메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages 303-339

Anticancer hybrids- a patent survey

Author keywords

Anticancer; Design; Drug; Hybrids; Microtubule; Steroids

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 84905637758     PISSN: 15748928     EISSN: 22123970     Source Type: Journal    
DOI: 10.2174/1574892809666140520150459     Document Type: Review
Times cited : (38)

References (183)
  • 1
    • 82055170422 scopus 로고    scopus 로고
    • The medicinal chemistry of hybrid-based drugs targeting multiple sites of action
    • Contelles JM, Soriano E. The medicinal chemistry of hybrid-based drugs targeting multiple sites of action. Curr Top Med Chem 2011; 11(22): 2714.
    • (2011) Curr Top Med Chem , vol.11 , Issue.22 , pp. 2714
    • Contelles, J.M.1    Soriano, E.2
  • 3
    • 33745109939 scopus 로고    scopus 로고
    • Novel approaches to antimalarial drug discov-ery
    • Biot C, Chibale K. Novel approaches to antimalarial drug discov-ery. Infec Dis Drug Targ 2006; 6: 173.
    • (2006) Infec Dis Drug Targ , vol.6 , pp. 173
    • Biot, C.1    Chibale, K.2
  • 4
    • 0141427680 scopus 로고    scopus 로고
    • Natural product hybrids as new leads for drug discovery
    • Tietze LF, Bell HP, Chandrasekhar S, Natural product hybrids as new leads for drug discovery. Angew Chem Int Ed 2003; 42 (34): 3996.
    • (2003) Angew Chem Int Ed , vol.42 , Issue.34 , pp. 3996
    • Tietze, L.F.1    Bell, H.P.2    Chandrasekhar, S.3
  • 5
    • 3242794178 scopus 로고    scopus 로고
    • From magic bullets to designed multiple ligands
    • Morphy R, Kay C, Rankovic Z. From magic bullets to designed multiple ligands. Drug Disc Today 2004; 9(15): 641.
    • (2004) Drug Disc Today , vol.9 , Issue.15 , pp. 641
    • Morphy, R.1    Kay, C.2    Rankovic, Z.3
  • 6
    • 34249008406 scopus 로고    scopus 로고
    • Chemical insights in the concept of hybrid drugs: The antitu-mor effect of nitric oxide-donating aspirin involves a quinone me-thide but not nitric oxide nor aspirin
    • Hulsman N, Medema JP, Bos C, Jongejan A, Leurs R, Smit MJ, et al. Chemical insights in the concept of hybrid drugs: The antitu-mor effect of nitric oxide-donating aspirin involves a quinone me-thide but not nitric oxide nor aspirin. J Med Chem 2007; 50: 2424.
    • (2007) J Med Chem , vol.50 , pp. 2424
    • Hulsman, N.1    Medema, J.P.2    Bos, C.3    Jongejan, A.4    Leurs, R.5    Smit, M.J.6
  • 7
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • Sawyers C. Targeted cancer therapy. Nature 2004; 432: 294.
    • (2004) Nature , vol.432 , pp. 294
    • Sawyers, C.1
  • 8
    • 41549108420 scopus 로고    scopus 로고
    • From single- to multi-target drugs in cancer therapy: When aspecificity becomes an advantage
    • Petrelli A, Giordano S. From single- to multi-target drugs in cancer therapy: When aspecificity becomes an advantage. Curr Med Chem 2008; 15(5): 422.
    • (2008) Curr Med Chem , vol.15 , Issue.5 , pp. 422
    • Petrelli, A.1    Giordano, S.2
  • 10
    • 67649470377 scopus 로고    scopus 로고
    • Cancer prevention research - then and now
    • Bode AM, Dong ZG. Cancer prevention research - then and now. Nat Rev Cancer 2009; 9: 508s.
    • (2009) Nat Rev Cancer , vol.9
    • Bode, A.M.1    Dong, Z.G.2
  • 11
    • 68449098788 scopus 로고    scopus 로고
    • Designed multiple ligands: An emerging anti-HIV drug discovery paradigm
    • Zhan P, Liu XY. Designed multiple ligands: an emerging anti-HIV drug discovery paradigm. Curr Pharm Des 2009; 15:1893.
    • (2009) Curr Pharm Des , vol.15 , pp. 1893
    • Zhan, P.1    Liu, X.Y.2
  • 12
    • 27144449695 scopus 로고    scopus 로고
    • Designed multiple ligands. An emerging drug discovery paradigm
    • Morphy R, Rankovic Z. Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem 2005; 48: 6523.
    • (2005) J Med Chem , vol.48 , pp. 6523
    • Morphy, R.1    Rankovic, Z.2
  • 13
    • 72949087797 scopus 로고    scopus 로고
    • Promise and challenges in drug discovery and development of hybrid anticancer drugs
    • Gediya LK, Njar VCO. Promise and challenges in drug discovery and development of hybrid anticancer drugs. Expert Opin Drug Discov 2009; 4(11): 1009.
    • (2009) Expert Opin Drug Discov , vol.4 , Issue.11 , pp. 1009
    • Gediya, L.K.1    Njar, V.C.O.2
  • 16
    • 84893814742 scopus 로고    scopus 로고
    • Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans
    • Federico A, Zappavigna S, Romano M, Grieco P, Luce A, Marra M, et al. Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans. Eur J Clin Invest 2014; 44: 285.
    • (2014) Eur J Clin Invest , vol.44 , pp. 285
    • Federico, A.1    Zappavigna, S.2    Romano, M.3    Grieco, P.4    Luce, A.5    Marra, M.6
  • 17
    • 78651306525 scopus 로고    scopus 로고
    • Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells
    • Grieco P, Franco R, Bozzuto G, Toccacieli L, Sgambato A, Marra M, et al. Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells. J Cell Biochem 2011; 112: 341.
    • (2011) J Cell Biochem , vol.112 , pp. 341
    • Grieco, P.1    Franco, R.2    Bozzuto, G.3    Toccacieli, L.4    Sgambato, A.5    Marra, M.6
  • 18
  • 23
    • 84885212161 scopus 로고    scopus 로고
    • Interleukin-2 and lanreotide in the treatment of medullary thyroid cancer: In vitro and in vivo studies
    • Vitale G, Lupoli G, Guarrasi R, Colao A, Dicitore A, Gaudenzi G, et al. Interleukin-2 and lanreotide in the treatment of medullary thyroid cancer: In vitro and in vivo studies. J Clin Endocrinol Me-tab 2013; 98:1567.
    • (2013) J Clin Endocrinol Me-tab , vol.98 , pp. 1567
    • Vitale, G.1    Lupoli, G.2    Guarrasi, R.3    Colao, A.4    Dicitore, A.5    Gaudenzi, G.6
  • 24
    • 78650507789 scopus 로고    scopus 로고
    • Somatostatin and dopamine receptors
    • Ferone D. Somatostatin and dopamine receptors. Tumor 2010; 96: 802.
    • (2010) Tumor , vol.96 , pp. 802
    • Ferone, D.1
  • 25
    • 69749088827 scopus 로고    scopus 로고
    • Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 receptors
    • Vendrell M, Soriano A, Casad V, Daz JL, Lavilla R, Canela EI, et al. Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 receptors. J Med Chem 2009; 4:1514.
    • (2009) J Med Chem , vol.4 , pp. 1514
    • Vendrell, M.1    Soriano, A.2    Casad, V.3    Daz, J.L.4    Lavilla, R.5    Canela, E.I.6
  • 26
    • 82155172862 scopus 로고    scopus 로고
    • Somatostatin-dopamine chimeras: A novel approach to treatment of neuroendocrine tumors
    • Culler MD. Somatostatin-dopamine chimeras: A novel approach to treatment of neuroendocrine tumors. Horm Metab Res 2011; 43: 854.
