Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

Genes and Development

Volumn 17, Issue 13, 2003, Pages 1581-1591

  Holt, Jason A ^a   Luo, Guizhen ^a   Billin, Andrew N ^a   Bisi, John ^a   McNeill, Y Yvette ^a   Kozarsky, Karen F ^a   Donahee, Mary ^a   Wang, Da Yuan ^a   Mansfield, Traci A ^b   Kliewer, Steven A ^a,c   Goodwin, Bryan ^a   Jones, Stacey A ^a  

^a GLAXOSMITHKLINE   (United States)

^b CURAGEN CORPORATION   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bile acid; CYP7A1; Fibroblast growth factor; FXR; JNK

Indexed keywords

BILE ACID; CELL NUCLEUS BILE ACID RECEPTOR; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 4 RECEPTOR; FXR RECEPTOR; GROWTH FACTOR; PROTEIN TYROSINE KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL CATABOLISM; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; LIVER CELL CULTURE; LIVER METABOLISM; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTHRACENES; BILE ACIDS AND SALTS; CELL LINE; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DNA-BINDING PROTEINS; ENZYME REPRESSION; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; ISOXAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0037663483     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1083503     Document Type: Article

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