Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 530-545

  Kamal, Ahmed ^a   Mallareddy, Adla ^a   Suresh, Paidakula ^a   Lakshma Nayak, V ^a   Shetti, Rajesh V C R N C ^a   Sankara Rao, N ^a   Tamboli, Jaki R ^a   Shaik, Thokhir B ^a   Vishnuvardhan, M V P S ^a,b   Ramakrishna, S ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Anticancer activity; Apoptosis; Caspase 3; Cell cycle analysis; Podophyllotoxin

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; 4BETA [2 [2 METHOXY 4 [3 (3 METHOXYPHENYL) 3 OXO 1 PROPENYL]PHENOXY]ACETAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [2 [2 METHOXY 4 [3 (3 NITROPHENYL) 3 OXO 1 PROPENYL]PHENOXY]ACETAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [2 [2 METHOXY 4 [3 (3,4,5 TRIMETHOXYPHENYL) 3 OXO 1 PROPENYL]PHENOXY]ACETAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [2 [2 METHOXY 4 [3 (4 FLUOROPHENYL) 3 OXO 1 PROPENYL]PHENOXY]ACETAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [2 [2 METHOXY 4 [3 (4 METHOXYPHENYL) 3 OXO 1 PROPENYL]PHENOXY]ACETAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [2 [2 METHOXY 5 [3 OXO 3 (3,4,5 TRIMETHOXYPHENYL) 1 PROPENYL]PHENOXY]ACETAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [2 [3 [3 OXO 3 (3,4,5 TRIMETHOXYPHENYL) 1 PROPENYL]PHENOXY]ACETAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [2 [4 [ 3 OXO 3 (3,4,5 TRIMETHOXYPHENYL) 1 PROPENYL]PHENOXY]ACETAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [3 (4 BROMOPHENYL) 2 PROPENAMIDO] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [3 (4 CHLOROPHENYL) 2 PROPENAMIDO] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [3 (4 FLUOROPHENYL) 2 PROPENAMIDO] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [3 (4 METHOXYPHENYL) 2 PROPENAMIDO] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [3 (4 NITROPHENYL) 2 PROPENAMIDO] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [3 (4 TRIFLUOROMETHYLPHENYL) 2 PROPENAMIDO] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [3 PHENYL 2 PROPENAMIDO] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [6 [2 METHOXY 4 [ 3 (3 METHOXYPHENYL) 3 OXO 1 PROPENYL]PHENOXY]HEXANAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [6 [2 METHOXY 4 [ 3 (3 NITROPHENYL) 3 OXO 1 PROPENYL]PHENOXY]HEXANAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [6 [2 METHOXY 4 [ 3 (3,4,5 TRIMETHOXYPHENYL) 3 OXO 1 PROPENYL]PHENOXY]HEXANAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [6 [2 METHOXY 4 [ 3 (4 METHOXYPHENYL) 3 OXO 1 PROPENYL]PHENOXY]HEXANAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [6 [2 METHOXY 4 [ 3 4 FLUOROPHENYL) 3 OXO 1 PROPENYL]PHENOXY]HEXANAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [6 [2 METHOXY 5 [ 3 OXO 3 (3,4,5 TRIMETHOXYPHENYL) 1 PROPENYL]PHENOXY]HEXANAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [6 [3 [3 OXO 3 (3,4,5 TRIMETHOXYPHENYL) 3 OXO 1 PROPENYL]PHENOXY]HEXANAMIDE] 4 DESOXY PODOPHYLLOTOXIN; 4BETA [6 [4 [3 OXO 3 (3,4,5 TRIMETHOXYPHENYL) 1 PROPENYL]PHENOXY]HEXANAMIDE] 4 DESOXY PODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; CASPASE 3; DOXORUBICIN; ETOPOSIDE; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HT29; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFICACY; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CHALCONE; CINNAMATES; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; PODOPHYLLOTOXIN;

EID: 84855785112     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.024     Document Type: Article

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