Transgenic expression of cholesterol 7α-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice

Hepatology

Volumn 52, Issue 2, 2010, Pages 678-690

  Li, Tiangang ^a   Owsley, Erika ^a   Matozel, Michelle ^a   Hsu, Peter ^a   Novak, Colleen M ^b   Chiang, John Y L ^a  

^a Northeast Ohio Medical University   (United States)

^b KENT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CONTROLLED STUDY; ENERGY EXPENDITURE; FATTY ACID OXIDATION; FATTY LIVER; GENE EXPRESSION; GENE OVEREXPRESSION; HOMEOSTASIS; INSULIN RESISTANCE; LIPID DIET; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

ANIMALS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DIETARY FATS; HOMEOSTASIS; INSULIN RESISTANCE; LIPID METABOLISM; LIPOPROTEINS, VLDL; LIVER; MICE; MICE, TRANSGENIC; OBESITY;

EID: 77955667250     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23721     Document Type: Article

References (30)

1. Schwartz SL. Diabetes and dyslipidaemia. Diabetes Obes Metab 2006;8:355-364.
2. Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 2006;68:123-158.
3. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. HEPATOLOGY 2006;43:S99-S112.
4. Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, et al. Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest 2002;110:109-117.
5. Miyake JH, Duong-Polk XT, Taylor JM, Du EZ, Castellani LW, Lusis AJ, et al. Transgenic expression of cholesterol-7α-hydroxylase prevents atherosclerosis in C57BL/6J mice. Arterioscler Thromb Vasc Biol 2002;22:121-126.
6. Chiang JY. Bile acids: regulation of synthesis. J Lipid Res 2009;50:1955-1966.
7. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009;89:147-191.
8. Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov 2008;7:678-693.
9. Grundy SM, Ahrens EH Jr, Salen G. Interruption of the enterohepatic circulation of bile acids in man: comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism. J Lab Clin Med 1971;78:94-121.
10. Angelin B, Einarsson K, Hellstrom K, Leijd B. Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia. J Lipid Res 1978;19:1017-1024. (Pubitemid 9059813)
11. Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004;113:1408-1418.
12. Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A 2006;103:1006-1011.
13. Yamagata K, Daitoku H, Shimamoto Y, Matsuzaki H, Hirota K, Ishida J, et al. Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J Biol Chem 2004;279:23158-23165.
14. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006;439:484-489.
15. Miyake JH, Doung XD, Strauss W, Moore GL, Castellani LW, Curtiss LK, et al. Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7α-hydroxylase. J Biol Chem 2001;276:23304-23311.
16. Chiang JY. Reversed-phase high-performance liquid chromatography assay of cholesterol 7α-hydroxylase. Methods Enzymol 1991;206:483-491.
17. Matsukuma KE, Bennett MK, Huang J, Wang L, Gil G, Osborne TF. Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase. J Lipid Res 2006;47:2754-2761.
18. Silver DL, Jiang XC, Tall AR. Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover. J Biol Chem 1999;274:4140-4146.
19. Silver DL, Wang N, Tall AR. Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptake. J Clin Invest 2000;105:151-159.
20. Gruen ML, Plummer MR, Zhang W, Posey KA, Linton MF, Fazio S, et al. Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res 2005;46:2007-2014.
21. Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol 2005;6:248-261.
22. Karalis KP, Giannogonas P, Kodela E, Koutmani Y, Zoumakis M, Teli T. Mechanisms of obesity and related pathology: linking immune responses to metabolic stress. FEBS J 2009;276:5747-5754.
23. Rossmeisl M, Barbatelli G, Flachs P, Brauner P, Zingaretti MC, Marelli M, et al. Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo. Eur J Biochem 2002;269:19-28.
24. Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 1995;96:2914-2923.
25. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509-1517.
26. Goldberg RB, Fonseca VA, Truitt KE, Jones MR. Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy. Arch Intern Med 2008;168:1531-1540.
27. Staels B. A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus. Postgrad Med 2009;121:25-30.
28. Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology 2008;134:556-567.
29. Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009;10:167-177.
30. Xie Y, Blanc V, Kerr TA, Kennedy S, Luo J, Newberry EP, et al. Decreased expression of cholesterol 7α-hydroxylase and altered bile acid metabolism in apobec-1-/- mice lead to increased gallstone susceptibility. J Biol Chem 2009;284:16860-16871.