Anti-influenza drug discovery: Structure-activity relationship and mechanistic insight into novel angelicin derivatives

Journal of Medicinal Chemistry

Volumn 53, Issue 4, 2010, Pages 1519-1533

  Yeh, Jiann Yih ^a   Coumar, Mohane Selvaraj ^a   Horng, Jim Tong ^c   Shiao, Hui Yi ^a,b   Kuo, Fu Ming ^a   Lee, Hui Ling ^a   Chen, In Chun ^a   Chang, Chun Wei ^a   Tang, Wen Fang ^c   Tseng, Sung Nain ^c   Chen, Chi Jene ^c   Shih, Shin Ru ^c   Hsu, John T A ^a,d   Liao, Chun Chen ^b,e   Chao, Yu Sheng ^a   Hsieh, Hsing Pang ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^e CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYL 9 PHENYL 8 (THIOPHENE 2 CARBONYL)FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 3 METHYL 9 PHENYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4 METHYL 9 (4 NITRO PHENYL)FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4 METHYL 9 4 TOLYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4 METHYL 9 NAPHTHALEN 1 YL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4 METHYL 9 NAPHTHALEN 2 YL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4 METHYL 9 PHENYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4 METHYL 9 PROPYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4 METHYL 9 THIOPHEN 2 YL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 4,9 DIMETHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (2 BROMO PHENYL) 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (3 BROMO PHENYL) 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (3 CHLORO PHENYL) 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (3 CYANO PHENYL) 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (3 METHYL PHENYL) 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (3 NITRO PHENYL) 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (3,5 DIBROMO PHENYL) 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (4 CHLORO PHENYL) 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 (4 METHOXYPHENYL) 4 METHYL 2H FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 DECYL 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 HEXYL 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZOYL 9 PHENYL FURO[2,3 H]CHROMEN 2 ONE; 8 BENZYL 9 FURAN 2 YL 4 METHYL FURO[2,3 H]CHROMEN 2 ONE; ANGELICIN; BUT 2 ENOIC ACID 2 BBENZOYL 3 PHENYL BENZOFURAN 4 YL ESTER; PHENYL(1 PHENYL NAPHTHO[2,1 B]FURAN 2 YL)METHANONE; PHENYL(3 PHENYL BENZOFURAN 2 YL)METHANONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZANAMIVIR;

ANIMAL CELL; ARTICLE; BABESIOSIS; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; INFLUENZA; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; KIDNEY CELL CULTURE; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; VIRUS STRAIN;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; DOGS; DRUG DISCOVERY; HUMANS; INFLUENZA A VIRUS; INFLUENZA B VIRUS; PSORALENS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 77649210704     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901570x     Document Type: Article

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