Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

Inflammopharmacology

Volumn 19, Issue 4, 2011, Pages 235-241

  Thiyagarajan, P ^a   Chandrasekaran, C V ^a   Deepak, H B ^a   Agarwal, Amit ^a  

^a Natural Remedies Pvt Ltd   (India)

Author keywords

Glycyrrhiza glabra; Inflammation; Phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin); Pro inflammatory mediators (NO, IL 1 beta and IL 6)

Indexed keywords

DEXAMETHASONE; GLABRIDIN; GLYCYRRHIZA GLABRA EXTRACT; GLYCYRRHIZIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOLIQUIRITIGENIN; LIPOPOLYSACCHARIDE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NITRIC OXIDE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; IC 50; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CHALCONES; CYTOKINES; DOWN-REGULATION; DRUG DISCOVERY; GLYCYRRHIZA; GLYCYRRHIZIC ACID; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; ISOFLAVONES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS;

EID: 79960236561     PISSN: 09254692     EISSN: 15685608     Source Type: Journal    
DOI: 10.1007/s10787-011-0080-x     Document Type: Article

References (35)

1. H Akamatsu J Komura Y Asada Y Niwa 1991 Mechanism of anti-inflammatory action of glycyrrhizin: effect on neutrophil functions including reactive oxygen species generation Planta Med 57 199 221 10.1055/s-2006-960045
2. MN Asl H Hosseinzadeh 2008 Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds Phytother Res 22 709 724 18446848 10.1002/ptr.2362 1:CAS:528:DC%2BD1cXpsVCqu7s%3D (Pubitemid 351955567)
3. JE Barbato E Tzeng 2004 Nitric oxide and arterial disease J Vasc Surg 40 187 193 15218485 10.1016/j.jvs.2004.03.043 (Pubitemid 38813085)
4. PA Belinky M Aviram B Fuhrman M Rosenblat J Vaya 1998 The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation Atherosclerosis 137 49 61 9568736 10.1016/S0021-9150(97)00251-7 1:CAS:528:DyaK1cXitlSmu70%3D (Pubitemid 28175376)
5. CV Chandrasekaran G Anumita A Amit 2010 Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro J Ethnopharmacol 129 203 207 20307638 10.1016/j.jep.2010.03.007 1:STN:280:DC%2BC3czjs1GhsA%3D%3D
6. Chandrasekaran CV, Deepak HB, Thiyagarajan P, Kathiresan S, Sangli GK (2010b) Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products. Phytomedicine. doi: 10.1016/j.phymed.2010.08.001
7. KK Dharmappa R Mohamed HV Shivaprasad BS Vishwanath 2010 Genistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation Inflammopharmacology 18 25 31 19894024 10.1007/s10787-009-0018- 8 1:CAS:528:DC%2BC3cXpslWhsQ%3D%3D
8. CA Dinarello 1996 Biological basis for interleukin -1 in disease Blood 87 2095 2147 8630372 1:CAS:528:DyaK28Xhs1CktLc%3D
9. C Fiore M Eisenhut E Ragazzi G Zanchin D Armanini 2005 A history of the therapeutic use of liquorice in Europe J Ethnopharmacol 99 317 324 15978760 10.1016/j.jep.2005.04.015 (Pubitemid 40854146)
10. S Fu KS Ramanujam A Wong GT Fantry CB Drachenberg SP James SJ Meltzer KT Wilson 1999 Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase-2 in Helicobacter pylori gastritis Gastroenterology 116 1319 1329 10348815 10.1016/S0016-5085(99)70496-8 1:CAS:528:DyaK1MXjvFOlu7k%3D (Pubitemid 29258880)
11. T Fukai K Satoh T Nomura H Sakagami 2003 Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza inflata Fitoterapia 74 624 629 14630165 10.1016/S0367-326X(03)00164-3 1:CAS:528:DC%2BD3sXptVeqtrw%3D (Pubitemid 37443449)
12. J Houghton TC Wang 2005 Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers Gastroenterology 128 1567 1578 15887152 10.1053/j.gastro.2005.03.037 1:CAS:528:DC%2BD2MXltlOgtb4%3D (Pubitemid 40692553)
13. H Inoue H Saito Y Koshihara S Murota 1986 Inhibitory effect of glycyrrhetinic acid derivatives on lipoxygenase and prostaglandin synthetase Chem Pharm Bull 34 897 901 3085963 1:CAS:528:DyaL28XitFykur4%3D (Pubitemid 16124658)
14. Kaczor T (2009) Deglycyrrhizinated licorice (DGL) for gastrointestinal ulcers: how can something so good be so poorly proven? Nat Med J 1
15. H Kakegawa H Matsumoto T Satoh 1992 Inhibitory effects of some natural products on the activation of hyaluronidase and their anti-allergic actions Chem Pharmaceut Bull (Tokyo) 40 1439 1442 1:CAS:528:DyaK38Xls1ems78%3D
