Natural product hybrids as new leads for drug discovery

Angewandte Chemie - International Edition

Volumn 42, Issue 34, 2003, Pages 3996-4028

  Tietze, Lutz F ^a   Bell, Hubertus P ^a   Chandrasekhar, Srivari ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Biological activity; Combinatorial chemistry; Drug design; Hybrids; Natural products

Indexed keywords

IMMUNOLOGY; ONCOLOGY; PRODUCT DEVELOPMENT;

BIOLOGICAL ACTIVITY;

DRUG PRODUCTS;

2 METHOXYESTRADIOL; AGRICULTURAL CHEMICAL; ANTIBIOTIC AGENT; ANTIMALARIAL AGENT; COLCHICINE; CYCLOSPORIN A; CYTOTOXIC AGENT; ERYTHROMYCIN; ESTRADIOL; ESTRONE; GELDANAMYCIN; GILVOCARCIN V; HOLOTHIN; MICHELLAMINE A; MICHELLAMINE B; MUSCLE RELAXANT AGENT; MYCOTOXIN; NATURAL PRODUCT; PACLITAXEL; PENICILLIN G; PSEUDOMONIC ACID; PYRETHRIN; RAPAMYCIN; SPINOSYN A; TALAROMYCIN; THIOMARINOL; TSUKUBAENOLIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VECURONIUM;

ALKYLATION; ALTEROMONAS; ANTIBODY SPECIFICITY; ANTINEOPLASTIC ACTIVITY; BACTERIAL STRAIN; BIOSYNTHESIS; CANCER CELL; CANCER REGRESSION; CELL ASSAY; CHEMICAL REACTION; CLINICAL PRACTICE; COMBINATORIAL CHEMISTRY; CONCENTRATION (PARAMETERS); CONJUGATE; CYCLIZATION; CYTOTOXICITY; DIMERIZATION; DNA BINDING; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG FORMULATION; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG USE; ELECTRON TRANSPORT; ENANTIOMER; ENZYME ACTIVATION; GENETIC ENGINEERING; HUMAN; HYBRID; IMMUNE DEFICIENCY; INFECTION; ISOMER; MALIGNANT NEOPLASTIC DISEASE; MEASUREMENT; MOLECULE; NONHUMAN; PHARMACOPHORE; PHOTODYNAMIC THERAPY; PHOTOSYNTHESIS; PHOTOTOXICITY; PLASMODIUM FALCIPARUM; POLYMERIZATION; RADIATION ABSORPTION; REVIEW; SAPONIFICATION; STEREOCHEMISTRY; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION;

ANIMALS; BIOLOGICAL FACTORS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS;

EID: 0141427680     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200200553     Document Type: Review

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