Synthesis of imidazole-derived steroidal hybrids as potent aromatase inhibitors

Medicinal Chemistry Research

Volumn 22, Issue 2, 2013, Pages 692-698

  Bansal, Ranju ^a   Guleria, Sheetal ^a   Thota, Sridhar ^a   Hartmann, Rolf W ^b   Zimmer, Christina ^b  

^a PANJAB UNIVERSITY   (India)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

16E Arylidenosteroids; Aromatase inhibitory activity; Breast cancer

Indexed keywords

16 [3 [3 (IMIDAZOL 1 YL)PROPOXY]BENZYLIDENE] 17 OXO 5 ANDROSTEN 3 ANDROSTEN 3BETA YL ACETATE; 16 [3 [3 (IMIDAZOL 1 YL)PROPOXY]BENZYLIDENE] 17 OXO 5 ANDROSTEN 3BETA OL; 16 [3 [3 (IMIDAZOL 1 YL)PROPOXY]BENZYLIDENE] 4 ANDROSTENE 3,17 DIONE; 16 [3 [3 (IMIDAZOL 1 YL)PROPOXY]BENZYLIDENE] 5 ANDROSTENE 3BETA,17BETA DIOL; 16 [3 [3 (IMIDAZOL 1 YL)PROPOXY]BENZYLIDENE] 5 ANDROSTENE 3BETA,17BETA DIOL DIACETATE; 16 [4 (3 CHLOROPROPOXY)BENZYLIDENE] 17 OXO 5 ANDROSTEN 3BETA OL; 16 [4 [3 (IMIDAZOL 1 YL)PROPOXY]BENZYLIDENE] 17 OXO 5 ANDROSTEN 3BETA OL; 16 [4 [3 (IMIDAZOL 1 YL)PROPOXY]BENZYLIDENE] 4 ANDROSTENE 3,17 DIONE; AROMATASE INHIBITOR; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; ALDOL REACTION; AROMATIZATION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; MICROSOME; OPPENAUER OXIDATION; STRUCTURE ACTIVITY RELATION;

EID: 84873987495     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0059-1     Document Type: Article

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