메뉴 건너뛰기




Volumn 4, Issue 11, 2009, Pages 1099-1111

Promise and challenges in drug discovery and development of hybrid anticancer drugs

Author keywords

Anticancer drugs; Cancer; Drug discovery and development; Hybrid drugs

Indexed keywords

ACETYLSALICYLIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; AZASTEROID NITROGEN MUSTARD; AZATOXIN; CAMPTOTHECIN; COLCHICINE; CYTARABINE; ELIPTICINE; EPIPODOPHYLLOTOXIN; ESTRAMUSTINE; ETOPOSIDE; FLUOROURACIL; GLYCYRRHETINIC ACID; LACTANDRATE; LACTESTOXATE; NITRIC OXIDE ACETYLSALICYLIC ACID; PACLITAXEL DERIVATIVE; RETINOIC ACID; UNCLASSIFIED DRUG;

EID: 72949087797     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460440903341705     Document Type: Review
Times cited : (210)

References (80)
  • 1
    • 72949110062 scopus 로고    scopus 로고
    • Dunham W. Report sees 7.6 million global 2007 cancer deaths. American Cancer Society; 2007
    • Dunham W. Report sees 7.6 million global 2007 cancer deaths. American Cancer Society; 2007
  • 3
    • 4043107044 scopus 로고    scopus 로고
    • The present and future role of photodynamic therapy in cancer treatment
    • Brown SB, Brown EA, Walker I. The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol 2004;5:497-508
    • (2004) Lancet Oncol , vol.5 , pp. 497-508
    • Brown, S.B.1    Brown, E.A.2    Walker, I.3
  • 4
    • 33845483437 scopus 로고    scopus 로고
    • Biological activity of designed photolabile metal nitrosyls: Light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta
    • Madhani M, Patra AK, Miller TW, et al. Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta. J Med Chem 2006;49:7325-7330
    • (2006) J Med Chem , vol.49 , pp. 7325-7330
    • Madhani, M.1    Patra, A.K.2    Miller, T.W.3
  • 5
    • 67650763063 scopus 로고    scopus 로고
    • Trisulfonated porphyrazines: New photosensitizers for the treatment of retinal and subretinal edema
    • van Lier JE, Tian H, Ali H, et al. Trisulfonated porphyrazines: new photosensitizers for the treatment of retinal and subretinal edema. J Med Chem 2009;52:889-905
    • (2009) J Med Chem , vol.52 , pp. 889-905
    • Van Lier, J.E.1    Tian, H.2    Ali, H.3
  • 6
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med 2002;53:615-627
    • (2002) Annu Rev Med , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 7
    • 0023009541 scopus 로고
    • Drug resistance of cancer cells probed
    • Marx JL. Drug resistance of cancer cells probed. Science 1986;234:818-820
    • (1986) Science , vol.234 , pp. 818-820
    • Marx, J.L.1
  • 8
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: When the whole is greater than the sum of the parts
    • Zimmermann GR, Lehár J, Keith CT. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 2007;12:34-42
    • (2007) Drug Discov Today , vol.12 , pp. 34-42
    • Zimmermann, G.R.1    Lehár, J.2    Keith, C.T.3
  • 9
    • 34447299673 scopus 로고    scopus 로고
    • Randomized phase II study of docetaxel plus estramustine and single-agent docetaxel in patients with metastatic hormone-refractory prostate cancer
    • Eymard JC, Priou F, Zannetti A, et al. Randomized phase II study of docetaxel plus estramustine and single-agent docetaxel in patients with metastatic hormone-refractory prostate cancer. Ann Oncol 2007;18:1064-1070
    • (2007) Ann Oncol , vol.18 , pp. 1064-1070
    • Eymard, J.C.1    Priou, F.2    Zannetti, A.3
  • 10
    • 35448959580 scopus 로고    scopus 로고
    • Meta-analysis of Estramustine in Prostate Cancer (MECaP) Trialists' Collaborative Group: Addition of estramustine to chemotherapy and survival of patients with castration-refractory prostate cancer: A meta-analysis of individual patient data
