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Volumn 52, Issue 1, 2012, Pages 59-69

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

Author keywords

Cytokines; Fatty acids; Free radicals; Inflammation; Mitochondria; NASH; Oxidation; Oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOKINE; FATTY ACID; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL;

EID: 84655169624     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.10.003     Document Type: Review
Times cited : (752)

References (220)
  • 1
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • DOI 10.1053/jhep.2003.50193
    • B. Neuschwander-Tetri, and S. Caldwell Nonalcoholic steatohepatitis: summary of an AASLD single topic conference Hepatology 37 2003 1202 1219 (Pubitemid 36538699)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 2
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease
    • J. Ludwig, T.R. Viggiano, D.B. McGill, and B.J. Oh Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease Mayo Clin. Proc. 55 1980 434 438 (Pubitemid 10057164)
    • (1980) Mayo Clinic Proceedings , vol.55 , Issue.7 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Ott, B.J.4
  • 3
    • 0032771475 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis
    • A.M. Diehl Nonalcoholic steatohepatitis Semin. Liver Dis. 19 1999 221 229
    • (1999) Semin. Liver Dis. , vol.19 , pp. 221-229
    • Diehl, A.M.1
  • 5
    • 1642355723 scopus 로고    scopus 로고
    • The spectrum expanded: Cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease
    • DOI 10.1016/j.jhep.2004.02.013, PII S0168827804000716
    • S.H. Caldwell, and D.M. Crespo The spectrum expanded: cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease J. Hepatol. 40 2004 578 584 (Pubitemid 38367778)
    • (2004) Journal of Hepatology , vol.40 , Issue.4 , pp. 578-584
    • Caldwell, S.H.1    Crespo, D.M.2
  • 6
    • 0043268063 scopus 로고    scopus 로고
    • Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
    • DOI 10.1053/jhep.2003.50320
    • J.M. Hui, J.G. Kench, S. Chitturi, A. Sud, G.C. Farrell, K. Byth, P. Hall, M. Khan, and J. George Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C Hepatology 38 2003 420 427 (Pubitemid 36919863)
    • (2003) Hepatology , vol.38 , Issue.2 , pp. 420-427
    • Hui, J.M.1    Kench, J.G.2    Chitturi, S.3    Sud, A.4    Farrell, G.C.5    Byth, K.6    Hall, P.7    Khan, M.8    George, J.9
  • 7
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: The dionysos nutrition and liver study
    • DOI 10.1002/hep.20734
    • G. Bedogni, L. Miglioli, F. Masutti, C. Tiribelli, G. Marchesini, and S. Bellentani Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos Nutrition and Liver Study Hepatology 42 2005 44 52 (Pubitemid 40911310)
    • (2005) Hepatology , vol.42 , Issue.1 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3    Tiribelli, C.4    Marchesini, G.5    Bellentani, S.6
  • 9
    • 71649109525 scopus 로고    scopus 로고
    • High prevalence of coronary heart disease in type 2 diabetic patients with non-alcoholic fatty liver disease
    • H. Lu, L. Zeng, B. Liang, X. Shu, and D. Xie High prevalence of coronary heart disease in type 2 diabetic patients with non-alcoholic fatty liver disease Arch. Med. Res. 40 2009 571 575
    • (2009) Arch. Med. Res. , vol.40 , pp. 571-575
    • Lu, H.1    Zeng, L.2    Liang, B.3    Shu, X.4    Xie, D.5
  • 10
    • 0029127584 scopus 로고
    • Inhibition of mitochondrial β-oxidation as a mechanism of hepatotoxicity
    • B. Fromenty, and D. Pessayre Inhibition of mitochondrial β-oxidation as a mechanism of hepatotoxicity Pharmacol. Ther. 67 1995 101 154
    • (1995) Pharmacol. Ther. , vol.67 , pp. 101-154
    • Fromenty, B.1    Pessayre, D.2
  • 12
    • 0036247430 scopus 로고    scopus 로고
    • Drugs and steatohepatitis
    • DOI 10.1055/s-2002-30106
    • G.C. Farrell Drugs and steatohepatitis Semin. Liver Dis. 22 2002 185 194 (Pubitemid 34496471)
    • (2002) Seminars in Liver Disease , vol.22 , Issue.2 , pp. 185-194
    • Farrell, G.C.1
  • 15
    • 0030865874 scopus 로고    scopus 로고
    • 2',3'-dideoxyinosine-induced mallory bodies in patients with HIV
    • B. Hu, and S.W. French 20,30-Dideoxyinosine-induced Mallory bodies in patients with HIV Am. J. Clin. Pathol. 108 1997 280 283 (Pubitemid 27371645)
    • (1997) American Journal of Clinical Pathology , vol.108 , Issue.3 , pp. 280-283
    • Hu, B.1    French, S.W.2
  • 16
    • 0035577396 scopus 로고    scopus 로고
    • Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: A report of 12 cases
    • DOI 10.1086/323783
    • M.E. Coglan, P. Sommadossi, N.C. Jhala, W.J. Many, M.S. Saag, and V.A. Johnson Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: a report of 12 cases Clin. Infect. Dis. 33 2001 1914 1921 (Pubitemid 33105134)
    • (2001) Clinical Infectious Diseases , vol.33 , Issue.11 , pp. 1914-1921
    • Coghlan, M.E.1    Sommadossi, J.-P.2    Jhala, N.C.3    Many, W.J.4    Saag, M.S.5    Johnson, V.A.6
  • 19
    • 32844458032 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it
    • K. Begriche, A. Igoudjil, D. Pessayre, and B. Fromenty Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it Mitochondrion 6 2006 1 28
    • (2006) Mitochondrion , vol.6 , pp. 1-28
    • Begriche, K.1    Igoudjil, A.2    Pessayre, D.3    Fromenty, B.4
  • 20
  • 21
    • 43749092334 scopus 로고    scopus 로고
    • Intracellular redox status and oxidative stress: Implications for cell proliferation, apoptosis, and carcinogenesis
    • J.M. Matés, J.A. Segura, F.J. Alonso, and J. Márquez Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis Arch. Toxicol. 82 2008 273 299
    • (2008) Arch. Toxicol. , vol.82 , pp. 273-299
    • Matés, J.M.1    Segura, J.A.2    Alonso, F.J.3    Márquez, J.4
  • 23
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
    • DOI 10.1038/nrm2256, PII NRM2256
    • B. D'Autréaux, and M.B. Toledano ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis Nat. Rev. Mol. Cell Biol. 8 2007 813 824 (Pubitemid 47462134)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.10 , pp. 813-824
    • D'Autreaux, B.1    Toledano, M.B.2
  • 25
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • J.S. Beckman, and W.H. Koppenol Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly Am. J. Physiol. 271 1996 C1424 C1437
    • (1996) Am. J. Physiol. , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 26
    • 0036890524 scopus 로고    scopus 로고
    • Peroxynitrite reactions and formation in mitochondria
    • DOI 10.1016/S0891-5849(02)01111-5, PII S0891584902011115
    • R. Radi, A. Cassina, R. Hodara, C. Quijano, and L. Castro Peroxynitrite reactions and formation in mitochondria Free Radic. Biol. Med. 33 2002 1451 1464 (Pubitemid 35351588)
    • (2002) Free Radical Biology and Medicine , vol.33 , Issue.11 , pp. 1451-1464
    • Radi, R.1    Cassina, A.2    Hodara, R.3    Quijano, C.4    Castro, L.5
  • 28
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • H. Østerbauer, R.J. Schaur, and H. Zollner Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radic. Biol. Med. 11 1991 81 128 (Pubitemid 121003917)
    • (1991) Free Radical Biology and Medicine , vol.11 , Issue.1 , pp. 81-128
    • Østerbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 29
    • 0024354775 scopus 로고
    • Oxygen radical chemistry of polyunsaturated fatty acids
    • DOI 10.1016/0891-5849(89)90102-0
    • H.W. Gardner Oxygen radical chemistry of polyunsaturated fatty acids Free Radic. Biol. Med. 7 1989 65 86 (Pubitemid 19165157)
    • (1989) Free Radical Biology and Medicine , vol.7 , Issue.1 , pp. 65-86
    • Gardner, H.W.1
  • 30
    • 0028207325 scopus 로고
    • Free radical-mediated lipid peroxidation in cells: Oxidizability is a function of cell lipid bis-allylic hydrogen content
    • B.A. Wagner, G.R. Buettner, and C.P. Burns Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content Biochemistry 33 1994 4449 4453 (Pubitemid 24145090)
