The bile acid receptor TGR5 activates the trpa1 channel to induce itch in mice

Gastroenterology

Volumn 147, Issue 6, 2014, Pages 1417-1428

  Lieu, Tinamarie ^a   Jayaweera, Gihan ^a   Zhao, Peishen ^a   Poole, Daniel P ^a,b   Jensen, Dane ^a   Grace, Megan ^c   McIntyre, Peter ^c   Bron, Romke ^b   Wilson, Yvette M ^b   Krappitz, Matteus ^d   Haerteis, Silke ^d   Korbmacher, Christoph ^d   Steinhoff, Martin S ^e   Nassini, Romina ^f   Materazzi, Serena ^f   Geppetti, Pierangelo ^f   Corvera, Carlos U ^g   Bunnett, Nigel W ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c RMIT UNIVERSITY   (Australia)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

^f UNIVERSITY OF FLORENCE   (Italy)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Itching; Liver; Mouse Model; Signal Transduction

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BILE ACID; BILE ACID SEQUESTRANT; CALCIUM ION; COLESTIPOL; G PROTEIN COUPLED BILE ACID RECPTOR 1 TGR5; G PROTEIN COUPLED RECEPTOR; GASTRIN RELEASING PEPTIDE; MESSENGER RNA; NEUROPEPTIDE; PROTEIN KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; GPBAR1 PROTEIN, MOUSE; NATRIURETIC FACTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID BLOOD LEVEL; CONTROLLED STUDY; HEK293 CELL LINE; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; MOUSE; NOCICEPTION; NONHUMAN; ONCOGENE C FOS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PRURITUS; SCRATCHING; SENSITIZATION; SENSORY NERVE; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL; SPINAL GANGLION; STIMULATION; TRANSGENIC MOUSE; ANIMAL; CHOLESTASIS; COMPLICATION; CYTOLOGY; DISEASE MODEL; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; OOCYTE; PAIN RECEPTOR; PRIMARY CELL CULTURE; SENSORY NERVE CELL; XENOPUS LAEVIS;

ANIMALS; BILE ACIDS AND SALTS; CHOLESTASIS; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; GASTRIN-RELEASING PEPTIDE; HEK293 CELLS; HUMANS; MICE, KNOCKOUT; NATRIURETIC PEPTIDES; NEURONS, AFFERENT; NOCICEPTORS; OOCYTES; PRIMARY CELL CULTURE; PRURITUS; RECEPTORS, G-PROTEIN-COUPLED; TRANSIENT RECEPTOR POTENTIAL CHANNELS; XENOPUS LAEVIS;

EID: 84913533041     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.08.042     Document Type: Article

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