메뉴 건너뛰기




Volumn 22, Issue 6, 2012, Pages 471-476

Gut-liver axis: The impact of gut microbiota on non alcoholic fatty liver disease

Author keywords

Bacterial translocation; Endotoxemia; Gut microbiota; Non alcoholic fatty liver disease; Probiotics

Indexed keywords

ANIMAL; BACTERIAL TRANSLOCATION; DISEASE MODEL; FATTY LIVER; GASTROINTESTINAL TRACT; HOMEOSTASIS; HUMAN; LIVER; METABOLIC DISORDER; METAGENOME; MICROBIOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW;

EID: 84861197530     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2012.02.007     Document Type: Review
Times cited : (369)

References (50)
  • 1
    • 77956825557 scopus 로고    scopus 로고
    • Contribution of gut bacteria to liver pathobiology
    • Epub 2010 Jul 28
    • Son G., Kremer M., Hines I.N. Contribution of gut bacteria to liver pathobiology. Gastroenterol Res Pract 2010, Epub 2010 Jul 28.
    • (2010) Gastroenterol Res Pract
    • Son, G.1    Kremer, M.2    Hines, I.N.3
  • 2
    • 0037425743 scopus 로고    scopus 로고
    • Gut flora in health and disease
    • Guarner F., Malagelada J.R. Gut flora in health and disease. Lancet 2003, 361(9356):512-519.
    • (2003) Lancet , vol.361 , Issue.9356 , pp. 512-519
    • Guarner, F.1    Malagelada, J.R.2
  • 3
    • 74549191082 scopus 로고    scopus 로고
    • The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis
    • Abt M.C., Artis D. The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis. Curr Opin Gastroenterol 2009, 25(6):496-502.
    • (2009) Curr Opin Gastroenterol , vol.25 , Issue.6 , pp. 496-502
    • Abt, M.C.1    Artis, D.2
  • 5
    • 33745594044 scopus 로고    scopus 로고
    • The gut flora as a forgotten organ
    • O'Hara A.M., Shanahan F. The gut flora as a forgotten organ. EMBO Rep 2006, 7(7):688-693.
    • (2006) EMBO Rep , vol.7 , Issue.7 , pp. 688-693
    • O'Hara, A.M.1    Shanahan, F.2
  • 6
    • 59849113547 scopus 로고    scopus 로고
    • Microbes in gastrointestinal health and disease
    • Neish A.S. Microbes in gastrointestinal health and disease. Gastroenterology 2009, 136(1):65-80.
    • (2009) Gastroenterology , vol.136 , Issue.1 , pp. 65-80
    • Neish, A.S.1
  • 7
    • 0035164415 scopus 로고    scopus 로고
    • Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity
    • Zhang G., Ghosh S. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest 2001, 107(1):13-19.
    • (2001) J Clin Invest , vol.107 , Issue.1 , pp. 13-19
    • Zhang, G.1    Ghosh, S.2
  • 8
    • 34249052239 scopus 로고    scopus 로고
    • Molecular interactions between bacteria, the epithelium, and the mucosal immune system in the intestinal tract: implications for chronic inflammation
    • Clavel T., Haller D. Molecular interactions between bacteria, the epithelium, and the mucosal immune system in the intestinal tract: implications for chronic inflammation. Curr Issues Intest Microbiol 2007, 8(2):25-43.
    • (2007) Curr Issues Intest Microbiol , vol.8 , Issue.2 , pp. 25-43
    • Clavel, T.1    Haller, D.2
  • 9
    • 0036885585 scopus 로고    scopus 로고
    • The host-microbe interface within the gut
    • Shanahan F. The host-microbe interface within the gut. Best Pract Res Clin Gastroenterol 2002, 16(6):915-931.
    • (2002) Best Pract Res Clin Gastroenterol , vol.16 , Issue.6 , pp. 915-931
    • Shanahan, F.1
  • 10
  • 11
  • 12
    • 67650604595 scopus 로고    scopus 로고
    • The role of the gut microbiota in energy metabolism and metabolic disease
    • Cani P.D., Delzenne N.M. The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des 2009, 15(13):1546-1558.
    • (2009) Curr Pharm Des , vol.15 , Issue.13 , pp. 1546-1558
    • Cani, P.D.1    Delzenne, N.M.2
  • 13
    • 36549032927 scopus 로고    scopus 로고
    • Alterations in intestinal microbial flora and human disease
    • Othman M., Agüero R., Lin H.C. Alterations in intestinal microbial flora and human disease. Curr Opin Gastroenterol 2008, 24(1):11-16.
    • (2008) Curr Opin Gastroenterol , vol.24 , Issue.1 , pp. 11-16
    • Othman, M.1    Agüero, R.2    Lin, H.C.3
  • 14
    • 38349078988 scopus 로고    scopus 로고
    • Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis
