Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 18, 2010, Pages 6666-6677

  Kamal, Ahmed ^a   Dastagiri, D ^a   Ramaiah, M Janaki ^a   Bharathi, E Vijaya ^a   Reddy, J Surendranadha ^a   Balakishan, G ^a   Sarma, Pranjal ^a   Pushpavalli, S N C V L ^a   Pal Bhadra, Manika ^a   Juvekar, Aarti ^b   Sen, Subrata ^b   Zingde, Surekha ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b Research and Education in Cancer   (India)

Author keywords

2,5 Diaryloxadiazoles; Anticancer activity; Apoptosis; Caspases; Cyclin dependent kinase 2 (CDK 2); p53; Pyrrolobenzodiazepine

Indexed keywords

7 METHOXY 8 [3 [5 [5 (4 FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YL] 2 METHOXYPHENYL]OXY]PROPYLOXY] 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 7 METHOXY 8 [3 [5 [5 (4 TRIFLUOROMETHYLPHENYL) 1,3,4 OXADIAZOL 2 YL] 2 METHOXYPHENYL]OXY]PROPYLOXY] 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 7 METHOXY 8 [5 [5 [5 (3,4 DIMETHOXYPHENYL) 1,3,4 OXADIAZOL 2 YL] 2 METHOXYPHENYL]OXY]PENTYLOXY] 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 7 METHOXY 8 [5 [5 [5 (3,4,5 TRIMETHOXYPHENYL) 1,3,4 OXADIAZOL 2 YL] 2 METHOXYPHENYL]OXY]PENTYLOXY] 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; BENZODIAZEPINE DERIVATIVE; CASPASE; OXADIAZOLE DERIVATIVE; PROTEIN BAX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MITOCHONDRION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZODIAZEPINES; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 2; HUMANS; MALE; MICE; MICE, INBRED NOD; MITOCHONDRIA; NEOPLASMS; OXADIAZOLES; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77956341962     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.067     Document Type: Article

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