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Volumn 125, Issue 4, 2015, Pages 1388-1389

Nuclear receptor PXR: Discovery of a pharmaceutical anti-target

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; CYTOCHROME P450 3A INDUCER; PREGNANE X RECEPTOR; XENOBIOTIC AGENT; CYP3A PROTEIN, HUMAN; LIGAND; STEROID RECEPTOR;

EID: 84926389705     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI81244     Document Type: Article
Times cited : (26)

References (12)
  • 2
    • 0027409436 scopus 로고
    • Regulation of cytochrome P450 genes: Molecular mechanisms
    • Gonzalez FJ, Liu SY, Yano M. Regulation of cytochrome P450 genes: molecular mechanisms. Pharmacogenetics. 1993;3(1):51-57.
    • (1993) Pharmacogenetics. , vol.3 , Issue.1 , pp. 51-57
    • Gonzalez, F.J.1    Liu, S.Y.2    Yano, M.3
  • 3
    • 0035042684 scopus 로고    scopus 로고
    • Cyp3A regulation: From pharmacology to nuclear receptors
    • Quattrochi LC, Guzelian PS. Cyp3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos. 2001;29(5):615-622.
    • (2001) Drug Metab Dispos. , vol.29 , Issue.5 , pp. 615-622
    • Quattrochi, L.C.1    Guzelian, P.S.2
  • 4
    • 0033617520 scopus 로고    scopus 로고
    • Orphan nuclear receptors: Shifting endocrinology into reverse
    • Kliewer SA, Lehmann JM, Willson TM. Orphan nuclear receptors: shifting endocrinology into reverse. Science. 1999;284(5415):757-760.
    • (1999) Science , vol.284 , Issue.5415 , pp. 757-760
    • Kliewer, S.A.1    Lehmann, J.M.2    Willson, T.M.3
  • 5
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the X-files
    • Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors and lipid physiology: opening the X-files. Science. 2001;294(5548):1866-1870.
    • (2001) Science , vol.294 , Issue.5548 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 6
    • 0032498303 scopus 로고    scopus 로고
    • An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
    • Kliewer SA, et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 1998;92(1):73-82.
    • (1998) Cell. , vol.92 , Issue.1 , pp. 73-82
    • Kliewer, S.A.1
  • 7
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest. 1998;102(5):1016-1023.
    • (1998) J Clin Invest. , vol.102 , Issue.5 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Willson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 8
    • 0032532134 scopus 로고    scopus 로고
    • SXR, a novel steroid and xenobiotic-sensing nuclear receptor
    • Blumberg B, et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev. 1998;12(20):3195-3205.
    • (1998) Genes Dev. , vol.12 , Issue.20 , pp. 3195-3205
    • Blumberg, B.1
  • 9
    • 13144260727 scopus 로고    scopus 로고
    • Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
    • Bertilsson G, et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A. 1998;95(21):12208-12213.
    • (1998) Proc Natl Acad Sci U S A. , vol.95 , Issue.21 , pp. 12208-12213
    • Bertilsson, G.1
  • 10
    • 0034721159 scopus 로고    scopus 로고
    • Humanized xenobiotic response in mice expressing nuclear receptor SXR
    • Xie W, et al. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature. 2000;406(6794):435-439.
    • (2000) Nature , vol.406 , Issue.6794 , pp. 435-439
    • Xie, W.1
  • 11
    • 23144467497 scopus 로고    scopus 로고
    • Structure and function of the human nuclear xenobiotic receptor PXR
    • Carnahan VE, Redinbo MR. Structure and function of the human nuclear xenobiotic receptor PXR. Curr Drug Metab. 2005;6(4):357-367.
    • (2005) Curr Drug Metab. , vol.6 , Issue.4 , pp. 357-367
    • Carnahan, V.E.1    Redinbo, M.R.2
  • 12
    • 33845491066 scopus 로고    scopus 로고
    • Pregnane X receptor and natural products: Beyond drug-drug interactions
    • Staudinger JL, Ding X, Lichti K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert Opin Drug Metab Toxicol. 2006;2(6):847-857.
    • (2006) Expert Opin Drug Metab Toxicol. , vol.2 , Issue.6 , pp. 847-857
    • Staudinger, J.L.1    Ding, X.2    Lichti, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.