    • Nagata K., Suzuki H., Sakaguchi S. Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. J Toxicol Sci 2007, 32(5):453-468.
    • (2007) J Toxicol Sci , vol.32 , Issue.5 , pp. 453-468
    • Nagata, K.1    Suzuki, H.2    Sakaguchi, S.3
  • 15
    • 0033825775 scopus 로고    scopus 로고
    • Gut-liver axis
    • Zeuzem S. Gut-liver axis. Int J Colorectal Dis 2000, 15(2):59-82.
    • (2000) Int J Colorectal Dis , vol.15 , Issue.2 , pp. 59-82
    • Zeuzem, S.1
  • 16
    • 0036898055 scopus 로고    scopus 로고
    • Intestinal endotoxemia as a pathogenetic mechanism in liver failure
    • Han D.W. Intestinal endotoxemia as a pathogenetic mechanism in liver failure. World J Gastroenterol 2002, 8(6):961-965.
    • (2002) World J Gastroenterol , vol.8 , Issue.6 , pp. 961-965
    • Han, D.W.1
  • 17
    • 33750999322 scopus 로고    scopus 로고
    • Role of Kupffer cells in host defense and liver disease
    • Bilzer M., Roggel F., Gerbes A.L. Role of Kupffer cells in host defense and liver disease. Liver Int 2006, 26(10):1175-1186.
    • (2006) Liver Int , vol.26 , Issue.10 , pp. 1175-1186
    • Bilzer, M.1    Roggel, F.2    Gerbes, A.L.3
  • 18
    • 0036451169 scopus 로고    scopus 로고
    • The role of the liver in the response to LPS: experimental and clinical findings
    • Jirillo E., Caccavo D., Magrone T., Piccigallo E., Amati L., Lembo A., et al. The role of the liver in the response to LPS: experimental and clinical findings. J Endotoxin Res 2002, 8(5):319-327.
    • (2002) J Endotoxin Res , vol.8 , Issue.5 , pp. 319-327
    • Jirillo, E.1    Caccavo, D.2    Magrone, T.3    Piccigallo, E.4    Amati, L.5    Lembo, A.6
  • 19
    • 85011152041 scopus 로고    scopus 로고
    • Relationship between fatty liver and glucose metabolism: a cross-sectional study in 571 obese children
    • [Epub ahead of print] PubMed PMID: 20880682
    • Bedogni G., Gastaldelli A., Manco M., De Col A., Agosti F., Tiribelli C., et al. Relationship between fatty liver and glucose metabolism: a cross-sectional study in 571 obese children. Nutr Metab Cardiovasc Dis 2010 Sep 27, [Epub ahead of print] PubMed PMID: 20880682.
    • (2010) Nutr Metab Cardiovasc Dis
    • Bedogni, G.1    Gastaldelli, A.2    Manco, M.3    De Col, A.4    Agosti, F.5    Tiribelli, C.6
  • 21
    • 80052404247 scopus 로고    scopus 로고
    • Obesity and metabolic syndrome: potential benefit from specific nutritional components
    • Abete I., Goyenechea E., Zulet M.A., Martínez J.A. Obesity and metabolic syndrome: potential benefit from specific nutritional components. Nutr Metab Cardiovasc Dis 2011, 21(Suppl. 2):B1-15.
    • (2011) Nutr Metab Cardiovasc Dis , vol.21 , Issue.SUPPL. 2
    • Abete, I.1    Goyenechea, E.2    Zulet, M.A.3    Martínez, J.A.4
  • 22
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon J.B., Bhathal P.S., O'Brien P.E. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001, 121(1):91-100.
    • (2001) Gastroenterology , vol.121 , Issue.1 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 23
    • 78049452485 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Law K., Brunt E.M. Nonalcoholic fatty liver disease. Clin Liver Dis 2010, 14(4):591-604.
    • (2010) Clin Liver Dis , vol.14 , Issue.4 , pp. 591-604
    • Law, K.1    Brunt, E.M.2
  • 24
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    • Tilg H., Moschen A.R. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010, 52(5):1836-1846.
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 25
    • 68949086365 scopus 로고    scopus 로고
    • The gut-liver axis in nonalcoholic fatty liver disease: another pathway to insulin resistance?
    • Vanni E., Bugianesi E. The gut-liver axis in nonalcoholic fatty liver disease: another pathway to insulin resistance?. Hepatology 2009, 49(6):1790-1792.
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1790-1792
    • Vanni, E.1    Bugianesi, E.2
  • 26
    • 0037879075 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics
    • Solga S.F., Diehl A.M. Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics. J Hepatol 2003, 38:681-687.
    • (2003) J Hepatol , vol.38 , pp. 681-687