    • (1994) Biochemistry , vol.33 , Issue.15 , pp. 4449-4453
    • Wagner, B.A.1    Buettner, G.R.2    Burns, C.P.3
  • 31
    • 4444268690 scopus 로고    scopus 로고
    • Mechanisms that regulate production of reactive oxygen species by cytochrome P450
    • DOI 10.1016/j.taap.2004.01.018, PII S0041008X04001231
    • R.C. Zangar, D.R. Davydov, and S. Verma Mechanisms that regulate production of reactive oxygen species by cytochrome P450 Toxicol. Appl. Pharmacol. 199 2004 316 331 (Pubitemid 39208731)
    • (2004) Toxicology and Applied Pharmacology , vol.199 , Issue.3 , pp. 316-331
    • Zangar, R.C.1    Davydov, D.R.2    Verma, S.3
  • 32
    • 31344464596 scopus 로고    scopus 로고
    • Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity
    • DOI 10.1016/j.freeradbiomed.2005.10.044, PII S0891584905006398
    • A.A. Caro, and A.I. Cederbaum Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity Free Radic. Biol. Med. 40 2006 364 375 (Pubitemid 43139672)
    • (2006) Free Radical Biology and Medicine , vol.40 , Issue.3 , pp. 364-375
    • Caro, A.A.1    Cederbaum, A.I.2
  • 34
    • 70449715463 scopus 로고    scopus 로고
    • Reactive oxygen species and peroxisomes: Struggling for balance
    • N.A. Bonekamp, A. Völkl, H.D. Fahimi, and M. Schrader Reactive oxygen species and peroxisomes: struggling for balance Biofactors 35 2009 346 355
    • (2009) Biofactors , vol.35 , pp. 346-355
    • Bonekamp, N.A.1    Völkl, A.2    Fahimi, H.D.3    Schrader, M.4
  • 35
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • M.P. Murphy How mitochondria produce reactive oxygen species Biochem. J. 417 2009 1 13
    • (2009) Biochem. J. , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 36
    • 77952541558 scopus 로고    scopus 로고
    • The sites and topology of mitochondrial superoxide production
    • M.D. Brand The sites and topology of mitochondrial superoxide production Exp. Gerontol. 45 2010 466 472
    • (2010) Exp. Gerontol. , vol.45 , pp. 466-472
    • Brand, M.D.1
  • 37
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • DOI 10.1113/jphysiol.2003.049478
    • J.F. Turrens Mitochondrial formation of reactive oxygen species J. Physiol. 552 2003 335 344 (Pubitemid 37321833)
    • (2003) Journal of Physiology , vol.552 , Issue.2 , pp. 335-344
    • Turrens, J.F.1
  • 40
    • 17144422877 scopus 로고    scopus 로고
    • Mitochondrial metabolism of reactive oxygen species
    • DOI 10.1007/s10541-005-0102-7
    • A.Y. Andreyev, Y.E. Kushnareva, and A.A. Starkov Mitochondrial metabolism of reactive oxygen species Biochemistry (Moscow) 70 2005 200 214 (Pubitemid 40512329)
    • (2005) Biochemistry (Moscow) , vol.70 , Issue.2 , pp. 200-214
    • Andreyev, A.Yu.1    Kushnareva, Yu.E.2    Starkov, A.A.3
  • 41
    • 0029765443 scopus 로고    scopus 로고
    • Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
    • V.P. Skulachev Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants Q. Rev. Biophys. 29 1996 169 202 (Pubitemid 26280789)
    • (1996) Quarterly Reviews of Biophysics , vol.29 , Issue.2 , pp. 169-202
    • Skulachev, V.P.1
  • 42
    • 4544354262 scopus 로고    scopus 로고
    • Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I)
    • DOI 10.1074/jbc.M406576200
    • A.J. Lambert, and M.D. Brand Inhibitors of the quinone binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I) J. Biol. Chem. 279 2004 39414 39420 (Pubitemid 39258206)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.38 , pp. 39414-39420
    • Lambert, A.J.1    Brand, M.D.2
  • 43
    • 0032564864 scopus 로고    scopus 로고
    • Uncoupling: New approaches to an old problem of bioenergetics
    • DOI 10.1016/S0005-2728(97)00091-1, PII S0005272897000911
    • V.P. Skulachev Uncoupling: new approaches to an old problem of bioenergetics Biochim. Biophys. Acta 1363 1998 100 124 (Pubitemid 28129344)
    • (1998) Biochimica et Biophysica Acta - Bioenergetics , vol.1363 , Issue.2 , pp. 100-124
    • Skulachev, V.P.1
  • 44
    • 0030729851 scopus 로고    scopus 로고
    • High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
    • DOI 10.1016/S0014-5793(97)01159-9, PII S0014579397011599
    • S.S. Korshunov, V.P. Skulachev, and A.A. Starkov High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria FEBS Lett. 416 1997 15 18 (Pubitemid 27470791)
    • (1997) FEBS Letters , vol.416 , Issue.1 , pp. 15-18
    • Korshunov, S.S.1    Skulachev, V.P.2    Starkov, A.A.3
  • 45
    • 0026689868 scopus 로고
    • Comparison of the effect of a mitochondrial uncoupler, 2,4-dinitrophenol and adrenaline on oxygen radical production in the isolated perfused rat liver
    • M. Okuda, H.C. Lee, C. Kumar, and B. Chance Comparison of the effect of a mitochondrial uncoupler, 2,4-dinitrophenol and adrenaline on oxygen radical production in the isolated perfused rat liver Acta Physiol. Scand. 145 1992 159 168
    • (1992) Acta Physiol. Scand. , vol.145 , pp. 159-168
    • Okuda, M.1    Lee, H.C.2    Kumar, C.3    Chance, B.4
  • 47
    • 80054051101 scopus 로고    scopus 로고
    • The regulation and physiology of mitochondrial proton leak
    • A.S. Divakaruni, and M.D. Brand The regulation and physiology of mitochondrial proton leak Physiology 26 2011 192 205
    • (2011) Physiology , vol.26 , pp. 192-205
    • Divakaruni, A.S.1    Brand, M.D.2
  • 48
    • 0035371184 scopus 로고    scopus 로고
    • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    • DOI 10.1016/S0891-5849(01)00480-4, PII S0891584901004804
    • F.Q. Schafer, and G.R. Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radic. Biol. Med. 30 2001 1191 1212 (Pubitemid 32463931)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.11 , pp. 1191-1212
    • Schafer, F.Q.1    Buettner, G.R.2
  • 49
    • 0035029170 scopus 로고    scopus 로고
    • Prolonged, but not acute, glutathione depletion promotes fas -mediated mitochondrial permeability transition and apoptosis in mice
    • DOI 10.1053/jhep.2001.24235
    • D. Haouzi, M. Lekehal, M. Tinel, N. Vadrot, L. Caussanel, P. Letteéron, A. Moreau, G. Feldmann, D. Fau, and D. Pessayre Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice Hepatology 33 2001 1181 1188 (Pubitemid 32378218)
    • (2001) Hepatology , vol.33 , Issue.5 , pp. 1181-1188
    • Haouzi, D.1    Lekehal, M.2    Tinel, M.3    Vadrot, N.4    Caussanel, L.5    Letteron, P.6    Moreau, A.7    Feldmann, G.8    Fau, D.9    Pessayre, D.10
  • 50
    • 17444381536 scopus 로고    scopus 로고
    • Hepatic mitochondrial glutathione: Transport and role in disease and toxicity
    • DOI 10.1016/j.taap.2004.10.001, Membrane Transporters in Toxicology
    • J.C. Fernandez-Checa, and N. Kaplowitz Hepatic mitochondrial glutathione: transport and role in disease and toxicity Toxicol. Appl. Pharmacol. 204 2005 263 273 (Pubitemid 40545231)
    • (2005) Toxicology and Applied Pharmacology , vol.204 , Issue.3 , pp. 263-273
    • Fernandez-Checa, J.C.1    Kaplowitz, N.2
  • 52
    • 70349779185 scopus 로고    scopus 로고
    • Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes
    • L.I. Rachek, L.V. Yuzefovych, S.P. Ledoux, N.L. Julie, and G.L. Wilson Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes Toxicol. Appl. Pharmacol. 240 2009 348 354
    • (2009) Toxicol. Appl. Pharmacol. , vol.240 , pp. 348-354
    • Rachek, L.I.1    Yuzefovych, L.V.2    Ledoux, S.P.3    Julie, N.L.4    Wilson, G.L.5
  • 55
    • 0033362107 scopus 로고    scopus 로고
    • Repair of mtDNA in vertebrates
    • D.F. Bogenhagen Repair of mtDNA in vertebrates Am. J. Hum. Genet. 64 1999 1276 1281
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 1276-1281
    • Bogenhagen, D.F.1
  • 56
    • 70450231612 scopus 로고    scopus 로고
    • Energetics, epigenetics, mitochondrial genetics
    • D.C. Wallace, and W. Fan Energetics, epigenetics, mitochondrial genetics Mitochondrion 10 2010 12 31
    • (2010) Mitochondrion , vol.10 , pp. 12-31
    • Wallace, D.C.1    Fan, W.2
  • 57
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two hits?
