메뉴 건너뛰기




Volumn 15, Issue 3, 2014, Pages 365-372

Obeticholic acid and budesonide for the treatment of primary biliary cirrhosis

Author keywords

Autoimmune liver disease; Bile acids; Cholestatic liver disease; Nuclear receptors

Indexed keywords

AMINOTRANSFERASE; AZATHIOPRINE; BILE ACID; BUDESONIDE; CELL NUCLEUS RECEPTOR; FARNESOID X RECEPTOR; GAMMA GLUTAMYLTRANSFERASE; IMMUNOGLOBULIN M; OBETICHOLIC ACID; PLACEBO; PREDNISONE; PREGNANE X RECEPTOR; RIFAMPICIN; URSODEOXYCHOLIC ACID;

EID: 84892743363     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2014.873404     Document Type: Review
Times cited : (47)

References (85)
  • 1
    • 0037487251 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • Talwalkar JA, Lindor KD. Primary biliary cirrhosis. Lancet 2003;362:53-61
    • (2003) Lancet , vol.362 , pp. 53-61
    • Talwalkar, J.A.1    Lindor, K.D.2
  • 3
    • 0031992882 scopus 로고    scopus 로고
    • Ludwig Symposium on biliary disorders-part II. Pathologic features and evolution of primary biliary cirrhosis and primary sclerosing cholangitis
    • Scheuer PJ. Ludwig Symposium on biliary disorders-part II. Pathologic features and evolution of primary biliary cirrhosis and primary sclerosing cholangitis. Mayo Clin Proc 1998. 73:179-83
    • (1998) Mayo Clin Proc , vol.73 , pp. 179-183
    • Scheuer, P.J.1
  • 4
    • 0028331716 scopus 로고
    • Ursodeoxycholic acid in the treatment of primary biliary cirrhosis
    • Lindor KD, Dickson ER, Baldus WP, et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994;106:1284-90
    • (1994) Gastroenterology , vol.106 , pp. 1284-1290
    • Lindor, K.D.1    Dickson, E.R.2    Baldus, W.P.3
  • 5
    • 0029911629 scopus 로고    scopus 로고
    • Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis
    • Lindor KD, Therneau TM, Jorgensen RA, et al. Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis. Gastroenterology 1996;110:1515-18
    • (1996) Gastroenterology , vol.110 , pp. 1515-1518
    • Lindor, K.D.1    Therneau, T.M.2    Jorgensen, R.A.3
  • 6
    • 0030852495 scopus 로고    scopus 로고
    • Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis
    • Poupon RE, Lindor KD, Cauch-Dudek K, et al. Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 1997;113:884-90
    • (1997) Gastroenterology , vol.113 , pp. 884-890
    • Poupon, R.E.1    Lindor, K.D.2    Cauch-Dudek, K.3
  • 7
    • 0033061129 scopus 로고    scopus 로고
    • Utilization of the Mayo risk score in patients with primary biliary cirrhosis receiving ursodeoxycholic acid
    • Angulo P, Lindor KD, Therneau TM, et al. Utilization of the Mayo risk score in patients with primary biliary cirrhosis receiving ursodeoxycholic acid. Liver 1999;19:115-21
    • (1999) Liver , vol.19 , pp. 115-121
    • Angulo, P.1    Lindor, K.D.2    Therneau, T.M.3
  • 8
    • 33644854254 scopus 로고    scopus 로고
    • Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid
    • Pares A, Caballeria L, Rodes J. Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid. Gastroenterology 2006;130:715-20
    • (2006) Gastroenterology , vol.130 , pp. 715-720
    • Pares, A.1    Caballeria, L.2    Rodes, J.3
  • 9
    • 0033036094 scopus 로고    scopus 로고
    • Ten-year survival in ursodeoxycholic acid-treated patients with primary biliary cirrhosis
    • The UDCAPBC Study Group
    • Poupon RE, Bonnand AM, Chretien Y, Poupon R. Ten-year survival in ursodeoxycholic acid-treated patients with primary biliary cirrhosis. The UDCAPBC Study Group. Hepatology 1999;29:1668-71
    • (1999) Hepatology , vol.29 , pp. 1668-1671
    • Poupon, R.E.1    Bonnand, A.M.2    Chretien, Y.3    Poupon, R.4
  • 10
    • 14644440885 scopus 로고    scopus 로고
    • Is the Mayo model for predicting survival useful after the introduction of ursodeoxycholic acid treatment for primary biliary cirrhosis?
