Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 11-19

  Duan, Ying Chao ^a   Ma, Yong Cheng ^a   Zhang, En ^a   Shi, Xiao Jing ^a   Wang, Meng Meng ^a   Ye, Xian Wei ^a   Liu, Hong Min ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

1,2,3 triazole; Anticancer; Apoptosis; Cell cycle arrest; Dithiocarbamate; Hybrid

Indexed keywords

1,2,3 TRIAZOLE DITHIOCARBAMIC ACID; [1 (2 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODIETHIOATE; [1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODITHIOATE; [1 (3,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLPIPERAZINE CARBODITHIOATE; [1 (3,4 TRIMETHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLPIPERAZINE CARBODITHIOATE; [1 (4 CHLOROBENZYL)1H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODITHIOATE; [1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODITHIOATE; [1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODITHIOATE; [1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODITHIOATE; ANTINEOPLASTIC AGENT; BENZYL 4 [[[1 (2 FLUOROBENZYL) 1H-1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; BENZYL 4 [[[1 (4 FLUOROBENZYL) 1H-1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; BENZYL 4 [[[1 (4 METHOBENZYL) 1H-1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; CARBAMIC ACID DERIVATIVE; FLUOROURACIL; TERT BUTYL 4 [[(1 (2 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (3 TRIFLUOROMETHYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (3,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (3,4,5 TRIMETHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (4 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (4 METHOXYPHENL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[(1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[[1 ((7 HYDROXY 2 OXO 2H CHROMEN 4 YL)1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[[1 (2 (2 OXO 2H CHROMEN 7 YLOXY)ETHYL) 1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[[1 (2 (4 METHYL 2 OXO 2H CHROMEN 7 YLOXY)1H 1,2,3 TRIAZOL 4 YL)METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL DEATH; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HYBRID; IC 50;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES; TRIAZOLES;

EID: 84872683595     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.046     Document Type: Article

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