    • C.P. Day, and O.F. James Steatohepatitis: a tale of two hits? Gastroenterology 114 1998 842 845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 58
    • 33745298222 scopus 로고    scopus 로고
    • Regulation of fat metabolism in the liver: Link to non-alcoholic hepatic steatosis and impact of physical exercise
    • J.M. Lavoie, and M.S. Gauthier Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise Cell. Mol. Life Sci. 63 2006 1393 1409
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 1393-1409
    • Lavoie, J.M.1    Gauthier, M.S.2
  • 60
    • 79954558287 scopus 로고    scopus 로고
    • Adipokines and redox signaling: Impact on fatty liver disease
    • M. Parola, and F. Marra Adipokines and redox signaling: impact on fatty liver disease Antioxid. Redox Signal. 15 2011 461 483
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 461-483
    • Parola, M.1    Marra, F.2
  • 62
    • 61349140201 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: The pathogenetic roles of insulin resistance and adipocytokines
    • S.A. Polyzos, J. Kountouras, and C. Zavos Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines Curr. Mol. Med. 9 2009 299 314
    • (2009) Curr. Mol. Med. , vol.9 , pp. 299-314
    • Polyzos, S.A.1    Kountouras, J.2    Zavos, C.3
  • 63
    • 3042744737 scopus 로고    scopus 로고
    • Beyond insulin resistance in NASH: TNF-α or adiponectin?
    • DOI 10.1002/hep.20280
    • J.M. Hui, A. Hodge, G.C. Farrell, J.G. Kench, A. Kriketos, and J. George Beyond insulin resistance in NASH: TNF-α or adiponectin? Hepatology 40 2004 46 54 (Pubitemid 38868922)
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 46-54
    • Hui, J.M.1    Hodge, A.2    Farrell, G.C.3    Kench, J.G.4    Kriketos, A.5    George, J.6
  • 65
    • 0035078484 scopus 로고    scopus 로고
    • Etiopathogenesis of nonalcoholic steatohepatitis
    • S. Chitturi, and G.C. Farrell Etiopathogenesis of nonalcoholic steatohepatitis Semin. Liver Dis. 21 2001 27 41 (Pubitemid 32240484)
    • (2001) Seminars in Liver Disease , vol.21 , Issue.1 , pp. 27-41
    • Chitturi, S.1    Farrell, G.C.2
  • 66
    • 0035991444 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    • DOI 10.1016/S0168-8278(02)00073-9, PII S0168827802000739
    • S. Seki, T. Kitada, T. Yamada, H. Sakaguchi, K. Nakatani, and K. Wakasa In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases J. Hepatol. 37 2002 56 62 (Pubitemid 34713055)
    • (2002) Journal of Hepatology , vol.37 , Issue.1 , pp. 56-62
    • Seki, S.1    Kitada, T.2    Yamada, T.3    Sakaguchi, H.4    Nakatani, K.5    Wakasa, K.6
  • 69
    • 33745828301 scopus 로고    scopus 로고
    • Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
    • Y. Wei, D. Wang, F. Topczewski, and M.J. Pagliassotti Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells Am. J. Physiol. Endocrinol. Metab. 291 2006 E275e81
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Wei, Y.1    Wang, D.2    Topczewski, F.3    Pagliassotti, M.J.4
  • 70
    • 18844389970 scopus 로고    scopus 로고
    • NASH: A mitochondrial disease
    • DOI 10.1016/j.jhep.2005.03.004, PII S0168827805001704
    • D. Pessayre, and B. Fromenty NASH: a mitochondrial disease J. Hepatol. 42 2005 928 940 (Pubitemid 40693212)
    • (2005) Journal of Hepatology , vol.42 , Issue.6 , pp. 928-940
    • Pessayre, D.1    Fromenty, B.2
  • 75
    • 0035991444 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    • DOI 10.1016/S0168-8278(02)00073-9, PII S0168827802000739
    • S. Seki, T. Kitada, T. Yamada, H. Sakaguchi, K. Nakatani, and K. Wakasa In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases J. Hepatol. 37 2002 56 62 (Pubitemid 34713055)
    • (2002) Journal of Hepatology , vol.37 , Issue.1 , pp. 56-62
    • Seki, S.1    Kitada, T.2    Yamada, T.3    Sakaguchi, H.4    Nakatani, K.5    Wakasa, K.6
  • 79
    • 54949089576 scopus 로고    scopus 로고
    • Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression
    • J.S. Teodoro, A.P. Rolo, F.V. Duarte, A.M. Simões, and C.M. Palmeira Differential alterations in mitochondrial function induced by a choline-deficient diet: understanding fatty liver disease progression Mitochondrion 8 2008 367 376
    • (2008) Mitochondrion , vol.8 , pp. 367-376
    • Teodoro, J.S.1    Rolo, A.P.2    Duarte, F.V.3    Simões, A.M.4    Palmeira, C.M.5
  • 80
    • 33645241135 scopus 로고    scopus 로고
    • Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis
    • J. Teodoro, A.P. Rolo, P.J. Oliveira, and C.M. Palmeira Decreased ANT content in Zucker fatty rats: relevance for altered hepatic mitochondrial bioenergetics in steatosis FEBS Lett. 580 2006 2153 2157
    • (2006) FEBS Lett. , vol.580 , pp. 2153-2157
    • Teodoro, J.1    Rolo, A.P.2    Oliveira, P.J.3    Palmeira, C.M.4
  • 82
    • 0043234701 scopus 로고    scopus 로고
    • Changed energy state and increased mitochondrial β-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling protein 2 (UCP-2) expression. Evidence for peroxisome proliferator-activated receptor-α independent induction of UCP-2 expression
    • DOI 10.1074/jbc.M303382200
    • H.J. Grav, K.J. Tronstad, O.A. Gudbrandsen, K. Berge, K.E. Fladmark, T.C. Martinsen, H. Waldum, H. Wergedahl, and R.K. Berge Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling protein 2 (UCP-2) expression: evidence for peroxisome proliferator-activated receptor-alpha independent induction of UCP-2 expression J. Biol. Chem. 278 2003 30525 30533 (Pubitemid 36994556)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.33 , pp. 30525-30533
    • Grav, H.J.1    Tronstad, K.J.2    Gudbrandsen, O.A.3    Berge, K.4    Fladmark, K.E.5    Martinsen, T.C.6    Waldum, H.7    Wergedahl, H.8    Berge, R.K.9
  • 83
    • 0032898080 scopus 로고    scopus 로고
    • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver
    • A. Rashid, T.C. Wu, C.C. Huang, C.H. Chen, H.Z. Lin, S.Q. Yang, F.Y. Lee, and A.M. Diehl Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver Hepatology 29 1999 1131 1138 (Pubitemid 29168747)
    • (1999) Hepatology , vol.29 , Issue.4 , pp. 1131-1138
    • Rashid, A.1    Wu, T.-C.2    Huang, C.-C.3    Chen, C.-H.4    Lin, H.Z.5    Yang, S.Q.6    Lee, F.Y.J.7    Diehl, A.M.8
  • 85
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
    • R.C. Scarpulla Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network Biochim. Biophys. Acta 1813 2011 1269 1278
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1269-1278
    • Scarpulla, R.C.1
  • 86
    • 79955575803 scopus 로고    scopus 로고
    • Regulation of mitochondrial biogenesis in metabolic syndrome
    • A.P. Rolo, A.P. Gomes, and C.M. Palmeira Regulation of mitochondrial biogenesis in metabolic syndrome Curr. Drug Targets 12 2011 872 878
    • (2011) Curr. Drug Targets , vol.12 , pp. 872-878
    • Rolo, A.P.1    Gomes, A.P.2    Palmeira, C.M.3
  • 88
    • 79959739128 scopus 로고    scopus 로고
    • Fatty liver is associated with impaired activity of PPARγ- coactivator 1α (PGC1α) and mitochondrial biogenesis in mice
    • M. Aharoni-Simon, M. Hann-Obercyger, S. Pen, Z. Madar, and O. Tirosh Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice Lab. Invest. 91 2011 1018 1028
    • (2011) Lab. Invest. , vol.91 , pp. 1018-1028
