Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling

Molecular and Cellular Endocrinology

Volumn 381, Issue 1-2, 2013, Pages 56-65

  Xie, Xi ^a,b   Chang, Xiuting ^a   Chen, Lei ^a   Huang, Kaipeng ^a   Huang, Juan ^a   Wang, Shaogui ^a   Shen, Xiaoyan ^a   Liu, Peiqing ^a   Huang, Heqing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b HAINAN UNIVERSITY   (China)

Author keywords

Berberine; Diabetic nephropathy; Fibronectin; NF B; RhoA ROCK

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACETYLCYSTEINE; BERBERINE; FIBRONECTIN; GLUCOSE; I KAPPA B ALPHA; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; IMMUNOPATHOLOGY; INTRACELLULAR SIGNALING; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; RENAL PROTECTION; STREPTOZOCIN DIABETES;

BERBERINE; DIABETIC NEPHROPATHY; DN; ECM; EXTRACELLULAR MATRIX; FIBRONECTIN; GLOMERULAR MESANGIAL CELLS; GMCS; ICAM-1; INTERCELLULAR ADHESIONMOLECULE-1; MALONDIALDEHYDE; MDA; MYOSIN PHOSPHATASE; MYPT; N-ACETYLCYSTEINE; NAC; NF-ΚB; NUCLEAR FACTOR-KAPPA B; REACTIVE OXYGEN SPECIES; RHO KINASE; RHOA/ROCK; ROCK; ROS; SOD; STREPTOZOCIN; STZ; SUPEROXIDE DISMUTASE; TGF-Β1; TRANSFORMING GROWTH FACTOR-BETA 1;

ACETYLCYSTEINE; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BERBERINE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DRUG EVALUATION, PRECLINICAL; FIBRONECTINS; FREE RADICAL SCAVENGERS; GENE EXPRESSION; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; MALE; MESANGIAL CELLS; NEPHRITIS; NF-KAPPA B; OXIDATIVE STRESS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84882766934     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.07.019     Document Type: Article

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