    • (2011) Horm Metab Res , vol.43 , pp. 854
    • Culler, M.D.1
  • 27
    • 84862937596 scopus 로고    scopus 로고
    • Targeting Interleukin-4 receptor with hybrid peptide for effective cancer therapy
    • Yang L, Horibe T, Kohno M, Haramoto M, Ohara K, Puri RK, et al. Targeting Interleukin-4 receptor with hybrid peptide for effective cancer therapy. Mol Cancer Ther 2012; 11: 235.
    • (2012) Mol Cancer Ther , vol.11 , pp. 235
    • Yang, L.1    Horibe, T.2    Kohno, M.3    Haramoto, M.4    Ohara, K.5    Puri, R.K.6
  • 28
    • 78651373656 scopus 로고    scopus 로고
    • Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent
    • Horibe T, Kohno M, Haramoto M, Ohara K, Kawakami K. Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. J Transl Med 2011; 9: 8.
    • (2011) J Transl Med , vol.9 , pp. 8
    • Horibe, T.1    Kohno, M.2    Haramoto, M.3    Ohara, K.4    Kawakami, K.5
  • 30
    • 0032006059 scopus 로고    scopus 로고
    • Microtubules and actin filaments: Dynamic targets for cancer chemotherapy
    • Jordan MA, Wilson L. Microtubules and actin filaments: Dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 1998; 10: 123.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 123
    • Jordan, M.A.1    Wilson, L.2
  • 31
    • 0034594624 scopus 로고    scopus 로고
    • Tubulin/microtubules: Still a promising target for new chemotherapeutic agents
    • Giannakakou P, Sackett D, Fojo TJ. Tubulin/microtubules: Still a promising target for new chemotherapeutic agents. Natl Cancer Inst 2003; 92:182.
    • (2003) Natl Cancer Inst , vol.92 , pp. 182
    • Giannakakou, P.1    Sackett, D.2    Fojo, T.J.3
  • 32
    • 84883345326 scopus 로고    scopus 로고
    • Strucure activity relationship of arylidene pyrrolo and pyrido [2,1-b] quinazolones as cytotoxic agents: Synthesis, SAR studies, biological evaluation and docking studies
    • Mangla V, Nepali K, Singh G, Singh J, Guru S, Gupta MK, et al.Strucure activity relationship of arylidene pyrrolo and pyrido [2,1-b] quinazolones as cytotoxic agents: Synthesis, SAR studies, biological evaluation and docking studies. Med Chem 2013; 9: 642.
    • (2013) Med Chem , vol.9 , pp. 642
    • Mangla, V.1    Nepali, K.2    Singh, G.3    Singh, J.4    Guru, S.5    Gupta, M.K.6
  • 33
    • 0031872051 scopus 로고    scopus 로고
    • Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
    • Jordan A, Hadfield JA, Lawrence NJ, McGown AT. Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle. Med Res Rev 1998; 18: 259.
    • (1998) Med Res Rev , vol.18 , pp. 259
    • Jordan, A.1    Hadfield, J.A.2    Lawrence, N.J.3    McGown, A.T.4
  • 34
    • 0031696078 scopus 로고    scopus 로고
    • New insights into microtubule structure and function from the atomic model of tubulin
    • Downing KH, Nogales E. New insights into microtubule structure and function from the atomic model of tubulin. Eur Biophys J 1998; 27:431.
    • (1998) Eur Biophys J , vol.27 , pp. 431
    • Downing, K.H.1    Nogales, E.2
  • 35
    • 0033214537 scopus 로고    scopus 로고
    • A structural view of microtubule dynamics
    • Nogales E. A structural view of microtubule dynamics. Cell Mol Life Sci 1999; 56:133.
    • (1999) Cell Mol Life Sci , vol.56 , pp. 133
    • Nogales, E.1
  • 36
    • 0019977155 scopus 로고
    • Interaction of vin-blastine with steady-state microtubules in vitro
    • Wilson L, Jordan MA, Morse A, Margolis RL. Interaction of vin-blastine with steady-state microtubules in vitro. J Mol Biol 1982; 159: 125.
    • (1982) J Mol Biol , vol.159 , pp. 125
    • Wilson, L.1    Jordan, M.A.2    Morse, A.3    Margolis, R.L.4
  • 37
    • 0035942226 scopus 로고    scopus 로고
    • The binding conformation of Taxol in beta-tubulin: A model based on electron crystallographic density
    • Snyder JP, Nettles JH, Cornett B, Downing KH, Nogales E. The binding conformation of Taxol in beta-tubulin: A model based on electron crystallographic density. PNAS 2001; 98: 5312.
    • (2001) PNAS , vol.98 , pp. 5312
    • Snyder, J.P.1    Nettles, J.H.2    Cornett, B.3    Downing, K.H.4    Nogales, E.5
  • 38
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff PB, Fant J, Horwiz SB. Promotion of microtubule assembly in vitro by taxol. Nature 1979; 277: 665.
    • (1979) Nature , vol.277 , pp. 665
    • Schiff, P.B.1    Fant, J.2    Horwiz, S.B.3
  • 39
    • 0034177962 scopus 로고    scopus 로고
    • Dissecting cellular processes using small molecules: Identification of colchicine-like, taxol-like and other small molecules that perturb mitosis
    • Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchinson TJ, et al. Dissecting cellular processes using small molecules: Identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem Biol 2000; 7: 275.
    • (2000) Chem Biol , vol.7 , pp. 275
    • Haggarty, S.J.1    Mayer, T.U.2    Miyamoto, D.T.3    Fathi, R.4    King, R.W.5    Mitchinson, T.J.6
  • 41
    • 0035433029 scopus 로고    scopus 로고
    • Past and future of the mitotic spindle as an oncology target
    • Wood KW, Cornwell WD, Jackson JR. Past and future of the mitotic spindle as an oncology target. Curr Opin Pharmacol 2001; 1: 370.
    • (2001) Curr Opin Pharmacol , vol.1 , pp. 370
    • Wood, K.W.1    Cornwell, W.D.2    Jackson, J.R.3
  • 46
    • 84855800613 scopus 로고    scopus 로고
    • 1,2,3-Triazole tethered p-lactam-chalcone bifunctional hybrids: Synthesis and anticancer evaluation
    • Singh P, Raj R, Kumar V, Mahajan MP, Bedi PMS, Kaur T, et al. 1,2,3-Triazole tethered p-lactam-chalcone bifunctional hybrids: Synthesis and anticancer evaluation. Eur J Med Chem 2012; 47: 594.
    • (2012) Eur J Med Chem , vol.47 , pp. 594
    • Singh, P.1    Raj, R.2    Kumar, V.3    Mahajan, M.P.4    Bedi, P.M.S.5    Kaur, T.6
  • 47
    • 84862796284 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors
    • Gu X, Ren Z, Tang X, Peng H, Mad Y, Lai Y, Peng S, Zhang Y, et al. Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors. Bioorg Med Chem 2012; 20: 2540.
    • (2012) Bioorg Med Chem , vol.20 , pp. 2540
    • Gu, X.1    Ren, Z.2    Tang, X.3    Peng, H.4    Mad, Y.5    Lai, Y.6    Peng, S.7    Zhang, Y.8
  • 48
    • 84878820199 scopus 로고    scopus 로고
    • Synthesis of 1,2,3-triazole tethered bifunctional hybrids by click chemistry and their cytotoxic studies
    • Singh J, Sharma S, Saxena AK, Nepali K, Bedi PMS. Synthesis of 1,2,3-triazole tethered bifunctional hybrids by click chemistry and their cytotoxic studies. Med Chem Res 2013; 22: 3160.