    • Fizazi K, Le Maitre A, Hudes G, et al. Meta-analysis of Estramustine in Prostate Cancer (MECaP) Trialists' Collaborative Group: addition of estramustine to chemotherapy and survival of patients with castration-refractory prostate cancer: a meta-analysis of individual patient data. Lancet Oncol 2007;8:994-1000
    • (2007) Lancet Oncol , vol.8 , pp. 994-1000
    • Fizazi, K.1    Le Maitre, A.2    Hudes, G.3
  • 11
    • 55949089682 scopus 로고    scopus 로고
    • Prospective randomized study comparing docetaxel, estramustine, and prednisone with docetaxel and prednisone in metastatic hormone-refractory prostate cancer
    • Machiels JP, Mazzeo F, Clausse M, et al. Prospective randomized study comparing docetaxel, estramustine, and prednisone with docetaxel and prednisone in metastatic hormone-refractory prostate cancer. J Clin Oncol 2008;26:5261-5268
    • (2008) J Clin Oncol , vol.26 , pp. 5261-5268
    • MacHiels, J.P.1    Mazzeo, F.2    Clausse, M.3
  • 12
    • 33745852174 scopus 로고    scopus 로고
    • Dichotomies in cancer research: Some suggestions for a new synthesis
    • Sporn MB. Dichotomies in cancer research: some suggestions for a new synthesis. Nat Clin Pract Oncol 2006;3:364-373
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 364-373
    • Sporn, M.B.1
  • 13
    • 0036637235 scopus 로고    scopus 로고
    • Chemoprevention: An essential approach to controlling cancer
    • Sporn MB, Suh N. Chemoprevention: an essential approach to controlling cancer. Nat Rev Cancer 2002;2:537-543
    • (2002) Nat Rev Cancer , vol.2 , pp. 537-543
    • Sporn, M.B.1    Suh, N.2
  • 14
    • 27144449695 scopus 로고    scopus 로고
    • Designed multiple ligands. An emerging drug discovery paradigm
    • Morphy R, Rankovic Z. Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem 2005;48:6523-6543
    • (2005) J Med Chem , vol.48 , pp. 6523-6543
    • Morphy, R.1    Rankovic, Z.2
  • 15
    • 33750546736 scopus 로고    scopus 로고
    • The trouble with making combination drugs
    • Frantz S. The trouble with making combination drugs. Nat Rev Drug Discov 2006;5:881-882
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 881-882
    • Frantz, S.1
  • 16
    • 3242794178 scopus 로고    scopus 로고
    • From magic bullets to designed multiple ligands
    • Morphy R, Kay C, Rankovic Z. From magic bullets to designed multiple ligands. Drug Discov Today 2004;9:641-651
    • (2004) Drug Discov Today , vol.9 , pp. 641-651
    • Morphy, R.1    Kay, C.2    Rankovic, Z.3
  • 17
    • 38949125112 scopus 로고    scopus 로고
    • Hybrid molecules with a dual mode of action: Dream or reality?
    • Meunier B. Hybrid molecules with a dual mode of action: dream or reality? Acc Chem Res 2008;41:69-77
    • (2008) Acc Chem Res , vol.41 , pp. 69-77
    • Meunier, B.1
  • 18
    • 0023256583 scopus 로고
    • Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine
    • Tew KD, Stearns ME. Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine. Urol Res 1987;15:155-160
    • (1987) Urol Res , vol.15 , pp. 155-160
    • Tew, K.D.1    Stearns, M.E.2
  • 19
    • 33749354945 scopus 로고    scopus 로고
    • Hybrid aza-steroid alkylators in the treatment of colon cancer
    • Trafalis DT. Hybrid aza-steroid alkylators in the treatment of colon cancer. Cancer Lett 2006;243:202-210
    • (2006) Cancer Lett , vol.243 , pp. 202-210
    • Trafalis, D.T.1
  • 20
    • 0030713374 scopus 로고    scopus 로고
    • Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine
    • Cline SD, Macdonald TL, Osheroff N. Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine. Biochemistry 1997;36:13095-13101
    • (1997) Biochemistry , vol.36 , pp. 13095-13101
    • Cline, S.D.1    MacDonald, T.L.2    Osheroff, N.3
  • 21
    • 34547484265 scopus 로고    scopus 로고
    • Molecular hybridization: A useful tool in the design of new drug prototypes
