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Volumn 8, Issue 2, 2015, Pages 2190-2196

As2O3 induces apoptosis in human hepatocellular carcinoma HepG2 cells through a ROS-mediated mitochondrial pathway and activation of caspases

Author keywords

Arsenic trioxide; Caspase; Hepatocellular carcinoma; Mitochondrial pathway; Reactive oxygen species

Indexed keywords

ARSENIC TRIOXIDE; CASPASE; CASPASE 3; CASPASE 6; CASPASE 9; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

EID: 84926361584     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (34)

References (29)
  • 1
    • 84885695576 scopus 로고    scopus 로고
    • Metastatic hepatocellular carcinoma in a juvenile rhesus macaque (Macaca mulatta)
    • Laing ST, Lemoy MJ, Sammak RL, Tarara RP. Metastatic hepatocellular carcinoma in a juvenile rhesus macaque (Macaca mulatta). Comp Med 2013; 63: 448-53.
    • (2013) Comp Med , vol.63 , pp. 448-453
    • Laing, S.T.1    Lemoy, M.J.2    Sammak, R.L.3    Tarara, R.P.4
  • 2
    • 46049111422 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Current management and recent advances
    • Lau WY, Lai EC. Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int 2008; 7: 237-57.
    • (2008) Hepatobiliary Pancreat Dis Int , vol.7 , pp. 237-257
    • Lau, W.Y.1    Lai, E.C.2
  • 3
    • 84880415678 scopus 로고    scopus 로고
    • Somatostatin receptor subtypes 2 and 5 are associated with better survival in operable hepatitis B-related hepatocellular carcinoma following octreotide long-acting release treatment
    • Liu Y, Jiang L, Mu Y. Somatostatin receptor subtypes 2 and 5 are associated with better survival in operable hepatitis B-related hepatocellular carcinoma following octreotide long-acting release treatment. Oncol Lett 2013; 6: 821-28. 4.
    • (2013) Oncol Lett , vol.6 , Issue.821-28 , pp. 4
    • Liu, Y.1    Jiang, L.2    Mu, Y.3
  • 4
    • 84880713859 scopus 로고    scopus 로고
    • Prospective evaluation of patients with early-/intermediate-stage hepatocellular carcinoma with disease progression following arterial locoregional therapy: Candidacy for systemic treatment or clinical trials
    • Memon K, Kulik L, Lewandowski RJ, Gupta R, Ryu RK, Miller FH, Vouche M, Atassi R, Ganger D, Mulcahy MF, Salem R. Prospective evaluation of patients with early-/intermediate-stage hepatocellular carcinoma with disease progression following arterial locoregional therapy: candidacy for systemic treatment or clinical trials. J Vasc Interv Radiol 2013; 24: 1189-97. e2.
    • (2013) J Vasc Interv Radiol , vol.24 , Issue.1189-97
    • Memon, K.1    Kulik, L.2    Lewandowski, R.J.3    Gupta, R.4    Ryu, R.K.5    Miller, F.H.6    Vouche, M.7    Atassi, R.8    Ganger, D.9    Mulcahy, M.F.10    Salem, R.11
  • 5
    • 33646528908 scopus 로고    scopus 로고
    • Effect of arsenic trioxide on multidrug resistant hepatocellular carcinoma cells
    • Chan JY, Siu KP, Fung KP. Effect of arsenic trioxide on multidrug resistant hepatocellular carcinoma cells. Cancer Lett 2006; 236: 250-8.
    • (2006) Cancer Lett , vol.236 , pp. 250-258
    • Chan, J.Y.1    Siu, K.P.2    Fung, K.P.3
  • 6
    • 84889010542 scopus 로고    scopus 로고
    • Scirrhous hepatocellular carcinoma on gadoxetic Acid-enhanced magnetic resonance imaging and diffusion-weighted imaging: Emphasis on the differentiation of intrahepatic cholangiocarcinoma
    • Park MJ, Kim YK, Park HJ, Hwang J, Lee WJ. Scirrhous hepatocellular carcinoma on gadoxetic Acid-enhanced magnetic resonance imaging and diffusion-weighted imaging: emphasis on the differentiation of intrahepatic cholangiocarcinoma. J Comput Assist Tomogr 2013; 37: 872-81.
    • (2013) J Comput Assist Tomogr , vol.37 , pp. 872-881
    • Park, M.J.1    Kim, Y.K.2    Park, H.J.3    Hwang, J.4    Lee, W.J.5
  • 7
    • 77958488937 scopus 로고    scopus 로고
    • As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland
    • Fu ZC, Zhang B, Fu ZJ. As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland. Med Hypotheses 2010; 75: 490-1.