    • Solga, S.F.1    Diehl, A.M.2
  • 27
    • 79952805978 scopus 로고    scopus 로고
    • Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
    • Diamant M., Blaak E.E., de Vos W.M. Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?. Obes Rev 2011, 12(4):272-281.
    • (2011) Obes Rev , vol.12 , Issue.4 , pp. 272-281
    • Diamant, M.1    Blaak, E.E.2    de Vos, W.M.3
  • 28
    • 49449083979 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
    • Thuy S., Ladurner R., Volynets V., Wagner S., Strahl S., Königsrainer A., et al. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr 2008, 138(8):1452-1455.
    • (2008) J Nutr , vol.138 , Issue.8 , pp. 1452-1455
    • Thuy, S.1    Ladurner, R.2    Volynets, V.3    Wagner, S.4    Strahl, S.5    Königsrainer, A.6
  • 29
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L., Valenza V., La Torre G., Montalto M., Cammarota G., Ricci R., et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009, 49(6):1877-1887.
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3    Montalto, M.4    Cammarota, G.5    Ricci, R.6
  • 30
    • 0026059003 scopus 로고
    • Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat
    • Pappo I., Bercovier E.M., Berry Y., Haviv R., Gallily H.R., Freund H. Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat. J Surg Res 1991, 51:106-112.
    • (1991) J Surg Res , vol.51 , pp. 106-112
    • Pappo, I.1    Bercovier, E.M.2    Berry, Y.3    Haviv, R.4    Gallily, H.R.5    Freund, H.6
  • 31
    • 0020065283 scopus 로고
    • Hepatic steatosis after intestinal bypass-prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition
    • Drenick E.J., Fisler J., Johnson D. Hepatic steatosis after intestinal bypass-prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition. Gastroenterology 1982, 82:535-548.
    • (1982) Gastroenterology , vol.82 , pp. 535-548
    • Drenick, E.J.1    Fisler, J.2    Johnson, D.3
  • 32
    • 78649908827 scopus 로고    scopus 로고
    • The role of the gut microbiota in nonalcoholic fatty liver disease
    • Abu-Shanab A., Quigley E.M. The role of the gut microbiota in nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2010, 7(12):691-701.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , Issue.12 , pp. 691-701
    • Abu-Shanab, A.1    Quigley, E.M.2
  • 33
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh P.J., Ley R.E., Mahowald M.A., Magrini V., Mardis E.R., Gordon J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444(7122):1027-1031.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 34
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Bäckhed F., Ding H., Wang T., Hooper L.V., Koh G.Y., Nagy A., et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004, 101(44):15718-15723.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.44 , pp. 15718-15723
    • Bäckhed, F.1    Ding, H.2    Wang, T.3    Hooper, L.V.4    Koh, G.Y.5    Nagy, A.6
  • 35
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: human gut microbes associated with obesity
    • Ley R.E., Turnbaugh P.J., Klein S., Gordon J.I. Microbial ecology: human gut microbes associated with obesity. Nature 2006 Dec 21, 444(7122):1022-1023.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 36
    • 79952316380 scopus 로고    scopus 로고
    • Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency
    • Spencer M.D., Hamp T.J., Reid R.W., Fischer L.M., Zeisel S.H., Fodor A.A. Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology 2011, 140(3):976-986.
    • (2011) Gastroenterology , vol.140 , Issue.3 , pp. 976-986
    • Spencer, M.D.1    Hamp, T.J.2    Reid, R.W.3    Fischer, L.M.4    Zeisel, S.H.5    Fodor, A.A.6
  • 37
    • 32044438279 scopus 로고    scopus 로고
    • Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4
    • Szabo G., Velayudham A., Romics L., Mandrekar P. Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4. Alcohol Clin Exp Res 2005, 29(11 Suppl.):140S-145S.
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.11 SUPPL.
    • Szabo, G.1    Velayudham, A.2    Romics, L.3    Mandrekar, P.4
  • 38
    • 79952230506 scopus 로고    scopus 로고
    • Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease
    • Miura K., Seki E., Ohnishi H., Brenner D.A. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease. Gastroenterol Res Pract 2010, 2010:362847.
    • (2010) Gastroenterol Res Pract , vol.2010 , pp. 362847
    • Miura, K.1    Seki, E.2    Ohnishi, H.3    Brenner, D.A.4
  • 39
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • Rivera C.A., Adegboyega P., van Rooijen N., Tagalicud A., Allman M., Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol 2007, 47(4):571-579.
    • (2007) J Hepatol , vol.47 , Issue.4 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    van Rooijen, N.3    Tagalicud, A.4    Allman, M.5    Wallace, M.6
  • 41
    • 77953891627 scopus 로고    scopus 로고
    • Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice
    • Miura K., Kodama Y., Inokuchi S., Schnabl B., Aoyama T., Ohnishi H., et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010, 139(1):323-334.
    • (2010) Gastroenterology , vol.139 , Issue.1 , pp. 323-334
    • Miura, K.1    Kodama, Y.2    Inokuchi, S.3    Schnabl, B.4    Aoyama, T.5    Ohnishi, H.6
  • 42
    • 63849124042 scopus 로고    scopus 로고
    • Probiotics for preventive health
    • Minocha A. Probiotics for preventive health. Nutr Clin Pract 2009, 24:227-241.
    • (2009) Nutr Clin Pract , vol.24 , pp. 227-241
    • Minocha, A.1
  • 43
    • 4844228675 scopus 로고    scopus 로고
    • Probiotics: a potential target for the prevention and treatment of steatohepatitis
    • Nardone G., Rocco A. Probiotics: a potential target for the prevention and treatment of steatohepatitis. J Clin Gastroenterol 2004, 38(Suppl. 6):S121-S122.
    • (2004) J Clin Gastroenterol , vol.38 , Issue.SUPPL. 6
    • Nardone, G.1    Rocco, A.2
  • 44
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li Z., Yang S., Lin H., Huang J., Watkins P.A., Moser A.B., et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003, 37(2):343-350.
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3    Huang, J.4    Watkins, P.A.5    Moser, A.B.6
  • 45
    • 34548757869 scopus 로고    scopus 로고
    • Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis
    • Ewaschuk J., Endersby R., Thiel D., Diaz H., Backer J., Ma M., et al. Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis. Hepatology 2007, 46(3):841-850.
    • (2007) Hepatology , vol.46 , Issue.3 , pp. 841-850
    • Ewaschuk, J.1    Endersby, R.2    Thiel, D.3    Diaz, H.4    Backer, J.5    Ma, M.6
  • 46
    • 53249101515 scopus 로고    scopus 로고
    • Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    • Ma X., Hua J., Li Z. Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol 2008, 49(5):821-830.
    • (2008) J Hepatol , vol.49 , Issue.5 , pp. 821-830
    • Ma, X.1    Hua, J.2    Li, Z.3
  • 47
    • 63349101854 scopus 로고    scopus 로고
    • VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice
    • Velayudham A., Dolganiuc A., Ellis M., Petrasek J., Kodys K., Mandrekar P., et al. VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology 2009, 49(3):989-997.
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 989-997
    • Velayudham, A.1    Dolganiuc, A.2    Ellis, M.3    Petrasek, J.4    Kodys, K.5    Mandrekar, P.6
  • 49
    • 80054873943 scopus 로고    scopus 로고
    • Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial
    • Aller R., De Luis D.A., Izaola O., Conde R., Gonzalez Sagrado M., Primo D., et al. Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. Eur Rev Med Pharmacol Sci 2011, 15(9):1090-1095.
    • (2011) Eur Rev Med Pharmacol Sci , vol.15 , Issue.9 , pp. 1090-1095
    • Aller, R.1    De Luis, D.A.2    Izaola, O.3    Conde, R.4    Gonzalez Sagrado, M.5    Primo, D.6
  • 50
    • 84859439842 scopus 로고    scopus 로고
    • The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance
    • Parnell J.A., Raman M., Rioux K.P., Reimer R.A. The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance. Liver Int 2011 Dec 30, 10.1111/j.1478-3231.2011.02730.x.
    • (2011) Liver Int
    • Parnell, J.A.1    Raman, M.2    Rioux, K.P.3    Reimer, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.