    • Viegas-Junior C, Danuello A, da Silva Bolzani V, et al. Molecular hybridization: a useful tool in the design of new drug prototypes. Curr Med Chem 2007;14:1829-1852
    • (2007) Curr Med Chem , vol.14 , pp. 1829-1852
    • Viegas-Junior, C.1    Danuello, A.2    Da Silva Bolzani, V.3
  • 22
    • 34249008406 scopus 로고    scopus 로고
    • Chemical insights in the concept of hybrid drugs: The antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin
    • Hulsman N, Medema JP, Bos C, et al. Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. J Med Chem 2007;50:2424-2431
    • (2007) J Med Chem , vol.50 , pp. 2424-2431
    • Hulsman, N.1    Medema, J.P.2    Bos, C.3
  • 23
    • 0034721174 scopus 로고    scopus 로고
    • Novel mutual prodrug of retinoic and butyric acids with enhanced anticancer activity
    • Nudelman A, Rephaeli A. novel mutual prodrug of retinoic and butyric acids with enhanced anticancer activity. J Med Chem 2000;43:2962-2966
    • (2000) J Med Chem , vol.43 , pp. 2962-2966
    • Nudelman, A.1    Rephaeli, A.2
  • 25
    • 0000658454 scopus 로고
    • (Acyloxy) alkyl carbamates as novel bioreversible prodrugs for amines: Increased permeation through biological membranes
    • Alexander J, Cargill R, Michelson SR, Schwam H. (Acyloxy) alkyl carbamates as novel bioreversible prodrugs for amines: increased permeation through biological membranes. J Med Chem 1988;31:318-322
    • (1988) J Med Chem , vol.31 , pp. 318-322
    • Alexander, J.1    Cargill, R.2    Michelson, S.R.3    Schwam, H.4
  • 26
    • 0033539039 scopus 로고    scopus 로고
    • Drug delivery systems employing 1, 4-or 1, 6-elimination: Poly (ethylene glycol) prodrugs of amine-containing compounds
    • Greenwald RB, Pendri A, Conover CD, et al. Drug delivery systems employing 1, 4-or 1, 6-elimination: poly (ethylene glycol) prodrugs of amine-containing compounds. J Med Chem 1999;42:3657-3667
    • (1999) J Med Chem , vol.42 , pp. 3657-3667
    • Greenwald, R.B.1    Pendri, A.2    Conover, C.D.3
  • 27
    • 1942522066 scopus 로고    scopus 로고
    • Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes
    • Barnes KR, Kutikov A, Lippard SJ. Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes. Chem Biol 2004;11:557-564
    • (2004) Chem Biol , vol.11 , pp. 557-564
    • Barnes, K.R.1    Kutikov, A.2    Lippard, S.J.3
  • 28
    • 0037025728 scopus 로고    scopus 로고
    • Preparation of optically active (acyloxy) alkyl esters from optically active O-acyl-alpha-hydroxy acids
    • Guzzo PR, Dinn SR, Lu J, Oettinger-Loomis S. Preparation of optically active (acyloxy) alkyl esters from optically active O-acyl-alpha-hydroxy acids. Tetrahedron Lett 2002;43:5685-5689
    • (2002) Tetrahedron Lett , vol.43 , pp. 5685-5689
    • Guzzo, P.R.1    Dinn, S.R.2    Lu, J.3    Oettinger-Loomis, S.4
  • 29
    • 22144475857 scopus 로고    scopus 로고
    • Recent progress in management of advanced prostate cancer
    • Kantoff P. Recent progress in management of advanced prostate cancer. Oncology (Williston) 2005;19:631-636
    • (2005) Oncology (Williston) , vol.19 , pp. 631-636
    • Kantoff, P.1
  • 30
    • 34249008406 scopus 로고    scopus 로고
    • Chemical insights in the concept of hybrid drugs: The antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin
    • Hulsman N, Medema JP, Bos C, et al. Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. J Med Chem 2007;50:2424-2431
    • (2007) J Med Chem , vol.50 , pp. 2424-2431
    • Hulsman, N.1    Medema, J.P.2    Bos, C.3
  • 31
    • 0035749803 scopus 로고    scopus 로고
    • The promise of retinoids to fight against cancer
    • Altucci L, Gronemeyer H. The promise of retinoids to fight against cancer. Nat Rev Cancer 2001;1:181-193
    • (2001) Nat Rev Cancer , vol.1 , pp. 181-193