    • Kilmurry MR, Heathcote EJ, Cauch-Dudek K, et al. Is the Mayo model for predicting survival useful after the introduction of ursodeoxycholic acid treatment for primary biliary cirrhosis? Hepatology 1996;23:1148-53
    • (1996) Hepatology , vol.23 , pp. 1148-1153
    • Kilmurry, M.R.1    Heathcote, E.J.2    Cauch-Dudek, K.3
  • 11
    • 51349157245 scopus 로고    scopus 로고
    • Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis
    • Corpechot C, Abenavoli L, Rabahi N, et al. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 2008;48:871-7
    • (2008) Hepatology , vol.48 , pp. 871-877
    • Corpechot, C.1    Abenavoli, L.2    Rabahi, N.3
  • 12
    • 62949221007 scopus 로고    scopus 로고
    • Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid
    • Kuiper EM, Hansen BE, de Vries RA, et al. Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid. Gastroenterology 2009;136:1281-7
    • (2009) Gastroenterology , vol.136 , pp. 1281-1287
    • Kuiper, E.M.1    Hansen, B.E.2    De Vries, R.A.3
  • 13
    • 0032815689 scopus 로고    scopus 로고
    • Low-dose methotrexate is ineffective in primary biliary cirrhosis: Long-term results of a placebo-controlled trial
    • Hendrickse MT, Rigney E, Giaffer MH, et al. Low-dose methotrexate is ineffective in primary biliary cirrhosis: long-term results of a placebo-controlled trial. Gastroenterology 1999;117:400-7
    • (1999) Gastroenterology , vol.117 , pp. 400-407
    • Hendrickse, M.T.1    Rigney, E.2    Giaffer, M.H.3
  • 14
    • 0029122841 scopus 로고
    • The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: The results of a pilot study
    • Lindor KD, Dickson ER, Jorgensen RA, et al. The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study. Hepatology 1995;22:1158-62
    • (1995) Hepatology , vol.22 , pp. 1158-1162
    • Lindor, K.D.1    Dickson, E.R.2    Jorgensen, R.A.3
  • 15
    • 10344254306 scopus 로고    scopus 로고
    • A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis
    • UDCA-PBC Study Group
    • Poupon RE, Huet PM, Poupon R, et al. A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis. UDCA-PBC Study Group. Hepatology 1996;24:1098-103
    • (1996) Hepatology , vol.24 , pp. 1098-1103
    • Poupon, R.E.1    Huet, P.M.2    Poupon, R.3
  • 16
    • 0343416897 scopus 로고    scopus 로고
    • The combination of ursodeoxycholic acid and methotrexate for primary biliary cirrhosis is not better than ursodeoxycholic acid alone
    • Gonzalez-Koch A, Brahm J, Antezana C, et al. The combination of ursodeoxycholic acid and methotrexate for primary biliary cirrhosis is not better than ursodeoxycholic acid alone. J Hepatol 1997;27:143-9
    • (1997) J Hepatol , vol.27 , pp. 143-149
    • Gonzalez-Koch, A.1    Brahm, J.2    Antezana, C.3
  • 17
    • 0026673728 scopus 로고
    • A controlled trial of prednisolone treatment in primary biliary cirrhosis. Three-year results
    • Mitchison HC, Palmer JM, Bassendine MF, et al. A controlled trial of prednisolone treatment in primary biliary cirrhosis. Three-year results. J Hepatol 1992;15:336-44
    • (1992) J Hepatol , vol.15 , pp. 336-344
    • Mitchison, H.C.1    Palmer, J.M.2    Bassendine, M.F.3
  • 18
    • 0024317437 scopus 로고
    • A pilot, double-blind, controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis: Hepatic improvement but greater bone loss
    • Mitchison HC, Bassendine MF, Malcolm AJ, et al. A pilot, double-blind, controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis: hepatic improvement but greater bone loss. Hepatology 1989;10:420-9
    • (1989) Hepatology , vol.10 , pp. 420-429
    • Mitchison, H.C.1    Bassendine, M.F.2    Malcolm, A.J.3
  • 19
    • 0030198972 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and prednisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis
    • Leuschner M, Guldutuna S, You T, et al. Ursodeoxycholic acid and prednisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis. J Hepatol 1996;25:49-57
    • (1996) J Hepatol , vol.25 , pp. 49-57
    • Leuschner, M.1    Guldutuna, S.2    You, T.3
  • 20
    • 0032873241 scopus 로고    scopus 로고
    • Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: Results of a prospective double-blind trial
    • Leuschner M, Maier KP, Schlichting J, et al. Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: results of a prospective double-blind trial. Gastroenterology 1999;117:918-25
    • (1999) Gastroenterology , vol.117 , pp. 918-925
    • Leuschner, M.1    Maier, K.P.2    Schlichting, J.3
  • 21
    • 0033966156 scopus 로고    scopus 로고
    • Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid
    • Angulo P, Jorgensen RA, Keach JC, et al. Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid. Hepatology 2000;31:318-23
    • (2000) Hepatology , vol.31 , pp. 318-323
    • Angulo, P.1    Jorgensen, R.A.2    Keach, J.C.3
  • 22
    • 0035185298 scopus 로고    scopus 로고
    • Incomplete response to ursodeoxycholic acid in primary biliary cirrhosis: Is a double dosage worthwhile?