    • (2013) Med Chem Res , vol.22 , pp. 3160
    • Singh, J.1    Sharma, S.2    Saxena, A.K.3    Nepali, K.4    Bedi, P.M.S.5
  • 49
    • 79151475531 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 3,5- diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents
    • Kamal A, Bharathi VB, Reddy JS, Ramaiah JM, Dastagiri D, Reddy MK, et al. Synthesis and biological evaluation of 3,5- diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents. Eur J Med Chem 2011; 46: 691.
    • (2011) Eur J Med Chem , vol.46 , pp. 691
    • Kamal, A.1    Bharathi, V.B.2    Reddy, J.S.3    Ramaiah, J.M.4    Dastagiri, D.5    Reddy, M.K.6
  • 50
    • 84861648492 scopus 로고    scopus 로고
    • Gallic acid based steroidal phenstatin analogs for selective targeting of breast cancer cells through inhibiting tubulin polymerization
    • Parihar S, Gupta A, Chaturvedi AK, Agarwal J, Luqman S, Chang-kija B, et al. Gallic acid based steroidal phenstatin analogs for selective targeting of breast cancer cells through inhibiting tubulin polymerization. Steroids 2012; 77: 878.
    • (2012) Steroids , vol.77 , pp. 878
    • Parihar, S.1    Gupta, A.2    Chaturvedi, A.K.3    Agarwal, J.4    Luqman, S.5    Chang-Kija, B.6
  • 51
    • 72049095563 scopus 로고    scopus 로고
    • Novel hybrids from lamellarin D and combretastatin A4 as cytotoxic agents
    • Li S, Yang X, Yang B, He Q, Hu Y. Novel hybrids from lamellarin D and combretastatin A4 as cytotoxic agents. Eur J Med Chem 2010; 45: 11.
    • (2010) Eur J Med Chem , vol.45 , pp. 11
    • Li, S.1    Yang, X.2    Yang, B.3    He, Q.4    Hu, Y.5
  • 52
    • 33646750713 scopus 로고    scopus 로고
    • 4,5- Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents
    • Banwell MG, Hamel E, Hockless DCR, Verdier-Pinard P, Willis AC, Wong DJ, et al. 4,5- Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents. Bioorg Med Chem 2006; 14:4267.
    • (2006) Bioorg Med Chem , vol.14 , pp. 4267
    • Banwell, M.G.1    Hamel, E.2    Hockless, D.C.R.3    Verdier-Pinard, P.4    Willis, A.C.5    Wong, D.J.6
  • 53
    • 84865960983 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents
    • Kamal A, Mallareddy A, Ramaiah MJ, Pushpavalli SNCVL, Suresh P, Kishor C, et al. Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents. Eur J Med Chem 2012; 56: 166.
    • (2012) Eur J Med Chem , vol.56 , pp. 166
    • Kamal, A.1    Mallareddy, A.2    Ramaiah, M.J.3    Pushpavalli, S.N.C.V.L.4    Suresh, P.5    Kishor, C.6
  • 54
    • 77955551128 scopus 로고    scopus 로고
    • Regioselective hydrostannation of diarylal-kynes directed by a labile ortho bromine atom: An easy access to sterodefined triaylolefins, hybrids of combretastatin A-4 and iso-combretastatin A-4
    • Rasolofonjatovo E, Provot O, Hamze A, Bignon J, Thoret S, Brion JD. Alami M, et al. Regioselective hydrostannation of diarylal-kynes directed by a labile ortho bromine atom: an easy access to sterodefined triaylolefins, hybrids of combretastatin A-4 and iso-combretastatin A-4. Eur J Med Chem 2010; 45: 3617.
    • (2010) Eur J Med Chem , vol.45 , pp. 3617
    • Rasolofonjatovo, E.1    Provot, O.2    Hamze, A.3    Bignon, J.4    Thoret, S.5    Brion, J.D.6    Alami, M.7
  • 55
    • 33645999933 scopus 로고    scopus 로고
    • Synthesis and anti-tubulin evaluation of chromone-based analogs of combretastatins
    • Quintin J, Roullie C, Thoret S, Lewin G. Synthesis and anti-tubulin evaluation of chromone-based analogs of combretastatins. Tetrahedron 2006; 62: 4038.
    • (2006) Tetrahedron , vol.62 , pp. 4038
    • Quintin, J.1    Roullie, C.2    Thoret, S.3    Lewin, G.4
  • 58
    • 79956118061 scopus 로고    scopus 로고
    • Synthesis and characterization of a novel tubulin-directed DO3A-colchicine conjugate with potential theranostic features
    • Wardle NJ, Kalber T, Bell JD, Bligh SWA. Synthesis and characterization of a novel tubulin-directed DO3A-colchicine conjugate with potential theranostic features. Bioorg Med Chem 2011; 21: 3346.
    • (2011) Bioorg Med Chem , vol.21 , pp. 3346
    • Wardle, N.J.1    Kalber, T.2    Bell, J.D.3    Bligh, S.W.A.4
  • 60
    • 0027483113 scopus 로고
    • Com-bretatropones-hybrids of combretastatin and colchicine-synthesis and biochemical evaluation
    • Andres CJ, Bernardo JE, Yan Q, Hastie SB, Macdonald TL. Com-bretatropones-hybrids of combretastatin and colchicine-synthesis and biochemical evaluation. Bioorg Med Chem Lett 1993; 3: 565.
    • (1993) Bioorg Med Chem Lett , vol.3 , pp. 565
    • Andres, C.J.1    Bernardo, J.E.2    Yan, Q.3    Hastie, S.B.4    Macdonald, T.L.5
  • 62
    • 84877794404 scopus 로고    scopus 로고
    • The discovery of colchicine - SAHA hybrids as a new class of antitumor agents
    • Zhang X, Zhang J, Tong L, Luo Y, Su M, Zang Y, et al. The discovery of colchicine - SAHA hybrids as a new class of antitumor agents. Bioorg Med Chem 2013; 21(11): 3240.
    • (2013) Bioorg Med Chem , vol.21 , Issue.11 , pp. 3240
    • Zhang, X.1    Zhang, J.2    Tong, L.3    Luo, Y.4    Su, M.5    Zang, Y.6
  • 63
    • 80052566973 scopus 로고    scopus 로고
    • Synthesis and SAR requirements of adamantane-colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities
    • Zefirova ON, Nurieva EV, Shishov DV, Baskin II, Fuchs F, Lemcke H, et al. Synthesis and SAR requirements of adamantane-colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities. Bioorg Med Chem 2011; 19: 5529.
    • (2011) Bioorg Med Chem , vol.19 , pp. 5529
    • Zefirova, O.N.1    Nurieva, E.V.2    Shishov, D.V.3    Baskin, I.I.4    Fuchs, F.5    Lemcke, H.6
  • 64
    • 3042716237 scopus 로고    scopus 로고
    • Design, synthesis, biological evaluation and QSAR studies of novel bisepipodophyllotoxins as cytotoxic agents
    • Kamal A, Laxman E, Khanna R, Reddy PSMM, Rehana T, Ari-fuddi AK, et al. Design, synthesis, biological evaluation and QSAR studies of novel bisepipodophyllotoxins as cytotoxic agents. Bioorg Med Chem 2004; 12: 4197.
    • (2004) Bioorg Med Chem , vol.12 , pp. 4197
    • Kamal, A.1    Laxman, E.2    Khanna, R.3    Reddy, P.S.M.M.4    Rehana, T.5    Ari-Fuddi, A.K.6
  • 65
    • 84868682662 scopus 로고    scopus 로고
    • Lignapurines: A new family of hybrids between cyclolignans and purines, synthesis and biological evaluation
    • Castro MA, del Corral JMM, García PA, Rojo MV, Bento AC, Mollinedo F, et al. Lignapurines: A new family of hybrids between cyclolignans and purines, synthesis and biological evaluation. Eur J Med Chem 2012; 58: 377.