    • Altucci, L.1    Gronemeyer, H.2
  • 32
  • 33
    • 0017886958 scopus 로고
    • Sodium butyrate inhibits histone deacetylation in cultured cells
    • Candido E, Reeves R, Davie JR. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 1978;14:105-113
    • (1978) Cell , vol.14 , pp. 105-113
    • Candido, E.1    Reeves, R.2    Davie, J.R.3
  • 34
    • 0023395729 scopus 로고
    • Rapid and reversible changes in nucleosome structure accompany the activation, repression, and superinduction of murine fibroblast protooncogenes c-fos and c-myc
    • Chen TA, Allfrey VG. Rapid and reversible changes in nucleosome structure accompany the activation, repression, and superinduction of murine fibroblast protooncogenes c-fos and c-myc. Proc Natl Acad Sci 1987;84:5252-5256
    • (1987) Proc Natl Acad Sci , vol.84 , pp. 5252-5256
    • Chen, T.A.1    Allfrey, V.G.2
  • 36
    • 0030606239 scopus 로고    scopus 로고
    • The transcriptional coactivators p300 and CBP are histone acetyltransferases
    • Ogryzko VV, Schiltz RL, Russanova V, et al. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 1996;87:953
    • (1996) Cell , vol.87 , pp. 953
    • Ogryzko, V.V.1    Schiltz, R.L.2    Russanova, V.3
  • 37
    • 0030922545 scopus 로고    scopus 로고
    • Sinful repression
    • Wolffe AP. Sinful repression. Nature 1997;387:16-17
    • (1997) Nature , vol.387 , pp. 16-17
    • Wolffe, A.P.1
  • 38
    • 0032546017 scopus 로고    scopus 로고
    • Role of the histone deacetylase complex in acute promyelocytic leukaemia
    • Lin RJ, Nagy L, Inoue S, et al. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 1998;391:811-814
    • (1998) Nature , vol.391 , pp. 811-814
    • Lin, R.J.1    Nagy, L.2    Inoue, S.3
  • 39
    • 17144458786 scopus 로고    scopus 로고
    • Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia
    • Grignani F, De Matteis S, Nervi C, et al. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 1998;391:815-818
    • (1998) Nature , vol.391 , pp. 815-818
    • Grignani, F.1    De Matteis, S.2    Nervi, C.3
  • 40
    • 0031941912 scopus 로고    scopus 로고
    • Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL
    • He LZ, Guidez F, Tribioli C, et al. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet 1998;18:126-135
    • (1998) Nat Genet , vol.18 , pp. 126-135
    • He, L.Z.1    Guidez, F.2    Tribioli, C.3
  • 41
    • 3643104150 scopus 로고    scopus 로고
    • Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase
    • Warrell RP, He LZ, Richon V, et al. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. J Natl Cancer Inst 1998;90:1621-1625
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1621-1625
    • Warrell, R.P.1    He, L.Z.2    Richon, V.3
  • 42
    • 0142089014 scopus 로고    scopus 로고
    • A retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis
    • Mann KK, Rephaeli A, Colosimo AL, et al. A retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis. Mol Cancer Res 2003;1:903-912
    • (2003) Mol Cancer Res , vol.1 , pp. 903-912
    • Mann, K.K.1    Rephaeli, A.2    Colosimo, A.L.3
  • 43
  • 45
    • 0344394175 scopus 로고    scopus 로고
    • Retinoids in cancer therapy and chemoprevention: Promise meets resistance
    • Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene 2003;22:7305-7315
    • (2003) Oncogene , vol.22 , pp. 7305-7315
    • Freemantle, S.J.1    Spinella, M.J.2    Dmitrovsky, E.3
  • 46
    • 0034595637 scopus 로고    scopus 로고
    • Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition
    • Sun SY, Wan H, Yue P, et al. Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition. J Biol Chem 2000;275:17149-17153
    • (2000) J Biol Chem , vol.275 , pp. 17149-17153
    • Sun, S.Y.1    Wan, H.2    Yue, P.3
  • 47
