Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue

Endocrinology

Volumn 150, Issue 2, 2009, Pages 651-661

  Narvaez, Carmen J ^a   Matthews, Donald ^a   Broun, Emily ^b   Chan, Michelle ^a,c   Welsh, Joellen ^a,b,d  

^a UNIVERSITY AT ALBANY   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

^c QUEEN S UNIVERSITY   (Canada)

^d STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; LEPTIN; UNCOUPLING PROTEIN 1; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOOD INTAKE; GENE EXPRESSION; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; WEIGHT GAIN; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, WHITE; ADIPOSITY; ANIMALS; BODY WEIGHT; DIET, ATHEROGENIC; DIETARY FATS; EATING; GENETIC PREDISPOSITION TO DISEASE; ION CHANNELS; LIPID METABOLISM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; OBESITY; ORGAN SIZE; PHENOTYPE; RECEPTORS, CALCITRIOL; THINNESS; UP-REGULATION; VITAMIN D DEFICIENCY;

EID: 59649099370     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1118     Document Type: Article

References (35)

1. Imai T, Jiang M, Chambon P, Metzger D 2001 Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recom binase (Cre-ERT2) in adipocytes. Proc Natl Acad Sci USA 98:224-228
2. Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ 2005 LXRs regulate the balance between fat storage and oxidation. Cell Metab 1:231-244
3. Sjögren M, Alkemade A, Mittag J, Nordstrom K, Katz A, Rozell B, Westerblad H, Arner A, Vennström B 2007 Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor α1. EMBO J 26:4535-4545
4. Kamei Y, Kawada T, Kazuki R, Ono T, Kato S, Sugimoto E 1993 Vitamin D receptor gene expression is up-regulated by 1, 25-dihydroxyvitamin D3 in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 193:948 -955
5. Imagawa M, Tsuchiya T, Nishihara T 1999 Identification of inducible genes at the early stage of adipocyte differentiation of 3T3-L1 cells. Biochem Biophys Res Commun 254:299-305
6. Fu M, Sun T, Bookout AL, Downes M, Yu RT, Evans RM, Mangelsdorf DJ 2005 A nuclear receptor atlas: 3T3-L1 adipogenesis. Mol Endocrinol 19:2437-2450
7. Bellows CG, Wang YH, Heersche JN, Aubin JE 1994 1,25-dihydroxyvitamin D3 stimulates adipocyte differentiation in cultures of fetal rat calvaria cells: comparison with the effects of dexamethasone. Endocrinology 134:2221-2229
8. Dace A, Martin-el Yazidi C, Bonne J, Planells R, Torresani J 1997 Calcitriol is a positive effector of adipose differentiation in the OB 17 cell line: relationship with the adipogenic action of triiodothyronine. Biochem Biophys Res Commun 232:771-776
9. Atmani H, Chappard D, Basle MF 2003 Proliferation and differentiation of osteoblasts and adipocytes in rat bone marrow stromal cell cultures: effects of dexamethasone and calcitriol. J Cell Biochem 89:364-372
10. Kong J, Li YC 2006 Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in3T3-L1 cells. Am J Physiol Endocrinol Metab 290:E916-E924
11. Blumberg JM, Tzameli I, Astapova I, Lam FS, Flier JS, Hollenberg AN 2006 Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem 281:11205-11213
12. Shi H, Norman AW, Okamura W, Sen A, Zemel MB 2002 1α,25-Dihy-droxyvitamin D3 inhibits uncoupling protein 2 expression in human a dipo- cytes. FASEB J 16:1808-1810
13. Zhang S, Chan M, Aubin JE 2006 Pleiotropic effects of the steroid hormone 1,25-dihydroxyvitamin D3 on the recruitment of mesenchymal lineage progenitors in fetal rat calvaria cell populations. J Mol Endocrinol 36:425-433
14. Guzey M, Jukic D, Arlotti J, Acquafondata M, Dhir R, Getzenberg RH 2004 Increased apoptosis of periprostatic adipose tissue in VDR null mice. J Cell Biochem 93:133-141
15. Zinser GM, Welsh JE 2004 Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice. Carcinogenesis 25:2361-2372
16. Cianferroti L, Demay MB 2007 VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cells. J Cell Biochem 101:80-88
17. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB 1997 Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94:9831-9835
18. Panda DK, Miao D, Bolivar I, Li J, Huo R, Hendy GN, Goltzman D 2004 Inactivation of the 25-hydroxyvitamin D 1 α-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J Biol Chem 279:16754-16766
19. Cianferroti L, Cox M, Skorija K, Demay MB 2007 Vitamin D receptor is essential for normal keratinocyte stem cell function. Proc Natl Acad Sci USA 104:9428-9433
20. Dardenne O, Prud'homme J, Arabian A, Glorieux FH, St-Arnaud R 2001 Targeted inactivation of the 25-hydroxyvitamin D(3)-1 α-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142:3135-3141
21. Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB 1998 Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139:4391-4396
22. Dardenne O, Prud'homme J, Hacking SA, Glorieux FH, St. Arnaud R 2003 Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1). Bone 32:332-340
23. Mathews CE, Bagley R, Leiter EH 2004 ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential. Diabetes 53:S125-S129
24. Malloy PJ, Pike WJ, Feldman D 2005 Hereditary 1,25- dihydroxyvitamin D resistant rickets. In: Feldman D, Pike JW, Gloriuex F, eds. Vitamin D. 2nd ed. Amsterdam: Elsevier; 1207-1237
25. Rowling MJ, Gliniak C, Welsh J, Fleet JC 2007 High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice. J Nutr 137:2608-2615
26. Kuro-o M 2008 Endocrine FGFs and Klothos: emerging concepts. Trends Endocrinol Metab 19:239-245
27. Sun X, Zemel MB 2004 Role of uncoupling protein 2 (UCP2) expression and 1 α, 25-dihydroxyvitamin D3 in modulating adipocyte apoptosis. FASEB J 18:1430-1432
28. Burne TH, McGrath JJ, Eyles DW, Mackay-Sim A 2005 Behavioural characterization of vitamin D receptor knock out mice.BehavBrainRes157:299-308
29. Norman AW, Frankel JB, Heldt AM, Grodsky GM 1980 Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 209:823-825
30. Lee S, Clark SA, Gill RK, Christakos S 1994 1,25-Dihydroxyvitamin D3 and pancreatic β-cell function: vitamin D receptors, gene expression, and insulin secretion. Endocrinology 134:1602-1610
31. ZeitzU, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG 2003 Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J 17:509-511
32. Brouwer DA, van Beek J, Ferwerda H, Brugman AM, van der Klis FR, van der Heiden HJ, Muskiet FA 1998 Rat adipose tissue rapidly accumulates and slowly releases an orally administered high vitamin D dose. Br J Nutr 79:527-532
33. Matsunuma A, Kawane T, Maeda T, Hamada S, Horiuchi N 2004 Leptin corrects increased gene expression of renal 25-hydroxyvitamin D3-1α-hydroxylase and 24-hydroxylase in leptin deficient, ob/ob mice. Endocrinology 145:1367-1375
34. Wolf G 2008 Energy regulation by the skeleton. Nutr Rev 66:229-233
35. Ferron M, Hinoi E, Karsenty G, Ducy P 2008 Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 105:5266-5270