    • (2012) Eur J Med Chem , vol.58 , pp. 377
    • Castro, M.A.1    Del Corral, J.M.M.2    García, P.A.3    Rojo, M.V.4    Bento, A.C.5    Mollinedo, F.6
  • 66
    • 79960561101 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 4(3- acrylamidopodo-phyllotoxin congeners as DNA damaging agents
    • Kamal A, Suresh P, Ramaiah J, Mallareddy A, Kumar BA, Raju P, et al. Synthesis and biological evaluation of 4(3- acrylamidopodo-phyllotoxin congeners as DNA damaging agents. Bioorg Med Chem 2011; 19: 4589.
    • (2011) Bioorg Med Chem , vol.19 , pp. 4589
    • Kamal, A.1    Suresh, P.2    Ramaiah, J.3    Mallareddy, A.4    Kumar, B.A.5    Raju, P.6
  • 67
    • 84855785112 scopus 로고    scopus 로고
    • Synthesis and anticancer activity of 4 (3-alkylamidochalcone and 4p-cinnamido linked podophyllotoxins as apoptotic inducing agents
    • Kamal A, Mallareddy A, Suresh P, Nayak VL, Shetti RVCRNC, Rao NS, et al. Synthesis and anticancer activity of 4 (3-alkylamidochalcone and 4p-cinnamido linked podophyllotoxins as apoptotic inducing agents. Eur J Med Chem 2012; 47: 530.
    • (2012) Eur J Med Chem , vol.47 , pp. 530
    • Kamal, A.1    Mallareddy, A.2    Suresh, P.3    Nayak, V.L.4    Shetti, R.V.C.R.N.C.5    Rao, N.S.6
  • 69
    • 80052808315 scopus 로고    scopus 로고
    • Design and synthesis of (+)- discodermolide- paclitaxel hybrids leading to enhanced biological activity
    • Smith AB, Sugasawa K, Atasoylu O, Yang C-P, Horwitz SB. Design and synthesis of (+)- discodermolide- paclitaxel hybrids leading to enhanced biological activity. J Med Chem 2011; 54(18): 6319.
    • (2011) J Med Chem , vol.54 , Issue.18 , pp. 6319
    • Smith, A.B.1    Sugasawa, K.2    Atasoylu, O.3    Yang, C.-P.4    Horwitz, S.B.5
  • 70
    • 59449089370 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids
    • Ngo QA, Roussi F, Cormier A, Thoret S, Knossow M, Guenard D, et al. Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids. J Med Chem 2009; 52: 134.
    • (2009) J Med Chem , vol.52 , pp. 134
    • Ngo, Q.A.1    Roussi, F.2    Cormier, A.3    Thoret, S.4    Knossow, M.5    Guenard, D.6
  • 71
    • 44449108627 scopus 로고    scopus 로고
    • Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III
    • Passarella D, Giardini A, Peretto B, Fontana G, Sacchetti A, Sil-vani A, et al. Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. Bioorg Med Chem 2008; 16: 6269.
    • (2008) Bioorg Med Chem , vol.16 , pp. 6269
    • Passarella, D.1    Giardini, A.2    Peretto, B.3    Fontana, G.4    Sacchetti, A.5    Sil-Vani, A.6
  • 72
    • 0038476590 scopus 로고    scopus 로고
    • Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models
    • Ma J, Li S, Reed K, Guo P, Gallo JM. Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models. J Pharmacol Exp Ther 2003; 305: 833.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 833
    • Ma, J.1    Li, S.2    Reed, K.3    Guo, P.4    Gallo, J.M.5
  • 73
    • 0035881591 scopus 로고    scopus 로고
    • A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells
    • Lane ME, Yu B, Rice A, Lipson C, Liang C, Sun L, et al. A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. Cancer Res 2001; 61: 6170.
    • (2001) Cancer Res , vol.61 , pp. 6170
    • Lane, M.E.1    Yu, B.2    Rice, A.3    Lipson, C.4    Liang, C.5    Sun, L.6
  • 74
    • 34648840812 scopus 로고    scopus 로고
    • Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity
    • Hamid MA, Hafez AA, El-Koussi N, Mahfouz N, Innocenti A, Supuran CT, et al. Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity. Bioorg Med Chem 2007; 15: 6975.
    • (2007) Bioorg Med Chem , vol.15 , pp. 6975
    • Hamid, M.A.1    Hafez, A.A.2    El-Koussi, N.3    Mahfouz, N.4    Innocenti, A.5    Supuran, C.T.6
  • 75
    • 0036558477 scopus 로고    scopus 로고
    • Azidonucleosides: Synthesis, reactions, and biological properties
    • Pathak T, Azidonucleosides: Synthesis, reactions, and biological properties. Chem Rev 2002; 102:1623.
    • (2002) Chem Rev , vol.102 , pp. 1623
    • Pathak, T.1
  • 76
    • 84868234211 scopus 로고    scopus 로고
    • Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation
    • Kumar K, Sagar S, Esau L, Kaur M, Kumar V. Synthesis of novel 1H-1,2,3-triazole tethered C-5 substituted uracil-isatin conjugates and their cytotoxic evaluation. Eur J Med Chem 2012; 58:153.
    • (2012) Eur J Med Chem , vol.58 , pp. 153
    • Kumar, K.1    Sagar, S.2    Esau, L.3    Kaur, M.4    Kumar, V.5
  • 77
    • 84865717991 scopus 로고    scopus 로고
    • Azide-alkyne cycloaddition en route to novel 1H- 1,2,3-triazole tethered isatin conjugates with in vitro cytotoxic evaluation
    • Singh P, Sharma P, Anand A, Bedi PMS, Kaur T, Saxena AK, Kumar V, et al. Azide-alkyne cycloaddition en route to novel 1H- 1,2,3-triazole tethered isatin conjugates with in vitro cytotoxic evaluation. Eur J Med Chem 2012; 55: 455.
    • (2012) Eur J Med Chem , vol.55 , pp. 455
    • Singh, P.1    Sharma, P.2    Anand, A.3    Bedi, P.M.S.4    Kaur, T.5    Saxena, A.K.6    Kumar, V.7
  • 78
    • 73949084441 scopus 로고    scopus 로고
    • Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity
    • Solomon VR, Hua C, Lee H. Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity. Bioorg Med Chem 2009; 17: 7585.
    • (2009) Bioorg Med Chem , vol.17 , pp. 7585
    • Solomon, V.R.1    Hua, C.2    Lee, H.3
  • 79
    • 75849120061 scopus 로고    scopus 로고
    • Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharma-cophore approach
    • Solomon VR, Hua C, Lee H. Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharma-cophore approach. Bioorg Med Chem 2010; 18: 1563.
    • (2010) Bioorg Med Chem , vol.18 , pp. 1563
    • Solomon, V.R.1    Hua, C.2    Lee, H.3
  • 80
    • 78650218170 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of some isatin-thiazolidinone hybrid analogs as anti-proliferative agents
    • Ramshid PK, Jagadeeshan S, Krishnan A, Mathew M, Nair SA, Pillai MR, et al. Synthesis and in vitro evaluation of some isatin-thiazolidinone hybrid analogs as anti-proliferative agents. Med Chem 2010; 6: 306.
    • (2010) Med Chem , vol.6 , pp. 306
    • Ramshid, P.K.1    Jagadeeshan, S.2    Krishnan, A.3    Mathew, M.4    Nair, S.A.5    Pillai, M.R.6
  • 81
    • 78751701180 scopus 로고    scopus 로고
    • Synthesis and evaluation of a class of new cou-marin triazole derivatives as potential antimicrobial agents
    • Shi Y, Zhou C. Synthesis and evaluation of a class of new cou-marin triazole derivatives as potential antimicrobial agents. Bioorg Med Chem Lett 2011; 21: 956.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 956
    • Shi, Y.1    Zhou, C.2
  • 82
    • 27744471632 scopus 로고    scopus 로고
    • Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress
    • Hur SY, Kim TE, Park YG, Kim JR, Kim JW. Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp Mol Med 2005; 37:436.
