Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 187-198

  Amin, Kamilia M ^a   Eissa, Amal A M ^a   Abou Seri, Sahar M ^a   Awadallah, Fadi M ^a   Hassan, Ghaneya S ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Antitumor activity; Coumarins; Phenylsulfonyl derivatives; Pyrazoline

Indexed keywords

7 METHOXY 8 [1 (PHENYLSULFONYL) 5 (THIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [1 (PHENYLSULFONYL) 5 [4 (TRIFLUOROMETHYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 3 YL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [1 (PHENYLSULFONYL)(4 METHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [5 (5 METHYLFURAN 2 YL) 1 (PHENYLSULFONYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [5 [4 (METHYLTHIO)PHENYL] 1 (PHENYLSULFONYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [5 PHENYL 1 (PHENYLSULFONYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 2H CHROMEN 2 ONE; 8 [1 (4 CHLOROPHENYLSULFONYL) 5 (4 METHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 CHLOROPHENYLSULFONYL) 5 (5 METHYLFURAN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 CHLOROPHENYLSULFONYL) 5 (THIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 CHLOROPHENYLSULFONYL) 5 [4 (METHYLTHIO)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 CHLOROPHENYLSULFONYL) 5 [4 (TRIFLUROMETHYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 CHLOROPHENYLSULFONYL) 5 PHENYL 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 METHYLPHENYLSULFONYL) 5 (4 METHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 METHYLPHENYLSULFONYL) 5 (5 METHYLFURAN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 METHYLPHENYLSULFONYL) 5 (THIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 METHYLPHENYLSULFONYL) 5 [4 (METHYLTHIO)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 METHYLPHENYLSULFONYL) 5 [4 (TRIFLUROMETHYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [1 (4 METHYLPHENYLSULFONYL) 5 PHENYL 2 YL 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [4,5 DIHYDRO 1 (4 SULFAMOYLPHENYL) 5 (THIOPHEN 2 YL) 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [4,5 DIHYDRO 1 (4 SULFAMOYLPHENYL) 5 [4 (TRIFLUROMETHYL)PHENYL) 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [4,5 DIHYDRO 1 (4 SULFAMOYLPHENYL) 5 PHENYL 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [4,5 DIHYDRO 5 (4 METHYLPHENYL) 1 (4 SULFAMOYLPHENYL) 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [4,5 DIHYDRO 5 (4 METHYLTHIO)PHENYL) 1 (4 SULFAMOYLPHENYL) 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; 8 [4,5 DIHYDRO 5 (5 METHYLFURAN 2 YL) 1 (4 SULFAMOYLPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL] 7 METHOXY 2H CHROMEN 2 ONE; ANTINEOPLASTIC AGENT; COUMARIN DERIVATIVE; DOXORUBICIN; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG SCREENING; DRUG SENSITIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871713110     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.004     Document Type: Article

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