    • (2010) Med Hypotheses , vol.75 , pp. 490-491
    • Fu, Z.C.1    Zhang, B.2    Fu, Z.J.3
  • 8
    • 0033792785 scopus 로고    scopus 로고
    • Arsenicals in hematologic cancers
    • Novick SC, Warrell RP Jr. Arsenicals in hematologic cancers. Semin Oncol 2000; 27: 495-501.
    • (2000) Semin Oncol , vol.27 , pp. 495-501
    • Novick, S.C.1    Warrell, R.P.2
  • 9
    • 0037036157 scopus 로고    scopus 로고
    • Effect of arsenic trioxide on human hepatocellular carcinoma HepG2 cells: Inhibition of proliferation and induction of apoptosis
    • Siu KP, Chan JY, Fung KP. Effect of arsenic trioxide on human hepatocellular carcinoma HepG2 cells: inhibition of proliferation and induction of apoptosis. Life Sci 2002; 71: 275-85.
    • (2002) Life Sci , vol.71 , pp. 275-285
    • Siu, K.P.1    Chan, J.Y.2    Fung, K.P.3
  • 10
    • 0010740572 scopus 로고    scopus 로고
    • Chen Z. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
    • Chen GQ, Zhu J, Shi XG, Ni JH, Zhong HJ, Si GY, Jin XL, Tang W, Li XS, Xong SM, Shen ZX, Sun GL, Ma J, Zhang P, Zhang TD, Gazin C, Naoe T, Chen SJ, Wang ZY, Chen Z. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood 1996; 88: 1052-61.
    • (1996) Blood , vol.88 , pp. 1052-1061
    • Chen, G.Q.1    Zhu, J.2    Shi, X.G.3    Ni, J.H.4    Zhong, H.J.5    Si, G.Y.6    Jin, X.L.7    Tang, W.8    Li, X.S.9    Xong, S.M.10    Shen, Z.X.11    Sun, G.L.12    Ma, J.13    Zhang, P.14    Zhang, T.D.15    Gazin, C.16    Naoe, T.17    Chen, S.J.18    Wang, Z.Y.19
  • 12
    • 84875047834 scopus 로고    scopus 로고
    • Arsenic trioxide-mediated oxidative stress and genotoxicity in human hepatocellular carcinoma cells
    • Alarifi S, Ali D, Alkahtani S, Siddiqui MA, Ali BA. Arsenic trioxide-mediated oxidative stress and genotoxicity in human hepatocellular carcinoma cells. Onco Targets Ther 2013; 6: 75-84.
    • (2013) Onco Targets Ther , vol.6 , pp. 75-84
    • Alarifi, S.1    Ali, D.2    Alkahtani, S.3    Siddiqui, M.A.4    Ali, B.A.5
  • 13
    • 0022445670 scopus 로고
    • Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
    • Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89: 271-7.
    • (1986) J Immunol Methods , vol.89 , pp. 271-277
    • Denizot, F.1
  • 14
    • 0024450183 scopus 로고
    • Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: Induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide
    • Aune TM, Pogue SL. Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. J Clin Invest 1989; 84: 863-75.
    • (1989) J Clin Invest , vol.84 , pp. 863-875
    • Aune, T.M.1    Pogue, S.L.2
  • 15
    • 0024425516 scopus 로고
    • Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha
    • Meier B, Radeke HH, Selle S, Younes M, Sies H, Resch K, Habermehl GG. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem J 1989; 263: 539-45.
    • (1989) Biochem J , vol.263 , pp. 539-545
    • Meier, B.1    Radeke, H.H.2    Selle, S.3    Younes, M.4    Sies, H.5    Resch, K.6    Habermehl, G.G.7
  • 16
    • 0024594885 scopus 로고
    • Walker carcinosarcoma cells damage endothelial cells by the generation of reactive oxygen species
    • Shaughnessy SG, Buchanan MR, Turple S, Richardson M, Orr FW. Walker carcinosarcoma cells damage endothelial cells by the generation of reactive oxygen species. Am J Pathol 1989; 134: 787-96.
    • (1989) Am J Pathol , vol.134 , pp. 787-796
    • Shaughnessy, S.G.1    Buchanan, M.R.2    Turple, S.3    Richardson, M.4    Orr, F.W.5
  • 17
    • 0026021362 scopus 로고
    • Production of large amounts of hydrogen peroxide by human tumor cells
    • Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991; 51: 794-8.
    • (1991) Cancer Res , vol.51 , pp. 794-798
    • Szatrowski, T.P.1    Nathan, C.F.2
  • 18
    • 0036606394 scopus 로고    scopus 로고
    • Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide
    • Fang J, Sawa T, Akaike T, Maeda H. Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer Res 2002; 62: 3138-43.
    • (2002) Cancer Res , vol.62 , pp. 3138-3143
    • Fang, J.1    Sawa, T.2    Akaike, T.3    Maeda, H.4