    • (2005) Exp Mol Med , vol.37 , pp. 436
    • Hur, S.Y.1    Kim, T.E.2    Park, Y.G.3    Kim, J.R.4    Kim, J.W.5
  • 83
    • 0025663358 scopus 로고
    • The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds
    • Egan DA, Cox D, Kennedy OR, Moran, Prosser E, Thornes RD, et al. The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds. Drugs Metab Rev 1990; 22: 503.
    • (1990) Drugs Metab Rev , vol.22 , pp. 503
    • Egan, D.A.1    Cox, D.2    Kennedy, O.R.3    Moran, P.E.4    Thornes, R.D.5
  • 84
    • 33750594445 scopus 로고    scopus 로고
    • In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydra-zine derivatives of coumarin and chromone
    • Modranka JN, Nawrot E, Graczyk J. In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydra-zine derivatives of coumarin and chromone. Eur J Med Chem 2006; 41:1301.
    • (2006) Eur J Med Chem , vol.41 , pp. 1301
    • Modranka, J.N.1    Nawrot, E.2    Graczyk, J.3
  • 85
    • 0037019131 scopus 로고    scopus 로고
    • Synthesis and antitu-bercular activity of 4-(3-coumarinyl)-3-cyclohexyl-4-thiazolin-2-one benzylidenehydrazones
    • Karali N, Kocabalkanli A, Gursoy A, Ates O. Synthesis and antitu-bercular activity of 4-(3-coumarinyl)-3-cyclohexyl-4-thiazolin-2-one benzylidenehydrazones. Farmaco 2002; 57: 589.
    • (2002) Farmaco , vol.57 , pp. 589
    • Karali, N.1    Kocabalkanli, A.2    Gursoy, A.3    Ates, O.4
  • 86
    • 33645368328 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of some derivatives of (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide
    • Cacic M, Trkovnik M, Cacic F, Schon EH. Synthesis and antimicrobial activity of some derivatives of (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide. Molecules 2006; 11:134.
    • (2006) Molecules , vol.11 , pp. 134
    • Cacic, M.1    Trkovnik, M.2    Cacic, F.3    Schon, E.H.4
  • 87
    • 0030176193 scopus 로고    scopus 로고
    • Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential
    • Hoult JRS, Paya M. Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential. Gen Pharmacol 1996; 27: 713.
    • (1996) Gen Pharmacol , vol.27 , pp. 713
    • Hoult, J.R.S.1    Paya, M.2
  • 90
    • 77249123906 scopus 로고    scopus 로고
    • Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide a with druggable profile
    • Xue H, Lu X, Zheng P, Liu L, Han C, Hun J, et al. Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide a with druggable profile. J Med Chem 2010; 53:1397.
    • (2010) J Med Chem , vol.53 , pp. 1397
    • Xue, H.1    Lu, X.2    Zheng, P.3    Liu, L.4    Han, C.5    Hun, J.6
  • 91
    • 79960909027 scopus 로고    scopus 로고
    • Diversity oriented design of various hydrazides and their in vitro evaluation against Mycobacterium tuberculosis H37Rv strains
    • Manvar A, Bavishi A, Radadiya A, Patel J, Vora V, Dodia N, et al. Diversity oriented design of various hydrazides and their in vitro evaluation against Mycobacterium tuberculosis H37Rv strains. Bioorg Med Chem Lett 2011; 21: 4728.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 4728
    • Manvar, A.1    Bavishi, A.2    Radadiya, A.3    Patel, J.4    Vora, V.5    Dodia, N.6
  • 92
    • 77649210704 scopus 로고    scopus 로고
    • Anti-influenza drug discovery: Structure-activity relationship and mechanistic insight into novel angelicin derivatives
    • Yeh J-Y, Coumar MS, Horng J-T, Shiao H-Y, Lee H-L. Anti-influenza drug discovery: Structure-activity relationship and mechanistic insight into novel angelicin derivatives. J Med Chem 2010; 53: 1519.
    • (2010) J Med Chem , vol.53 , pp. 1519
    • Yeh, J.-Y.1    Coumar, M.S.2    Horng, J.-T.3    Shiao, H.-Y.4    Lee, H.-L.5
  • 93
    • 84856221609 scopus 로고    scopus 로고
    • A review on coumarins as acetylcho-linesterase inhibitors for Alzheimer's disease
    • Anand P, Singh B, Singh N. A review on coumarins as acetylcho-linesterase inhibitors for Alzheimer's disease. Bioorg Med Chem 2012; 20: 1175.
    • (2012) Bioorg Med Chem , vol.20 , pp. 1175
    • Anand, P.1    Singh, B.2    Singh, N.3
  • 94
    • 37549066630 scopus 로고    scopus 로고
    • Multi-target-directed coumarin derivatives: HAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
    • Piazzi L, Cavalli A, Colizzi F, Belluti F, Bartolini M, Mancinni F, et al. Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorg Med Chem Lett 2008; 18:423.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 423
    • Piazzi, L.1    Cavalli, A.2    Colizzi, F.3    Belluti, F.4    Bartolini, M.5    Mancinni, F.6
  • 95
  • 97
    • 78751701180 scopus 로고    scopus 로고
    • Synthesis and evaluation of a class of new cou-marin triazole derivatives as potential antimicrobial agents
    • Shi Y, Zhou C. Synthesis and evaluation of a class of new cou-marin triazole derivatives as potential antimicrobial agents. Bioorg Med Chem Lett 2011; 21: 956.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 956
    • Shi, Y.1    Zhou, C.2
  • 98
    • 84871713110 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitu-mor agents
    • Amin KM, Eissa AAM, Abou-Seri SM, Awadallah FM, Hassan GS. Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitu-mor agents. Eur J Med Chem 2013; 60:187.
    • (2013) Eur J Med Chem , vol.60 , pp. 187
    • Amin, K.M.1    Eissa, A.A.M.2    Abou-Seri, S.M.3    Awadallah, F.M.4    Hassan, G.S.5
  • 99
    • 77953134777 scopus 로고    scopus 로고
    • Design, synthesis and anticancer activities of stilbene- coumarin hybrid compounds: Identification of novel proapoptotic agents
    • Belluti F, Fontana G, Bo LD, Carenini N, Giommarelli C, Zunino F, et al. Design, synthesis and anticancer activities of stilbene- coumarin hybrid compounds: Identification of novel proapoptotic agents. Bioorg Med Chem 2010; 18: 3543.
    • (2010) Bioorg Med Chem , vol.18 , pp. 3543
    • Belluti, F.1    Fontana, G.2    Bo, L.D.3    Carenini, N.4    Giommarelli, C.5    Zunino, F.6
  • 100
    • 84878112035 scopus 로고    scopus 로고
    • Synthesis of new conjugated cou-marin-benzimidazole hybrids and their anticancer activity
    • Paul K, Bindal S, Luxami V. Synthesis of new conjugated cou-marin-benzimidazole hybrids and their anticancer activity. Bioorg Med Chem 2013; 23(12): 3667.
    • (2013) Bioorg Med Chem , vol.23 , Issue.12 , pp. 3667
    • Paul, K.1    Bindal, S.2    Luxami, V.3
  • 101
    • 78449284852 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents
    • Sashidhara KV, Kumar A, Kumar M, Sarkar J, Sinha S. Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents. Bioorg Med Chem 2010; 10: 7205.