16. J Kamei R Nakamura H Ichiki M Kubo 2003 Antitussive principles of Glycyrrhiza radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang) Eur J Pharmacol 469 159 163 12782198 10.1016/S0014-2999(03) 01728-X 1:CAS:528:DC%2BD3sXktFGlurg%3D (Pubitemid 36629562)
17. JS Kang YD Yoon IJ Cho MH Han CW Lee SK Park HM Kim 2005 Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock J Pharmacol Exp Therapeut 312 1187 1194 10.1124/jpet.104.077107 1:CAS:528:DC%2BD2MXitVOgs74%3D (Pubitemid 40293780)
18. JK Kim SM Oh HS Kwon YS Oh SS Lim HK Shin 2006 Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide-induced inflammatory responses in murine macrophages Biochem Biophys Res Comm 345 1215 1223 16716255 10.1016/j.bbrc.2006.05.035 1:CAS:528:DC%2BD28Xlt1CmsLw%3D (Pubitemid 44218790)
19. JY Kim SJ Park KJ Yun YW Cho HJ Park KT Lee 2008 Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappa B in RAW264.7 macrophages Eur J Pharmacol 584 175 184 18295200 10.1016/j.ejphar.2008.01.032 1:CAS:528:DC%2BD1cXktVKrsLY%3D
20. KH Kwon A Murakami R Hayashi H Ohigashi 2005 Interleukin-1 beta targets interleukin-6 in progressing dextran sulfate sodium induced experimental colitis Biochem Biophys Res Commun 337 647 654 16202978 10.1016/j.bbrc.2005.09.107 1:CAS:528:DC%2BD2MXhtFWhsbbI (Pubitemid 41429334)
21. T Mosmann 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Meth 65 55 63 10.1016/0022-1759(83)90303-4 1:STN:280:DyaL2c%2FovFSmtw%3D%3D (Pubitemid 14203433)
22. M Mukherjee N Bhaskaran R Srinath HN Shivaprasad JJ Allan D Shekhar A Agarwal 2010 Anti-ulcer and anti-oxidant activity of GutGard™ Indian J Exp Biol 48 269 274 21046980
23. KhM Nasyrov DN Lazareva 1980 Study of the anti-inflammatory activity of glycyrrhizic acid derivatives Farmakol Toksikol (Moscow) 43 399 404 1:CAS:528:DyaL3cXlsl2msrg%3D (Pubitemid 11231054)
24. 2 production by activated peritoneal macrophages from rats Prostaglandins Med 7 457 463 6798590 10.1016/0161-4630(81)90033-1 1:CAS:528:DyaL38XhtFGlt7w%3D (Pubitemid 12249608)
25. A Olukoga D Donaldson 2000 Liquorice and its health implications J Roy Soc Health 120 83 89 10.1177/146642400012000203 1:STN:280:DC%2BD3cvjvVemsQ%3D%3D (Pubitemid 30458457)
26. S Omoigui 2007 The Interleukin-6 inflammation pathway from cholesterol to aging-role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases Immun Ageing 4 1 17374166 10.1186/1742-4933-4-1 (Pubitemid 46534042)
27. Park SH, Kang JS, Yoon YD, Lee K, Kim KJ, Lee KH, Lee CW, Moon EY, Han SB, Kim BH, Kim HM, Park SK (2009) Glabridin inhibits lipopolysaccharide-induced activation of a microglial cell line, BV-2, by blocking NF-kappa B and AP-1. Phytother Res 24:S29-S34
28. 4 and PAF Mediat Inflamm 1 5 8 10.1155/ S0962935192000024
29. United States Pharmacoepia (USP) NF (2009) vol 32
30. J Vaya PA Belinky M Aviram 1997 Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation Free Radic Biol Med 23 302 313 9199893 10.1016/S0891-5849(97)00089-0 1:CAS:528:DyaK2sXktFOnurc%3D (Pubitemid 27276611)
31. BA Weissman SS Gross 2001 Measurement of NO and NO synthase Curr Protoc Neurosci 7 13 18428524
32. KL Wolfe RH Liu 2007 Cellular antioxidant activity (CAA) assay for assessing antioxidants, foods, and dietary supplements J Agric Food Chem 55 8896 8907 17902627 10.1021/jf0715166 1:CAS:528:DC%2BD2sXhtFSnsLzK (Pubitemid 350105534)
33. T Yokota H Nishio Y Kubota M Mizoguchi 1998 The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation Pigment Cell Res 11 355 361 9870547 10.1111/j.1600-0749.1998.tb00494.x 1:CAS:528: DyaK1MXitVSqtA%3D%3D (Pubitemid 128531532)
34. WJ Yoon YM Ham SS Kim BS Yoo JY Moon JS Baik NH Lee CG Hyun 2009 Suppression of pro-inflammatory cytokines, iNOS, and COX-2 expression by brown algae Sargassum micracanthum in RAW 264.7 macrophages EurAsia J BioSci 3 130 143 10.5053/ejobios.2009.3.0.17
35. S Zhou HL Koh Y Gao ZY Gong EJ Lee 2004 Herbal bioactivation: the good, and the bad and the ugly Life Sci 74 935 968 14672753 10.1016/j.lfs.2003.09.035 1:CAS:528:DC%2BD3sXps1GqsL8%3D (Pubitemid 37522131)