Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines

Steroids

Volumn 77, Issue 5, 2012, Pages 403-412

  Descôteaux, Caroline ^a   Brasseur, Kevin ^a   Leblanc, Valérie ^a   Parent, Sophie ^a   Asselin, Éric ^a   Bérubé, Gervais ^a  

^a UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

Author keywords

Biological activity; Chlorambucil; Estrogen receptor alpha; Female cancers; Ortho , meta and para hydroxyphenyl tyrosinamide chlorambucil derivatives

Indexed keywords

2 HYDROXYPHENYLTYROSINAMIDE CHLORAMBUCIL DERIVATIVE; 3 HYDROXYPHENYLTYROSINAMIDE CHLORAMBUCIL DERIVATIVE; 4 HYDROXYPHENYLTYROSINAMIDE CHLORAMBUCIL DERIVATIVE; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CHLORMETHINE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG TARGETING; ELECTROSPRAY MASS SPECTROMETRY; ESTROGEN ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HYBRID; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIGAND BINDING; MOLECULE; OVARY CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; UTERUS CANCER;

ANTINEOPLASTIC AGENTS, ALKYLATING; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHLORAMBUCIL; DRUG DESIGN; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OVARIAN NEOPLASMS; TYROSINE; UTERINE NEOPLASMS;

EID: 84858343513     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.12.021     Document Type: Article

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