    • (2010) Bioorg Med Chem , vol.10 , pp. 7205
    • Sashidhara, K.V.1    Kumar, A.2    Kumar, M.3    Sarkar, J.4    Sinha, S.5
  • 102
  • 103
    • 39549121459 scopus 로고    scopus 로고
    • DNA interaction with novel antitumor estradiol-platinum(II) hybrid molecule: A comparative study with cisplatin drug
    • Soukpoe-Kossi CNN, Teaux CD, Asselin E, Riahi TH, Ali G. Berube. DNA interaction with novel antitumor estradiol-platinum(II) hybrid molecule: A comparative study with cisplatin drug. DNA and Cell Biol 2008; 27:101.
    • (2008) DNA and Cell Biol , vol.27 , pp. 101
    • Soukpoe-Kossi, C.N.N.1    Teaux, C.D.2    Asselin, E.3    Riahi, T.H.4    Berube, A.G.5
  • 104
    • 76749151307 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of estradiol-chlorambucil hybrids as anticancer agents
    • Gupta A, Saha P, Descôteaux C, Leblanc V, Asselin E, Bérubé G, et al. Design, synthesis and biological evaluation of estradiol-chlorambucil hybrids as anticancer agents. Bioorg Med Chem Lett 2010; 20:1614.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 1614
    • Gupta, A.1    Saha, P.2    Descôteaux, C.3    Leblanc, V.4    Asselin, E.5    Bérubé, G.6
  • 107
    • 74049106561 scopus 로고    scopus 로고
    • Hybrid anticancer agents: Isothiocyanate-progesterone conjugates as che-motherapeutic agents and insights into their cytotoxicities
    • Adsule S, Banerjee S, Ahmed F, Padhye S, Sarkar FH. Hybrid anticancer agents: Isothiocyanate-progesterone conjugates as che-motherapeutic agents and insights into their cytotoxicities. Bioorg Med Chem Lett 2010; 20:1247.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 1247
    • Adsule, S.1    Banerjee, S.2    Ahmed, F.3    Padhye, S.4    Sarkar, F.H.5
  • 108
    • 33749354945 scopus 로고    scopus 로고
    • Hybrid aza-steroid alkylators in the treatment of colon cancer
    • Trafalis DTP. Hybrid aza-steroid alkylators in the treatment of colon cancer. Cancer Lett 2006; 43: 202.
    • (2006) Cancer Lett , vol.43 , pp. 202
    • Trafalis, D.T.P.1
  • 109
    • 39549121459 scopus 로고    scopus 로고
    • DNA interaction with novel antitumor estradiol-platinum(II) hybrid molecule: A comparative study with cisplatin drug
    • Soukpoe-Kossi CNN, Teaux CD, Asselin E, Ali H Riahi T, Berube G. DNA interaction with novel antitumor estradiol-platinum(II) hybrid molecule: A comparative study with cisplatin drug. Dna and Cell Biology 2008; 27:101.
    • (2008) Dna and Cell Biology , vol.27 , pp. 101
    • Soukpoe-Kossi, C.N.N.1    Teaux, C.D.2    Asselin, E.3    Ali, H.4    Riahi, T.5    Berube, G.6
  • 110
    • 78650510566 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of estra-diol-PEG-linked platinum(II) hybrid molecules: Comparative molecular modeling study of three distinct families of hybrids
    • Mandeville JP, Debnath C, Mandal SK, Leblanc V, Parent S, As-selin É, et al. Design, synthesis and biological evaluation of estra-diol-PEG-linked platinum(II) hybrid molecules: Comparative molecular modeling study of three distinct families of hybrids. Steroids 2011; 76: 94.
    • (2011) Steroids , vol.76 , pp. 94
    • Mandeville, J.P.1    Debnath, C.2    Mandal, S.K.3    Leblanc, V.4    Parent, S.5    As-Selin, É.6
  • 111
    • 84873987495 scopus 로고    scopus 로고
    • Synthesis of imidazole-derived steroidal hybrids as potent aromatase inhibitors
    • Bansal R, Guleria S, Thota S, Hartmann RW, Zimmer C. Synthesis of imidazole-derived steroidal hybrids as potent aromatase inhibitors. Med Chem Res 2013; 22: 692.
    • (2013) Med Chem Res , vol.22 , pp. 692
    • Bansal, R.1    Guleria, S.2    Thota, S.3    Hartmann, R.W.4    Zimmer, C.5
  • 112
    • 0036083053 scopus 로고    scopus 로고
    • Recent developments in the design, synthesis and structure-activity relationship studies of pyrrolo[2,1-c][1,4]benzodiazepines as DNA-interactive antitumor antibiotics
    • Kamal A, Rao MV, Laxman N, Ramesh G, Reddy GSK. Recent developments in the design, synthesis and structure-activity relationship studies of pyrrolo[2,1-c][1,4]benzodiazepines as DNA-interactive antitumor antibiotics. Curr Med Chem Anti-Cancer Agents 2002; 2: 215.
    • (2002) Curr Med Chem Anti-Cancer Agents , vol.2 , pp. 215
    • Kamal, A.1    Rao, M.V.2    Laxman, N.3    Ramesh, G.4    Reddy, G.S.K.5
  • 114
    • 0018568879 scopus 로고
    • Proposed structure of the anthramycin-DNA adduct
    • Hurley LH, Petrusek RL. Proposed structure of the anthramycin-DNA adduct. Nature 1979; 282: 529.
    • (1979) Nature , vol.282 , pp. 529
    • Hurley, L.H.1    Petrusek, R.L.2
  • 115
    • 0000143411 scopus 로고
    • Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines
    • Thurston DE, Bose DS. Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines. Chem Rev 1994; 94: 433.
    • (1994) Chem Rev , vol.94 , pp. 433
    • Thurston, D.E.1    Bose, D.S.2
  • 116
    • 0021272759 scopus 로고
    • Pyrrolo[1,4]benzodiazepine antitumor antibiotics: Chemistry, Interaction with DNA and biological implications
    • Hurley LH, Thurston DE. Pyrrolo[1,4]benzodiazepine antitumor antibiotics: Chemistry, Interaction with DNA and biological implications. Pharm Res 1984; 1: 99.
    • (1984) Pharm Res , vol.1 , pp. 99
    • Hurley, L.H.1    Thurston, D.E.2
  • 117
    • 0017642450 scopus 로고
    • Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin
    • Hurley LH. Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin. J Antibiot 1977; 30: 349.
    • (1977) J Antibiot , vol.30 , pp. 349
    • Hurley, L.H.1
  • 118
    • 0016233526 scopus 로고
    • Effects of daunomycin and anthramycin on electrocardiogram and mitochondrial metabolism of the rat heart
    • Cargill C, Bachmann E, Zbinden G. Effects of daunomycin and anthramycin on electrocardiogram and mitochondrial metabolism of the rat heart. J Natl Cancer Inst 1974; 53: 481.
    • (1974) J Natl Cancer Inst , vol.53 , pp. 481
    • Cargill, C.1    Bachmann, E.2    Zbinden, G.3
  • 119
    • 77954217880 scopus 로고    scopus 로고
    • Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodia-zepine conjugates
    • Kamal A, Reddy KS, Khan MN, Shetti RV, Ramaiah MJ, Push-pavalli SN, et al. Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodia-zepine conjugates. Bioorg Med Chem 2010; 18: 4747.
    • (2010) Bioorg Med Chem , vol.18 , pp. 4747
    • Kamal, A.1    Reddy, K.S.2    Khan, M.N.3    Shetti, R.V.4    Ramaiah, M.J.5    Push-Pavalli, S.N.6
  • 120
    • 77955559364 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents
    • Kamal A, Reddy JS, Ramaiah MJ, Dastagiri D, Bharathi EV, Azhar MA, et al. Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. Eur J Med Chem 2010; 45: 3924.
    • (2010) Eur J Med Chem , vol.45 , pp. 3924
    • Kamal, A.1    Reddy, J.S.2    Ramaiah, M.J.3    Dastagiri, D.4    Bharathi, E.V.5    Azhar, M.A.6
  • 121
    • 47649103799 scopus 로고    scopus 로고
    • Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT
    • Kamal A, Tekumalla V, Krishnan A, Bhadra MP, Bhadra U. Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT, Chem. Med Chem 2008; 3: 794.
