메뉴 건너뛰기




Volumn 57, Issue 1, 2012, Pages 133-140

Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health

Author keywords

Bile; Biotransformation; Cholestasis; Clinical trial; Drug transport

Indexed keywords

BILE ACID; BREAST CANCER RESISTANCE PROTEIN; CHENODEOXYCHOLIC ACID; GLYCOPROTEIN P; TAURINE; URSODEOXYCHOLIC ACID;

EID: 84862663864     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.02.014     Document Type: Article
Times cited : (93)

References (36)
  • 1
    • 67649205149 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines. Management of cholestatic liver diseases
    • EASL Clinical Practice Guidelines. Management of cholestatic liver diseases. J Hepatol 2009;51:237-267.
    • (2009) J Hepatol , vol.51 , pp. 237-267
  • 3
    • 51349157245 scopus 로고    scopus 로고
    • Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis
    • Corpechot C, Abenavoli L, Rabahi N, et al. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 2008;48:871-877.
    • (2008) Hepatology , vol.48 , pp. 871-877
    • Corpechot, C.1    Abenavoli, L.2    Rabahi, N.3
  • 4
    • 62949221007 scopus 로고    scopus 로고
    • Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursode-oxycholic acid
    • Kuiper EM, Hansen BE, de Vries RA, et al. Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursode-oxycholic acid. Gastroenterology 2009;136:1281-1287.
    • (2009) Gastroenterology , vol.136 , pp. 1281-1287
    • Kuiper, E.M.1    Hansen, B.E.2    De Vries, R.A.3
  • 5
    • 33644854254 scopus 로고    scopus 로고
    • Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid
    • Pares A, Caballeria L, Rodes J. Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid. Gastroenterology 2006;130:715-720.
    • (2006) Gastroenterology , vol.130 , pp. 715-720
    • Pares, A.1    Caballeria, L.2    Rodes, J.3
  • 6
    • 77957851364 scopus 로고    scopus 로고
    • Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis
    • Kumagi T, Guindi M, Fischer SE, et al. Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis. Am J Gastroenterol 2010;105:2186-2194.
    • (2010) Am J Gastroenterol , vol.105 , pp. 2186-2194
    • Kumagi, T.1    Guindi, M.2    Fischer, S.E.3
  • 7
    • 33744920572 scopus 로고    scopus 로고
    • Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis
    • Beuers U. Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 2006;3:318-328.
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.3 , pp. 318-328
    • Beuers, U.1
  • 8
    • 0036725044 scopus 로고    scopus 로고
    • Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
    • Paumgartner G, Beuers U. Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology 2002;36: 525-531.
    • (2002) Hepatology , vol.36 , pp. 525-531
    • Paumgartner, G.1    Beuers, U.2
  • 9
    • 0032173265 scopus 로고    scopus 로고
    • Relationship between biliary and serum bile acids and response to ursodeoxycholic acid in patients with primary biliary cirrhosis
    • Lindor KD, Lacerda MA, Jorgensen RA, et al. Relationship between biliary and serum bile acids and response to ursodeoxycholic acid in patients with primary biliary cirrhosis. Am J Gastroenterol 1998;93:1498-1504.
    • (1998) Am J Gastroenterol , vol.93 , pp. 1498-1504
    • Lindor, K.D.1    Lacerda, M.A.2    Jorgensen, R.A.3
  • 10
    • 0026352217 scopus 로고
    • Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration
    • Crosignani A, Podda M, Battezzati PM, et al. Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 1991;14:1000-1007.
    • (1991) Hepatology , vol.14 , pp. 1000-1007
    • Crosignani, A.1    Podda, M.2    Battezzati, P.M.3
  • 11
    • 0027265104 scopus 로고
    • Effect of long-term treatment with ursodiol on clinical and biochemical features and biliary bile acid metabolism in patients with primary biliary cirrhosis
    • Batta AK, Salen G, Mirchandani R, et al. Effect of long-term treatment with ursodiol on clinical and biochemical features and biliary bile acid metabolism in patients with primary biliary cirrhosis. Am J Gastroenterol 1993;88:691-700.
    • (1993) Am J Gastroenterol , vol.88 , pp. 691-700
    • Batta, A.K.1    Salen, G.2    Mirchandani, R.3
  • 12
    • 0036020544 scopus 로고    scopus 로고
    • Improved liver test and greater biliary enrichment with high dose ursodeoxycholic acid in early stage primary biliary cirrhosis
    • Roda E, Azzaroli F, Nigro G, et al. Improved liver test and greater biliary enrichment with high dose ursodeoxycholic acid in early stage primary biliary cirrhosis. Dig Liver Dis 2002;34:523-527.