    • Angulo P, Jorgensen RA, Lindor KD. Incomplete response to ursodeoxycholic acid in primary biliary cirrhosis: is a double dosage worthwhile? Am J Gastroenterol 2001;96:3152-7
    • (2001) Am J Gastroenterol , vol.96 , pp. 3152-3157
    • Angulo, P.1    Jorgensen, R.A.2    Lindor, K.D.3
  • 23
    • 79952227694 scopus 로고    scopus 로고
    • Nuclear receptors in liver disease
    • Wagner M, Zollner G, Trauner M. Nuclear receptors in liver disease. Hepatology 2011;53:1023-34.
    • (2011) Hepatology , vol.53 , pp. 1023-1034
    • Wagner, M.1    Zollner, G.2    Trauner, M.3
  • 24
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, et al. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000;102:731-44
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3
  • 25
    • 11244327692 scopus 로고    scopus 로고
    • Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice
    • Uppal H, Toma D, Saini SP, et al. Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. Hepatology 2005;41:168-76
    • (2005) Hepatology , vol.41 , pp. 168-176
    • Uppal, H.1    Toma, D.2    Saini, S.P.3
  • 26
    • 0041323002 scopus 로고    scopus 로고
    • FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice
    • Wittenburg H, Lyons MA, Li R, et al. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 2003;125:868-81
    • (2003) Gastroenterology , vol.125 , pp. 868-881
    • Wittenburg, H.1    Lyons, M.A.2    Li, R.3
  • 27
    • 36549040038 scopus 로고    scopus 로고
    • Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans
    • Kovacs P, Kress R, Rocha J, et al. Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans. J Hepatol 2008;48:116-24
    • (2008) J Hepatol , vol.48 , pp. 116-124
    • Kovacs, P.1    Kress, R.2    Rocha, J.3
  • 28
    • 70350050982 scopus 로고    scopus 로고
    • Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy
    • Zimmer V, Mullenbach R, Simon E, et al. Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy. Liver Int 2009;29:1286-8
    • (2009) Liver Int , vol.29 , pp. 1286-1288
    • Zimmer, V.1    Mullenbach, R.2    Simon, E.3
  • 29
    • 34547515667 scopus 로고    scopus 로고
    • Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy
    • Van Mil SW, Milona A, Dixon PH, et al. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology 2007;133:507-16
    • (2007) Gastroenterology , vol.133 , pp. 507-516
    • Van Mil, S.W.1    Milona, A.2    Dixon, P.H.3
  • 30
    • 33748113966 scopus 로고    scopus 로고
    • Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis
    • Karlsen TH, Lie BA, Frey Froslie K, et al. Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis. Gastroenterology 2006;131:781-7
    • (2006) Gastroenterology , vol.131 , pp. 781-787
    • Karlsen, T.H.1    Lie, B.A.2    Frey Froslie, K.3
  • 31
    • 19944427556 scopus 로고    scopus 로고
    • Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis
    • Kimura Y, Selmi C, Leung PS, et al. Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis. Hepatology 2005;41:55-63
    • (2005) Hepatology , vol.41 , pp. 55-63
    • Kimura, Y.1    Selmi, C.2    Leung, P.S.3
  • 32
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayanan M, Balasubramanian N, Makishima M, et al. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 2001;276:28857-65
    • (2001) J Biol Chem , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.2    Makishima, M.3
  • 33
    • 58949097425 scopus 로고    scopus 로고
    • Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
    • Song KH, Li T, Owsley E, et al. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 2009;49:297-305
    • (2009) Hepatology , vol.49 , pp. 297-305
    • Song, K.H.1    Li, T.2    Owsley, E.3
  • 34
    • 0037101810 scopus 로고    scopus 로고
    • 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
    • Pellicciari R, Fiorucci S, Camaioni E, et al. 6alpha-ethyl- chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 2002;45:3569-72
    • (2002) J Med Chem , vol.45 , pp. 3569-3572
    • Pellicciari, R.1    Fiorucci, S.2    Camaioni, E.3
  • 35
    • 34347325158 scopus 로고    scopus 로고
