 217-222
    • Gan, L.1    Zhang, S.-H.2    Liu, Q.3    Xu, H.-B.4
  • 6
    • 34247259664 scopus 로고    scopus 로고
    • Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice
    • DOI 10.1016/j.jep.2006.12.024, PII S0378874106006775
    • Li XM, Ma YL and Liu XJ: Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J Ethnopharmacol 111: 504-511, 2007. (Pubitemid 46617095)
    • (2007) Journal of Ethnopharmacology , vol.111 , Issue.3 , pp. 504-511
    • Li, X.M.1    Ma, Y.L.2    Liu, X.J.3
  • 7
    • 13844299309 scopus 로고    scopus 로고
    • Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: Inhibition of proliferation and induction of apoptosis
    • DOI 10.1016/j.lfs.2004.11.009
    • Zhang M, Chen H, Huang J, Li Z, Zhu C and Zhang S: Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci 76: 2115-2124, 2005. (Pubitemid 40249369)
    • (2005) Life Sciences , vol.76 , Issue.18 , pp. 2115-2124
    • Zhang, M.1    Chen, H.2    Huang, J.3    Li, Z.4    Zhu, C.5    Zhang, S.6
  • 8
    • 27644476944 scopus 로고    scopus 로고
    • Experimental study on the enhancement of murine splenic lymphocyte proliferation by Lycium barbarum glycopeptide
    • Du G, Liu L and Fang J: Experimental study on the enhancement of murine splenic lymphocyte proliferation by Lycium barbarum glycopeptide. J Huazhong Univ Sci Technolog Med Sci 24: 518-520, 527, 2004.
    • (2004) J Huazhong Univ Sci Technolog Med Sci , vol.24
    • Du, G.1    Liu, L.2    Fang, J.3
  • 9
    • 77949501928 scopus 로고    scopus 로고
    • Intake of a milk-based wolfberry formulation enhances the immune response of young-adult and aged mice
    • Vidal K, Benyacoub J, Sanchez-Garcia J, et al: Intake of a milk-based wolfberry formulation enhances the immune response of young-adult and aged mice. Rejuvenation Res 13: 47-53, 2010.
    • (2010) Rejuvenation Res , vol.13 , pp. 47-53
    • Vidal, K.1    Benyacoub, J.2    Sanchez-Garcia, J.3
  • 10
    • 35448999375 scopus 로고    scopus 로고
    • Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity
    • Yu MS, Lai CS, Ho YS, et al: Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity. Int J Mol Med 20: 261-268, 2007.
    • (2007) Int J Mol Med , vol.20 , pp. 261-268
    • Yu, M.S.1    Lai, C.S.2    Ho, Y.S.3
  • 12
    • 79551517589 scopus 로고    scopus 로고
    • Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury
    • Li SY, Yang D, Yeung CM, et al: Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS One 6: e16380, 2011.
    • (2011) PLoS One , vol.6
    • Li, S.Y.1    Yang, D.2    Yeung, C.M.3
  • 13
    • 84871438199 scopus 로고    scopus 로고
    • Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L
    • Jin M, Huang Q, Zhao K and Shang P: Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L. Int J Biol Macromol 54: 16-23, 2013.
    • (2013) Int J Biol Macromol , vol.54 , pp. 16-23
    • Jin, M.1    Huang, Q.2    Zhao, K.3    Shang, P.4
  • 14
    • 0033552638 scopus 로고    scopus 로고
    • Twenty years of p53 research: Structural and functional aspects of the p53 protein
    • May P and May E: Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene 18: 7621-7636, 1999. (Pubitemid 30052689)
    • (1999) Oncogene , vol.18 , Issue.53 , pp. 7621-7636
    • May, P.1    May, E.2
  • 15
    • 84866085174 scopus 로고    scopus 로고
    • Lycium barbarum polysaccharide stimulates proliferation of MCF-7 cells by the ERK pathway
    • Shen L and Du G: Lycium barbarum polysaccharide stimulates proliferation of MCF-7 cells by the ERK pathway. Life Sci 91: 353-357, 2012.
