Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity

Journal of Medicinal Chemistry

Volumn 54, Issue 18, 2011, Pages 6319-6327

  Smith, Amos B ^a   Sugasawa, Keizo ^a,c   Atasoylu, Onur ^a   Yang, Chia Ping Huang ^b   Horwitz, Susan Band ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DISCODERMOLIDE; PACLITAXEL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ALKANES; ANTINEOPLASTIC AGENTS; BINDING SITES; CARBAMATES; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTONES; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PACLITAXEL; PROTEIN BINDING; PYRONES; SOLUTIONS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 80052808315     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200692n     Document Type: Article

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