    • (2008) Chem. Med Chem , vol.3 , pp. 794
    • Kamal, A.1    Tekumalla, V.2    Krishnan, A.3    Bhadra, M.P.4    Bhadra, U.5
  • 122
    • 0141851816 scopus 로고    scopus 로고
    • Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents
    • Kamal A, Ramesh G, Ramulu P, Srinivas O, Rehana T, Sheelu G, et al. Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents. Bioorg Med Chem lett 2003; 13: 3451.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 3451
    • Kamal, A.1    Ramesh, G.2    Ramulu, P.3    Srinivas, O.4    Rehana, T.5    Sheelu, G.6
  • 123
    • 0346729862 scopus 로고    scopus 로고
    • Synthesis and anti-tumor activity of pyrene-linked pyrrolo [2,1-c]benzodiazepine hybrids
    • Kamal A, Ramesh G, Srinivas O, Ramulu P. Synthesis and anti-tumor activity of pyrene-linked pyrrolo [2,1-c]benzodiazepine hybrids. Bioorg Med Chem Lett 2004; 14: 471.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 471
    • Kamal, A.1    Ramesh, G.2    Srinivas, O.3    Ramulu, P.4
  • 124
    • 84858447279 scopus 로고    scopus 로고
    • Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of ben-zothiazoles
    • Bose DS, Idrees M, Todewale IK, Jakka NM, Rao JK. Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of ben-zothiazoles. Eur J Med Chem 2012; 50: 27.
    • (2012) Eur J Med Chem , vol.50 , pp. 27
    • Bose, D.S.1    Idrees, M.2    Todewale, I.K.3    Jakka, N.M.4    Rao, J.K.5
  • 126
    • 33144473207 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates as anticancer agents
    • Wang J-J, Shen Y-K, Hu W-P, Hsieh MC, Lin F-L, Hsu M-K, et al. Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates as anticancer agents. J Med Chem 2006; 49:1442.
    • (2006) J Med Chem , vol.49 , pp. 1442
    • Wang, J.-J.1    Shen, Y.-K.2    Hu, W.-P.3    Hsieh, M.C.4    Lin, F.-L.5    Hsu, M.-K.6
  • 128
    • 0037025467 scopus 로고    scopus 로고
    • Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumor agents
    • Kamal A, Reddy BSN, Reddy GSK, Ramesh G. Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumor agents. Bioorg Med Chem Lett 2002; 12: 1933.
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 1933
    • Kamal, A.1    Reddy, B.S.N.2    Reddy, G.S.K.3    Ramesh, G.4
  • 129
    • 77956341962 scopus 로고    scopus 로고
    • Synthesis, anticancer activity and mitochon-drial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates
    • Kamal A, Dastagiri D, Ramaiah MJ, Bharathi EV, Reddy JS, Balakishan G, et al. Synthesis, anticancer activity and mitochon-drial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates. Bioorg Med Chem 2010; 18: 6666.
    • (2010) Bioorg Med Chem , vol.18 , pp. 6666
    • Kamal, A.1    Dastagiri, D.2    Ramaiah, M.J.3    Bharathi, E.V.4    Reddy, J.S.5    Balakishan, G.6
  • 130
    • 0038460855 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of psorosper-min/quinobenzoxazine hybrids as structurally novel antitumor agents
    • Kim M-Y, Na Y, Vankayalapati H, Gleason-Guzman M, Hurley LH. Design, synthesis, and evaluation of psorosper-min/quinobenzoxazine hybrids as structurally novel antitumor agents. J Med Chem 2003; 46: 2958.
    • (2003) J Med Chem , vol.46 , pp. 2958
    • Kim, M.-Y.1    Na, Y.2    Vankayalapati, H.3    Gleason-Guzman, M.4    Hurley, L.H.5
  • 131
    • 77949357034 scopus 로고    scopus 로고
    • Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors
    • Song Y, Shao Z, Dexheimer TS, Scher ES, Pommier Y, Cushman M, et al. Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors. J Med Chem 2010; 53: 1979.
    • (2010) J Med Chem , vol.53 , pp. 1979
    • Song, Y.1    Shao, Z.2    Dexheimer, T.S.3    Scher, E.S.4    Pommier, Y.5    Cushman, M.6
  • 132
    • 84883449658 scopus 로고    scopus 로고
    • Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: Novel hybrid heterocycles as anticancer agents
    • Murty MSR, Rao BR, Katiki MR, Nath NLR, Anto RJ. Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: Novel hybrid heterocycles as anticancer agents. Med Chem Res 2013; 22: 4980.
    • (2013) Med Chem Res , vol.22 , pp. 4980
    • Murty, M.S.R.1    Rao, B.R.2    Katiki, M.R.3    Nath, N.L.R.4    Anto, R.J.5
  • 133
    • 84864777428 scopus 로고    scopus 로고
    • SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines
    • Teaux CD, Brasseur K, Leblanc V, Parent S, Asselin E, Berube G, et al. SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines. Med Chem Res 2012; 43: 923.
    • (2012) Med Chem Res , vol.43 , pp. 923
    • Teaux, C.D.1    Brasseur, K.2    Leblanc, V.3    Parent, S.4    Asselin, E.5    Berube, G.6
  • 134
    • 84866338453 scopus 로고    scopus 로고
    • Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents
    • Graham LA, Suryadi J, West TK, Kucera GL, Bierbach U. Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents. J Med Chem 2012; 55: 7817.
    • (2012) J Med Chem , vol.55 , pp. 7817
    • Graham, L.A.1    Suryadi, J.2    West, T.K.3    Kucera, G.L.4    Bierbach, U.5
  • 135
    • 4744344334 scopus 로고    scopus 로고
    • Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation
    • Natarajan A, Guo Y, Harbinski F, Fan Y-H, Chen H, Luus L, et al. Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation. J Med Chem 2004; 47: 4979.
    • (2004) J Med Chem , vol.47 , pp. 4979
    • Natarajan, A.1    Guo, Y.2    Harbinski, F.3    Fan, Y.-H.4    Chen, H.5    Luus, L.6
  • 136
    • 65149100170 scopus 로고    scopus 로고
    • Design, synthesis and anticancer activities of hybrids of indole and barbituric acids--identification of highly promising leads
    • Verma P, Kaur M, Singh P. Design, synthesis and anticancer activities of hybrids of indole and barbituric acids--identification of highly promising leads. Bioorg Med Chem Lett 2009; 19: 3054.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 3054
    • Verma, P.1    Kaur, M.2    Singh, P.3
  • 137
    • 84858343513 scopus 로고    scopus 로고
    • Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines
    • Descoteaux C, Brasseur K, Leblanc V, Parent S, Asselin E, Berube G. Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines. Steroids 2012; 77: 403.
    • (2012) Steroids , vol.77 , pp. 403
    • Descoteaux, C.1    Brasseur, K.2    Leblanc, V.3    Parent, S.4    Asselin, E.5    Berube, G.6
  • 138
    • 34247537137 scopus 로고    scopus 로고
    • Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha- bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells
    • Romagnol R, Baraldi PG, Carrion MD, Cruz-Lopez O, Preti D, Tabrizi MA, et al. Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha- bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells. Bioorg Med Chem Lett 2007; 17: 2844.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 2844
    • Romagnol, R.1    Baraldi, P.G.2    Carrion, M.D.3    Cruz-Lopez, O.4    Preti, D.5    Tabrizi, M.A.6
  • 139
    • 84862822269 scopus 로고    scopus 로고
    • Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
    • Yang X-D, Wan W-C, Deng X-Y, Li Y, Yang L-J, Li L, et al. Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole. Bioorg Med Chem Lett 2012; 22: 2726.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 2726
    • Yang, X.-D.1    Wan, W.-C.2    Deng, X.-Y.3    Li, Y.4    Yang, L.-J.5    Li, L.6
  • 140
    • 84872687427 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
    • Wang X-Q, Liu L-X, Li Y, Sun CJ, Chen W, Li L, et al. Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents. Eur J Med Chem 2013; 62: 111.