    • 0034673671 scopus 로고    scopus 로고
    • Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells
    • Sirchia SM, Ferguson AT, Sironi E, et al. Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells. Oncogene 2000;19:1556-1563
    • (2000) Oncogene , vol.19 , pp. 1556-1563
    • Sirchia, S.M.1    Ferguson, A.T.2    Sironi, E.3
  • 48
    • 0034679027 scopus 로고    scopus 로고
    • Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer
    • Widschwendter M, Berger J, Hermann M, et al. Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer. J Natl Cancer Inst 2000;92:826-832
    • (2000) J Natl Cancer Inst , vol.92 , pp. 826-832
    • Widschwendter, M.1    Berger, J.2    Hermann, M.3
  • 49
    • 40949102209 scopus 로고    scopus 로고
    • Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts
    • Gediya LK, Belosay A, Khandelwal A, et al. Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts. Bioorg Med Chem 2008;16:3352-3360
    • (2008) Bioorg Med Chem , vol.16 , pp. 3352-3360
    • Gediya, L.K.1    Belosay, A.2    Khandelwal, A.3
  • 50
    • 22744459936 scopus 로고    scopus 로고
    • A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells
    • Gediya LK, Chopra P, Purushottamachar P, et al. A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells. J Med Chem 2005;48:5047-5051
    • (2005) J Med Chem , vol.48 , pp. 5047-5051
    • Gediya, L.K.1    Chopra, P.2    Purushottamachar, P.3
  • 51
    • 34447101115 scopus 로고    scopus 로고
    • MS-275, a potent orally available inhibitor of histone deacetylases-the development of an anticancer agent
    • Hess-Stumpp H, Bracker TU, Henderson D, Politz O. MS-275, a potent orally available inhibitor of histone deacetylases-the development of an anticancer agent. Int J Biochem Cell Biol 2007;39:1388-1405
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1388-1405
    • Hess-Stumpp, H.1    Bracker, T.U.2    Henderson, D.3    Politz, O.4
  • 52
    • 34250641175 scopus 로고    scopus 로고
    • Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs
    • Verheul HMW, Qian DZ, Carducci MA, Pili R. Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs. Cancer Chemother Pharmacol 2007;60:329-339
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 329-339
    • Verheul, H.M.W.1    Qian, D.Z.2    Carducci, M.A.3    Pili, R.4
  • 53
    • 46849096306 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro
    • Gediya LK, Khandelwal A, Patel J, et al. Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro. J Med Chem 2008;51:3895-3904
    • (2008) J Med Chem , vol.51 , pp. 3895-3904
    • Gediya, L.K.1    Khandelwal, A.2    Patel, J.3
  • 54
    • 0038387494 scopus 로고    scopus 로고
    • 5-fluorouracil: Mechanisms of action and clinical strategies
    • Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003;3:330-338
    • (2003) Nat Rev Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 55
    • 0033028272 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of antimetabolic cytotoxic drugs
    • Lennard L. Therapeutic drug monitoring of antimetabolic cytotoxic drugs. Br J Clin Pharmacol 1999;47:131
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 131
    • Lennard, L.1
  • 56
    • 0031450531 scopus 로고    scopus 로고
    • Synthesis and reactivity of 5-fluorouracil/cytarabine mutual prodrugs
    • Menger FM, Rourk MJ. Synthesis and reactivity of 5-fluorouracil/ cytarabine mutual prodrugs. J Org Chem 1997;62:9083-9088
    • (1997) J Org Chem , vol.62 , pp. 9083-9088
    • Menger, F.M.1    Rourk, M.J.2
  • 57
    • 4444243813 scopus 로고    scopus 로고
    • Comparison of the efficacy, toxicity, and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: Joint United States and Japan study of UFT/LV
