Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules

Pharmacological Research

Volumn 104, Issue , 2016, Pages 9-21

  Copple, Bryan L ^a   Li, Tiangang ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Bile acids; Farnesoid X receptor; Pregnane X receptor; Sphingosine 1 phosphate receptor 2; TGR5; Vitamin D receptor

Indexed keywords

APICAL SODIUM DEPENDENT BILE ACID TRANSPORTER; BILE ACID; BILE ACID RECEPTOR; BILE SALT EXPORT PUMP; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CELL PROTEIN; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; DETERGENT; FARNESOID X RECEPTOR; FOCAL ADHESION KINASE; G PROTEIN COUPLED BILE ACID RECEPTOR 1; LITHOCHOLIC ACID; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OBETICHOLIC ACID; PREGNANE X RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; TAUROURSODEOXYCHOLIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; VITAMIN D RECEPTOR; CELL RECEPTOR;

ACID SECRETION; BILE ACID METABOLISM; BILE ACID SECRETION; BILE ACID SYNTHESIS; BILE FLOW; CHOLESTASIS; CYP7A1 GENE; CYTOKINE PRODUCTION; DETOXIFICATION; DISEASE ASSOCIATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVATION; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HOMEOSTASIS; HUMAN; INFLAMMATORY BOWEL DISEASE; INSULIN SENSITIVITY; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID SOLUBILITY; LIPID STORAGE; LIVER TOXICITY; MOLECULARLY TARGETED THERAPY; MULTICENTER STUDY (TOPIC); NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN D DEFICIENCY; ANIMAL; METABOLISM;

ANIMALS; BILE ACIDS AND SALTS; HUMANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 84952332338     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.12.007     Document Type: Review

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