    • (2012) Life Sci , vol.91 , pp. 353-357
    • Shen, L.1    Du, G.2
  • 16
    • 7944220591 scopus 로고    scopus 로고
    • The use of mature zebrafish (Danio rerio) as a model for human aging and disease
    • DOI 10.1016/j.cca.2004.04.001, PII S1532045604000699, Aquatic Animal Models of Human Disease
    • Keller ET and Murtha JM: The use of mature zebrafish (Danio rerio) as a model for human aging and disease. Comp Biochem Physiol C Toxicol Pharmacol 138: 335-341, 2004. (Pubitemid 39469068)
    • (2004) Comparative Biochemistry and Physiology - C Toxicology and Pharmacology , vol.138 , Issue.3 , pp. 335-341
    • Keller, E.T.1    Murtha, J.M.2
  • 19
    • 0036696549 scopus 로고    scopus 로고
    • Life spans and senescent phenotypes in two strains of zebrafish (Danio rerio)
    • Gerhard GS, Kauffman EJ, Wang X, et al: Life spans and senescent phenotypes in two strains of zebrafish (Danio rerio). Exp Gerontol 37: 1055-1068, 2002.
    • (2002) Exp Gerontol , vol.37 , pp. 1055-1068
    • Gerhard, G.S.1    Kauffman, E.J.2    Wang, X.3
  • 22
    • 7044271148 scopus 로고    scopus 로고
    • Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum
    • DOI 10.1016/j.lfs.2004.04.056, PII S0024320504007829
    • Luo Q, Cai Y, Yan J, Sun M and Corke H: Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci 76: 137-149, 2004. (Pubitemid 39425220)
    • (2004) Life Sciences , vol.76 , Issue.2 , pp. 137-149
    • Luo, Q.1    Cai, Y.2    Yan, J.3    Sun, M.4    Corke, H.5
  • 23
    • 50849120727 scopus 로고    scopus 로고
    • The identification of zebrafish mutants showing alterations in senescence-associated biomarkers
    • Kishi S, Bayliss PE, Uchiyama J, et al: The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet 4: e1000152, 2008.
    • (2008) PLoS Genet , vol.4
    • Kishi, S.1    Bayliss, P.E.2    Uchiyama, J.3
  • 25
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP, Lee X, Basile G, et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3
  • 26
    • 0037439071 scopus 로고    scopus 로고
    • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the brca1 full-length isoform
    • DOI 10.1101/gad.1050003
    • Cao L, Li W, Kim S, Brodie SG and Deng CX: Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev 17: 201-213, 2003. (Pubitemid 36105893)
    • (2003) Genes and Development , vol.17 , Issue.2 , pp. 201-213
    • Cao, L.1    Li, W.2    Kim, S.3    Brodie, S.G.4    Deng, C.-X.5
  • 27
    • 24344447780 scopus 로고    scopus 로고
    • p63 deficiency activates a program of cellular senescence and leads to accelerated aging
    • DOI 10.1101/gad.342305
    • Keyes WM, Wu Y, Vogel H, Guo X, Lowe SW and Mills AA: p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 19: 1986-1999, 2005. (Pubitemid 41247957)
    • (2005) Genes and Development , vol.19 , Issue.17 , pp. 1986-1999
    • Keyes, W.M.1    Wu, Y.2    Vogel, H.3    Guo, X.4    Lowe, S.W.5    Mills, A.A.6
  • 28
    • 0031267760 scopus 로고    scopus 로고
    • Activation of the metaphase checkpoint and an apoptosis programme in the early zebrafish embryo, by treatment with the spindle-destabilising agent nocodazole
    • Ikegami R, Zhang J, Rivera-Bennetts AK and Yager TD: Activation of the metaphase checkpoint and an apoptosis programme in the early zebrafish embryo, by treatment with the spindle-destabilising agent nocodazole. Zygote 5: 329-350, 1997. (Pubitemid 127594322)
    • (1997) Zygote , vol.5 , Issue.4 , pp. 329-350
    • Ikegami, R.1    Zhang, J.2    Rivera-Bennetts, A.K.3    Yager, T.D.4
  • 29
    • 1542781659 scopus 로고    scopus 로고
    • When cells get stressed: An integrative view of cellular senescence
    • DOI 10.1172/JCI200420663
    • Ben-Porath I and Weinberg RA: When cells get stressed: an integrative view of cellular senescence. J Clin Invest 113: 8-13, 2004. (Pubitemid 38541623)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.1 , pp. 8-13
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 30
    • 84877011170 scopus 로고    scopus 로고
    • The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy
    • Concetti F, Lucarini N, Carpi FM, et al: The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy. Exp Gerontol 48: 587-592, 2013.