    • Aharoni-Simon, M.1    Hann-Obercyger, M.2    Pen, S.3    Madar, Z.4    Tirosh, O.5
  • 89
    • 79960555502 scopus 로고    scopus 로고
    • Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo
    • S. Wang, A. Kamat, P. Pergola, A. Swamy, F. Tio, and K. Cusi Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo Metabolism 60 2011 1090 1099
    • (2011) Metabolism , vol.60 , pp. 1090-1099
    • Wang, S.1    Kamat, A.2    Pergola, P.3    Swamy, A.4    Tio, F.5    Cusi, K.6
  • 93
    • 10744220267 scopus 로고    scopus 로고
    • Mitochondrial and Metabolic Effects of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Mice Receiving One of Five Single- and Three Dual-NRTI Treatments
    • DOI 10.1128/AAC.47.11.3384-3392.2003
    • R. Note, C. Maisonneuve, P. Lettéron, G. Peytavin, F. Djouadi, A. Igoudjil, M.C. Guimont, M. Biour, D. Pessayre, and B. Fromenty Mitochondrial and metabolic effects of nucleoside reverse-transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments Antimicrob. Agents Chemother. 47 2003 3384 3392 (Pubitemid 37345694)
    • (2003) Antimicrobial Agents and Chemotherapy , vol.47 , Issue.11 , pp. 3384-3392
    • Note, R.1    Maisonneuve, C.2    Letteron, P.3    Peytavin, G.4    Djouadi, F.5    Igoudjil, A.6    Guimont, M.-C.7    Biour, M.8    Pessayre, D.9    Fromenty, B.10
  • 95
    • 0032189850 scopus 로고    scopus 로고
    • Adverse effects of reverse transcriptase inhibitors: Mitochondrial toxicity as common pathway
    • K. Brinkman, H.J. ter Hofstede, D.M. Burger, J.A. Smeitink, and P.P. Koopmans Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway AIDS 12 1998 1735 1744 (Pubitemid 28454438)
    • (1998) AIDS , vol.12 , Issue.14 , pp. 1735-1744
    • Brinkman, K.1    Ter Hofstede, H.J.M.2    Burger, D.M.3    Smeitink, J.A.M.4    Koopmans, P.P.5
  • 97
    • 33750049931 scopus 로고    scopus 로고
    • Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo
    • DOI 10.1016/j.hepres.2006.07.005, PII S1386634606002385
    • A. Haque, M. Nishikawa, W. Qian, M. Mashimo, M. Hirose, S. Nishiguchi, and M. Inoue Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo Hepatol. Res. 36 2006 209 216 (Pubitemid 44575928)
    • (2006) Hepatology Research , vol.36 , Issue.3 , pp. 209-216
    • Haque, A.1    Nishikawa, M.2    Qian, W.3    Mashimo, M.4    Hirose, M.5    Nishiguchi, S.6    Inoue, M.7
  • 99
    • 33846290302 scopus 로고    scopus 로고
    • Mutation of mitochondrial DNA in livers from patients with alcoholic hepatitis and nonalcoholic steatohepatitis
    • H. Kawahara, M. Fukura, M. Tsuchishima, and S. Takase Mutation of mitochondrial DNA in livers from patients with alcoholic hepatitis and nonalcoholic steatohepatitis Alcohol. Clin. Exp. Res. 31 2007 S54 S60
    • (2007) Alcohol. Clin. Exp. Res. , vol.31
    • Kawahara, H.1    Fukura, M.2    Tsuchishima, M.3    Takase, S.4
  • 100
    • 18244387691 scopus 로고    scopus 로고
    • Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease
    • DOI 10.1172/JCI200524930
    • S. Tamura, and I. Shimomura Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease J. Clin. Invest. 115 2005 1139 1142 (Pubitemid 40629030)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.5 , pp. 1139-1142
    • Tamura, S.1    Shimomura, I.2
  • 101
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • G. Musso, R. Gambino, and M. Cassader Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD) Prog. Lipid Res. 48 2009 1 26
    • (2009) Prog. Lipid Res. , vol.48 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 102
    • 0000847623 scopus 로고
    • Non-esterified fatty acids in blood of obese and lean subjects
    • E.S. Gorden Non-esterified fatty acids in blood of obese and lean subjects Am. J. Clin. Nutr. 8 1960 740 747
    • (1960) Am. J. Clin. Nutr. , vol.8 , pp. 740-747
    • Gorden, E.S.1
  • 104
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.11.038, PII S0016508507021154
    • E. Fabbrini, B.S. Mohammed, F. Magkos, K.M. Korenblat, B.W. Patterson, and S. Klein Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease Gastroenterology 134 2008 424 431 (Pubitemid 351173050)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 105
    • 0003109076 scopus 로고    scopus 로고
    • Regulation of the fatty acid synthase promoter by insulin
    • H.S. Sul, M.J. Latasa, Y. Moon, and K.H. Kim Regulation of the fatty acid synthase promoter by insulin J. Nutr. 130 2000 315S 320S (Pubitemid 30073737)
    • (2000) Journal of Nutrition , vol.130 , Issue.SUPPL.2
    • Sul, H.S.1    Latasa, M.-J.2    Moon, Y.3    Kim, K.-H.4
  • 106
    • 0029935392 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation of hepatic gene transcription
    • S.D. Clarke, and D.B. Jump Polyunsaturated fatty acid regulation of hepatic gene transcription Lipids 31 1996 S7 S11
    • (1996) Lipids , vol.31
    • Clarke, S.D.1    Jump, D.B.2
  • 107
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • DOI 10.1042/CS20030326
    • J. Araya, R. Rodrigo, L.A. Videla, L. Thielemann, M. Orellana, P. Pettinelli, and J. Poniachik Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease Clin. Sci. (Lond.) 106 2004 635 643 (Pubitemid 38797577)
    • (2004) Clinical Science , vol.106 , Issue.6 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6    Poniachik, J.7
  • 108
    • 0032567445 scopus 로고    scopus 로고
    • Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
    • DOI 10.1074/jbc.273.52.35299
    • I. Shimomura, H. Shimano, B.S. Korn, Y. Bashmakov, and J.D. Horton Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver J. Biol. Chem. 273 1998 35299 35306 (Pubitemid 29028238)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.52 , pp. 35299-35306
    • Shimomura, I.1    Shimano, H.2    Korn, B.S.3    Bashmakov, Y.4    Horton, J.D.5
  • 111
    • 0036711553 scopus 로고    scopus 로고
    • New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: A role for the transcription factor sterol regulatory element binding protein-1c
    • DOI 10.1042/BJ20020430
    • F. Foufelle, and P. Ferré New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c Biochem. J. 366 2002 377 391 (Pubitemid 35001682)
    • (2002) Biochemical Journal , vol.366 , Issue.2 , pp. 377-391
    • Foufelle, F.1    Ferre, P.2
  • 112
    • 14544289119 scopus 로고    scopus 로고
    • Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): Two key regulators of glucose metabolism and lipid synthesis in liver
    • DOI 10.1016/j.biochi.2004.11.008
    • R. Dentin, J. Girard, and C. Postic Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver Biochimie 87 2005 81 86 (Pubitemid 40298769)
    • (2005) Biochimie , vol.87 , Issue.SPEC. ISS.1 , pp. 81-86
    • Dentin, R.1    Girard, J.2    Postic, C.3
  • 113
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis
    • J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis J. Clin. Invest. 114 2004 147 152
    • (2004) J. Clin. Invest. , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 115
    • 0344874201 scopus 로고    scopus 로고
    • Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease
    • F. Diraison, P. Moulin, and M. Beylot Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease Diabetes Metab. 29 2003 5478 5485
    • (2003) Diabetes Metab. , vol.29 , pp. 5478-5485
    • Diraison, F.1    Moulin, P.2    Beylot, M.3
