Modulation of bile acid metabolism by 1α-hydroxyvitamin D3 administration in mice

Drug Metabolism and Disposition

Volumn 37, Issue 10, 2009, Pages 2037-2044

  Nishida, Shigeru ^a   Ozeki, Jun ^a   Makishima, Makoto ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALFACALCIDOL; CHENODEOXYCHOLIC ACID; CHOLIC ACID; DEOXYCHOLIC ACID; LITHOCHOLIC ACID; MULTIDRUG RESISTANCE PROTEIN 4;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BILE COMPOSITION; CONTROLLED STUDY; DRUG ACTIVATION; DRUG METABOLISM; IMMUNOBLOTTING; IN VIVO STUDY; INTRAHEPATIC BILE DUCT; LIVER; MALE; MASS FRAGMENTOGRAPHY; MODULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; URINARY EXCRETION; VITAMIN SUPPLEMENTATION;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELL LINE; CELL LINE, TUMOR; CHENODEOXYCHOLIC ACID; CHOLECALCIFEROL; CHOLIC ACID; HOMEOSTASIS; KIDNEY; LIVER; MALE; MICE; MICE, INBRED C57BL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RECEPTORS, CALCITRIOL; RNA, MESSENGER;

MUS;

EID: 70349286775     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027334     Document Type: Article

References (32)

1. Alrefai WA and Gill RK (2007) Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res 24:1803-1823. (Pubitemid 47389235)
2. Botham KM and Boyd GS (1983) The metabolism of chenodeoxycholic acid to β-muricholic acid in rat liver. Eur J Biochem 134:191-196.
3. Canaff L, Petit JL, Kisiel M, Watson PH, Gascon-Barré M, and Hendy GN (2001) Extracellular calcium-sensing receptor is expressed in rat hepatocytes. coupling to intracellular calcium mobilization and stimulation of bile flow. J Biol Chem 276:4070-4079. (Pubitemid 37371490)
4. Chen X, Chen F, Liu S, Glaeser H, Dawson PA, Hofmann AF, Kim RB, Shneider BL, and Pang KS (2006) Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1α,25-dihydroxyvitamin D3 via the vitamin D receptor. Mol Pharmacol 69:1913-1923. (Pubitemid 43894308)
5. 14 in the rat. J Biol Chem 238:1973-1978.
6. Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, et al. (2006) Identification of a hormonal basis for gallbladder filling. Nat Med 12:1253-1255. (Pubitemid 44706926)
7. Echchgadda I, Song CS, Roy AK, and Chatterjee B (2004) Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Mol Pharmacol 65:720-729. (Pubitemid 38264040)
8. Eyssen H, De Pauw G, Stragier J, and Verhulst A (1983) Cooperative formation of ω-muricholic acid by intestinal microorganisms. Appl Environ Microbiol 45:141-147. (Pubitemid 13175289)
9. Fromm H, Sarva RP, and Bazzoli F (1983) Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate. J Lipid Res 24:841-853.
10. Gascon-Barré M, Demers C, Mirshahi A, Néron S, Zalzal S, and Nanci A (2003) The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells. Hepatology 37:1034-1042. (Pubitemid 36538680)
11. 3. Endocrinology 129:2335-2344.
12. Hofmann AF (1999) The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med 159:2647-2658.
13. 3 prolong survival time of mice inoculated with myeloid leukemia cells. Proc Natl Acad Sci U S A 80:201-204.
14. Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, and Makishima M (2008) Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia. J Lipid Res 49:763-772.
15. Keller S and Jahreis G (2004) Determination of underivatised sterols and bile acid trimethyl silyl ether methyl esters by gas chromatography-mass spectrometry-single ion monitoring in faeces. J Chromatogr B Analyt Technol Biomed Life Sci 813:199-207. (Pubitemid 39535447)
16. Makishima M (2005) Nuclear receptors as targets for drug development: regulation of cholesterol and bile acid metabolism by nuclear receptors. J Pharmacol Sci 97:177-183.
17. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, and Mangelsdorf DJ (2002) Vitamin D receptor as an intestinal bile acid sensor. Science 296:1313-1316. (Pubitemid 34522785)
18. Matsubara T, Yoshinari K, Aoyama K, Sugawara M, Sekiya Y, Nagata K, and Yamazoe Y (2008) Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro and in vivo. Drug Metab Dispos 36:2058-2063.
19. McCarthy TC, Li X, and Sinal CJ (2005) Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids. J Biol Chem 280:23232-23242. (Pubitemid 40853235)
20. Nehring JA, Zierold C, and DeLuca HF (2007) Lithocholic acid can carry out in vivo functions of vitamin D. Proc Natl Acad Sci U S A 104:10006-10009. (Pubitemid 47175253)
21. Ogura M, Nishida S, Ishizawa M, Sakurai K, Shimizu M, Matsuo S, Amano S, Uno S, and Makishima M (2009) Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice. J Pharmacol Exp Ther 328:564-570.
22. Parmentier G and Eyssen H (1975) Synthesis of the specific monosulfates of cholic acid. Steroids 26:721-729.
23. Ridlon JM, Kang DJ, and Hylemon PB (2006) Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47:241-259.
24. Russell DW (2003) The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72:137-174. (Pubitemid 36930444)
25. Setchell KD, Lawson AM, Tanida N, and Sjövall J (1983) General methods for the analysis of metabolic profiles of bile acids and related compounds in feces. J Lipid Res 24:1085-1100.
26. Setchell KD and Worthington J (1982) A rapid method for the quantitative extraction of bile acids and their conjugates from serum using commercially available reverse-phase octadecylsilane bonded silica cartridges. Clin Chim Acta 125:135-144.
27. Stedman C, Robertson G, Coulter S, and Liddle C (2004) Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice. J Biol Chem 279:11336-11343. (Pubitemid 38401631)
28. Thummel KE, Brimer C, Yasuda K, Thottassery J, Senn T, Lin Y, Ishizuka H, Kharasch E, Schuetz J, and Schuetz E (2001) Transcriptional control of intestinal cytochrome P-4503A by 1α,25-dihydroxy vitamin D3. Mol Pharmacol 60:1399-1406. (Pubitemid 33144911)
29. Xie W and Evans RM (2001) Orphan nuclear receptors: the exotics of xenobiotics. J Biol Chem 276:37739-37742. (Pubitemid 37384015)
30. Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, and Evans RM (2001) An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A 98:3375-3380. (Pubitemid 32220853)
31. Zollner G, Marschall HU, Wagner M, and Trauner M (2006a) Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharm 3:231-251. (Pubitemid 44021431)
32. Zollner G, Wagner M, Moustafa T, Fickert P, Silbert D, Gumhold J, Fuchsbichler A, Halilbasic E, Denk H, Marschall HU, et al. (2006b) Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-α/β in the adaptive response to bile acids. Am J Physiol Gastrointest Liver Physiol 290:G923-G932.