Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents

European Journal of Medicinal Chemistry

Volumn 56, Issue , 2012, Pages 166-178

  Kamal, Ahmed ^a   Mallareddy, Adla ^a   Janaki Ramaiah, M ^a   Pushpavalli, S N C V L ^a   Suresh, Paidakula ^a   Kishor, Chandan ^a   Murty, J N S R C ^a   Rao, N Sankara ^a   Ghosh, Sowjanya ^a   Addlagatta, Anthony ^a   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Anticancer activity; CA 4; Cell cycle; ERK; Molecular modeling; Tubulin

Indexed keywords

2 [2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENOXY] N (2 METHYLBENZO[D]THIAZOL 6 YL)ACETAMIDE; 2 [2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENOXY] N (6 FLUOROBENZO[D]THIAZOL 2 YL)ACETAMIDE; 2 [2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENOXY] N (6 METHOXYBENZO[D]THIAZOL 2 YL)ACETAMIDE; 2 [2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENOXY] N (6 TRIFLUOROMETHOXYBENZO[D]THIAZOL 2 YL)ACETAMIDE; 2 [2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENOXY] N (6 TRIFLUOROMETHYLBENZO[D]THIAZOL 2 YL)ACETAMIDE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; BETA ACTIN; COMBRETASTATIN A4; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N (BENZO[D]THIAZOL 2 YL) 2 [2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENOXY]ACETAMIDE; NOCODAZOLE; PACLITAXEL; PROTEIN C JUN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; MOLECULAR MODEL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANTIMITOTIC AGENTS; BENZOTHIAZOLES; BIBENZYLS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; POLYMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 84865960983     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.021     Document Type: Article

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