    • (2013) Exp Gerontol , vol.48 , pp. 587-592
    • Concetti, F.1    Lucarini, N.2    Carpi, F.M.3
  • 31
    • 78650990326 scopus 로고    scopus 로고
    • Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
    • Jaskelioff M, Muller FL, Paik JH, et al: Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469: 102-106, 2011.
    • (2011) Nature , vol.469 , pp. 102-106
    • Jaskelioff, M.1    Muller, F.L.2    Paik, J.H.3
  • 33
    • 46149090121 scopus 로고    scopus 로고
    • Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?
    • DOI 10.1007/s10571-007-9181-x
    • Chang RC and So KF: Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell Mol Neurobiol 28: 643-652, 2008. (Pubitemid 351905068)
    • (2008) Cellular and Molecular Neurobiology , vol.28 , Issue.5 , pp. 643-652
    • Chang, R.C.-C.1    So, K.-F.2
  • 34
    • 74349093922 scopus 로고    scopus 로고
    • Goji (Lycium barbarum and L. Chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity
    • Potterat O: Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 76: 7-19, 2010.
    • (2010) Planta Med , vol.76 , pp. 7-19
    • Potterat, O.1
  • 35
    • 84863346634 scopus 로고    scopus 로고
    • Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke
    • Yang D, Li SY, Yeung CM, et al: Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke. PLoS One 7: e33596, 2012.
    • (2012) PLoS One , vol.7
    • Yang, D.1    Li, S.Y.2    Yeung, C.M.3
  • 36
    • 0037115548 scopus 로고    scopus 로고
    • Chemoradiation of cervical cancer cells: Targeting human papillomavirus E6 and p53 leads to either augmented or attenuated apoptosis depending on the platinum carrier ligand
    • Koivusalo R, Krausz E, Ruotsalainen P, Helenius H and Hietanen S: Chemoradiation of cervical cancer cells: targeting human papillomavirus E6 and p53 leads to either augmented or attenuated apoptosis depending on the platinum carrier ligand. Cancer Res 62: 7364-7371, 2002. (Pubitemid 36025260)
    • (2002) Cancer Research , vol.62 , Issue.24 , pp. 7364-7371
    • Koivusalo, R.1    Krausz, E.2    Ruotsalainen, P.3    Helenius, H.4    Hietanen, S.5
  • 37
    • 33846277976 scopus 로고    scopus 로고
    • p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: A novel target of p53 in apoptosis
    • DOI 10.1016/j.febslet.2006.12.035, PII S0014579306014931
    • Singh S, Upadhyay AK, Ajay AK and Bhat MK: p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis. FEBS Lett 581: 289-295, 2007. (Pubitemid 46110832)
    • (2007) FEBS Letters , vol.581 , Issue.2 , pp. 289-295
    • Singh, S.1    Upadhyay, A.K.2    Ajay, A.K.3    Bhat, M.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.