    • (2002) Dig Liver Dis , vol.34 , pp. 523-527
    • Roda, E.1    Azzaroli, F.2    Nigro, G.3
  • 13
    • 0038121949 scopus 로고    scopus 로고
    • Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary cirrhosis: An observational study
    • Serfaty L, De Leusse A, Rosmorduc O, et al. Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary cirrhosis: an observational study. Hepatology 2003;38:203-209.
    • (2003) Hepatology , vol.38 , pp. 203-209
    • Serfaty, L.1    De Leusse, A.2    Rosmorduc, O.3
  • 14
    • 0037382288 scopus 로고    scopus 로고
    • Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis
    • Pardi DS, Loftus Jr EV, Kremers WK, et al. Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis. Gastroenterology 2003;124:889-893.
    • (2003) Gastroenterology , vol.124 , pp. 889-893
    • Pardi, D.S.1    Loftus Jr., E.V.2    Kremers, W.K.3
  • 15
    • 27644479849 scopus 로고    scopus 로고
    • The impact of ursodeoxycholic acid on cancer, dysplasia and mortality in ulcerative colitis patients with primary sclerosing cholangitis
    • Wolf JM, Rybicki LA, Lashner BA. The impact of ursodeoxycholic acid on cancer, dysplasia and mortality in ulcerative colitis patients with primary sclerosing cholangitis. Aliment Pharmacol Ther 2005;22:783-788.
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 783-788
    • Wolf, J.M.1    Rybicki, L.A.2    Lashner, B.A.3
  • 16
    • 33244460809 scopus 로고    scopus 로고
    • Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis
    • Hruz P, Zimmermann C, Gutmann H, et al. Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis. Gut 2006;55:395-402.
    • (2006) Gut , vol.55 , pp. 395-402
    • Hruz, P.1    Zimmermann, C.2    Gutmann, H.3
  • 17
    • 65549145901 scopus 로고    scopus 로고
    • Nuclear receptors as therapeutic targets in cholestatic liver diseases
    • Zollner G, Trauner M. Nuclear receptors as therapeutic targets in cholestatic liver diseases. Br J Pharmacol 2009;156:7-27.
    • (2009) Br J Pharmacol , vol.156 , pp. 7-27
    • Zollner, G.1    Trauner, M.2
  • 18
    • 61949416918 scopus 로고    scopus 로고
    • Medical treatment of primary sclerosing cholangitis: A role for novel bile acids and other (post-) transcriptional modulators?
    • Beuers U, Kullak-Ublick GA, Pusl T, et al. Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-) transcriptional modulators? Clin Rev Allergy Immunol 2009;36:52-61.
    • (2009) Clin Rev Allergy Immunol , vol.36 , pp. 52-61
    • Beuers, U.1    Kullak-Ublick, G.A.2    Pusl, T.3
  • 19
    • 23244465392 scopus 로고    scopus 로고
    • Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
    • Marschall HU, Wagner M, Zollner G, et al. Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. Gastroenterology 2005;129:476-485.
    • (2005) Gastroenterology , vol.129 , pp. 476-485
    • Marschall, H.U.1    Wagner, M.2    Zollner, G.3
  • 21
    • 7344229937 scopus 로고    scopus 로고
    • A randomized trial in primary biliary cirrhosis comparing ursodeoxycholic acid in daily doses of either 10 mg/kg or 20 mg/kg
    • Dutch Multicentre PBC Study Group
    • Van Hoogstraten HJ, De Smet MB, Renooij W, et al. A randomized trial in primary biliary cirrhosis comparing ursodeoxycholic acid in daily doses of either 10 mg/kg or 20 mg/kg. Dutch Multicentre PBC Study Group. Aliment Pharmacol Ther 1998;12:965-971.
    • (1998) Aliment Pharmacol Ther , vol.12 , pp. 965-971
    • Van Hoogstraten, H.J.1    De Smet, M.B.2    Renooij, W.3
  • 22
    • 0015305749 scopus 로고
    • Serum bile acids in primary biliary cirrhosis
    • Murphy GM, Ross A, Billing BH. Serum bile acids in primary biliary cirrhosis. Gut 1972;13:201-206.
    • (1972) Gut , vol.13 , pp. 201-206
    • Murphy, G.M.1    Ross, A.2    Billing, B.H.3
  • 23
    • 0031021891 scopus 로고    scopus 로고
    • Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis
    • Medina JF, Martinez A, Vazquez JJ, et al. Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatology 1997;25:12-17.
    • (1997) Hepatology , vol.25 , pp. 12-17
    • Medina, J.F.1    Martinez, A.2    Vazquez, J.J.3
  • 24
    • 0033033458 scopus 로고    scopus 로고
    • Assessment of biliary bicarbonate secretion in humans by positron emission tomography
    • Prieto J, Garcia N, Marti-Climent JM, et al. Assessment of biliary bicarbonate secretion in humans by positron emission tomography. Gastroenterology 1999;117:167-172.
    • (1999) Gastroenterology , vol.117 , pp. 167-172
    • Prieto, J.1    Garcia, N.2    Marti-Climent, J.M.3
