Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents

Journal of Medicinal Chemistry

Volumn 55, Issue 17, 2012, Pages 7817-7827

  Graham, Leigh A ^a   Suryadi, Jimmy ^a   West, Tiffany K ^b   Kucera, Gregory L ^b   Bierbach, Ulrich ^a  

^a WAKE FOREST UNIVERSITY   (United States)

^b WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID; CHLORIDE; CISPLATIN; DNA; ESTER; PLATINUM COMPLEX;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; LUNG NON SMALL CELL CANCER; OVARY CANCER; PANCREAS CANCER; PLASMID;

CARBOXYLIC ACIDS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERS; HUMANS; PLATINUM; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; WATER;

EID: 84866338453     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300879k     Document Type: Article

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