Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis

Toxicology and Applied Pharmacology

Volumn 283, Issue 3, 2015, Pages 168-177

  Woolbright, Benjamin L ^a   Dorko, Kenneth ^a   Antoine, Daniel J ^b   Clarke, Joanna I ^b   Gholami, Parviz ^a   Li, Feng ^a   Kumer, Sean C ^a   Schmitt, Timothy M ^a   Forster, Jameson ^a   Fan, Fang ^a   Jenkins, Rosalind E ^b   Park, B Kevin ^b   Hagenbuch, Bruno ^a   Olyaee, Mojtaba ^a   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Bile acids; Biomarkers; HMGB1; Inflammation; Obstructive cholestasis; Primary human hepatocytes

Indexed keywords

BILE ACID; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CYTOKERATIN 18; GLYCOCHENODEOXYCHOLIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; BIOLOGICAL MARKER; HMGB1 PROTEIN, HUMAN; KRT18 PROTEIN, HUMAN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BILE COMPOSITION; BILE DUCT INJURY; BILE DUCT LIGATION; CELL DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; EXTRAHEPATIC BILE DUCT OBSTRUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; LIVER INJURY; LIVER NECROSIS; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; QUADRUPOLE MASS SPECTROMETRY; RAT; REAL TIME POLYMERASE CHAIN REACTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WESTERN BLOTTING; ACETYLATION; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NECROSIS; OBSTRUCTIVE JAUNDICE; PATHOLOGY; PRIMARY CELL CULTURE; SPECIES DIFFERENCE;

RODENTIA;

ACETYLATION; ANIMALS; BILE ACIDS AND SALTS; BIOMARKERS; CELLS, CULTURED; CHOLESTASIS, EXTRAHEPATIC; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOCHENODEOXYCHOLIC ACID; HEPATOCYTES; HMGB1 PROTEIN; HUMANS; JAUNDICE, OBSTRUCTIVE; KERATIN-18; MICE, INBRED C57BL; NECROSIS; PRIMARY CELL CULTURE; SPECIES SPECIFICITY;

EID: 84921976620     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.01.015     Document Type: Article

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