Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice

Journal of Lipid Research

Volumn 55, Issue 3, 2014, Pages 455-465

  Cheng, Jie ^a,b   Fang, Zhong Ze ^a   Kim, Jung Hwan ^a   Krausz, Kristopher W ^a   Tanaka, Naoki ^a   Chiang, John Y L ^b   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Northeast Ohio Medical University   (United States)

Author keywords

Bile acids; Metabolomics; Vitamin D receptor

Indexed keywords

BILE ACID; CYTOCHROME P450 3A4; LITHOCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; VITAMIN D RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BILE LEVEL; CONTROLLED STUDY; DETOXIFICATION; HEPATITIS; IN VITRO STUDY; INTESTINE; LIVER LEVEL; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE; TISSUE SPECIFICITY; URINE LEVEL;

BILE ACIDS; METABOLOMICS; VITAMIN D RECEPTOR;

ANIMALS; BILE; BILE ACIDS AND SALTS; BLOTTING, WESTERN; CHOLESTEROL; CYTOCHROME P-450 CYP3A; DRUG-INDUCED LIVER INJURY; GALLBLADDER; INTESTINES; LITHOCHOLIC ACID; LIVER; MALE; METABOLOMICS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, CALCITRIOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84894765975     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M044420     Document Type: Article

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