    • Targeting farnesoid X receptor for liver and metabolic disorders
    • Fiorucci S, Rizzo G, Donini A, et al. Targeting farnesoid X receptor for liver and metabolic disorders. Trends Mol Med 2007;13:298-309
    • (2007) Trends Mol Med , vol.13 , pp. 298-309
    • Fiorucci, S.1    Rizzo, G.2    Donini, A.3
  • 36
    • 23944521260 scopus 로고    scopus 로고
    • Farnesoid X receptor: From structure to potential clinical applications
    • Pellicciari R, Costantino G, Fiorucci S. Farnesoid X receptor: from structure to potential clinical applications. J Med Chem 2005;48:5383-403
    • (2005) J Med Chem , vol.48 , pp. 5383-5403
    • Pellicciari, R.1    Costantino, G.2    Fiorucci, S.3
  • 37
    • 22944449688 scopus 로고    scopus 로고
    • A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis
    • Fiorucci S, Rizzo G, Antonelli E, et al. A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. J Pharmacol Exp Ther 2005;314:584-95
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 584-595
    • Fiorucci, S.1    Rizzo, G.2    Antonelli, E.3
  • 38
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009;89:147-91
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3
  • 39
    • 25644443217 scopus 로고    scopus 로고
    • Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferatoractivated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis
    • Fiorucci S, Rizzo G, Antonelli E, et al. Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferatoractivated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. J Pharmacol Exp Ther 2005;315:58-68
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 58-68
    • Fiorucci, S.1    Rizzo, G.2    Antonelli, E.3
  • 40
    • 7644244675 scopus 로고    scopus 로고
    • The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
    • Fiorucci S, Antonelli E, Rizzo G, et al. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology 2004;127:1497-512
    • (2004) Gastroenterology , vol.127 , pp. 1497-1512
    • Fiorucci, S.1    Antonelli, E.2    Rizzo, G.3
  • 41
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid x receptor agonist obeticholic Acid in patients with type 2 diabetes and nonalcoholic Fatty liver disease
    • Mudaliar S, Henry RR, Sanyal AJ, et al. Efficacy and safety of the farnesoid x receptor agonist obeticholic Acid in patients with type 2 diabetes and nonalcoholic Fatty liver disease. Gastroenterology 2013;145:574-82 e1.
    • (2013) Gastroenterology , vol.145
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3
  • 42
    • 20944450029 scopus 로고    scopus 로고
    • Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis
    • Fiorucci S, Clerici C, Antonelli E, et al. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther 2005;313:604-12
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 604-612
    • Fiorucci, S.1    Clerici, C.2    Antonelli, E.3
  • 43
    • 33746605104 scopus 로고    scopus 로고
    • Benefit of farnesoid X receptor inhibition in obstructive cholestasis
    • Stedman C, Liddle C, Coulter S, et al. Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proc Natl Acad Sci USA 2006;103:11323-8
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11323-11328
    • Stedman, C.1    Liddle, C.2    Coulter, S.3
  • 44
    • 67651123303 scopus 로고    scopus 로고
    • Farnesoid X receptor agonists in biliary tract disease
    • Fiorucci S, Baldelli F. Farnesoid X receptor agonists in biliary tract disease. Curr Opin Gastroenterol 2009;25:252-9
    • (2009) Curr Opin Gastroenterol , vol.25 , pp. 252-259
    • Fiorucci, S.1    Baldelli, F.2
  • 45
    • 77955334203 scopus 로고    scopus 로고
    • Farnesoid-X receptor agonists: A new class of drugs for the treatment of PBC? An international study evaluating the addition of INT-747 to ursodeoxycholic acid
    • Mason A, Luketic V, Lindor K, et al. Farnesoid-X receptor agonists: a new class of drugs for the treatment of PBC? An international study evaluating the addition of INT-747 to ursodeoxycholic acid. J Hepatol 2010;52(Suppl 1):745-58
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1 , pp. 745-758
