Acupuncture combined with curcumin disrupts platelet-derived growth factor β receptor/extracellular signal-regulated kinase signalling and stimulates extracellular matrix degradation in carbon tetrachloride-induced hepatic fibrosis in rats

Acupuncture in Medicine

Volumn 30, Issue 4, 2012, Pages 324-330

  Zhang, Xiao Ping ^a   Zhang, Feng ^a   Zhang, Zi Li ^a   Ma, Jin ^a   Kong, De Song ^a   Ni, Guang Xia ^a   Wang, Ai Yun ^a   Chen, Wen Xing ^a   Lu, Yin ^a   Zheng, Shi Zhong ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; CURCUMIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR;

ACUPUNCTURE; ANIMAL; ARTICLE; EXTRACELLULAR MATRIX; GENETICS; HUMAN; LIVER CIRRHOSIS; MALE; METABOLISM; MULTIMODALITY CANCER THERAPY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ACUPUNCTURE THERAPY; ANIMALS; CARBON TETRACHLORIDE; COMBINED MODALITY THERAPY; CURCUMIN; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LIVER CIRRHOSIS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION;

EID: 84873722552     PISSN: 09645284     EISSN: None     Source Type: Journal    
DOI: 10.1136/acupmed-2012-010167     Document Type: Article

References (27)

1. Lee UE, Friedman SL. Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol 2011;25:195-206.
2. Friedman SL. Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008;88:125-72.
3. Bonner JC. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 2004;15:255-73. (Pubitemid 38781050)
4. Pinzani M, Milani S, Herbst H, et al. Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am J Pathol 1996;148:785-800. (Pubitemid 126660671)
5. Gressner OA, Gressner AM. Connective tissue growth factor: A fibrogenic master switch in fibrotic liver diseases. Liver Int 2008;28:1065-79.
6. Hemmann S, Graf J, Roderfeld M, et al. Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 2007;46:955-75. (Pubitemid 46529049)
7. Liu HW, Liu MC, Tsao CM, et al. Electro-acupuncture at 'Neiguan' (PC6) attenuates liver injury in endotoxaemic rats. Acupunct Med 2011;29:284-8.
8. Zhang F, Ma J, Lu Y, et al. Acupuncture combined with curcumin attenuates carbon tetrachloride-induced hepatic fibrosis in rats. Acupunct Med 2012;30:132-8.
9. Zhou Y, Zheng S, Lin J, et al. The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. Lab Invest 2007;87:488-98. (Pubitemid 46633122)
10. Fu Y, Zheng S, Lin J, et al. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol 2008;73:399-409. (Pubitemid 351159210)
11. Schmittgen TD, Zakrajsek BA, Mills AG, et al. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: Comparison of endpoint and real-time methods. Anal Biochem 2000;285:194-204.
12. Han YP. Matrix metalloproteinases, the pros and cons, in liver fibrosis. J Gastroenterol Hepatol 2006;21(Suppl 3):S88-91.
13. Xu JN, Zhang Q, Xie P, et al. Clinical observation of combined acupuncture and herbs in treating fatty liver disease. Shanghai J Tradit Chin Med 2011;45:55-7.
14. Zhang YM, Zhang Q, Xu JN, et al. Combined acupuncture and medication for treating fatty liver disease. Shanghai J Acu-mox 2011;30:291-2.
15. Ikura Y, Morimoto H, Ogami M, et al. Expression of platelet-derived growth factor and its receptor in livers of patients with chronic liver disease. J Gastroenterol 1997;32:496-501. (Pubitemid 27367980)
16. Marra F, Arrighi MC, Fazi M, et al. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology 1999;30:951-8. (Pubitemid 29458284)
17. Zheng SM, Jiang MD, Zeng WZ, et al. Effects of extracellular signal-regulated kinase on rat cultured hepatic stellate cells stimulated by acetaldehyde. J Dig Dis 2007;8:148-53. (Pubitemid 47161788)
18. Bradham DM, Igarashi A, Potter RL, et al. Connective-tissue growth-factor - a cysteine-rich mitogen secreted by human vascular endothelial-cells is related to the src-induced immediate early gene-product Cef-10. J Cell Biol 1991;114:1285-94. (Pubitemid 21909886)
19. Li G, Xie Q, Shi Y, et al. Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats. J Gene Med 2006;8:889-900. (Pubitemid 44097143)
20. Paradis V, Dargere D, Bonvoust F, et al. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 2002;82:767-74.
21. Liu YS, Lu Y, Liu W, et al. Connective tissue growth factor is a downstream mediator for preptin-induced proliferation and differentiation in human osteoblasts. Amino Acids 2010;38:763-9.
22. Yan C, Zhou L, Han YP. Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. Liver Int 2008;28:959-71. (Pubitemid 352044444)
23. Roderfeld M, Weiskirchen R, Wagner S, et al. Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice. FASEB J 2006;20:444-54. (Pubitemid 44933321)
24. Olle EW, Ren X, McClintock SD, et al. Matrix metalloproteinase-9 is an important factor in hepatic regeneration after partial hepatectomy in mice. Hepatology 2006;44:540-9. (Pubitemid 44433710)
25. Chen XJ. Influence of acupuncture and moxibustion on α1(I) collagen III of liver tissue in hepatic fibrosis rats. Shenzhen J Integr Tradit Chin West Med 2002;12:330-1.
26. Hasegawa-Baba Y, Doi K. Changes in TIMP-1 and -2 expression in the early stage of porcine serum-induced liver fibrosis in rats. Exp Toxicol Pathol 2011;63:357-61.
27. McCrudden R, Iredale JP. Liver fibrosis, the hepatic stellate cell and tissue inhibitors of metalloproteinases. Histol Histopathol 2000;15:1159-68.