Farnesoid X-activated receptor induces apolipoprotein C-II transcription: A molecular mechanism linking plasma triglyceride levels to bile acids

Molecular Endocrinology

Volumn 15, Issue 10, 2001, Pages 1720-1728

  Kast, Heidi Rachelle ^a   Nguyen, Catherine M ^a   Sinal, Christopher J ^b   Jones, Stacey A ^c   Laffitte, Bryan A ^a   Reue, Karen ^a   Gonzalez, Frank J ^b   Willson, Timothy M ^c   Edwards, Peter A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN C2; CELL NUCLEUS RECEPTOR; CHOLIC ACID; FARNESOID X RECEPTOR; HORMONE RECEPTOR; MESSENGER RNA; PHOSPHOLIPID TRANSFER PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENHANCER REGION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPERLIPIDEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; TRANSCRIPTION INITIATION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0034791544     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.15.10.0712     Document Type: Article

References (36)

1. The nuclear receptor superfamily: The second decade
2. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
3. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
4. Identification of a nuclear receptor that is activated by farnesol metabolites
5. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
6. Isolation of proteins that interact specifically with the retinoid X receptor: Two novel orphan receptors
7. Activation of the orphan receptor RIP14 by retinoids
8. Identification of a nuclear receptor for bile acids
9. Bile acids: Natural ligands for an orphan nuclear receptor
10. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
11. Chenodeoxycholate: The bile acid. The drug. A review
12. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer
13. The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression
14. Regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
15. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
16. Identification of a chemical tool for the orphan nuclear receptor FXR
17. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
18. Nuclear orphan receptors: The search for novel ligands and signaling pathways
19. Catabolites of cholesterol synthesis pathways and forskolin as activators of the farnesoid X-activated nuclear receptor
20. A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice
21. Localization of a liver-specific enhancer in the apolipoprotein E/C-I/C-II gene locus
22. Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice
23. Evolutionary duplication of a hepatic control region in the human apolipoprotein E gene locus. Identification of a second region that confers high level and liver-specific expression of the human apolipoprotein E gene in transgenic mice
24. Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster
25. A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2
26. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus
27. Variation in susceptibility to atherosclerosis among inbred strains of mice
28. Role of ApoCs in lipoprotein metabolism: Functional differences between ApoC1, ApoC2, and ApoC3
29. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels
30. Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus
31. Genetic dyslipoproteinemias: Role of lipoprotein lipase and apolipoprotein C-II
32. A single nucleotide substitution in the promoter region of the apolipoprotein C-II gene identified in individuals with chylomicronemia
33. Chenodeoxycholic acid: A review of its pharmacological properties and therapeutic use
34. Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids
35. Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries
36. Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice