Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 691-703

  Kamal, Ahmed ^a   Bharathi, E Vijaya ^a   Reddy, J Surendranadha ^a   Ramaiah, M Janaki ^a   Dastagiri, D ^a   Reddy, M Kashi ^a   Viswanath, A ^a   Reddy, T Lakshminarayan ^a   Shaik, T Basha ^a   Pushpavalli, S N C V L ^a   Bhadra, Manika Pal ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

2,3 Dihydroquinazolinones; 3,5 Diaryl isoxazoline isoxazole; Cell cycle effects; Cytotoxicity; Tubulin depolymerization

Indexed keywords

2 (3 (4 (2,6 DIMETHOXY 4 (3 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOL 5 YL)PHENOXY) BUTOXY) 4 METHOXYPHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (3 (4 BROMOBUTOXY) 4 METHOXYPHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (3 METHOXY 4 (3 (2 METHOXY 5 (3 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOL 5 YL)PHENOXY)PROPOXY)PHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (3 METHOXY 4 (4 (2 METHOXY 5 (3 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDRO ISOXAZOL 5 YL)PHENOXY)BUTOXY)PHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (3 METHOXY 4 (5 (2 METHOXY 5 (3 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDRO ISOXAZOL 5 YL)PHENOXY)PENTYLOXY)PHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (4 (3 (2,6 DIMETHOXY 4 (5 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOL 3 YL)PHENOXY)PROPOXY) 3 METHOXYPHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (4 (3 BROMOPROPOXY) 3 METHOXYPHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (4 (4 (2,6 DIMETHOXY 4 (5 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOL 3 YL)PHENOXY)BUTOXY) 3 METHOXYPHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (4 (4 BROMOBUTOXY) 3 METHOXYPHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (4 (5 (2,6 DIMETHOXY 4 (5 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOLE 3 YL)PHENOXY)PENTYLOXY) 3 METHOXYPHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (4 (5 BROMOPENTYLOXY) 3 METHOXYPHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 (4 METHOXY 3 (4 (2 METHOXY 5 (5 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOL 3 YL) PHENOXY)BUTOXY)PHENYL) 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 2 METHOXY 5 (3 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOL 5 YL)PHENOL; 2 METHOXY 5 (3 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOL 5 YL)PHENOL; 2,6 DIMETHOXY 4 (3 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOL 5 YL)PHENOL; 2,6 DIMETHOXY 4 (5 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOL 3 YL) PHENOL; ANTINEOPLASTIC AGENT; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOXAZOLES; MOLECULAR STRUCTURE; QUINAZOLINONES; STEREOISOMERISM;

EID: 79151475531     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.12.004     Document Type: Article

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