Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

Biochemical and Biophysical Research Communications

Volumn 427, Issue 3, 2012, Pages 600-605

  Kumar, Divya P ^b   Rajagopal, Senthilkumar ^b   Mahavadi, Sunila ^b   Mirshahi, Faridoddin ^a   Grider, John R ^b   Murthy, Karnam S ^b   Sanyal, Arun J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Bile salts; G protein coupled receptor; Incretins; Insulin resistance; Oleanolic acid; TGR5 receptor

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; BILE ACID; CALCIUM CHELATING AGENT; CALCIUM ION; CHOLIC ACID DERIVATIVE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; G PROTEIN COUPLED RECEPTOR; INSULIN; LITHOCHOLIC ACID; OLEANOLIC ACID; PHOSPHATIDYLINOSITIDE; TRANSMEMBRANE BILE ACID RECEPTOR TGR5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; HUMAN; HUMAN CELL; HYDROLYSIS; INSULIN RELEASE; MOUSE; MYRISTYLATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BENZENESULFONATES; BILE ACIDS AND SALTS; CALCIUM; CELL LINE, TUMOR; CELL MEMBRANE; CHOLIC ACIDS; ESTRENES; GLUCOSE; HUMANS; HYDROLYSIS; INSULIN; INSULIN-SECRETING CELLS; MICE; OLEANOLIC ACID; PHOSPHATIDYLINOSITOLS; PYRROLIDINONES; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84867886430     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.09.104     Document Type: Article

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