  • 118
    • 0029796038 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation
    • E.F. Johnson, C.N. Palmer, K.J. Griffin, and M.H. Hsu Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation FASEB J. 10 1996 1241 1248 (Pubitemid 26307509)
    • (1996) FASEB Journal , vol.10 , Issue.11 , pp. 1241-1248
    • Johnson, E.F.1    Palmer, C.N.A.2    Griffin, K.J.3    Hsu, M.-H.4
  • 119
    • 0023654079 scopus 로고
    • Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA
    • G.A. Cook, and M.S. Gamble Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA J. Biol. Chem. 262 1987 2050 2055
    • (1987) J. Biol. Chem. , vol.262 , pp. 2050-2055
    • Cook, G.A.1    Gamble, M.S.2
  • 120
    • 78149359713 scopus 로고    scopus 로고
    • Mitochondria in response to nutrients and nutrient-sensitive pathways
    • C. Baltzer, S.K. Tiefenböck, and C. Frei Mitochondria in response to nutrients and nutrient-sensitive pathways Mitochondrion 10 2010 589 597
    • (2010) Mitochondrion , vol.10 , pp. 589-597
    • Baltzer, C.1    Tiefenböck, S.K.2    Frei, C.3
  • 121
    • 0018864840 scopus 로고
    • Regulation of hepatic fatty acid oxidation and ketone body production
    • J.D. McGarry, and D.W. Foster Regulation of hepatic fatty acid oxidation and ketone body production Annu. Rev. Biochem. 49 1980 395 420
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 395-420
    • McGarry, J.D.1    Foster, D.W.2
  • 122
    • 0024347643 scopus 로고
    • Hepatic peroxisomal abnormalities in abetalipoproteinemia
    • J.C. Collins, I.H. Scheinberg, D.R. Giblin, and I. Sternlieb Hepatic peroxisomal abnormalities in abetalipoproteinemia Gastroenterology 97 1989 766 770 (Pubitemid 19205153)
    • (1989) Gastroenterology , vol.97 , Issue.3 , pp. 766-770
    • Collins, J.C.1    Scheinberg, I.H.2    Giblin, D.R.3    Sternlieb, I.4
  • 123
    • 0037369729 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
    • DOI 10.1053/jhep.2003.50095
    • N. Chalasani, J.C. Gorki, M.S. Asghar, A. Asghar, B. Foresman, S.D. Hall, and D.W. Crabb Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis Hepatology 37 2003 544 550 (Pubitemid 36258775)
    • (2003) Hepatology , vol.37 , Issue.3 , pp. 544-550
    • Chalasani, N.1    Christopher Gorski, J.2    Asghar, M.S.3    Asghar, A.4    Foresman, B.5    Hall, S.D.6    Crabb, D.W.7
  • 125
    • 0022007068 scopus 로고
    • Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice
    • L.J. Brady, P.S. Brady, D.R. Romsos, and C.L. Hoppel Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice Biochem. J. 231 1985 439 444 (Pubitemid 15244016)
    • (1985) Biochemical Journal , vol.231 , Issue.2 , pp. 439-444
    • Brady, L.J.1    Brady, P.S.2    Romsos, D.R.3    Hoppel, C.L.4
  • 126
    • 0019821333 scopus 로고
    • Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats
    • J.D. McGarry, and D.W. Foster Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase: studies with fed and starved rats Biochem. J. 200 1981 217 223 (Pubitemid 12218245)
    • (1981) Biochemical Journal , vol.200 , Issue.2 , pp. 217-223
    • McGarry, J.D.1    Foster, D.W.2
  • 129
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptors: nuclear control of metabolism Endocr. Rev. 20 1999 649 688 (Pubitemid 30650602)
    • (1999) Endocrine Reviews , vol.20 , Issue.5 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 130
    • 77951126550 scopus 로고    scopus 로고
    • Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome
    • M. Schreurs, F. Kuipers, and F.R. van der Leij Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome Obes. Rev. 11 2010 380 388
    • (2010) Obes. Rev. , vol.11 , pp. 380-388
    • Schreurs, M.1    Kuipers, F.2    Van Der Leij, F.R.3
  • 131
  • 132
    • 0033695790 scopus 로고    scopus 로고
    • Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice
    • R.A. Memon, L.H. Tecott, K. Nonogaki, A. Beigneux, A.H. Moser, C. Grunfeld, and K.R. Feingold Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice Endocrinology 141 2000 4021 4031
    • (2000) Endocrinology , vol.141 , pp. 4021-4031
    • Memon, R.A.1    Tecott, L.H.2    Nonogaki, K.3    Beigneux, A.4    Moser, A.H.5    Grunfeld, C.6    Feingold, K.R.7
  • 133
    • 0037088649 scopus 로고    scopus 로고
    • Mechanism for peroxisome proliferator-activated receptor-α activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes
    • DOI 10.1074/jbc.M110132200
    • T. Nakatani, N. Tsuboyama-Kasaoka, M. Takahashi, S. Miura, and O. Ezaki Mechanism for peroxisome proliferator-activated receptor-α activator-induced up-regulation of UCP-2 mRNA in rodent hepatocytes J. Biol. Chem. 277 2002 9562 9569 (Pubitemid 34953045)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.11 , pp. 9562-9569
    • Nakatani, T.1    Tsuboyama-Kasaoka, N.2    Takahashi, M.3    Miura, S.4    Ezaki, O.5
  • 134
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • DOI 10.1128/MCB.20.5.1868-1876.2000
    • R.B. Vega, J.M. Huss, and D.P. Kelly The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in the transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes Mol. Cell. Biol. 20 2000 1868 1876 (Pubitemid 30100203)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.5 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 135
    • 0344081177 scopus 로고    scopus 로고
    • Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
    • DOI 10.1210/en.2003-0982
    • D.G. Hardie The AMP-activated protein kinase cascade: the key sensor of cellular energy status Endocrinology 144 2003 5179 5183 (Pubitemid 37476044)
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5179-5183
    • Hardie, D.G.1
  • 139
    • 4444382031 scopus 로고    scopus 로고
    • Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis
    • DOI 10.1111/j.1572-0241.2004.30159.x
    • N. Chalasani, M.A. Deeg, and D.W. Crab Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with non-alcoholic steatohepatitis Am. J. Gastroenterol. 99 2004 1497 1502 (Pubitemid 39193189)
    • (2004) American Journal of Gastroenterology , vol.99 , Issue.8 , pp. 1497-1502
    • Chalasani, N.1    Deeg, M.A.2    Crabb, D.W.3
  • 142
    • 0342716457 scopus 로고    scopus 로고
    • Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice
    • DOI 10.1016/S0168-8278(96)80030-4
    • P. Lettéron, B. Fromenty, B. Terris, C. Degott, and D. Pessayre Acute and chronic steatosis lead to in vivo lipid peroxidation in mice J. Hepatol. 24 1996 200 208 (Pubitemid 26059117)
    • (1996) Journal of Hepatology , vol.24 , Issue.2 , pp. 200-208
    • Letteron, P.1    Fromenty, B.2    Terris, B.3    Degott, C.4    Pessayre, D.5
  • 144
    • 0035991444 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    • DOI 10.1016/S0168-8278(02)00073-9, PII S0168827802000739
    • S. Seki, T. Kitada, T. Yamada, H. Sakaguchi, K. Nakatani, and K. Wakasa In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases J. Hepatol. 37 2002 56 62 (Pubitemid 34713055)
    • (2002) Journal of Hepatology , vol.37 , Issue.1 , pp. 56-62
    • Seki, S.1    Kitada, T.2    Yamada, T.3    Sakaguchi, H.4    Nakatani, K.5    Wakasa, K.6
  • 145
    • 14244251463 scopus 로고    scopus 로고
    • Oxidation, lipoproteins, and atherosclerosis: Which is wrong, the antioxidants or the theory?