  • 19
    • 0034699513 scopus 로고    scopus 로고
    • Superoxide dismutase as a target for the selective killing of cancer cells
    • Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000; 407: 390-5.
    • (2000) Nature , vol.407 , pp. 390-395
    • Huang, P.1    Feng, L.2    Oldham, E.A.3    Keating, M.J.4    Plunkett, W.5
  • 20
    • 0032100603 scopus 로고    scopus 로고
    • Redox signaling and the emerging therapeutic potential of thiol antioxidants
    • Sen CK. Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochem Pharmacol 1998; 55: 1747-58.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1747-1758
    • Sen, C.K.1
  • 21
    • 0036479049 scopus 로고    scopus 로고
    • Mitochondrial intermembrane junctional complexes and their involvement in cell death
    • Crompton M, Barksby E, Johnson N, Capano M. Mitochondrial intermembrane junctional complexes and their involvement in cell death. Biochimie 2002; 84: 143-52.
    • (2002) Biochimie , vol.84 , pp. 143-152
    • Crompton, M.1    Barksby, E.2    Johnson, N.3    Capano, M.4
  • 22
    • 0032775550 scopus 로고    scopus 로고
    • Cupric nitrilotriacetate-induced apoptosis in HL-60 cells association with lipid peroxidation, release of cytochrome C from mitochondria, and activation of caspase-3
    • Ma Y, Ogino T, Kawabata T, Li J, Eguchi K, Okada S. Cupric nitrilotriacetate-induced apoptosis in HL-60 cells association with lipid peroxidation, release of cytochrome C from mitochondria, and activation of caspase-3. Free Radic Biol Med 1999; 27: 227-33.
    • (1999) Free Radic Biol Med , vol.27 , pp. 227-233
    • Ma, Y.1    Ogino, T.2    Kawabata, T.3    Li, J.4    Eguchi, K.5    Okada, S.6
  • 23
    • 0034650523 scopus 로고    scopus 로고
    • Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
    • Antonsson B, Montessuit S, Lauper S, Eskes R, Martinou JC. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J 2000; 345 Pt 2: 271-8.
    • (2000) Biochem J , vol.345 , pp. 271-278
    • Antonsson, B.1    Montessuit, S.2    Lauper, S.3    Eskes, R.4    Martinou, J.C.5
  • 24
    • 0034711236 scopus 로고    scopus 로고
    • Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death
    • Atlante A, Calissano P, Bobba A, Azzariti A, Mar-ra E, Passarella S. Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death. J Biol Chem 2000; 275: 37159-66.
    • (2000) J Biol Chem , vol.275 , pp. 37159-37166
    • Atlante, A.1    Calissano, P.2    Bobba, A.3    Azzariti, A.4    Mar-Ra, E.5    Passarella, S.6
  • 25
    • 0033927797 scopus 로고    scopus 로고
    • Assays for cytochrome c release from mitochondria during apoptosis
    • Bossy-Wetzel E, Green DR. Assays for cytochrome c release from mitochondria during apoptosis. Methods Enzymol 2000; 322: 235-42.
    • (2000) Methods Enzymol , vol.322 , pp. 235-242
    • Bossy-Wetzel, E.1    Green, D.R.2
  • 26
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: The executioners of apoptosis
    • Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997; 326: 1-16.
    • (1997) Biochem J , vol.326 , pp. 1-16
    • Cohen, G.M.1
  • 27
    • 3242743111 scopus 로고    scopus 로고
    • Apoptosis in Bio-chemistry and Structural Biology
    • 3-8 February 2004, Keystone, CO, USA
    • Denault JB, Boatright K. Apoptosis in Bio-chemistry and Structural Biology. 3-8 February 2004, Keystone, CO, USA. IDrugs 2004; 7: 315-7.
    • (2004) Idrugs , vol.7 , pp. 315-317
    • Denault, J.B.1    Boatright, K.2
  • 28
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-6.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 29
    • 0033580926 scopus 로고    scopus 로고
    • Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
    • Saleh A, Srinivasula SM, Acharya S, Fishel R, Alnemri ES. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J Biol Chem 1999; 274: 17941-5.
    • (1999) J Biol Chem , vol.274 , pp. 17941-17945
    • Saleh, A.1    Srinivasula, S.M.2    Acharya, S.3    Fishel, R.4    Alnemri, E.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.