Azide-alkyne cycloaddition en route to novel 1H-1,2,3-triazole tethered isatin conjugates with in vitro cytotoxic evaluation

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 455-461

  Singh, Pardeep ^a   Sharma, Pooja ^a   Anand, Amit ^a   Bedi, P M S ^a   Kaur, Tandeep ^b   Saxena, A K ^b   Kumar, Vipan ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

1H 1,2,3 Triazole; Anticancer evaluation; Click chemistry; Isatin conjugates; Structure activity relationship

Indexed keywords

1 [1 [2 (2,3 DIOXO 2,3 DIHYDRO INDOL 1 YL) ETHYL] 1 [1,2,3]TRIAZOL 4 YLMETHYL ] 1 INDOLE 2,3 DIONE; 1 [1 [2 (2,3 DIOXO 2,3 DIHYDRO INDOL 1 YL) ETHYL] 1 [1,2,3]TRIAZOL 4 YLMETHYL] 5 METHYL 1 INDOLE 2,3 DIONE; 1 [2 [4 (2,3 DIOXO 2,3 DIHYDRO 5 METHYL INDOL 1 YLMETHYL) [1,2,3]TRIAZOL 1 YL] ETHYL] 5 CHLORO 1 INDOLE 2,3 DIONE; 5 BROMO 1 [1 [2 (2,3 DIOXO 2,3 DIHYDRO INDOL 1 YL) ETHYL] 1 [1,2,3]TRIAZOL 4 YLMETHYL] 1 INDOLE 2,3 DIONE; 5 CHLORO 1 [1 [2 (2,3 DIOXO 2,3 DIHYDRO INDOL 1 YL) ETHYL] 1 [1,2,3]TRIAZOL 4 YLMETHYL] 1 INDOLE 2,3 DIONE; ALKYNE; ANTINEOPLASTIC AGENT; AZIDE; FLUOROURACIL; HYDROGEN; ISATIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN CACO 2; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; ELECTRON; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

ALKYNES; ANTINEOPLASTIC AGENTS; AZIDES; CELL LINE, TUMOR; CYCLOADDITION REACTION; HUMANS; ISATIN; TRIAZOLES;

EID: 84865717991     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.057     Document Type: Article

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