    • K.J. Williams, and E.A. Fisher Oxidation, lipoproteins, and atherosclerosis: which is wrong, the antioxidants or the theory? Curr. Opin. Clin. Nutr. Metab. Care 8 2005 139 146
    • (2005) Curr. Opin. Clin. Nutr. Metab. Care , vol.8 , pp. 139-146
    • Williams, K.J.1    Fisher, E.A.2
  • 146
    • 0033955887 scopus 로고    scopus 로고
    • Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: A common denominator in the pathophysiology of diseases of oxidative phosphorylation and β-oxidation
    • DOI 10.1016/S0014-5793(00)01083-8, PII S0014579300010838
    • J.P. Infante, and V.A. Huszagh Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation FEBS Lett. 468 2002 1 5 (Pubitemid 30101670)
    • (2000) FEBS Letters , vol.468 , Issue.1 , pp. 1-5
    • Infante, J.P.1    Huszagh, V.A.2
  • 148
    • 33645765312 scopus 로고    scopus 로고
    • Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
    • A.P. Rolo, and C.M. Palmeira Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress Toxicol. Appl. Pharmacol. 212 2006 167 178
    • (2006) Toxicol. Appl. Pharmacol. , vol.212 , pp. 167-178
    • Rolo, A.P.1    Palmeira, C.M.2
  • 149
    • 0742306111 scopus 로고    scopus 로고
    • CYP2E1: From ASH to NASH
    • DOI 10.1016/j.hepres.2003.08.001, PII S1386634603003577
    • C.S. Lieber CYP2E1: from ASH to NASH Hepatol. Res. 28 2004 1 11 (Pubitemid 38145781)
    • (2004) Hepatology Research , vol.28 , Issue.1 , pp. 1-11
    • Lieber, C.S.1
  • 150
    • 33644955272 scopus 로고    scopus 로고
    • Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    • Q.M. Anstee, and R.D. Goldin Mouse models in non-alcoholic fatty liver disease and steatohepatitis research Int. J. Exp. Pathol. 87 2006 1 16
    • (2006) Int. J. Exp. Pathol. , vol.87 , pp. 1-16
    • Anstee, Q.M.1    Goldin, R.D.2
  • 151
    • 0037195906 scopus 로고    scopus 로고
    • Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin
    • DOI 10.1074/jbc.M207841200
    • A. Moncion, N.T. Truong, A. Garrone, P. Beaune, R. Barouki, and I. De Waziers Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin J. Biol. Chem. 277 2002 45904 45910 (Pubitemid 35417572)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.48 , pp. 45904-45910
    • Moncion, A.1    Truong, N.T.2    Garrone, A.3    Beaune, P.4    Barouki, R.5    De Waziers, I.6
  • 152
    • 34250375240 scopus 로고    scopus 로고
    • Induction of cytochrome promotes liver injury in ob/ob mice
    • DOI 10.1002/hep.21603
    • A. Dey, and A.I. Cederbaum Induction of cytochrome P450 2E1 promotes liver injury in ob/ob mice Hepatology 45 2007 1355 1365 (Pubitemid 46918319)
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1355-1365
    • Dey, A.1    Cederbaum, A.I.2
  • 153
    • 0021809180 scopus 로고
    • Effect of Reye's syndrome serum on isolated chinchilla liver mitochondria
    • J.H. Tonsgard, and G.S. Getz Effect of Reye's syndrome serum on isolated chinchilla liver mitochondria J. Clin. Invest. 76 1985 816 825 (Pubitemid 15023140)
    • (1985) Journal of Clinical Investigation , vol.76 , Issue.2 , pp. 816-825
    • Tonsgard, J.H.1    Getz, G.S.2
  • 154
    • 1642292288 scopus 로고    scopus 로고
    • Antioxidant defence mechanisms: New players in the pathogenesis of non-alcoholic steatohepatitis?
    • DOI 10.1042/CS20030368
    • I.A. Leclercq Antioxidant defence mechanisms: new players in the pathogenesis of non-alcoholic steatohepatitis? Clin. Sci. (Lond.) 106 2004 235 237 (Pubitemid 38365828)
    • (2004) Clinical Science , vol.106 , Issue.3 , pp. 235-237
    • Leclercq, I.A.1
  • 156
    • 0038461088 scopus 로고    scopus 로고
    • Hepatic gene expression in histologically progressive nonalcoholic steatohepatitis
    • DOI 10.1053/jhep.2003.50290
    • R. Sreekumar, B. Rosado, D. Rasmussen, and M. Charlton Hepatic gene expression in histologically progressive nonalcoholic steatohepatitis Hepatology 38 2003 244 251 (Pubitemid 36775817)
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 244-251
    • Sreekumar, R.1    Rosado, B.2    Rasmussen, D.3    Charlton, M.4
  • 166
    • 38449120093 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: Evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis
    • A.G. Ruiz, F. Casafont, J. Crespo, A. Cayón, M. Mayorga, A. Estebanez, J.C. Fernadez-Escalante, and F. Pons-Romero Lipopolysaccharide- binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis Obes. Surg. 17 2007 1374 1380
    • (2007) Obes. Surg. , vol.17 , pp. 1374-1380
    • Ruiz, A.G.1    Casafont, F.2    Crespo, J.3    Cayón, A.4    Mayorga, M.5    Estebanez, A.6    Fernadez-Escalante, J.C.7    Pons-Romero, F.8
  • 168
    • 44949233003 scopus 로고    scopus 로고
    • Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
    • DOI 10.1111/j.1572-0241.2007.01774.x
    • A. Wieckowska, B.G. Papouchado, Z. Li, R. Lopez, N.N. Zein, and A.E. Feldstein Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis Am. J. Gastroenterol. 103 2008 1372 1379 (Pubitemid 351813900)
    • (2008) American Journal of Gastroenterology , vol.103 , Issue.6 , pp. 1372-1379
    • Wieckowska, A.1    Papouchado, B.G.2    Li, Z.3    Lopez, R.4    Zein, N.N.5    Feldstein, A.E.6
  • 169
    • 41849123475 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: Implications for treatment
    • DOI 10.1111/j.1572-0241.2007.01709.x
    • C. Carter-Kent, N.N. Zein, and A.E. Feldstein Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment Am. J. Gastroenterol. 103 2008 1036 1042 (Pubitemid 351501089)
    • (2008) American Journal of Gastroenterology , vol.103 , Issue.4 , pp. 1036-1042
    • Carter-Kent, C.1    Zein, N.N.2    Feldstein, A.E.3
  • 170
    • 0026713818 scopus 로고
    • Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions: Evidence for the involvement of mitochondrial radical generation
    • K. Schulze-Osthoff, A.C. Bakker, B. Vanhaesebroeck, R. Beyaert, W.A. Jacob, and W. Fiers Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions: evidence for the involvement of mitochondrial radical generation J. Biol. Chem. 267 1992 5317 5323
    • (1992) J. Biol. Chem. , vol.267 , pp. 5317-5323
    • Schulze-Osthoff, K.1    Bakker, A.C.2    Vanhaesebroeck, B.3    Beyaert, R.4    Jacob, W.A.5    Fiers, W.6
  • 171
    • 0036293621 scopus 로고    scopus 로고
    • Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-α-induced apoptosis in cultured mouse hepatocytes
    • DOI 10.1053/jhep.2002.33995
    • H. Nagai, K. Matsumaru, G. Feng, and N. Kaplowitz Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor alpha-induced apoptosis in cultured mouse hepatocytes Hepatology 36 2002 55 64 (Pubitemid 34700762)
    • (2002) Hepatology , vol.36 , Issue.1 , pp. 55-64
    • Nagai, H.1    Matsumaru, K.2    Feng, G.3    Kaplowitz, N.4