  • 25
    • 77957940106 scopus 로고    scopus 로고
    • The biliary HCO(3)(-) umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
    • Beuers U, Hohenester S, De Buy Wenniger LJ, Kremer AE, Jansen PL, Elferink RP. The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology 2010;52:1489-1496.
    • (2010) Hepatology , vol.52 , pp. 1489-1496
    • Beuers, U.1    Hohenester, S.2    De Buy Wenniger, L.J.3    Kremer, A.E.4    Jansen, P.L.5    Elferink, R.P.6
  • 26
    • 0034733547 scopus 로고    scopus 로고
    • The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
    • Rust C, Karnitz LM, Paya CV, et al. The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem 2000;275:20210-20216.
    • (2000) J Biol Chem , vol.275 , pp. 20210-20216
    • Rust, C.1    Karnitz, L.M.2    Paya, C.V.3
  • 27
    • 77957338101 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase p110gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells
    • Hohenester S, Gates A, Wimmer R, et al. Phosphatidylinositol-3-kinase p110gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. J Hepatol 2010;53:918-926.
    • (2010) J Hepatol , vol.53 , pp. 918-926
    • Hohenester, S.1    Gates, A.2    Wimmer, R.3
  • 28
    • 59149105842 scopus 로고    scopus 로고
    • Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent
    • Rust C, Wild N, Bernt C, et al. Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent. J Biol Chem 2009;284:2908-2916.
    • (2009) J Biol Chem , vol.284 , pp. 2908-2916
    • Rust, C.1    Wild, N.2    Bernt, C.3
  • 29
    • 84862650368 scopus 로고    scopus 로고
    • Differential induction of mitochondrial failure by bile acids in a direct and Ca-independent fashion
    • abstract
    • Schulz S, Wimmer R, Zischka H, et al. Differential induction of mitochondrial failure by bile acids in a direct and Ca-independent fashion [abstract]. J Hepatol 2011;54:S280.
    • (2011) J Hepatol , vol.54
    • Schulz, S.1    Wimmer, R.2    Zischka, H.3
  • 30
    • 84155175630 scopus 로고    scopus 로고
    • A biliary HCO(3)(-) umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
    • Hohenester S, de Buy Wenniger LJ, Paulusma CC, et al. A biliary HCO(3)(-) umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology 2012;55:173-183.
    • (2012) Hepatology , vol.55 , pp. 173-183
    • Hohenester, S.1    De Buy Wenniger, L.J.2    Paulusma, C.C.3
  • 31
    • 14244269427 scopus 로고    scopus 로고
    • No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis
    • Dilger K, Denk A, Heeg MH, et al. No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis. Hepatology 2005;41:595-602.
    • (2005) Hepatology , vol.41 , pp. 595-602
    • Dilger, K.1    Denk, A.2    Heeg, M.H.3
  • 32
    • 0035054725 scopus 로고    scopus 로고
    • The gut as a barrier to drug absorption: Combined role of cytochrome P450 3A and P-glycoprotein
    • Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet 2001;40: 159-168.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 159-168
    • Zhang, Y.1    Benet, L.Z.2
  • 33
    • 33646482714 scopus 로고    scopus 로고
    • Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans
    • Becquemont L, Glaeser H, Drescher S, et al. Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans. Clin Pharmacol Ther 2006;79:449-460.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 449-460
    • Becquemont, L.1    Glaeser, H.2    Drescher, S.3
  • 34
    • 77958025244 scopus 로고    scopus 로고
    • Structure and function of the human breast cancer resistance protein (BCRP/ABCG2)
    • Ni Z, Bikadi Z, Rosenberg MF, et al. Structure and function of the human breast cancer resistance protein (BCRP/ABCG2). Curr Drug Metab 2010;11:603-617.
    • (2010) Curr Drug Metab , vol.11 , pp. 603-617
    • Ni, Z.1    Bikadi, Z.2    Rosenberg, M.F.3
  • 35
    • 0034811602 scopus 로고    scopus 로고
    • Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers
    • Taipalensuu J, Törnblom H, Lindberg G, et al. Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J Pharmacol Exp Ther 2001;299:164-170.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 164-170
    • Taipalensuu, J.1    Törnblom, H.2    Lindberg, G.3
  • 36
    • 33846706434 scopus 로고    scopus 로고
    • The apical conjugate efflux pump ABCC2 (MRP2)
    • Nies AT, Keppler D. The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Arch 2007;453:643-659.
    • (2007) Pflugers Arch , vol.453 , pp. 643-659
    • Nies, A.T.1    Keppler, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.