    • Mason, A.1    Luketic, V.2    Lindor, K.3
  • 46
    • 84892772374 scopus 로고    scopus 로고
    • An international study evaluating the farnesoid X receptor agonist obeticholic stabilized on ursodiol
    • [Epub ahead of print]
    • Kowdley KV, Jones D, Luketic V, et al. An international study evaluating the farnesoid X receptor agonist obeticholic stabilized on ursodiol. Aliment Pharmacol Ther 2008 [Epub ahead of print]
    • (2008) Aliment Pharmacol Ther
    • Kowdley, K.V.1    Jones, D.2    Luketic, V.3
  • 47
    • 84868680318 scopus 로고    scopus 로고
    • The farnesoid X receptor (FXR) agonist obeticholic acid (OCA) increases plasma FGF-19 concentrations and decreases bile acid synthesis in primary biliary cirrhosis (PBC)
    • Marschall HU, Luketic V, Lovgren-Sandblom A, et al. The farnesoid X receptor (FXR) agonist obeticholic acid (OCA) increases plasma FGF-19 concentrations and decreases bile acid synthesis in primary biliary cirrhosis (PBC). J Hepatol 2012;56(Suppl 2):S377
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 2
    • Marschall, H.U.1    Luketic, V.2    Lovgren-Sandblom, A.3
  • 48
    • 0031453660 scopus 로고    scopus 로고
    • Review article: Drug development in inflammatory bowel disease: Budesonide-A model of targeted therapy
    • discussion 07-8
    • Hamedani R, Feldman RD, Feagan BG. Review article: drug development in inflammatory bowel disease: budesonide-a model of targeted therapy. Aliment Pharmacol Ther 1997;11(Suppl 3):98-107; discussion 07-8
    • (1997) Aliment Pharmacol Ther , vol.11 , Issue.SUPPL. 3 , pp. 98-107
    • Hamedani, R.1    Feldman, R.D.2    Feagan, B.G.3
  • 49
    • 0038121959 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic action of budesonide in early-and late-stage primary biliary cirrhosis
    • Hempfling W, Grunhage F, Dilger K, et al. Pharmacokinetics and pharmacodynamic action of budesonide in early-and late-stage primary biliary cirrhosis. Hepatology 2003;38:196-202
    • (2003) Hepatology , vol.38 , pp. 196-202
    • Hempfling, W.1    Grunhage, F.2    Dilger, K.3
  • 50
    • 0028071632 scopus 로고
    • Oral budesonide for active Crohn's disease
    • Canadian Inflammatory Bowel Disease Study Group
    • Greenberg GR, Feagan BG, Martin F, et al. Oral budesonide for active Crohn's disease. Canadian Inflammatory Bowel Disease Study Group. N Engl J Med 1994;331:836-41
    • (1994) N Engl J Med , vol.331 , pp. 836-841
    • Greenberg, G.R.1    Feagan, B.G.2    Martin, F.3
  • 51
    • 0037108916 scopus 로고    scopus 로고
    • Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)
    • Sonoda J, Xie W, Rosenfeld JM, et al. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Proc Natl Acad Sci USA 2002;99:13801-6
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13801-13806
    • Sonoda, J.1    Xie, W.2    Rosenfeld, J.M.3
  • 52
    • 33745830106 scopus 로고    scopus 로고
    • Pregnane X receptor is a target of farnesoid X receptor
    • Jung D, Mangelsdorf DJ, Meyer UA. Pregnane X receptor is a target of farnesoid X receptor. J Biol Chem 2006;281:19081-91
    • (2006) J Biol Chem , vol.281 , pp. 19081-19091
    • Jung, D.1    Mangelsdorf, D.J.2    Meyer, U.A.3
  • 53
    • 0021878377 scopus 로고
    • Effect of rifampicin treatment on hepatic drug metabolism and serum bile acids in patients with primary biliary cirrhosis
    • Hoensch HP, Balzer K, Dylewizc P, et al. Effect of rifampicin treatment on hepatic drug metabolism and serum bile acids in patients with primary biliary cirrhosis. Eur J Clin Pharmacol 1985;28:475-7
    • (1985) Eur J Clin Pharmacol , vol.28 , pp. 475-477
    • Hoensch, H.P.1    Balzer, K.2    Dylewizc, P.3
  • 54
    • 0023846078 scopus 로고
    • Treatment of pruritus in primary biliary cirrhosis with rifampin. Results of a double-blind, crossover, randomized trial
    • Ghent CN, Carruthers SG. Treatment of pruritus in primary biliary cirrhosis with rifampin. Results of a double-blind, crossover, randomized trial. Gastroenterology 1988;94:488-93
    • (1988) Gastroenterology , vol.94 , pp. 488-493