  • 173
    • 0036703753 scopus 로고    scopus 로고
    • A bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death
    • R.A. Kirkland, J.A. Windelborn, J.M. Kasprzak, and J.L. Franklin A Bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death J. Neurosci. 22 2002 6480 6490 (Pubitemid 35386404)
    • (2002) Journal of Neuroscience , vol.22 , Issue.15 , pp. 6480-6490
    • Kirkland, R.A.1    Windelborn, J.A.2    Kasprzak, J.M.3    Franklin, J.L.4
  • 174
    • 77951498306 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: Mechanisms and implications for obesity prevention
    • C.C. Tai, and S.T. Ding N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: mechanisms and implications for obesity prevention J. Nutr. Biochem. 21 2010 357 363
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 357-363
    • Tai, C.C.1    Ding, S.T.2
  • 175
    • 0025915113 scopus 로고
    • Demonstration of cross-linked cytokeratin polypeptides in transplantable rat hepatoma cells
    • K. Fukuda, R. Xie, and J.F. Chiu Demonstration of cross-linked cytokeratin polypeptides in transplantable rat hepatoma cells Biochem. Biophys. Res. Commun. 176 1991 441 446
    • (1991) Biochem. Biophys. Res. Commun. , vol.176 , pp. 441-446
    • Fukuda, K.1    Xie, R.2    Chiu, J.F.3
  • 176
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
    • V.A. Fadok, D.L. Bratton, A. Konowal, P.W. Freed, J.Y. Westcott, and P.M. Henson Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF J. Clin. Invest. 101 1998 890 898 (Pubitemid 28096086)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.4 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 178
    • 0030756676 scopus 로고    scopus 로고
    • The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor β1 expression in the macrophage lineage: A link between oxidative injury and fibrosclerosis
    • G. Leonarduzzi, A. Scavazza, F. Biasi, E. Chiarpotto, S. Camandola, S. Vogel, R. Dargel, and G. Poli The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor β1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis FASEB J. 11 1997 851 857 (Pubitemid 27371894)
    • (1997) FASEB Journal , vol.11 , Issue.11 , pp. 851-857
    • Leonarduzzi, G.1    Scavazza, A.2    Biasi, F.3    Chiarpotto, E.4    Camandola, S.5    Vogl, S.6    Dargel, R.7    Poli, G.8
  • 179
    • 0345186310 scopus 로고    scopus 로고
    • Vitamin e but not glutathione precursors inhibits hepatic fibrosis in experimental NASH exhibiting oxidative stress and mitochondrial abnormalities
    • N. Phung, G. Farrell, G. Robertson, and J. George Vitamin E but not glutathione precursors inhibits hepatic fibrosis in experimental NASH exhibiting oxidative stress and mitochondrial abnormalities Hepatology 34 2001 361
    • (2001) Hepatology , vol.34 , pp. 361
    • Phung, N.1    Farrell, G.2    Robertson, G.3    George, J.4
  • 180
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-β1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: A pilot study
    • DOI 10.1046/j.1365-2036.2001.01083.x
    • T. Hasegawa, M. Yoneda, K. Nakamura, I. Makino, and A. Terano Plasma transforming growth factor-β1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis Aliment. Pharmacol. Ther. 15 2001 1667 1672 (Pubitemid 32912411)
    • (2001) Alimentary Pharmacology and Therapeutics , vol.15 , Issue.10 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3    Makino, I.4    Terano, A.5
  • 182
    • 19544378172 scopus 로고    scopus 로고
    • The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology
    • X. Ding, N.K. Saxena, S. Lin, A. Xu, S. Srinivasan, and F.A. Anania The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology Am. J. Pathol. 166 2005 1655 1669 (Pubitemid 40734389)
    • (2005) American Journal of Pathology , vol.166 , Issue.6 , pp. 1655-1669
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Xu, A.4    Srinivasan, S.5    Anania, F.A.6
  • 185
    • 14144249423 scopus 로고    scopus 로고
    • Is adiponectin involved in the pathogenesis of nonalcoholic steatohepatitis? A preliminary human study
    • DOI 10.1097/01.mcg.0000152747.79773.2f
    • R. Vuppalanchi, S. Marri, D. Kolwankar, R.V. Considine, and N. Chalasani Is adiponectin involved in the pathogenesis of nonalcoholic steatohepatitis? A preliminary human study J. Clin. Gastroenterol. 39 2005 237 242 (Pubitemid 40283961)
    • (2005) Journal of Clinical Gastroenterology , vol.39 , Issue.3 , pp. 237-242
    • Vuppalanchi, R.1    Marri, S.2    Kolwankar, D.3    Considine, R.V.4    Chalasani, N.5
  • 186
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • DOI 10.1172/JCI200317797
    • A. Xu, Y. Wang, H. Keshaw, L.Y. Xu, K.S. Lam, and G.J. Cooper The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice J. Clin. Invest. 112 2003 91 100 (Pubitemid 38056380)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.1 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.L.5    Cooper, G.J.S.6
  • 190
    • 4544334655 scopus 로고    scopus 로고
    • Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
    • DOI 10.1016/j.bbrc.2004.08.145, PII S0006291X04019126
    • A.M. Wolf, D. Wolf, H. Rumpold, B. Enrich, and H. Tilg Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes Biochem. Biophys. Res. Commun. 323 2004 630 635 (Pubitemid 39221142)
    • (2004) Biochemical and Biophysical Research Communications , vol.323 , Issue.2 , pp. 630-635
    • Wolf, A.M.1    Wolf, D.2    Rumpold, H.3    Enrich, B.4    Tilg, H.5
  • 191
    • 3042699353 scopus 로고    scopus 로고
    • Adiponectin protects LPS-induced liver injury through modulation of TNF-α in KK-Ay obese mice
    • DOI 10.1002/hep.20282
    • T. Masaki, S. Chiba, H. Tatsukawa, T. Yasuda, H. Noguchi, M. Seike, and H. Yoshimatsu Adiponectin protects LPS-induced liver injury through modulation of TNFalpha in KK-Ay obese mice Hepatology 40 2004 177 184 (Pubitemid 38868936)
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 177-184
    • Masaki, T.1    Chiba, S.2    Tatsukawa, H.3    Yasuda, T.4    Noguchi, H.5    Seike, M.6    Yoshimatsu, H.7
  • 192
    • 0036511213 scopus 로고    scopus 로고
    • ACRP30/adiponectin: An adipokine regulating glucose and lipid metabolism
    • DOI 10.1016/S1043-2760(01)00524-0, PII S1043276001005240
    • A.H. Berg, T.P. Combs, and P.E. Scherer ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism Trends Endocrinol. Metab. 13 2002 84 89 (Pubitemid 36740452)
    • (2002) Trends in Endocrinology and Metabolism , vol.13 , Issue.2 , pp. 84-89
    • Berg, A.H.1    Combs, T.P.2    Scherer, P.E.3
  • 193
    • 14844327755 scopus 로고    scopus 로고
    • Adiponectin: A relevant player in PPARγ-agonist-mediated improvements in hepatic insulin sensitivity?
