Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol

Gastroenterology

Volumn 146, Issue 4, 2014, Pages 1048-1059.e7

  Chow, Edwin C Y ^a   Magomedova, Lilia ^a   Quach, Holly P ^a   Patel, Rucha ^a   Durk, Matthew R ^a   Fan, Jianghong ^a   Maeng, Han Joo ^a   Irondi, Kamdi ^a   Anakk, Sayeepriyadarshini ^b   Moore, David D ^b   Cummins, Carolyn L ^a   Pang, K Sandy ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Bile Acid; Farnesoid X Receptor; Liver; Transcriptional Regulation

Indexed keywords

CALCITRIOL; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; NUCLEAR PROTEIN; SMALL HETERODIMER PARTNER PROTEIN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; DRUG BLOOD LEVEL; ENHANCER REGION; FEEDBACK SYSTEM; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HUMAN; HYPERCALCEMIA; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

BILE ACID; FARNESOID X RECEPTOR; LIVER; TRANSCRIPTIONAL REGULATION;

ANIMALS; BINDING SITES; CALCITRIOL; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HEPATOCYTES; HUMANS; HYPERCHOLESTEROLEMIA; ILEUM; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROMOTER REGIONS, GENETIC; RECEPTORS, CALCITRIOL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; STEROID HYDROXYLASES; TIME FACTORS; TRANSFECTION;

EID: 84896445018     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.12.027     Document Type: Article

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