    • Ghent, C.N.1    Carruthers, S.G.2
  • 55
    • 0024591301 scopus 로고
    • Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis
    • Bachs L, Pares A, Elena M, et al. Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis. Lancet 1989;1:574-6
    • (1989) Lancet , vol.1 , pp. 574-576
    • Bachs, L.1    Pares, A.2    Elena, M.3
  • 56
    • 0025854479 scopus 로고
    • Treatment of pruritus of primary biliary cirrhosis with rifampin
    • Podesta A, Lopez P, Terg R, et al. Treatment of pruritus of primary biliary cirrhosis with rifampin. Dig Dis Sci 1991;36:216-20
    • (1991) Dig Dis Sci , vol.36 , pp. 216-220
    • Podesta, A.1    Lopez, P.2    Terg, R.3
  • 57
    • 0026548603 scopus 로고
    • Effects of long-term rifampicin administration in primary biliary cirrhosis
    • Bachs L, Pares A, Elena M, et al. Effects of long-term rifampicin administration in primary biliary cirrhosis. Gastroenterology 1992;102:2077-80
    • (1992) Gastroenterology , vol.102 , pp. 2077-2080
    • Bachs, L.1    Pares, A.2    Elena, M.3
  • 58
    • 0036179358 scopus 로고    scopus 로고
    • Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis
    • Prince MI, Burt AD, Jones DE. Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis. Gut 2002;50:436-9
    • (2002) Gut , vol.50 , pp. 436-439
    • Prince, M.I.1    Burt, A.D.2    Jones, D.E.3
  • 59
    • 16244417776 scopus 로고    scopus 로고
    • Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: A three-year randomized trial
    • Rautiainen H, Karkkainen P, Karvonen AL, et al. Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: a three-year randomized trial. Hepatology 2005;41:747-52
    • (2005) Hepatology , vol.41 , pp. 747-752
    • Rautiainen, H.1    Karkkainen, P.2    Karvonen, A.L.3
  • 60
    • 34249023304 scopus 로고    scopus 로고
    • Overlap of autoimmune hepatitis and primary biliary cirrhosis: Long-term outcomes
    • Silveira MG, Talwalkar JA, Angulo P, Lindor KD. Overlap of autoimmune hepatitis and primary biliary cirrhosis: long-term outcomes. Am J Gastroenterol 2007;102:1244-50
    • (2007) Am J Gastroenterol , vol.102 , pp. 1244-1250
    • Silveira, M.G.1    Talwalkar, J.A.2    Angulo, P.3    Lindor, K.D.4
  • 61
    • 76349119699 scopus 로고    scopus 로고
    • Autoimmune hepatitis-PBC overlap syndrome: A simplified scoring system may assist in the diagnosis
    • Neuhauser M, Bjornsson E, Treeprasertsuk S, et al. Autoimmune hepatitis-PBC overlap syndrome: a simplified scoring system may assist in the diagnosis. Am J Gastroenterol 2010;105(2):345-53
    • (2010) Am J Gastroenterol , vol.105 , Issue.2 , pp. 345-353
    • Neuhauser, M.1    Bjornsson, E.2    Treeprasertsuk, S.3
  • 62
    • 77952711598 scopus 로고    scopus 로고
    • Diagnosis and management of autoimmune hepatitis
    • Manns MP, Czaja AJ, Gorham JD, et al. Diagnosis and management of autoimmune hepatitis. Hepatology 2010;51:2193-213
    • (2010) Hepatology , vol.51 , pp. 2193-2213
    • Manns, M.P.1    Czaja, A.J.2    Gorham, J.D.3
  • 63
    • 0028080375 scopus 로고
    • Oral budesonide for treatment of autoimmune chronic active hepatitis
    • Danielsson A, Prytz H. Oral budesonide for treatment of autoimmune chronic active hepatitis. Aliment Pharmacol Ther 1994;8:585-90
    • (1994) Aliment Pharmacol Ther , vol.8 , pp. 585-590
    • Danielsson, A.1    Prytz, H.2
  • 65
    • 44649191187 scopus 로고    scopus 로고
    • The use of budesonide in the treatment of autoimmune hepatitis in Canada
    • Zandieh I, Krygier D, Wong V, et al. The use of budesonide in the treatment of autoimmune hepatitis in Canada. Can J Gastroenterol 2008;22:388-92
    • (2008) Can J Gastroenterol , vol.22 , pp. 388-392
    • Zandieh, I.1    Krygier, D.2    Wong, V.3
  • 66
    • 26044432469 scopus 로고    scopus 로고
    • Budesonide in previously untreated autoimmune hepatitis
    • Wiegand J, Schuler A, Kanzler S, et al. Budesonide in previously untreated autoimmune hepatitis. Liver Int 2005;25:927-34
    • (2005) Liver Int , vol.25 , pp. 927-934
    • Wiegand, J.1    Schuler, A.2    Kanzler, S.3
  • 67
    • 77957345684 scopus 로고    scopus 로고
    • Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis
    • Manns MP, Woynarowski M, Kreisel W, et al. Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis. Gastroenterology 2010;139:1198-206
    • (2010) Gastroenterology , vol.139 , pp. 1198-1206
    • Manns, M.P.1    Woynarowski, M.2    Kreisel, W.3
  • 68
    • 0031879659 scopus 로고    scopus 로고
    • Primary biliary cirrhosisautoimmune hepatitis overlap syndrome: Clinical features and response to therapy
    • Chazouilleres O, Wendum D, Serfaty L, et al. Primary biliary cirrhosisautoimmune hepatitis overlap syndrome: clinical features and response to therapy. Hepatology 1998;28:296-301
    • (1998) Hepatology , vol.28 , pp. 296-301
    • Chazouilleres, O.1    Wendum, D.2    Serfaty, L.3
  • 69
    • 30344478833 scopus 로고    scopus 로고
    • Long term outcome and response to therapy of primary biliary cirrhosisautoimmune hepatitis overlap syndrome
    • Chazouilleres O, Wendum D, Serfaty L, et al. Long term outcome and response to therapy of primary biliary cirrhosisautoimmune hepatitis overlap syndrome. J Hepatol 2006;44:400-6
    • (2006) J Hepatol , vol.44 , pp. 400-406
    • Chazouilleres, O.1    Wendum, D.2    Serfaty, L.3
  • 70
    • 20644452022 scopus 로고    scopus 로고
    • Characterization of the overlap syndrome of primary biliary cirrhosis (PBC) and autoimmune hepatitis: Evidence for it being a hepatitic form of PBC in genetically susceptible individuals
    • Lohse AW, zum Buschenfelde KH, Franz B, et al. Characterization of the overlap syndrome of primary biliary cirrhosis (PBC) and autoimmune hepatitis: evidence for it being a hepatitic form of PBC in genetically susceptible individuals. Hepatology 1999;29:1078-84
    • (1999) Hepatology , vol.29 , pp. 1078-1084
    • Lohse, A.W.1    Zum Buschenfelde, K.H.2    Franz, B.3
  • 71
    • 0036377947 scopus 로고    scopus 로고
    • Clinical and biochemical features and therapy responses in primary biliary cirrhosis and primary biliary cirrhosisautoimmune hepatitis overlap syndrome
    • Gunsar F, Akarca US, Ersoz G, et al. Clinical and biochemical features and therapy responses in primary biliary cirrhosis and primary biliary cirrhosisautoimmune hepatitis overlap syndrome. Hepatogastroenterology 2002;49:1195-200
    • (2002) Hepatogastroenterology , vol.49 , pp. 1195-1200
    • Gunsar, F.1    Akarca, U.S.2    Ersoz, G.3
  • 72
    • 33846815253 scopus 로고    scopus 로고
    • Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: A retrospective study of 115 cases of autoimmune liver disease
    • Heurgue A, Vitry F, Diebold MD, et al. Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: a retrospective study of 115 cases of autoimmune liver disease. Gastroenterol Clin Biol 2007;31:17-25
    • (2007) Gastroenterol Clin Biol , vol.31 , pp. 17-25
    • Heurgue, A.1    Vitry, F.2    Diebold, M.D.3
  • 73
    • 84857500754 scopus 로고    scopus 로고
    • Liver fibrosis may reduce the efficacy of budesonide in the treatment of autoimmune hepatitis and overlap syndrome
    • Efe C, Ozaslan E, Kav T, et al. Liver fibrosis may reduce the efficacy of budesonide in the treatment of autoimmune hepatitis and overlap syndrome. Autoimmun Rev 2012;11:330-4
    • (2012) Autoimmun Rev , vol.11 , pp. 330-334
    • Efe, C.1    Ozaslan, E.2    Kav, T.3
  • 74
    • 84868689299 scopus 로고    scopus 로고
    • Primary biliary cirrhosis and bile acids
    • Corpechot C. Primary biliary cirrhosis and bile acids. Clin Res Hepatol Gastroenterol 2012;36(Suppl 1):S13-20
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , Issue.SUPPL. 1
    • Corpechot, C.1
  • 75
    • 77954236019 scopus 로고    scopus 로고
    • American Association for the Study of Liver Diseases endpoints conference: Design and endpoints for clinical trials in primary biliary cirrhosis
    • Silveira MG, Brunt EM, Heathcote J, et al. American Association for the Study of Liver Diseases endpoints conference: design and endpoints for clinical trials in primary biliary cirrhosis. Hepatology 2010;52:349-59
    • (2010) Hepatology , vol.52 , pp. 349-359