    • M. Bouskila, U.B. Pajvani, and P.E. Scherer Adiponectin: a relevant player in PPARγ-agonist-mediated improvements in hepatic insulin sensitivity? Int. J. Obes. Relat. Metab. Disord. 29 2005 S17 S23
    • (2005) Int. J. Obes. Relat. Metab. Disord. , vol.29
    • Bouskila, M.1    Pajvani, U.B.2    Scherer, P.E.3
  • 195
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of bodyweight in mammals
    • J.M. Friedman, and J.L. Halaas Leptin and the regulation of bodyweight in mammals Nature 395 1998 763 770
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 196
    • 0036329894 scopus 로고    scopus 로고
    • Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity?
    • DOI 10.1053/jhep.2002.34738
    • S. Chitturi, G. Farrell, L. Frost, A. Kriketos, R. Lin, C. Fung, C. Liddle, D. Samarasinghe, and J. George Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity Hepatology 36 2002 403 409 (Pubitemid 34810360)
    • (2002) Hepatology , vol.36 , Issue.2 , pp. 403-409
    • Chitturi, S.1    Farrell, G.2    Frost, L.3    Kriketos, A.4    Lin, R.5    Liddle, C.6    Samarasinghe, D.7    George, J.8
  • 197
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • DOI 10.1016/S0168-8278(02)00102-2, PII S0168827802001022
    • I.A. Leclercq, G.C. Farrell, R. Schriemer, and G.R. Robertson Leptin is essential for the hepatic fibrogenic response to chronic liver injury J. Hepatol. 37 2002 206 213 (Pubitemid 34833082)
    • (2002) Journal of Hepatology , vol.37 , Issue.2 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 199
    • 0036204924 scopus 로고    scopus 로고
    • Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells in lean littermates of ob/ob mice
    • 762-371
    • N.K. Saxena, K. Ikeda, D.C. Rockey, S.L. Friedman, and F.A. Anania Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells in lean littermates of ob/ob mice Hepatology 35 2002 762-371
    • (2002) Hepatology , vol.35
    • Saxena, N.K.1    Ikeda, K.2    Rockey, D.C.3    Friedman, S.L.4    Anania, F.A.5
  • 200
    • 0036031768 scopus 로고    scopus 로고
    • Leptin enhances the effect of transforming growth factor β in increasing type I collagen formation
    • DOI 10.1016/S0006-291X(02)02300-8, PII S0006291X02023008
    • M. Tang, J.J. Potter, and E. Mezey Leptin enhances the effect of transforming growth factor β in increasing type I collagen formation Biochem. Biophys. Res. Commun. 297 2002 906 911 (Pubitemid 35230336)
    • (2002) Biochemical and Biophysical Research Communications , vol.297 , Issue.4 , pp. 906-911
    • Tang, M.1    Potter, J.J.2    Mezey, E.3
  • 202
    • 23844556589 scopus 로고    scopus 로고
    • Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes
    • DOI 10.1210/en.2005-0087
    • Y. Toyoshima, O. Gavrilova, S. Yakar, W. Jou, S. Pack, Z. Asghar, M.B. Wheeler, and D. LeRoith Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes Endocrinology 146 2005 4024 4035 (Pubitemid 41175774)
    • (2005) Endocrinology , vol.146 , Issue.9 , pp. 4024-4035
    • Toyoshima, Y.1    Gavrilova, O.2    Yakar, S.3    Jou, W.4    Pack, S.5    Asghar, Z.6    Wheeler, M.7    LeRoith, D.8
  • 203
    • 0033638542 scopus 로고    scopus 로고
    • Development of leptin resistance in rat soleus muscle in response to high-fat diets
    • G.R. Steinberg, and D.J. Dyck Development of leptin resistance in rat soleus muscle in response to high-fat diets Am. J. Physiol. Endocrinol. Metab. 279 2000 E1374 E1382
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279
    • Steinberg, G.R.1    Dyck, D.J.2
  • 204
    • 0036298225 scopus 로고    scopus 로고
    • Leptin increases FA oxidation in lean but not obese human skeletal muscle: Evidence of peripheral leptin resistance
    • G.R. Steinberg, M.L. Parolin, G.J. Heigenhauser, and D.J. Dyck Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance Am. J. Physiol. Endocrinol. Metab. 283 2002 E187 E192
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283
    • Steinberg, G.R.1    Parolin, M.L.2    Heigenhauser, G.J.3    Dyck, D.J.4
  • 209
    • 54749129969 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis
    • J.N. Baumgardner, K. Shankar, L. Hennings, E. Albano, T.M. Badger, and M.J. Ronis N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis J. Nutr. 138 2008 1872 1879
    • (2008) J. Nutr. , vol.138 , pp. 1872-1879
    • Baumgardner, J.N.1    Shankar, K.2    Hennings, L.3    Albano, E.4    Badger, T.M.5    Ronis, M.J.6
  • 210
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: A pilot study
    • 1667-1672
    • T. Hasegawa, M. Yoneda, K. Nakamura, I. Makino, and A. Terano Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study Aliment. Pharmacol. Ther. 15 2001 1667-1672
    • (2001) Aliment. Pharmacol. Ther. , vol.15
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3    Makino, I.4    Terano, A.5
  • 212
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and Vitamin C Treatment Improves Fibrosis in Patients with Nonalcoholic Steatohepatitis
    • DOI 10.1111/j.1572-0241.2003.08699.x
    • S.A. Harrison, S. Torgerson, P. Hayashi, J. Ward, and S. Schenker Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis Am. J. Gastroenterol. 98 2003 2485 2490 (Pubitemid 37448761)
    • (2003) American Journal of Gastroenterology , vol.98 , Issue.11 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3    Ward, J.4    Schenker, S.5
  • 214
    • 77952049390 scopus 로고    scopus 로고
    • The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease
    • S.A. Polyzos, J. Kountouras, C. Zavos, and E. Tsiaousi The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease Diabetes Obes. Metab. 12 2010 365 383
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 365-383
    • Polyzos, S.A.1    Kountouras, J.2    Zavos, C.3    Tsiaousi, E.4
  • 215
    • 33745212925 scopus 로고    scopus 로고
    • Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
    • R. Gutierrez-Juarez, A. Pocai, C. Mulas, H. Ono, S. Bhanot, B.P. Monia, and L. Rossetti Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance J. Clin. Invest. 116 2006 1686 1695
    • (2006) J. Clin. Invest. , vol.116 , pp. 1686-1695
    • Gutierrez-Juarez, R.1    Pocai, A.2    Mulas, C.3    Ono, H.4    Bhanot, S.5    Monia, B.P.6    Rossetti, L.7
  • 217
    • 33745166337 scopus 로고    scopus 로고
    • Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
    • DOI 10.1016/j.freeradbiomed.2006.02.014, PII S0891584906001249
    • S. Kume, M. Haneda, K. Kanasaki, T. Sugimoto, S. Araki, M. Isono, K. Isshiki, T. Uzu, A. Kashiwagi, and D. Koya Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation Free Radic. Biol. Med. 40 2006 2175 2182 (Pubitemid 43903102)
    • (2006) Free Radical Biology and Medicine , vol.40 , Issue.12 , pp. 2175-2182
    • Kume, S.1    Haneda, M.2    Kanasaki, K.3    Sugimoto, T.4    Araki, S.-i.5    Isono, M.6    Isshiki, K.7    Uzu, T.8    Kashiwagi, A.9    Koya, D.10
  • 218
    • 34547101692 scopus 로고    scopus 로고
    • The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats
    • X.Q. Deng, L.L. Chen, and N.X. Li The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats Liver Int. 27 2007 708 715
    • (2007) Liver Int. , vol.27 , pp. 708-715
    • Deng, X.Q.1    Chen, L.L.2    Li, N.X.3
  • 220
    • 60549098942 scopus 로고    scopus 로고
    • Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway
    • G.L. Wang, Y.C. Fu, W.C. Xu, Y.Q. Feng, S.R. Fang, and X.H. Zhou Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway Biochem. Biophys. Res. Commun. 380 2009 644 649
    • (2009) Biochem. Biophys. Res. Commun. , vol.380 , pp. 644-649
    • Wang, G.L.1    Fu, Y.C.2    Xu, W.C.3    Feng, Y.Q.4    Fang, S.R.5    Zhou, X.H.6


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