A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Molecular Cell

Volumn 6, Issue 3, 2000, Pages 517-526

  Goodwin, Bryan ^a   Jones, Stacey A ^a   Price, Roger R ^a   Watson, Michael A ^a   McKee, David D ^a   Moore, Linda B ^a   Galardi, Cristin ^a   Wilson, Joan G ^a   Lewis, Michael C ^a   Roth, Matthew E ^b   Maloney, Patrick R ^a   Willson, Timothy M ^a   Kliewer, Steven A ^a  

^a GLAXOSMITHKLINE   (United States)

^b CURAGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; BILE ACID; CELL NUCLEUS RECEPTOR; CYTOCHROME P450; ISOXAZOLE; LIGAND;

ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; LIVER CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; TRANSCRIPTION INITIATION;

ANIMALIA;

EID: 0033637121     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00051-4     Document Type: Article

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