    • Silveira, M.G.1    Brunt, E.M.2    Heathcote, J.3
  • 76
    • 84881550708 scopus 로고    scopus 로고
    • Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis
    • Cash WJ, O'Neill S, O'Donnell ME, et al. Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis. Liver Int 2013;33:1166-74
    • (2013) Liver Int , vol.33 , pp. 1166-1174
    • Cash, W.J.1    O'Neill, S.2    O'Donnell, M.E.3
  • 77
    • 43049145251 scopus 로고    scopus 로고
    • Rituximab for primary biliary cirrhosis refractory to ursodeoxycholic acid
    • Myers R, Shaheen A, Swain M, et al. Rituximab for primary biliary cirrhosis refractory to ursodeoxycholic acid. Hepatology 2007;46:550A
    • (2007) Hepatology , vol.46
    • Myers, R.1    Shaheen, A.2    Swain, M.3
  • 78
    • 50849132518 scopus 로고    scopus 로고
    • Clinical trial: Randomized controlled trial of zidovudine and lamivudine for patients with primary biliary cirrhosis stabilized on ursodiol
    • [Epub ahead of print]
    • Mason AL, Lindor KD, Bacon BR, et al. Clinical trial: randomized controlled trial of zidovudine and lamivudine for patients with primary biliary cirrhosis stabilized on ursodiol. Aliment Pharmacol Ther 2008 [Epub ahead of print]
    • (2008) Aliment Pharmacol Ther
    • Mason, A.L.1    Lindor, K.D.2    Bacon, B.R.3
  • 79
    • 84925581702 scopus 로고    scopus 로고
    • Lysophosphatidic acid is a potential mediator of cholestatic pruritus
    • 18 e1
    • Kremer AE, Martens JJ, Kulik W, et al. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology 2010;139:1008-18; 18 e1
    • (2010) Gastroenterology , vol.139 , pp. 1008-1018
    • Kremer, A.E.1    Martens, J.J.2    Kulik, W.3
  • 80
    • 84864357786 scopus 로고    scopus 로고
    • Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions
    • Kremer AE, van Dijk R, Leckie P, et al. Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. Hepatology 2012;56:1391-400
    • (2012) Hepatology , vol.56 , pp. 1391-1400
    • Kremer, A.E.1    Van Dijk, R.2    Leckie, P.3
  • 81
    • 0033989267 scopus 로고    scopus 로고
    • Combination therapy of bezafibrate and ursodeoxycholic acid in primary biliary cirrhosis: A preliminary study
    • Nakai S, Masaki T, Kurokohchi K, et al. Combination therapy of bezafibrate and ursodeoxycholic acid in primary biliary cirrhosis: a preliminary study. Am J Gastroenterol 2000;95:326-7
    • (2000) Am J Gastroenterol , vol.95 , pp. 326-327
    • Nakai, S.1    Masaki, T.2    Kurokohchi, K.3
  • 82
    • 0033792659 scopus 로고    scopus 로고
    • Bezafibrate in the treatment of primary biliary cirrhosis: Comparison with ursodeoxycholic acid
    • Kurihara T, Niimi A, Maeda A, et al. Bezafibrate in the treatment of primary biliary cirrhosis: comparison with ursodeoxycholic acid. Am J Gastroenterol 2000;95:2990-2
    • (2000) Am J Gastroenterol , vol.95 , pp. 2990-2992
    • Kurihara, T.1    Niimi, A.2    Maeda, A.3
  • 83
    • 0037821923 scopus 로고    scopus 로고
    • Bezafibrate treatment: A new medical approach for PBC patients?
    • Kanda T, Yokosuka O, Imazeki F, Saisho H. Bezafibrate treatment: a new medical approach for PBC patients? J Gastroenterol 2003;38:573-8
    • (2003) J Gastroenterol , vol.38 , pp. 573-578
    • Kanda, T.1    Yokosuka, O.2    Imazeki, F.3    Saisho, H.4
  • 84
    • 67149095289 scopus 로고    scopus 로고
    • Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants
    • Hirschfield GM, Liu X, Xu C, et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med 2009;360:2544-55
    • (2009) N Engl J Med , vol.360 , pp. 2544-2555
    • Hirschfield, G.M.1    Liu, X.2    Xu, C.3
  • 85
    • 51349157015 scopus 로고    scopus 로고
    • What is the potential role of antifibrotic agents for the treatment of liver disease?
    • Schnabl B, Scholten D, Brenner DA. What is the potential role of antifibrotic agents for the treatment of liver disease? Nat Clin Pract Gastroenterol Hepatol 2008;5:496-7
    • (2008) Nat Clin Pract Gastroenterol Hepatol , vol.5 , pp. 496-497
    • Schnabl, B.1    Scholten, D.2    Brenner, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.