Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4] benzodiazepine and indole conjugates as anticancer agents

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1442-1449

  Wang, Jeh Jeng ^a   Shen, Yu Kai ^a   Hu, Wan Ping ^a   Hsieh, Ming Chu ^a   Lin, Fu Lung ^a   Hsu, Ming Kuan ^a   Hsu, Mei Hui ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 2 INDOLECARBOXYLIC ACID; 8 (1H 2 INDOLECARBONYLOXY) 7 METHOXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 8 [3 (1H 2 INDOLYLCARBOXAMIDO)]BUTOXYL 7 METHOXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 8 [3 (1H 2 INDOLYLCARBOXAMIDO)]HEXOXYL 7 METHOXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 8 [3 (1H 2 INDOLYLCARBOXAMIDO)]PENTOXYL 7 METHOXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 8 [3 (1H 2 INDOLYLCARBOXAMIDO)]PROPOXYL 7 METHOXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; INDOLE DERIVATIVE; LIPOCORTIN 5; PROPIDIUM IODIDE; PYRROLO[2,1 C]BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HT29; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZODIAZEPINES; CELL CYCLE; CELL LINE, TUMOR; DNA; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MELANOMA; MEMBRANE POTENTIALS; MITOCHONDRIAL MEMBRANES; MODELS, MOLECULAR; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33144473207     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050956q     Document Type: Article

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