    • Shirao K, Hoff P, Ohtsu A, et al. Comparison of the efficacy, toxicity, and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: joint United States and Japan study of UFT/LV. J Clin Oncol 2004;22:3466
    • (2004) J Clin Oncol , vol.22 , pp. 3466
    • Shirao, K.1    Hoff, P.2    Ohtsu, A.3
  • 58
    • 38349093869 scopus 로고    scopus 로고
    • Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties
    • Engel D, Nudelman A, Tarasenko N, et al. Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties. J Med Chem 2008;51:314-323
    • (2008) J Med Chem , vol.51 , pp. 314-323
    • Engel, D.1    Nudelman, A.2    Tarasenko, N.3
  • 59
    • 0037377327 scopus 로고    scopus 로고
    • Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents
    • Ohtsu H, Nakanishi Y, Bastow KF, et al. Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents. Bioorg Med Chem 2003;11:1851-1857
    • (2003) Bioorg Med Chem , vol.11 , pp. 1851-1857
    • Ohtsu, H.1    Nakanishi, Y.2    Bastow, K.F.3
  • 60
    • 0035813468 scopus 로고    scopus 로고
    • Antitumor agents 210. Synthesis and evaluation of taxoid- epipodophyllotoxin conjugates as novel cytotoxic agents
    • Shi Q, Wang HK, Bastow KF, et al. Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents. Bioorg Med Chem 2001;9:2999-3004
    • (2001) Bioorg Med Chem , vol.9 , pp. 2999-3004
    • Shi, Q.1    Wang, H.K.2    Bastow, K.F.3
  • 61
    • 0030747053 scopus 로고    scopus 로고
    • Antitumor agents-CLXXIII. Synthesis and evaluation of camptothecin-4 beta-amino-4¢-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents
    • Bastow KF, Wang HK, Cheng YC, Lee KH. Antitumor agents-CLXXIII. Synthesis and evaluation of camptothecin-4 beta-amino-4¢-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents. Bioorg Med Chem 1997;5:1481-1488
    • (1997) Bioorg Med Chem , vol.5 , pp. 1481-1488
    • Bastow, K.F.1    Wang, H.K.2    Cheng, Y.C.3    Lee, K.H.4
  • 63
    • 0030466324 scopus 로고    scopus 로고
    • Synthesis and biological activity of DNA damaging agents that form decoy binding sites for the estrogen receptor
    • Rink SM, Yarema KJ, Solomon MS, et al. Synthesis and biological activity of DNA damaging agents that form decoy binding sites for the estrogen receptor. Proc Natl Acad Sci USA 1996;93:15063-15068
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15063-15068
    • Rink, S.M.1    Yarema, K.J.2    Solomon, M.S.3
  • 64
    • 0037028969 scopus 로고    scopus 로고
    • A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells
    • Mitra K, Marquis JC, Hillier SM, et al. A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells. J Am Chem Soc 2002;124:1862-1863
    • (2002) J Am Chem Soc , vol.124 , pp. 1862-1863
    • Mitra, K.1    Marquis, J.C.2    Hillier, S.M.3
  • 65
    • 2942635300 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents
    • Sharma U, Marquis JC, Nicole Dinaut A, et al. Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents. Bioorg Med. Chem Lett 2004;14:3829-3833
    • (2004) Bioorg Med. Chem Lett , vol.14 , pp. 3829-3833
    • Sharma, U.1    Marquis, J.C.2    Nicole Dinaut, A.3
  • 66
    • 0000311768 scopus 로고
    • Platinum anti-cancer agents
    • Barnard C. Platinum anti-cancer agents. Platinum Metals Rev 1989;33:162-167
    • (1989) Platinum Metals Rev , vol.33 , pp. 162-167
    • Barnard, C.1
  • 67
    • 10644265058 scopus 로고    scopus 로고
    • A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells
    • Hess SM, Anderson JG, Bierbach U. A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells. Bioorg Med. Chem Lett 2005;15:443-446
    • (2005) Bioorg Med. Chem Lett , vol.15 , pp. 443-446
    • Hess, S.M.1    Anderson, J.G.2    Bierbach, U.3
  • 68
    • 72949122217 scopus 로고    scopus 로고
    • Platinum-based drugs in cancer therapy
    • Inc.