    • (2013) Eur J Med Chem , vol.62 , pp. 111
    • Wang, X.-Q.1    Liu, L.-X.2    Li, Y.3    Sun, C.J.4    Chen, W.5    Li, L.6
  • 141
    • 85039630739 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
    • Zhou Y, Zhao Y, Boyle KMO, Murphy PV. Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents. Bioorg Med Chem Lett 2006; 18: 954.
    • (2006) Bioorg Med Chem Lett , vol.18 , pp. 954
    • Zhou, Y.1    Zhao, Y.2    Boyle, K.M.O.3    Murphy, P.V.4
  • 142
    • 84862995584 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents
    • Li D, Wang L, Cai H, Zhang Y, Xu J. Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents. Molecules 2012; 17: 7556.
    • (2012) Molecules , vol.17 , pp. 7556
    • Li, D.1    Wang, L.2    Cai, H.3    Zhang, Y.4    Xu, J.5
  • 144
    • 84872683595 scopus 로고    scopus 로고
    • Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents
    • Duan Y-C, Ma Y-C, Zhang E, Shi X-J, Wang M-M, Ye X-W, et al. Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents. Eur J Med Chem 2013; 62: 11.
    • (2013) Eur J Med Chem , vol.62 , pp. 11
    • Duan, Y.-C.1    Ma, Y.-C.2    Zhang, E.3    Shi, X.-J.4    Wang, M.-M.5    Ye, X.-W.6
  • 145
    • 84877013373 scopus 로고    scopus 로고
    • Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole-dithiocarbamate-urea hybrids
    • Duan Y-C, Zheng YC, Li XC, Wang MM, Ye XW, Guan YY, et al. Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole-dithiocarbamate-urea hybrids. Eur J Med Chem 2013; 64: 99.
    • (2013) Eur J Med Chem , vol.64 , pp. 99
    • Duan, Y.-C.1    Zheng, Y.C.2    Li, X.C.3    Wang, M.M.4    Ye, X.W.5    Guan, Y.Y.6
  • 146
    • 77950862822 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity evaluation of (tetrahydro-beta-carboline)-1,3,5-triazine hybrids as anticancer agents
    • Kumar R, Gupta L, Pal P, Khan S, Singh N, Katiyar SB, et al. Synthesis and cytotoxicity evaluation of (tetrahydro-beta-carboline)-1,3,5-triazine hybrids as anticancer agents. Eur J Med Chem 2010; 45: 2265.
    • Eur J Med Chem , vol.2010 , pp. 45
    • Kumar, R.1    Gupta, L.2    Pal, P.3    Khan, S.4    Singh, N.5    Katiyar, S.B.6
  • 147
    • 82255183088 scopus 로고    scopus 로고
    • A fragment based click chemistry approach towards hybrid G-quadruplex ligands: Design, synthesis and biophysical evaluation
    • Ritson DJ, Moses JE. A fragment based click chemistry approach towards hybrid G-quadruplex ligands: Design, synthesis and biophysical evaluation. Tetrahedron 2012; 68: 197.
    • (2012) Tetrahedron , vol.68 , pp. 197
    • Ritson, D.J.1    Moses, J.E.2
  • 149
    • 77957844566 scopus 로고    scopus 로고
    • Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities--development of highly efficacious cy-totoxic agents
    • Singh P, Kaur M, Holzer W. Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities--development of highly efficacious cy-totoxic agents. Eur J Med Chem 2010; 45: 4968.
    • (2010) Eur J Med Chem , vol.45 , pp. 4968
    • Singh, P.1    Kaur, M.2    Holzer, W.3
  • 151
    • 84863632014 scopus 로고    scopus 로고
    • Synthesis of novel isoxazole-benzoquinone hybrids via 1,3-dipolar cy-cloaddition reaction as key step
    • Kumar PR, Behera M, Raghavulu K, Shree AJ, Yennam S. Synthesis of novel isoxazole-benzoquinone hybrids via 1,3-dipolar cy-cloaddition reaction as key step. Tetrahed 2012; 53: 4108.
    • (2012) Tetrahed , vol.53 , pp. 4108
    • Kumar, P.R.1    Behera, M.2    Raghavulu, K.3    Shree, A.J.4    Yennam, S.5
  • 152
    • 0043160197 scopus 로고    scopus 로고
    • Molecular design, chemical synthesis and biological evaluation of quinoxaline-carbohydrate hybrids as novel and selective photo-induced DNA cleaving and cytotoxic agents
    • Toshima K, Kimura T, Takano R, Ozawa T, Ariga A, Shima Y, et al. Molecular design, chemical synthesis and biological evaluation of quinoxaline-carbohydrate hybrids as novel and selective photo-induced DNA cleaving and cytotoxic agents. Tetrahed 2003; 59: 7057.
    • (2003) Tetrahed , vol.59 , pp. 7057
    • Toshima, K.1    Kimura, T.2    Takano, R.3    Ozawa, T.4    Ariga, A.5    Shima, Y.6
  • 153
    • 39849093730 scopus 로고    scopus 로고
    • Synthesis of hybrid acetogenins, alpha, beta-unsaturated-gamma-lactone-free nitrogen-containing heterocyclic analogs, and their cytotoxicity against human cancer cell lines
    • Kojima N, Fushimi T, Maezaki N, Tanaka T, Yamori T. Synthesis of hybrid acetogenins, alpha, beta-unsaturated-gamma-lactone-free nitrogen-containing heterocyclic analogs, and their cytotoxicity against human cancer cell lines. Bioorg Med Chem Lett 2008; 18(5):1637.
    • (2008) Bioorg Med Chem Lett , vol.18 , Issue.5 , pp. 1637
    • Kojima, N.1    Fushimi, T.2    Maezaki, N.3    Tanaka, T.4    Yamori, T.5
  • 154
    • 66349098288 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups
    • Alexander R. Kheradi, Saluta RA, Kucera G, Day GL, Bierbach CS. Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups. Bioorg & Med Chem Lett 2009; 19: 3423.
    • (2009) Bioorg & Med Chem Lett , vol.19 , pp. 3423
    • Kheradi, A.R.1    Saluta, R.A.2    Kucera, G.3    Day, G.L.4    Bierbach, C.S.5
  • 155
    • 34249008406 scopus 로고    scopus 로고
    • Chemical insights in the concept of hybrid drugs: The antitu-mor effect of nitric oxide-donating aspirin involves a quinone me-thide but not nitric oxide nor aspirin
    • Hulsman N, Medema JP, Bos C, Jongejan A, Leurs R, Smit MJ, et al. Chemical insights in the concept of hybrid drugs: The antitu-mor effect of nitric oxide-donating aspirin involves a quinone me-thide but not nitric oxide nor aspirin. J Med Chem 2007; 50: 2424.
    • (2007) J Med Chem , vol.50 , pp. 2424
    • Hulsman, N.1    Medema, J.P.2    Bos, C.3    Jongejan, A.4    Leurs, R.5    Smit, M.J.6
  • 156
    • 84858289256 scopus 로고    scopus 로고
    • NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model
    • Chattopadhyay M, Kodela R, Olson KR, Kashfi K. NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model. Biochem Biophys Res Commun 2012; 419: 523.
    • (2012) Biochem Biophys Res Commun , vol.419 , pp. 523
    • Chattopadhyay, M.1    Kodela, R.2    Olson, K.R.3    Kashfi, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.