    • Kelland LR, Farrell N. Platinum-based drugs in cancer therapy. Humana Pr, Inc.; 2000
    • (2000) Humana Pr
    • Kelland, L.R.1    Farrell, N.2
  • 69
    • 41149121789 scopus 로고    scopus 로고
    • Synthesis of 17beta-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines
    • Provencher-Mandeville J, Descoteaux C, Mandal SK, et al. Synthesis of 17beta-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines. Bioorg Med. Chem Lett 2008;18:2282-2287
    • (2008) Bioorg Med. Chem Lett , vol.18 , pp. 2282-2287
    • Provencher-Mandeville, J.1    Descoteaux, C.2    Mandal, S.K.3
  • 70
    • 22544462553 scopus 로고    scopus 로고
    • Disruption of gene expression and induction of apoptosis in prostate cancer cells by a DNA-damaging agent tethered to an androgen receptor ligand
    • Marquis JC, Hillier SM, Dinaut AN, et al. Disruption of gene expression and induction of apoptosis in prostate cancer cells by a DNA-damaging agent tethered to an androgen receptor ligand. Chem Biol 2005;12:779-787
    • (2005) Chem Biol , vol.12 , pp. 779-787
    • Marquis, J.C.1    Hillier, S.M.2    Dinaut, A.N.3
  • 71
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods 2000;44:235-249
    • (2000) J Pharmacol Toxicol Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 72
    • 0037030653 scopus 로고    scopus 로고
    • Molecular properties that influence the oral bioavailability of drug candidates
    • Veber DF, Johnson SR, Cheng HY, et al. Molecular properties that influence the oral bioavailability of drug candidates. J Med Chem 2005;45(12):2615-2623
    • (2005) J Med Chem , vol.45 , Issue.12 , pp. 2615-2623
    • Veber, D.F.1    Johnson, S.R.2    Cheng, H.Y.3
  • 73
    • 1842484230 scopus 로고    scopus 로고
    • The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate
    • Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med. Chem 2004;11:1009-1021
    • (2004) Curr Med. Chem , vol.11 , pp. 1009-1021
    • Bradshaw, T.D.1    Westwell, A.D.2
  • 74
    • 0031981201 scopus 로고    scopus 로고
    • Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir: 1. Interactions with peptides, organic anions and organic cations in rats
    • Sinko PJ, Balimane PV. Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir: 1. Interactions with peptides, organic anions and organic cations in rats. Biopharm Drug Dispos 1998;19(4):209-217
    • (1998) Biopharm Drug Dispos , vol.19 , Issue.4 , pp. 209-217
    • Sinko, P.J.1    Balimane, P.V.2
  • 75
    • 22944459555 scopus 로고    scopus 로고
    • Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-Dribofuranosyl) benzimidazole enhance metabolic stability in vitro and in vivo
    • Lorenzi PL, Landowski CP, Song X, et al. Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-Dribofuranosyl) benzimidazole enhance metabolic stability in vitro and in vivo. J Pharmacol Exp Ther 2005;314:883-890
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 883-890
    • Lorenzi, P.L.1    Landowski, C.P.2    Song, X.3
  • 76
  • 77
    • 0029036955 scopus 로고
    • The search for synergy: A critical review from a response surface perspective
    • Greco WR, Bravo G, Parsons JC. The search for synergy: a critical review from a response surface perspective. Pharmacol Rev 1995;47:331-385
    • (1995) Pharmacol Rev , vol.47 , pp. 331-385
    • Greco, W.R.1    Bravo, G.2    Parsons, J.C.3
  • 78
    • 9744254768 scopus 로고    scopus 로고
    • Evaluation of combination chemotherapy: Integration of nonlinear regression, curve shift, isobologram, and combination index analyses
    • Zhao L, Wientjes MG, Au JL. Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses. Clin Cancer Res 2004;10:7994-8004
    • (2004) Clin Cancer Res , vol.10 , pp. 7994-8004
    • Zhao, L.1    Wientjes, M.G.2    Au, J.L.3
  • 79
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 2006;58:621
    • (2006) Pharmacol Rev , vol.58 , pp. 621
    • Chou, T.C.1
  • 80
    • 0021321680 scopus 로고
    • Pharmacokinetics of estramustine phosphate (Estracyt®) in prostatic cancer patients
    • Gunnarsson P, Andersson SB, Johansson SÅ, et al. Pharmacokinetics of estramustine phosphate (Estracyt®) in prostatic cancer patients. Eur J Clin Pharmacol 1984;26(1):113-119
    • (1984) Eur J Clin Pharmacol , vol.26 , Issue.1 , pp. 113-119
    • Gunnarsson, P.1    Andersson, S.B.2    Johansson, S.Å.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.